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公开(公告)号：US09864190B2
公开(公告)日：2018-01-09
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T. C. Liu , Hyejun Ra , Jae Eun Hwang
IPC分类号： A61B10/04 , G02B26/10 , G02B21/00 , G02B23/24 , G02B23/26 , A61B1/00 , A61B1/04 , A61B5/00 , A61B8/12 , A61B8/00 , A61B8/08 , G02B17/08
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
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公开(公告)号：US20120330157A1
公开(公告)日：2012-12-27
申请号：US13403614
申请日：2012-02-23
申请人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
发明人： Michael Mandella , Gordon S. Kino , Christopher H. Contag , Olav Solgaard , Butrus Khuri-Yakub , Omer Oralkan , Jae-Woong Jeong , Paul Cristman , Jonathan T.C. Liu , Hyejun Ra , Jae Eun Hwang
CPC分类号： G02B26/101 , A61B1/00105 , A61B1/043 , A61B5/0068 , A61B8/12 , A61B8/4483 , A61B8/483 , G02B17/0808 , G02B21/0028 , G02B23/2423 , G02B23/26
摘要： Aspects of the present invention are directed to apparatuses, arrangements, systems and methods for collecting information using one or more modalities. As consistent with one or more embodiments, an apparatus includes first and second scanning mirror arrangements having different scanning axes and respectively facing different directions. The first scanning mirror arrangement directs source light and image light in two paths, and the second scanning mirror arrangement directs image light from a target to the first scanning mirror arrangement. The first and second scanning mirror arrangements cooperatively scan source light from the first scanning mirror and via the second scanning mirror to target locations with at least two degrees of freedom, and direct image light from the target locations.
摘要翻译： 本发明的方面涉及使用一种或多种方式收集信息的装置，装置，系统和方法。 与一个或多个实施例一致，装置包括具有不同扫描轴并且分别朝向不同方向的第一和第二扫描镜装置。 第一扫描镜装置将源光和图像光引导成两条路径，第二扫描镜装置将来自目标的图像光引导到第一扫描反射镜装置。 第一和第二扫描镜装置将来自第一扫描反射镜的源光和经由第二扫描镜的源光协同扫描至至少两个自由度的目标位置，以及来自目标位置的直接图像光。
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公开(公告)号：US20140316255A1
公开(公告)日：2014-10-23
申请号：US14241790
申请日：2012-08-23
申请人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
发明人： Ellis Garai , Cristina Zavaleta , Michael Mandella , Jonathan Liu , Sanjiv Sam Gambhir , Christopher H. Contag
CPC分类号： A61B5/0075 , A61B1/07 , A61B5/0079 , A61B5/0084 , A61B10/02 , A61B34/20 , A61B2034/2057 , A61K49/0095 , B82Y15/00 , G01J1/0433 , G01J3/0213 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/44 , G01N21/658
摘要： In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to Raman imaging devices (e.g., Raman endoscope probes) or systems, methods of using Raman agents, Raman imaging devices, and/or systems to image or detect a signal, and the like.
摘要翻译： 根据本公开的目的，如本文所体现和广泛描述的，本公开的实施例在一个方面涉及拉曼成像装置（例如，拉曼内窥镜探针）或系统，使用拉曼剂的方法 ，拉曼成像装置和/或用于对信号进行成像或检测的系统等。
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公开(公告)号：US20130028875A1
公开(公告)日：2013-01-31
申请号：US13470558
申请日：2012-05-14
CPC分类号： A61K35/17 , A61K35/13 , A61K39/0011 , A61K48/00 , A61K2035/124 , A61K2039/5156 , A61K2039/5158 , C12N5/0636 , C12N5/0638 , C12N5/0646 , C12N2710/24132
摘要： Compositions and methods are provided for the treatment of cancer. An immune effector cell population is pre-infected with an oncolytic virus. The combined therapeutic is safe and highly effective, producing an enhanced anti-tumor effect compared to either therapy alone. The methods of the invention thus provide for a synergistic effect based on the combined biotherapeutics.
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公开(公告)号：US06916462B2
公开(公告)日：2005-07-12
申请号：US10319588
申请日：2002-12-16
IPC分类号： A61K39/112 , C07K14/195 , C12N1/21 , C12Q1/02 , C12Q1/66 , G01N33/58 , A61B10/00
CPC分类号： G01N33/582 , C07K14/195 , C12Q1/02 , C12Q1/66 , Y10S435/968 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
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公开(公告)号：US06638752B2
公开(公告)日：2003-10-28
申请号：US09183566
申请日：1998-10-30
IPC分类号： C12N121
CPC分类号： C12N9/0069 , C12Q1/04 , C12Q1/66 , G01N33/54366 , G01N33/569 , G01N33/56988
摘要： The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a molecular switching mechanism to express a reporter gene upon interaction with target substances. The invention further relates to methods using such biodetectors for detecting and quantifying selected substances with high specificity and high sensitivity.
摘要翻译： 本发明涉及用于检测和定量液体，气体或基质中的分子的生物检测器。 更具体地，本发明涉及包含在与靶物质相互作用时表达报告基因的分子切换机制的生物检测器。 本发明还涉及使用这种生物检测器来检测和定量高特异性和高灵敏度的选定物质的方法。
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公开(公告)号：US08545814B2
公开(公告)日：2013-10-01
申请号：US11818208
申请日：2007-06-13
IPC分类号： A61B5/00
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , A61K49/0045 , A61K49/0097 , C07K14/195 , C12N2830/60 , C12Q1/02 , C12Q1/66 , G01N33/582 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
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8.发明授权Method for regulating protein function in cells in vivo using synthetic small molecules 有权使用合成小分子调节体内细胞蛋白质功能的方法公开(公告)号：US08530636B2
公开(公告)日：2013-09-10
申请号：US12437279
申请日：2009-05-07
申请人： Thomas J. Wandless , Laura A. Banaszynski , Mark A. Sellmyer , Christopher H. Contag , Steven H. Thorne
发明人： Thomas J. Wandless , Laura A. Banaszynski , Mark A. Sellmyer , Christopher H. Contag , Steven H. Thorne
CPC分类号： A61K38/52 , A61K31/445 , A61K31/5377 , A61K31/7088 , A61K35/12 , A61K38/00 , C07K14/525 , C07K14/55 , C07K2319/35 , C12N9/90 , C12N2799/027
摘要： Methods and compositions for the rapid and reversible destabilizing of specific proteins in vivo using cell-permeable, synthetic molecules are described.
摘要翻译： 描述了使用细胞可渗透的合成分子在体内快速和可逆地去稳定特定蛋白质的方法和组合物。
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公开(公告)号：US06649143B1
公开(公告)日：2003-11-18
申请号：US09233698
申请日：1999-01-19
IPC分类号： A61K4900
CPC分类号： G01N33/582 , C07K14/195 , C12Q1/02 , C12Q1/66 , Y10S435/968 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
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公开(公告)号：US07255851B2
公开(公告)日：2007-08-14
申请号：US11143422
申请日：2005-06-02
IPC分类号： A61K49/00
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0393 , A61K49/0045 , A61K49/0097 , C07K14/195 , C12N2830/60 , C12Q1/02 , C12Q1/66 , G01N33/582 , Y10S436/80
摘要： Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
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