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    Method and multiple reservoir apparatus for fabrication of biomolecular arrays
    2.
    发明授权
    Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
    用于制造生物分子阵列的方法和多储层装置

    公开(公告)号：US06461812B2

    公开(公告)日：2002-10-08

    申请号：US09150507

    申请日：1998-09-09

    申请人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    发明人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    IPC分类号： C12Q168

    CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00722 ,  B41J2/14145 ,  B41J2002/14387 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14

    摘要： Apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological material, includes a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.

    摘要翻译： 用于将多个不同生物材料输送到接收表面上的离散位置上的装置，例如制造不同生物材料的阵列，包括孔口构件中的多个孔，至少六个输送腔，其各自与 所述孔中的至少一个，多个储存器，每个储存器各自与至少一个输送室流体连通，与每个孔相关联的装置，用于将流体从与所述孔流体导通关系的输送室相推进， 以及用于通常排放至少两个储存器的通风口。 在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。 此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

    Method and multiple reservoir apparatus for fabrication of biomolecular arrays
    3.
    发明授权
    Method and multiple reservoir apparatus for fabrication of biomolecular arrays 失效
    用于制造生物分子阵列的方法和多储层装置

    公开(公告)号：US07026124B2

    公开(公告)日：2006-04-11

    申请号：US10267913

    申请日：2002-10-08

    申请人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    发明人： Phillip W. Barth ,  Michael P. Caren ,  William H. McAllister ,  Carol T. Schembri ,  Arthur Schleifer

    IPC分类号： C12Q1/68 ,  C12M1/00 ,  G01N15/06 ,  B01L3/02

    CPC分类号： B01L3/0268 ,  B01J19/0046 ,  B01J2219/00378 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00722 ,  B41J2/14145 ,  B41J2002/14387 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14

    摘要： Methods and apparatus for delivering a plurality of different biological materials onto discrete locations on a receiving surface, as for example to fabricate an array of different biological materials. The apparatus and methods may include a plurality of orifices in an orifice member, at least six delivery chambers each in fluid conducting relationship with at least one of the orifices, a plurality of reservoirs each in fluid communication with at least one of the delivery chambers, means associated with each orifice for propelling fluid through the associated orifice from the delivery chamber that is in fluid conducting relationship with the orifice, and a vent for commonly venting at least two of the reservoirs. In some embodiments the chambers and reservoirs are loaded with fluids containing selected biomolecules by drawing the selected fluids into the chambers through the orifices; in other embodiments the fluids are introduced into the reservoirs. Also, methods for depositing biological materials onto a surface, as for example to fabricate a biomolecular array, employ the apparatus.

    摘要翻译： 用于将多种不同生物材料递送到接收表面上的离散位置上的方法和装置，例如制造不同生物材料的阵列。 该装置和方法可以包括孔口构件中的多个孔口，至少六个输送腔室，其各自与至少一个孔口形成流体传导关系;多个储存器，每个储存器与至少一个输送室流体连通， 与每个孔口相关联的装置，用于将流体从与所述孔口处于流体导通关系的输送室相关联的孔口推进，以及用于通常排放至少两个储存器的通风口。 在一些实施例中，腔室和储存器通过将所选择的流体通过孔抽入室中来装载含有选定的生物分子的流体; 在其它实施例中，将流体引入储存器。 此外，用于将生物材料沉积到表面上的方法，例如制备生物分子阵列，采用该装置。

    Multiple array format
    10.
    发明授权
    Multiple array format 有权
    多数组格式

    公开(公告)号：US07371348B2

    公开(公告)日：2008-05-13

    申请号：US10173292

    申请日：2002-06-14

    申请人： Arthur Schleifer ,  Michael P Caren

    发明人： Arthur Schleifer ,  Michael P Caren

    IPC分类号： B01L3/00 ,  G01N1/28

    CPC分类号： B01L3/502707 ,  B01J2219/00351 ,  B01J2219/00662 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2300/0822 ,  B01L2300/0861 ,  B01L2300/0887 ,  C40B60/14

    摘要： A multiple array substrate having multiple assay chambers, each assay chamber containing one or more arrays. The assay chambers include a form-in-place gasket between a substrate and a cover. Methods of forming such multiple array substrates are described. The assay chambers may further be associated with an analysis site for analyzing a sample solution contained within the assay chamber. Each assay chamber is in fluid communication with a port, and the ports are positioned in a spatial format adapted to interface to standard laboratory equipment for handling multiple fluids in parallel.

    摘要翻译： 具有多个分析室的多阵列基底，每个测定室含有一个或多个阵列。 分析室包括在基板和盖之间的就地形成垫圈。 描述形成这种多阵列基板的方法。 分析室还可以与用于分析测定室内包含的样品溶液的分析位点相关联。 每个测定室与端口流体连通，并且端口以适于与标准实验室设备接合的空间格式定位，以并行处理多种流体。