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1.发明申请MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE AND DIFFERENTIATION 审中-公开具有促进内皮细胞粘附和分化的涂层的医疗装置公开(公告)号：US20130172988A1
公开(公告)日：2013-07-04
申请号：US13632611
申请日：2012-10-01
CPC分类号： A61L31/16 , A61L27/08 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/084 , A61L31/088 , A61L31/10 , A61L31/125 , A61L2300/258 , A61L2300/45 , B82Y30/00
摘要： Compositions and methods are provided for producing a medical device such as a stent, a stent graft, a synthetic vascular graft, heart valves, coated with a biocompatible matrix which incorporates antibodies, antibody fragments, or small molecules, which recognize, bind to and/or interact with a progenitor cell surface antigen to immobilize the cells at the surface of the device. The coating on the device can also contain a compound or growth factor for promoting the progenitor endothelial cell to accelerate adherence, growth and differentiation of the bound cells into mature and functional endothelial cells on the surface of the device to prevent intimal hyperplasia. Methods for preparing such medical devices, compositions, and methods for treating a mammal with vascular disease such as restenosis, artherosclerosis or other types of vessel obstructions are disclosed.
摘要翻译： 提供组合物和方法用于生产诸如支架，支架移植物，合成血管移植物，心脏瓣膜的医疗装置，其包被生物相容性基质，其包含抗体，抗体片段或小分子，其识别，结合和/ 或与祖细胞表面抗原相互作用以将细胞固定在装置的表面。 器件上的涂层还可以含有用于促进祖细胞内皮细胞的化合物或生长因子，以加速结合细胞在装置表面上的成熟和功能性内皮细胞的粘附，生长和分化，以防止内膜增生。 公开了制备用于治疗诸如再狭窄，动脉粥样硬化或其它类型的血管障碍的血管疾病的哺乳动物的医疗装置，组合物和方法的方法。
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2.发明授权Medical device with coating for capturing genetically-altered cells and methods for using same 有权具有用于捕获遗传改变的细胞的包衣的医疗装置及其使用方法公开(公告)号：US09522217B2
公开(公告)日：2016-12-20
申请号：US10835767
申请日：2004-04-30
IPC分类号： A01N63/00 , C12N5/071 , C12N15/00 , A61F2/04 , A61L27/08 , A61L27/30 , A61L27/44 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/12 , A61L31/16 , B82Y30/00
CPC分类号： A61L27/08 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/084 , A61L31/10 , A61L31/125 , A61L31/16 , A61L2300/258 , A61L2300/45 , B82Y30/00
摘要： Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and a therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
摘要翻译： 治疗和药物递送系统以医疗装置的形式提供，其具有用于在体内捕获和固定靶细胞如循环祖细胞或遗传改变的哺乳动物细胞的包衣。 遗传改变的细胞用组成型或受控方式表达标记基因和治疗基因的遗传物质转染。 标记基因是血流中循环细胞中未发现的细胞膜抗原，治疗基因编码用于治疗疾病如血管疾病和癌症的肽。 医疗装置上的涂层可以是生物相容性基质，其包含识别和结合靶细胞的至少一种类型的配体，例如抗体，抗体片段，其他肽和小分子。 治疗和/或药物递送系统可以具有信号源，例如用于刺激修饰的细胞以表达和分泌所需标记物和治疗基因产物的活化剂分子。
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公开(公告)号：US09072723B2
公开(公告)日：2015-07-07
申请号：US13589907
申请日：2012-08-20
IPC分类号： A61F2/06 , A61K38/39 , A61L27/08 , A61L27/22 , A61L27/30 , A61L27/44 , A61L27/54 , A61L29/10 , A61L29/12 , A61L29/16 , A61L31/04 , A61L31/08 , A61L31/12 , A61L31/16 , C12N5/071 , A61K38/36 , A61K39/395 , C07K16/28 , B82Y30/00
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.
摘要翻译： 本发明涉及一种通过在具有内腔和内腔表面以及外表面的可植入金属支架上体内融合内皮自体细胞层的形成来治愈血管的方法。 更具体地，该方法包括在需要其的患者体内植入具有涂层的支架; 其中所述涂层包括一层或多层共价粘附在所述支架的所述管腔和外表面上的基质，其在所述外表面上含有一种或多种药物物质，治疗有效量的单一类型抗体，抗体片段或其组合为 与外周血中循环的自体内皮祖细胞的特异性细胞表面抗原有选择性结合。 此外，遗传工程化的内皮祖细胞可以在体内在支架的所述腔表面上捕获，以增殖以迅速形成原位融合的内皮。
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4.发明授权公开(公告)号：US09364565B2
公开(公告)日：2016-06-14
申请号：US11119291
申请日：2005-04-29
IPC分类号： A61F2/06 , A61F2/82 , A61K48/00 , C12N15/87 , A61K47/48 , A61L27/30 , A61L27/34 , A61L27/38 , A61L27/54 , A61L29/08 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/10 , A61L31/16 , C12N5/071 , A61K35/12
CPC分类号： A61K47/48992 , A61K35/12 , A61K47/6957 , A61K48/005 , A61L27/303 , A61L27/34 , A61L27/3808 , A61L27/54 , A61L29/085 , A61L29/103 , A61L29/16 , A61L31/084 , A61L31/10 , A61L31/16 , A61L2300/258 , A61L2300/416 , A61L2300/64 , C12N5/0692 , C12N2510/00
摘要： Therapeutic and drug delivery systems are provided in the form of medical devices with coatings for capturing and immobilizing target cells such as circulating progenitor or genetically-altered mammalian cells in vivo. The genetically-altered cells are transfected with genetic material for expressing a marker gene and at least one therapeutic gene in a constitutively or controlled manner. The marker gene is a cell membrane antigen not found in circulating cells in the blood stream and therapeutic gene encodes a peptide for the treatment of disease, such as, vascular disease and cancer. The coating on the medical device may be a biocompatible matrix comprising at least one type of ligand, such as antibodies, antibody fragments, other peptides and small molecules, which recognize and bind the target cells. The therapeutic and/or drug delivery systems may be provided with a signal source such as activator molecules for stimulating the modified cells to express and secrete the desired marker and therapeutic gene products.
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5.发明授权Progenitor endothelial cell capturing with a drug eluting implantable medical device 有权用药物洗脱可植入医疗器械的祖细胞内皮细胞捕获公开(公告)号：US08460367B2
公开(公告)日：2013-06-11
申请号：US11560352
申请日：2006-11-15
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/91 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/082 , A61L31/10 , A61L31/12 , A61L31/121 , A61L2300/256 , C12N5/0692 , C12N2510/00
摘要： A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.
摘要翻译： 提供用于植入体内血管或腔内结构的医疗装置，其刺激正血管重塑。 诸如支架和合成移植物之类的医疗装置涂覆有由控释基质和一种或多种用于将药物直接递送到周围组织的药物物质组成的药物组合物。 医疗装置上的涂层还包含配体，例如肽，抗体或小分子，用于在装置的血液接触表面中捕获祖细胞内皮细胞，用于在损伤部位恢复内皮。 特别地，药物涂层的支架用于例如用于预防或抑制再狭窄的球囊血管成形术程序。
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公开(公告)号：US5882335A
公开(公告)日：1999-03-16
申请号：US608850
申请日：1996-02-29
CPC分类号： A61F2/958 , A61F2/88 , A61F2/885 , A61F2250/0067 , A61F2250/0068
摘要： The drug delivery stent assembly includes a hollow tubular wire stent which extends in a path defining a generally cylindrical envelope and which has side walls facing outwardly of the cylindrical envelope with holes therein for delivery of liquid to a site in a vessel where the stent is placed. The method for delivering a liquid solution to the interior wall surface of a vessel using the hollow tubular wire stent comprises: placing the stent on a balloon of a balloon on a wire guidewire or on a balloon catheter; inserting the stent on the balloon assembly at a desired site in a vessel; causing the balloon to expand the stent to a larger cylindrical shape; supplying liquid with a liquid supply source to the stent prior to or after placement of the stent so that liquid can be delivered from the outer holes in the stent to the site of placement of the stent in a vessel; disengaging the liquid supply source from the stent prior to or after placement of the stent in a vessel; and allowing the liquid solution to leak from the stent through the outwardly facing holes in the stent.
摘要翻译： 药物递送支架组件包括中空管状线支架，其以限定大致圆柱形外壳的路径延伸，并且其侧壁面向圆柱形外壳的外侧，其中具有孔，用于将液体输送到放置支架的容器中的位置 。 使用中空管状钢丝支架将液体溶液输送到血管内壁表面的方法包括：将支架放置在气球导管或球囊导管上的球囊上; 将所述支架插入所述球囊组件的容器中的所需位置; 使气囊将支架膨胀成更大的圆柱形状; 在放置支架之前或之后将液体供应液体供应到支架，使得液体可以从支架的外孔输送到支架放置在容器中的位置; 在支架放置在容器中之前或之后将液体供应源与支架分离; 并且允许液体溶液从支架通过支架中向外的孔泄漏。
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公开(公告)号：US5505700A
公开(公告)日：1996-04-09
申请号：US259534
申请日：1994-06-14
申请人： James E. Leone , Stephen M. Rowland
发明人： James E. Leone , Stephen M. Rowland
CPC分类号： A61M25/1011 , A61F2/958 , A61M25/10 , A61N1/30 , A61M2025/105 , A61M2025/1052 , A61M2025/1065 , A61M25/00
摘要： An infusion catheter is provided for delivering treatment fluids including medicaments, drugs, pharmaceuticals, cancer treatment agents and the like directly to a location within a living body such as within a vessel or body cavity. Electro-osmotic infusion is carried out by iontophoretic and/or iontohydrokinesis procedures. The infusion catheter includes both an internal electrode and an integral electrode, both of which are components of or closely associated with a distal portion of the catheter itself. When electrically joined to an EMF source, the electrodes are oppositely charged. The treatment fluid or components of the treatment fluid have an electrical charge which is the same as the internal electrode, as a result of which the medicament moves away from the internal electrode and to the body component being treated.
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公开(公告)号：US5588961A
公开(公告)日：1996-12-31
申请号：US582328
申请日：1996-01-05
申请人： James E. Leone , Stephen M. Rowland
发明人： James E. Leone , Stephen M. Rowland
CPC分类号： A61M25/1011 , A61F2/958 , A61M25/10 , A61N1/30 , A61M2025/105 , A61M2025/1052 , A61M2025/1065 , A61M25/00
摘要： An infusion catheter is provided for delivering treatment fluids including medicaments, drugs, pharmaceuticals, cancer treatment agents and the like directly to a location within a living body such as within a vessel or body cavity. Electro-osmotic infusion is carried out by iontophoretic and/or iontohydrokinesis procedures. The infusion catheter includes both an internal electrode and an integral electrode, both of which are components of or closely associated with a distal portion of the catheter itself. When electrically joined to an EMF source, the electrodes are oppositely charged. The treatment fluid or components of the treatment fluid have an electrical charge which is the same as the internal electrode, as a result of which the medicament moves away from the internal electrode and to the body component being treated.
摘要翻译： 提供输液导管，用于将包括药物，药物，药物，癌症治疗剂等的治疗流体直接输送到诸如容器或体腔内的活体内的位置。 电离渗透是通过离子电渗和/或离子动力学过程进行的。 输注导管包括内部电极和整体电极，两者都是导管本身的远端部分或紧密相关的部件。 当电连接到EMF源时，电极相反地带电。 处理流体或处理流体的组分具有与内部电极相同的电荷，其结果是药物从内部电极移动到被处理的身体部件。
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公开(公告)号：US5041100A
公开(公告)日：1991-08-20
申请号：US345102
申请日：1989-04-28
CPC分类号： A61M25/0045 , A61L29/085 , A61L29/16 , A61L2300/606
摘要： A friction-reducing coating may be applied to a base material, for example the outer surface of a catheter, to provide a significant reduction in catheter friction, particularly when the friction-reducing coating is hydrated. The coating comprises an intimate mixture of a structural plastic material, for example polyurethane, and high molecular weight poly(ethylene oxide).
摘要翻译： 减少摩擦的涂层可以施加到基底材料，例如导管的外表面上，以提供显着降低的导管摩擦，特别是当摩擦减小涂层水合时。 涂层包括结构塑料材料（例如聚氨酯）和高分子量聚（环氧乙烷）的紧密混合物。
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10.发明授权Method for delivering a liquid solution to the interior wall surface of a vessel 失效将液体溶液输送到容器的内壁表面的方法
公开(公告)号：US5902266A
公开(公告)日：1999-05-11
申请号：US87873
申请日：1998-06-01
CPC分类号： A61F2/958 , A61F2/88 , A61F2/885 , A61F2250/0067 , A61F2250/0068
摘要： The drug delivery stent assembly includes a hollow tubular wire stent which extends in a path defining a generally cylindrical envelope and which has side walls facing outwardly of the cylindrical envelope with holes therein for delivery of liquid to a site in a vessel where the stent is placed. The method for delivering a liquid solution to the interior wall surface of a vessel using the hollow tubular wire stent comprises: placing the stent on a balloon of a balloon on a wire guidewire or on a balloon catheter; inserting the stent on the balloon assembly at a desired site in a vessel; causing the balloon to expand the stent to a larger cylindrical shape; supplying liquid with a liquid supply source to the stent prior to or after placement of the stent so that liquid can be delivered from the outer holes in the stent to the site of placement of the stent in a vessel; disengaging the liquid supply source from the stent prior to or after placement of the stent in a vessel; and allowing the liquid solution to leak from the stent through the outwardly facing holes in the stent.
摘要翻译： 药物递送支架组件包括中空管状线支架，其以限定大致圆柱形外壳的路径延伸，并且其侧壁面向圆柱形外壳的外侧，其中具有孔，用于将液体输送到放置支架的容器中的位置 。 使用中空管状钢丝支架将液体溶液输送到血管内壁表面的方法包括：将支架放置在气球导管或球囊导管上的球囊上; 将所述支架插入所述球囊组件的容器中的所需位置; 使气囊将支架膨胀成更大的圆柱形状; 在放置支架之前或之后将液体供应液体供应到支架，使得液体可以从支架的外孔输送到支架放置在容器中的位置; 在支架放置在容器中之前或之后将液体供应源与支架分离; 并且允许液体溶液从支架通过支架中向外的孔泄漏。
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