公开(公告)号：US20050089426A1

公开(公告)日：2005-04-28

申请号：US10945990

申请日：2004-09-22

申请人： Michael Kurz ,  Joachim Boltz

发明人： Michael Kurz ,  Joachim Boltz

IPC分类号： F02M45/08 ,  F02M47/02 ,  F02M63/02 ,  F04B7/04 ,  F04B39/10

CPC分类号： F02M47/027 ,  F02M45/086 ,  F02M63/0225 ,  F02M2200/46

摘要： An injection nozzle for an internal combustion engine, having a first nozzle needle for controlling the fuel injection through a first injection port, a second nozzle needle for controlling the fuel injection through a second injection port, a first control chamber in which a first control face drive-coupled to the second nozzle needle for introducing closing forces is disposed, and a control line for controlling the pressure in the first control chamber. Especially exact instants of the end of injection can be attained if in the first control chamber, a second control face is disposed that is drive-coupled to the first nozzle needle; a first coupling path connects the first control chamber directly or indirectly to a pressure source; a second coupling path connects the first control chamber directly or indirectly to the pressure source; and the second coupling path is controlled as a function of the stroke of the first nozzle needle such that it is blocked beyond a prestroke of the first nozzle needle.

摘要翻译： 一种用于内燃机的喷嘴，具有用于控制通过第一喷射口的燃料喷射的第一喷嘴针，用于控制通过第二喷射口的燃料喷射的第二喷嘴针，第一控制面， 设置有驱动联接到第二喷嘴针以引导关闭力的控制线，以及用于控制第一控制室中的压力的​​控制线。 如果在第一控制室中设置驱动联接到第一喷嘴针的第二控制面，则可以获得注射结束的特别精确的时刻。 第一联接路径将第一控制室直接或间接地连接到压力源; 第二联接路径将第一控制室直接或间接地连接到压力源; 并且第二联接路径被控制为第一喷嘴针的行程的函数，使得其被阻挡超过第一喷嘴针的前冲程。

公开(公告)号：US08875241B2

公开(公告)日：2014-10-28

申请号：US10552288

申请日：2004-03-25

申请人： Andreas Winter ,  Michael Kurz

发明人： Andreas Winter ,  Michael Kurz

IPC分类号： G06F17/30 ,  G11B20/00 ,  G06F21/10

CPC分类号： G06F21/10 ,  G06F2221/0744 ,  G06F2221/2153 ,  G11B20/00086 ,  G11B20/00173 ,  G11B20/00202 ,  G11B20/00659 ,  G11B20/00688 ,  G11B20/00695 ,  G11B20/00884 ,  G11B20/00927

摘要： A method to protect content within protected data areas on a target optical record carrier against unauthorized reading and/or copying with a computer, comprises the steps of—determining whether a target optical record carrier or a non-target optical record carrier is inserted into a drive of the computer, and—in case a target optical record carrier is inserted into the drive of the computer—modifying read requests to the protected data areas so that no data is read or the read data is useless, and/or—modifying write commands in respect to the data within the protected data areas to a recordable record carrier or other storage so that the written data is useless.

摘要翻译： 一种用于保护目标光学记录载体上的受保护数据区域内的内容以防止未经授权的读取和/或与计算机复制的方法包括以下步骤：确定目标光学记录载体或非目标光学记录载体是否被插入到 并且在目标光学记录载体被插入计算机修改读取请求的驱动器到受保护数据区域的情况下，使得没有数据被读取或读取数据是无用的，和/或修改写入 关于受保护数据区域内的数据到可记录记录载体或其他存储器的命令，使得写入的数据是无用的。

公开(公告)号：US07153846B2

公开(公告)日：2006-12-26

申请号：US10971228

申请日：2004-10-22

申请人： Holger Hoffmann ,  Sabine Haag-Richter ,  Michael Kurz ,  Heiko Tietgen

发明人： Holger Hoffmann ,  Sabine Haag-Richter ,  Michael Kurz ,  Heiko Tietgen

IPC分类号： C07D223/12 ,  A61K31/55 ,  A61P35/00

CPC分类号： C12R1/01 ,  C07D223/12 ,  C12P17/10

摘要： The present invention relates to bengamide derivatives which are formed, during fermentation, by the microorganism Myxococcus virescens ST200611 (DSM 15898), to their use for treating cancer diseases, to pharmaceuticals which comprise bengamide derivatives, to a process for preparing bengamides of the formula (V) and to the microorganism Myxococcus virescens ST200611 (DSM 15898)

摘要翻译： 本发明涉及在发酵期间由微生物粘球菌ST200611（DSM15898）在治疗癌症疾病中用于治疗癌症疾病的孟加拉酰胺衍生物，涉及制备式（b）的班格酰胺的方法， V）和微生物粘液菌（Myxococcus virescens）ST200611（DSM 15898）

公开(公告)号：US07148254B2

公开(公告)日：2006-12-12

申请号：US10972546

申请日：2004-10-25

申请人： Laszlo Vertesy ,  Michael Kurz ,  Astrid Markus-Erb ,  Luigi Toti

发明人： Laszlo Vertesy ,  Michael Kurz ,  Astrid Markus-Erb ,  Luigi Toti

IPC分类号： A61K31/34 ,  C07D307/86 ,  C12P17/04 ,  C12N1/18

CPC分类号： C12R1/66 ,  C07D307/86 ,  C12P17/04

摘要： The present invention relates to 2-phenylbenzofurans of formula (I) which are formed, during fermentation, by the microorganism Aspergillus flavipes ST003878 (DSM 15290), to a process for preparing them and to their use as pharmaceuticals for the treatment and/or prophylaxis of bacterial infectious diseases or mycoses.

摘要翻译： 本发明涉及式（I）的2-苯基苯并呋喃，其在发酵过程中由微生物黄曲霉ST003878（DSM15290）制成，涉及其制备方法及其作为药物用于治疗和/或预防的用途 的细菌感染性疾病或真菌病。

公开(公告)号：US07067112B2

公开(公告)日：2006-06-27

申请号：US10411144

申请日：2003-04-11

申请人： Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

发明人： Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

IPC分类号： A61K49/00 ,  A61K38/10 ,  C07K7/08

CPC分类号： C07K7/08 ,  A61K38/00

摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R   (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser,   (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.

摘要翻译： 本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

公开(公告)号：US06994280B2

公开(公告)日：2006-02-07

申请号：US10296705

申请日：2002-03-22

申请人： Michael Kurz ,  Gerd Wahr

发明人： Michael Kurz ,  Gerd Wahr

IPC分类号： F02M59/00 ,  F02M61/00 ,  F02M63/00 ,  F02M47/02 ,  B05B1/00

CPC分类号： F02M61/168 ,  F02M61/16

摘要： A fuel injector for internal combustion engines, includes a base body, an injection housing and a fastening device. The fastening device includes at least one lock nut with an annular land and an annular shoulder on the injection housing. By means of the fastening device, the injection housing is braced axially against the base body. A fuel inlet and at least one valve element are also provided. To improve the seal between the base body and the injection housing, the fastening device has at least one annular face which is oriented toward the annular land of the lock nut and is curved convexly in the manner of a spherical-segmental face.

摘要翻译： 一种用于内燃机的燃料喷射器，包括基体，注射壳体和紧固装置。 紧固装置包括至少一个具有环形接合面的锁紧螺母和注射壳体上的环形肩部。 通过紧固装置，注射壳体轴向地支撑在基体上。 还提供燃料入口和至少一个阀元件。 为了改善基体和注射壳体之间的密封，紧固装置具有至少一个朝向锁定螺母的环形平台的环形面，并且以球形节面的方式凸出地弯曲。

公开(公告)号：US06624143B1

公开(公告)日：2003-09-23

申请号：US09623022

申请日：2000-08-25

申请人： Laszló Vértesy ,  Werner Aretz ,  Heinrich Decker ,  Eberhard Ehlers ,  Michael Kurz ,  Frank Rainer Schmidt

发明人： Laszló Vértesy ,  Werner Aretz ,  Heinrich Decker ,  Eberhard Ehlers ,  Michael Kurz ,  Frank Rainer Schmidt

IPC分类号： A61K3800

CPC分类号： C12R1/045 ,  A61K38/00 ,  C07K7/56

摘要： The invention relates to a calcium salt of the compound of formula (II), where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.

摘要翻译： 本发明涉及式（II）化合物的钙盐，其中R 1是具有8至22个碳原子的直链或支链，饱和或不饱和的脂族酰基，其可任选地被一个或多个 更多的苯基或环烷基并且任选被氧中断。 本发明还涉及一种生产所述钙盐和用作药物的方法。

公开(公告)号：US06582949B1

公开(公告)日：2003-06-24

申请号：US09563505

申请日：2000-05-03

申请人： László Vértesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

发明人： László Vértesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

IPC分类号： C07K708

CPC分类号： C07K7/08 ,  A61K38/00

摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R  (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are va; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser  (II), wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.

摘要翻译： 本发明涉及式Iin化合物，其中R为Phe-ol或Phe-al，w，x，y和z具有以下含义：a）w为Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是va; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 矿石）w是Gly; x和y是Aib，z是Iva;或者其中X是Hyp或Pro的式II，其在发酵过程中被Acremonium tubakii FH 1685 DSM 12774合成并释放到培养基中，从头孢曲松 培养基和它们的纯化，以及将头孢吡肟作为药理学活性化合物的用途，特别是用于控制寄生虫。

公开(公告)号：US09226166B2

公开(公告)日：2015-12-29

申请号：US13810217

申请日：2011-07-07

申请人： Michael Kurz

发明人： Michael Kurz

IPC分类号： H04W24/00 ,  H04W4/02 ,  G01S5/02 ,  H04L29/08 ,  H04W24/10 ,  H04W48/08 ,  H04W64/00 ,  H04W84/18

CPC分类号： H04W24/00 ,  G01S5/0289 ,  H04L67/18 ,  H04L67/303 ,  H04W4/02 ,  H04W24/10 ,  H04W48/08 ,  H04W64/00 ,  H04W84/18

摘要： A method for locating mobile devices in a mobile radio network having first, second, and third mobile devices in first, second, and third locations, includes: transmitting a pilot signal to the second mobile device; measuring a signal strength of the pilot signal; transmitting information related to the signal strength of the pilot signal to the first mobile device; determining the second location relative to the first location based on the information related to the signal strength; transmitting a further pilot signal to the third mobile device; measuring a further signal strength of the further pilot signal; transmitting further information related to the further signal strength to the second mobile device; determining the third location relative to the second location based on the further information related to the further signal strength; and transmitting information related to the third location to the first mobile device.

摘要翻译： 一种用于在第一，第二和第三位置具有第一，第二和第三移动设备的移动无线电网络中定位移动设备的方法包括：向第二移动设备发送导频信号; 测量导频信号的信号强度; 将与导频信号的信号强度有关的信息发送给第一移动设备; 基于与信号强度相关的信息确定相对于第一位置的第二位置; 向所述第三移动设备发送另外的导频信号; 测量另外的导频信号的另外的信号强度; 向所述第二移动设备发送与所述另外的信号强度有关的进一步信息; 基于与所述另外的信号强度有关的进一步信息来确定相对于所述第二位置的所述第三位置; 以及将与所述第三位置相关的信息发送到所述第一移动设备。

公开(公告)号：US08765799B2

公开(公告)日：2014-07-01

申请号：US13056751

申请日：2009-07-16

申请人： Cosima Dufour-Schroif ,  Joachim Wink ,  Martin Gerlitz ,  Hélène Olivan ,  Michael Kurz

发明人： Cosima Dufour-Schroif ,  Joachim Wink ,  Martin Gerlitz ,  Hélène Olivan ,  Michael Kurz

IPC分类号： A61K31/407 ,  C07D491/107 ,  C07D498/10

CPC分类号： C07D498/10 ,  C07D491/107

摘要： The invention relates to streptospirole derivatives of the general formula (I), wherein R1, R2, R3, X1, X2, Y1 and Y2 are as defined herein, a process for the preparation of said compounds by fermenting the microorganism Streptomyces sp. ST 108140 (DSM 19369) and optionally derivatizing the compounds produced by said microorganism, a pharmaceutical composition comprising at least one compound of the formula (I), and the use of a compound of the formula (I) for the preparation of a medicament for the treatment and/or prophylaxis of bacterial infections.

摘要翻译： 本发明涉及通式（I）的链霉菌素衍生物，其中R1，R2，R3，X1，X2，Y1和Y2如本文所定义，通过发酵微生物Streptomyces sp。 ST108404（DSM19369），并任选地衍生由所述微生物产生的化合物，包含至少一种式（I）化合物的药物组合物和式（I）化合物在制备药物中的应用 治疗和/或预防细菌感染。