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公开(公告)号：US20120030602A1
公开(公告)日：2012-02-02
申请号：US13198578
申请日：2011-08-04
IPC分类号： G06F3/048
CPC分类号： G16B45/00
摘要： A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.
摘要翻译： 提供了一种用于查看实验数据的计算机实现方法。 在某些实施方案中，该方法包括：a）将基因组阵列数据和细胞遗传学数据输入到计算机存储器中; 以及b）产生图形用户界面，其包括：i）所述基因组阵列数据的染色体图，其包括指示染色体图上的位置的第一位置指示符; 和ii）细胞遗传学数据的细胞遗传学图谱，其包括指示细胞遗传学图谱上的位置的第二位置指示剂。
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公开(公告)号：US08027823B2
公开(公告)日：2011-09-27
申请号：US11473869
申请日：2006-06-23
CPC分类号： G06F19/26
摘要： A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.
摘要翻译： 提供了一种用于查看实验数据的计算机实现方法。 在某些实施方案中，该方法包括：a）将基因组阵列数据和细胞遗传学数据输入到计算机存储器中; 以及b）产生图形用户界面，其包括：i）所述基因组阵列数据的染色体图，其包括指示染色体图上的位置的第一位置指示符; 和ii）细胞遗传学数据的细胞遗传学图谱，其包括指示细胞遗传学图谱上的位置的第二位置指示剂。
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公开(公告)号：US20070299616A1
公开(公告)日：2007-12-27
申请号：US11473869
申请日：2006-06-23
IPC分类号： G06F19/00
CPC分类号： G06F19/26
摘要： A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosomal map of the genomic array data comprising a first positional indicator that indicates a position on the chromosomal map; and ii) a cytogenetic map of the cytogenetic data comprising a second positional indicator that indicates a position on the cytogenetic map.
摘要翻译： 提供了一种用于查看实验数据的计算机实现方法。 在某些实施方案中，该方法包括：a）将基因组阵列数据和细胞遗传学数据输入到计算机存储器中; 以及b）产生图形用户界面，其包括：i）所述基因组阵列数据的染色体图，其包括指示染色体图上的位置的第一位置指示符; 和ii）细胞遗传学数据的细胞遗传学图谱，其包括指示细胞遗传学图谱上的位置的第二位置指示物。
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公开(公告)号：US20070238104A1
公开(公告)日：2007-10-11
申请号：US11400475
申请日：2006-04-07
CPC分类号： C12Q1/6816 , C12Q2525/186
摘要： The present invention generally relates to competitive oligonucleotides and, in some embodiments, to competitive oligonucleotides for use in comparative genomic hybridization (CGH) and related techniques. One aspect is generally directed to a blocking composition constructed and arranged to be used in an assay of a nucleic acid. The blocking composition may comprise oligonucleotides comprising sequences selected to hybridize to the nucleic acid used in the assay. Another aspect is generally directed to performing CGH assays and similar techniques on genomic DNA, in the absence of a Cot-1 fraction, such that the genomic DNA does not substantially cross-hybridize. Yet other aspects of the invention are directed to devices or kits for making or using competitive oligonucleotides, methods of promoting such competitive oligonucleotides, or the like.
摘要翻译： 本发明一般涉及竞争性寡核苷酸，在一些实施方案中涉及用于比较基因组杂交（CGH）和相关技术的竞争性寡核苷酸。 一个方面通常涉及构建和排列用于核酸测定中的阻断组合物。 封闭组合物可以包含寡核苷酸，其包含选择用于与测定中使用的核酸杂交的序列。 另一方面通常涉及在不存在Cot-1级分的情况下对基因组DNA进行CGH测定和类似技术，使得基因组DNA基本上不交叉杂交。 本发明的其它方面涉及用于制备或使用竞争性寡核苷酸的装置或试剂盒，促进这种竞争性寡核苷酸的方法等。
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公开(公告)号：US07078505B2
公开(公告)日：2006-07-18
申请号：US10165783
申请日：2002-06-06
申请人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
发明人： Jay K. Bass , Maryam Mobed-Miremadi , Michelle M. Maranowski , Roy H. Kanemoto , Bill J. Peck , Eric M. Leproust , Michael P. Caren
CPC分类号： C03C17/32 , B01J2219/00286 , B01J2219/00378 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00689 , B01J2219/00695 , B01J2219/00698 , B01J2219/00722 , B01L3/0241 , C03C17/002 , C40B40/06 , C40B60/14
摘要： Methods are disclosed for synthesizing a plurality of compounds on the surface of supports. The synthesis comprises a series of cycles of steps in which reagents for conducting the synthesis are deposited on the surface of the support to form the chemical compounds. At least one physical parameter of the deposition varies between cycles The method comprises conducting the synthesis in at least two sets of cycles, arbitrarily designated as a first set and a second set. Each cycle comprises at least one step of depositing reagents on a surface by means of droplet dispensing elements that traverse the surface of the support. At least one, and desirably all, of the following deposition parameters are employed as indicated: The number of times of repetition for a step of depositing reagents in at least one cycle of the second set is less than the number of times of repetition for a corresponding step in at least one cycle of the first set. The rate of deposition in at least one cycle of the second set is slower than or equal to the rate of deposition in at least one cycle of the first set. The rate of traversal of the dispensing elements over the surface of the support in at least one cycle of the second set is greater than such rate of traversal in at least one cycle of the first set.
摘要翻译： 公开了在载体表面上合成多种化合物的方法。 该合成包括一系列循环的步骤，其中用于进行合成的试剂沉积在载体的表面上以形成化合物。 沉积物的至少一个物理参数在循环之间变化。该方法包括以任意指定为第一组和第二组的至少两组循环进行合成。 每个循环包括至少一个步骤，其通过穿过载体表面的液滴分配元件在表面上沉积试剂。 如下所示使用以下沉积参数中的至少一个，期望地全部以下沉积参数：在第二组的至少一个循环中沉积试剂的步骤的重复次数小于第二组的重复次数 在第一组的至少一个循环中的对应步骤。 在第二组的至少一个循环中的沉积速率慢于或等于第一组的至少一个循环中的沉积速率。 在第二组的至少一个循环中，分配元件在支撑体表面上的遍历速率大于在第一组的至少一个循环中的穿过速率。
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公开(公告)号：US07008037B2
公开(公告)日：2006-03-07
申请号：US10952234
申请日：2004-09-27
IPC分类号： B41J2/165
CPC分类号： B41J2/1707 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B41J2/16552 , C40B40/06 , C40B60/14
摘要： A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
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公开(公告)号：US06796634B2
公开(公告)日：2004-09-28
申请号：US10233116
申请日：2002-08-30
IPC分类号： B41J2165
CPC分类号： B41J2/1707 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00722 , B41J2/16552 , C40B40/06 , C40B60/14
摘要： A method is described for removing residue from a fluid deposited on the interior surface of an inkjet printhead after the printhead has contained or dispensed the fluid at least once. The method makes use of a reverse flushing technique optionally used in combination with sonication. A cleaning station for flushing an inkjet printhead with a wash fluid, rinse fluid, and/or inert gas is provided as well.
摘要翻译： 描述了一种用于在打印头已经包含或分配流体至少一次之后从沉积在喷墨打印头的内表面上的流体去除残留物的方法。 该方法利用可选地与超声波结合使用的反冲洗技术。 还提供了用于冲洗具有洗涤流体，冲洗流体和/或惰性气体的喷墨打印头的清洁站。
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公开(公告)号：US06372483B2
公开(公告)日：2002-04-16
申请号：US09820476
申请日：2001-03-28
IPC分类号： C12M134
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00729 , B01J2219/00731 , C40B40/06 , C40B40/10 , C40B40/12 , C40B40/14 , C40B60/14 , G01N35/1074 , G01N2035/1041
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can dispense droplets onto a substrate, the jet including a chamber with an orifice, and including an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes positioning the head with the orifice facing the substrate. Multiple droplets of the biopolymer or biomonomer fluid are dispensed from the head orifice so as to form an array of droplets on the substrate. A gas flow is directed through a venturi which has a throat opening communicating with the dispensing head chamber. A venturi control valve which particularly communicate with an outlet of the venturi, is adjusted to alter the chamber pressure. The venturi may be driven by a source of inert anhydrous compressed gas which assists in maintaining fluid in the head isolated from moisture.
摘要翻译： 一种使用生物聚合物或生物混合物流体，并使用流体分配头在衬底上制造生物聚合物阵列的方法和装置。 头部具有至少一个喷射器，其可以将液滴分配到基底上，喷射器包括具有孔口的腔室，并且包括喷射器，当被激活时，喷射器使得液滴从孔口喷出。 该方法包括将头部定位成孔口面向衬底。 生物聚合物或生物混合物流体的多个液滴从头孔分配，以在基底上形成液滴阵列。 气流被引导通过文丘里管，其具有与分配头腔室连通的喉部开口。 特别与文丘里管的出口连通的文氏管控制阀被调节以改变腔室压力。 文氏管可以由惰性无水压缩气体源驱动，这有助于保持与水分隔离的头部中的流体。
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公开(公告)号：US06884580B2
公开(公告)日：2005-04-26
申请号：US10059957
申请日：2001-11-26
IPC分类号： B01J19/00 , C40B40/06 , C40B40/10 , C40B60/14 , C12G1/68 , C07H21/02 , C07H21/04 , C12M1/34 , C12P19/34
CPC分类号： B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , C40B40/06 , C40B40/10 , C40B60/14 , Y10T436/2575
摘要： A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a dispensing head. The head has a reservoir chamber and at least one jet which can dispense droplets onto a substrate. The jet includes a capillary delivery chamber communicating with the reservoir chamber, which delivery chamber has an orifice. The jet further includes an ejector which, when activated, causes a droplet to be ejected from the orifice. The method includes loading the head by positioning the head with the orifice adjacent and facing a biomonomer or biopolymer fluid, and providing a load pressure to the reservoir chamber. The load pressure is sufficiently negative such that the fluid is drawn into the reservoir chamber through the orifice and delivery chamber, while simultaneously being insufficient to result in ambient atmosphere entering the delivery chamber through the orifice once the head has been loaded and no further fluid is facing and adjacent the orifice. The head is positioned with the orifice facing the substrate and multiple droplets are dispensed from the head orifice so as to form an array of droplets on the substrate.
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10.发明授权Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效用于制造生物分子阵列的方法和多储层装置公开(公告)号：US06461812B2
公开(公告)日：2002-10-08
申请号：US09150507
申请日：1998-09-09
申请人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
发明人： Phillip W. Barth , Michael P. Caren , William H. McAllister , Carol T. Schembri , Arthur Schleifer
IPC分类号： C12Q168
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00722 , B41J2/14145 , B41J2002/14387 , C12Q1/6837 , C40B40/06 , C40B60/14
摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.
摘要翻译： 用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与 所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进， 以及用于通常排放至少两个储存器的通风口。 在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。 此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。
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