利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

179 条记录 (耗时 0.038 秒)

    Patterning of ionic polymers
    1.
    发明授权
    Patterning of ionic polymers 有权
    离子聚合物图案化

    公开(公告)号：US09023458B2

    公开(公告)日：2015-05-05

    申请号：US12311811

    申请日：2007-10-18

    申请人： Michal Lahav ,  Adam Winkleman ,  Max Narovlyansky ,  Raquel Perez-Castillejos ,  Emily A. Weiss ,  Leonard N. J. Rodriguez ,  George M. Whitesides

    发明人： Michal Lahav ,  Adam Winkleman ,  Max Narovlyansky ,  Raquel Perez-Castillejos ,  Emily A. Weiss ,  Leonard N. J. Rodriguez ,  George M. Whitesides

    IPC分类号： B32B3/00 ,  B05D3/06 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/00

    CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  Y10T428/24479

    摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL-PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone-novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.

    摘要翻译： 一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。 这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。 在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与 解决方案。 在另一个实施方案中，构图离子型聚合物的方法涉及光刻。 在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的暴露区域可以通过水溶液进行蚀刻。 有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。 例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

    PATTERNING OF IONIC POLYMERS
    2.
    发明申请
    PATTERNING OF IONIC POLYMERS 有权
    离子聚合物的构图

    公开(公告)号：US20100233434A1

    公开(公告)日：2010-09-16

    申请号：US12311811

    申请日：2007-10-18

    申请人： Michal Lahav ,  Adam Winkleman ,  Max Narovlyansky ,  Raquel Perez-Castillejos ,  Emily A. Weiss ,  Leonard N.J. Rodriguez ,  George M. Whitesides

    发明人： Michal Lahav ,  Adam Winkleman ,  Max Narovlyansky ,  Raquel Perez-Castillejos ,  Emily A. Weiss ,  Leonard N.J. Rodriguez ,  George M. Whitesides

    IPC分类号： B01J41/12 ,  B32B3/00 ,  B05D3/06 ,  G03F7/20

    CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  Y10T428/24479

    摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL-PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone-novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.

    摘要翻译： 一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。 这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。 在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与 解决方案。 在另一个实施方案中，构图离子型聚合物的方法涉及光刻。 在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的暴露区域可以通过水溶液进行蚀刻。 有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。 例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

    Fluidic structures including meandering and wide channels
    5.
    发明授权
    Fluidic structures including meandering and wide channels 有权
    流体结构包括曲折和宽通道

    公开(公告)号：US08501416B2

    公开(公告)日：2013-08-06

    申请号：US11887487

    申请日：2006-04-19

    申请人： Vincent Linder ,  Samuel K. Sia ,  George M. Whitesides ,  Max Narovlyansky ,  Adam Siegel

    发明人： Vincent Linder ,  Samuel K. Sia ,  George M. Whitesides ,  Max Narovlyansky ,  Adam Siegel

    IPC分类号： G01N33/53

    CPC分类号： G01N33/54366 ,  B01L3/502746 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/0883 ,  B01L2400/0406 ,  G01N21/01 ,  G01N21/82 ,  G01N33/54373

    摘要： The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analysis due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.

    摘要翻译： 本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。 微流控系统可以提供用于执行各种反应和分析的有利环境，因为与常规系统相比，所需的样品和试剂量的减少，操作系统的尺寸的减小和反应时间的减少。 不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。 一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。 尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

    MICROFLUIDIC, ELECTROCHEMICAL DEVICES
    6.
    发明申请
    MICROFLUIDIC, ELECTROCHEMICAL DEVICES 有权
    微电子，电化学设备

    公开(公告)号：US20120181184A1

    公开(公告)日：2012-07-19

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  G01N27/416

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。

    Microfluidic, electrochemical devices
    7.
    发明授权
    Microfluidic, electrochemical devices 有权
    微流控，电化学装置

    公开(公告)号：US09192933B2

    公开(公告)日：2015-11-24

    申请号：US13254967

    申请日：2010-03-08

    申请人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    发明人： George M. Whitesides ,  Zhihong Nie ,  Christian Nijhuis ,  Xin Chen ,  Andres W. Martinez ,  Max Narovlyansky

    IPC分类号： G01N27/26 ,  B01L3/00 ,  G01N27/327

    CPC分类号： B01L3/5027 ,  B01L3/502 ,  B01L2300/0645 ,  B01L2300/0887 ,  G01N27/3272

    摘要： Microfluidic, electrochemical devices are described. The microfluidic, electrochemical device comprises one or more electrode(s) on a substrate and a patterned porous, hydrophilic layer having a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic channels within the patterned porous, hydrophilic layer, wherein the hydrophilic channel(s) comprises a hydrophilic region which is in fluidic communication with the electrode(s). In some embodiments, the electrodes comprise a working electrode, a counter electrode, and a reference electrode. In some embodiments, the microfluidic, electrochemical device further comprises a fluid sink. The method of assembling the microfluidic, electrochemical device is described. The method of using the device for electrochemical analysis of one or more analytes is also described.

    摘要翻译： 描述了微流体，电化学装置。 微流体电化学装置包括在基底上的一个或多个电极和图案化的多孔亲水层，其具有基本上渗透多孔亲水层的厚度的流体不可渗透屏障，并限定一个或多个亲水性通道的边界 所述图案化的多孔亲水层，其中所述亲水沟道包括与所述电极流体连通的亲水区域。 在一些实施例中，电极包括工作电极，对电极和参考电极。 在一些实施例中，微流体，电化学装置还包括流体槽。 描述了组装微流体，电化学装置的方法。 还描述了使用该装置进行一种或多种分析物的电化学分析的方法。