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    STABILIZED CHEMICAL DEHYDRATION OF BIOLOGICAL MATERIAL
    1.
    发明申请
    STABILIZED CHEMICAL DEHYDRATION OF BIOLOGICAL MATERIAL 审中-公开
    稳定化学生物材料的脱盐

    公开(公告)号：US20120100522A1

    公开(公告)日：2012-04-26

    申请号：US13081436

    申请日：2011-04-06

    申请人： Michael Saghbini ,  Michael Hogan ,  Chunnian Shi ,  Brian Dalby ,  David Wong

    发明人： Michael Saghbini ,  Michael Hogan ,  Chunnian Shi ,  Brian Dalby ,  David Wong

    IPC分类号： C12N5/078 ,  C12N1/20 ,  C12N5/071 ,  C12N7/00 ,  C12N1/00 ,  C09K3/00 ,  C12N1/14

    CPC分类号： C12Q1/6806 ,  A01N1/021 ,  C07K17/02 ,  C12N1/04 ,  C12N9/96 ,  G01N33/54313

    摘要： The present invention provides compositions and methods that enable the stabilization and storage of samples by contacting a sample with an assembly of particles, and reducing the water activity level of the contacted sample. By reducing the water activity level of the sample, the assembly of particles minimizes the degradation of the sample. Stabilizers may or may not be added to the assembly of particles to further minimize the degradation of the sample. Subsequently to storage in the assembly of particles, the samples are recoverable by eluting the assembly of particles with a fluid solution. In one embodiment, the entire assembly of particles will dissolve into the solution. In another embodiment, only part of the assembly of particles will dissolve into the solution. The assembly of particles provides the advantage that while it is porous, it comprises non-porous particulate material.

    摘要翻译： 本发明提供了通过使样品与颗粒组合接触并降低接触样品的水活度水平来使样品稳定和储存的组合物和方法。 通过降低样品的水分活度水平，颗粒的组装使样品的降解最小化。 稳定剂可以或可以不被添加到颗粒组合中以进一步使样品的降解最小化。 随后存储在颗粒的组装中，可以通过用流体溶液洗脱颗粒的组合来回收样品。 在一个实施例中，颗粒的整个组件将溶解到溶液中。 在另一个实施方案中，只有部分颗粒组合将溶解到溶液中。 颗粒的组合提供了这样的优点：当它是多孔的时，其包括无孔颗粒材料。

    Biosample storage devices and methods of use thereof
    6.
    发明申请
    Biosample storage devices and methods of use thereof 审中-公开
    生物样品储存装置及其使用方法

    公开(公告)号：US20100209957A1

    公开(公告)日：2010-08-19

    申请号：US12489400

    申请日：2009-06-22

    申请人： Michael Hogan ,  Ferdinand Stupka ,  David Wong

    发明人： Michael Hogan ,  Ferdinand Stupka ,  David Wong

    IPC分类号： C12Q1/02 ,  G01N1/28 ,  B01L3/00 ,  B01L9/00 ,  C12M1/00 ,  G01N1/00

    CPC分类号： G01N1/28 ,  A61B10/0096 ,  B01L3/508 ,  B01L9/00 ,  B01L2200/0689 ,  B01L2200/185 ,  B01L2300/069 ,  B01L2300/123 ,  Y10T436/25

    摘要： The present invention provides sample collection, shipping, and storage devices and methods of using the same. These devices and methods are useful, for example, for collecting, shipping, and storing biological samples, such as blood, serum, buccal samples, tissue homogenates, or cell lysates in a dry state. The devices and methods facilitate the rapid drying of biological samples collected on the devices, thereby improving the quality of the stored sample, particularly the protein and small molecule components of the stored sample. The present invention further provides methods of recovering biological samples from such devices.

    摘要翻译： 本发明提供样品收集，运输和存储装置及其使用方法。 这些装置和方法例如用于在干燥状态下收集，运输和储存生物样品，例如血液，血清，颊样品，组织匀浆或细胞裂解物。 这些装置和方法促进了在装置上收集的生物样品的快速干燥，从而提高储存的样品，特别是储存样品的蛋白质和小分子组分的质量。 本发明还提供从这些装置回收生物样品的方法。

    Low-ductility turbine shroud flowpath and mounting arrangement therefor
    7.
    发明授权
    Low-ductility turbine shroud flowpath and mounting arrangement therefor 有权
    低延性涡轮机罩流路及其安装布置

    公开(公告)号：US08926270B2

    公开(公告)日：2015-01-06

    申请号：US12971893

    申请日：2010-12-17

    申请人： Apostolos Pavlos Karafillis ,  William Hasting ,  Michael Hogan

    发明人： Apostolos Pavlos Karafillis ,  William Hasting ,  Michael Hogan

    IPC分类号： F01D25/28 ,  F01D9/02 ,  F01D11/08

    CPC分类号： F01D9/02 ,  F01D11/08 ,  F01D25/246 ,  F05D2250/75 ,  F05D2260/38 ,  F05D2300/518 ,  F05D2300/6033

    摘要： A turbine flowpath apparatus is provided for a gas turbine engine having a centerline axis. The apparatus includes: an annular flowpath member of low-ductility material, the flowpath member having a flowpath surface and an opposed back surface, and having a cross-sectional shape comprising a generally cylindrical forward section and an aft section that extends aft and radially outward at a non-perpendicular, non-parallel angle to the centerline axis; an annular stationary structure surrounding the flowpath member; and an annular centering spring disposed between the stationary structure and the flowpath member, the centering spring urging the flowpath member towards a centered position within the stationary structure.

    摘要翻译： 为具有中心线轴线的燃气涡轮发动机提供涡轮流路装置。 该装置包括：低延性材料的环形流路构件，流路构件具有流路表面和相对的后表面，并且具有横截面形状，该横截面形状包括大致圆柱形的前部和在尾部和径向向外延伸的后部 与中心线轴线成非垂直非平行角; 围绕流路构件的环形固定结构; 以及设置在所述固定结构和所述流路构件之间的环形定心弹簧，所述定心弹簧将所述流路构件推向所述固定结构内的居中位置。

    Gas-enhanced surgical instrument
    8.
    发明授权
    Gas-enhanced surgical instrument 有权
    气体增强手术器械

    公开(公告)号：US08226644B2

    公开(公告)日：2012-07-24

    申请号：US12503738

    申请日：2009-07-15

    申请人： Joe D. Sartor ,  Michael Hogan ,  Gene H. Arts ,  Ronald J. Podhajsky ,  Arlan J. Reschke

    发明人： Joe D. Sartor ,  Michael Hogan ,  Gene H. Arts ,  Ronald J. Podhajsky ,  Arlan J. Reschke

    IPC分类号： A61B18/14

    CPC分类号： A61B18/042

    摘要： A gas-enhanced electrosurgical instrument includes a hand-held applicator and a portable actuator assembly. The hand-held applicator has a gas delivery member adapted to deliver pressurized ionizable gas to the proximity of an electrode located adjacent a distal end of the applicator. The portable actuator assembly is capable of holding a source of pressurized ionizable gas, such as a cylinder or cartridge, and includes at least one controller to control the delivery of the gas from the source to the hand-held applicator and to control the delivery of electrosurgical energy to the hand-held applicator.

    摘要翻译： 气体增强型电外科器械包括手持式敷贴器和便携式致动器组件。 手持施加器具有适于将加压的可离子化气体输送到位于邻近施用器的远端的电极附近的气体输送构件。 便携式致动器组件能够保持加压的可电离气体源，例如气缸或筒，并且包括至少一个控制器，用于控制气体从源到手持式施放器的输送，并且控制输送 电手术能量到手持式敷贴器。

    Software development
    9.
    发明授权
    Software development 有权
    软件开发

    公开(公告)号：US08051404B2

    公开(公告)日：2011-11-01

    申请号：US10415466

    申请日：2001-10-26

    申请人： Fergal McGovern ,  Martin Chapman ,  Garrett Conaty ,  Philip Head ,  Michael Hogan

    发明人： Fergal McGovern ,  Martin Chapman ,  Garrett Conaty ,  Philip Head ,  Michael Hogan

    IPC分类号： G06F9/44

    CPC分类号： G06F8/10

    摘要： A method of developing software capable of performing a task, the task comprising at least one task step required to perform the task. The task step has a resultant effect. The method comprises recording a use case comprising one or more scenarios, that comprise one of more further steps; recording the scenario or one of the scenarios as a main success scenarios such that the resultant effect of the main success scenario is the same as the resultant effect of the task step. Use cases which have been stripped of context-specific information may be re-used. Such information may be included in a reference to the re-used use case.

    摘要翻译： 一种开发能够执行任务的软件的方法，所述任务包括执行任务所需的至少一个任务步骤。 任务步骤具有结果效果。 该方法包括记录包括一个或多个情景的用例，其包括更进一步的步骤之一; 将场景或场景之一记录为主要成功场景，使得主要成功场景的最终效果与任务步骤的最终效果相同。 可能会重新使用已被剥离上下文相关信息的用例。 这样的信息可以被包括在对重用的用例的引用中。

    PRODUCTS AND METHODS FOR TISSUE PRESERVATION
    10.
    发明申请
    PRODUCTS AND METHODS FOR TISSUE PRESERVATION 审中-公开
    用于组织保存的产品和方法

    公开(公告)号：US20110256530A1

    公开(公告)日：2011-10-20

    申请号：US13085302

    申请日：2011-04-12

    申请人： Michael Hogan

    发明人： Michael Hogan

    IPC分类号： C12Q1/68 ,  C07H21/00 ,  G01N1/28

    CPC分类号： G01N1/30

    摘要： The present application relates to methods for increasing stability of formalin fixed, optionally paraffin embedded biological material. In one example, DNAse inhibitors and/or RNAse inhibitors are combined with the biological material or formalin at the time of fixation or shortly prior.

    摘要翻译： 本申请涉及增加福尔马林固定，任选石蜡包埋的生物材料的稳定性的方法。 在一个实例中，DNAse抑制剂和/或RNA酶抑制剂在固定时或不久之前与生物材料或福尔马林组合。