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29 条记录 (耗时 0.028 秒)

    Radial tire for heavy duty vehicle including a folded belt layer
    1.
    发明授权
    Radial tire for heavy duty vehicle including a folded belt layer 失效
    用于重型车辆的径向轮胎，包括折叠的皮带层

    公开(公告)号：US5201969A

    公开(公告)日：1993-04-13

    申请号：US555625

    申请日：1990-07-23

    申请人： Minoru Nishi ,  Yoshiyuki Takada ,  Naoki Asakawa

    发明人： Minoru Nishi ,  Yoshiyuki Takada ,  Naoki Asakawa

    IPC分类号： B60C9/00 ,  B60C9/18 ,  B60C9/20 ,  B60C9/26

    CPC分类号： B60C9/26 ,  Y10T152/10792 ,  Y10T152/1081

    摘要： A radial tire for heavy duty vehicles having a steel belt layer with triangular structure which is composed of at least three belt plies of steel belt disposed on a carcass, and a middle layer which contains cords of aromatic polyamide fibers which is laid between first belt ply and second belt ply viewed from tread surface side among the belt plies.The middle layer has skirts which are folded over from a main portion of the middle layer and laid between the first and second belt plies so as to wrap around each axial outer end of the first belt ply.The cords of the first belt play and the cords of the second belt ply cross each other at an angle of from 10 to 30 deg. against the tire equator, and the cords of the middle layer slant in the same direction as that of first belt ply at an angle of 3 deg. or less against that of first belt ply.

    Dispersant for sustained release preparations
    3.
    发明申请
    Dispersant for sustained release preparations 审中-公开
    分散剂用于缓释制剂

    公开(公告)号：US20060088595A1

    公开(公告)日：2006-04-27

    申请号：US10545723

    申请日：2004-02-18

    申请人： Naoki Asakawa ,  Masuhisa Hori

    发明人： Naoki Asakawa ,  Masuhisa Hori

    IPC分类号： A61K38/27 ,  A61K9/22 ,  A61K36/48

    CPC分类号： A61K9/0019 ,  A61K9/1647 ,  A61K38/27 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44

    摘要： The present invention provides a bilayer dispersing agent for a sustained-release preparation, which contains a non water-soluble solvent and an aqueous solvent, and a sustained-release preparation wherein a microcapsule containing a physiologically active substance is dispersed in the aforementioned dispersing agent. When this preparation is subcutaneously administered, the initial release of a physiologically active substance immediately after administration is strikingly suppressed, a constant amount of a physiologically active substance is released for a long period of time from immediately after administration, superior dispersibility is afforded, and the preparation can readily pass through a needle as an injection.

    摘要翻译： 本发明提供一种含有非水溶性溶剂和水性溶剂的缓释制剂的双层分散剂，其中含有生理活性物质的微胶囊分散在上述分散剂中的缓释制剂。 当皮下给药该制剂时，立即给药后的生理活性物质的初次释放被明显地抑制，一定量的生理活性物质从给药后立即长时间释放，分散性优异， 制剂可以容易地作为注射通过针。

    Injections
    7.
    发明授权
    Injections 失效
    注射

    公开(公告)号：US07396841B2

    公开(公告)日：2008-07-08

    申请号：US10344805

    申请日：2001-08-17

    申请人： Takayuki Doen ,  Masao Nagao ,  Naoki Asakawa ,  Nobuyuki Takechi

    发明人： Takayuki Doen ,  Masao Nagao ,  Naoki Asakawa ,  Nobuyuki Takechi

    IPC分类号： A61K31/4439 ,  C07D401/12

    CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K31/404 ,  A61K31/4184 ,  A61K31/4439 ,  A61K47/02 ,  A61K47/18 ,  A61K47/26

    摘要： An injectable composition comprises a benzimidazole compound having an antiulcer action and a strong alkali (e.g., an alkali metal hydroxide such as sodium hydroxide) in a proportion of about 1 equivalent of the latter relative to 1 mol of the former, and is substantially free from a nonaqueous solvent. The injectable composition may comprise N-methylglucamine, and a saccharide (such as mannitol). The injectable composition may be a freeze-dried preparation. The freeze-dried preparation is dissolvable in or dilutive with a distilled water for injection or an infusion solution without a nonaqueous solvent. The injectable composition is useful as an antiulcer agent.

    摘要翻译： 可注射组合物包含具有抗溃疡作用的苯并咪唑化合物和强碱（例如，碱金属氢氧化物如氢氧化钠），其比例相对于前者为1摩尔为约1当量，并且基本上不含 非水溶剂。 可注射组合物可以包含N-甲基葡糖胺和糖（如甘露糖醇）。 可注射组合物可以是冷冻干燥制剂。 冷冻干燥制剂可用注射用蒸馏水或不含非水溶剂的输液进行溶解或稀释。 可注射组合物可用作抗溃疡剂。

    Method for producing granules
    9.
    发明授权
    Method for producing granules 有权
    生产颗粒的方法

    公开(公告)号：US08871273B2

    公开(公告)日：2014-10-28

    申请号：US11884498

    申请日：2006-02-24

    申请人： Naoki Nagahara ,  Naoki Asakawa ,  Muneo Nonomura

    发明人： Naoki Nagahara ,  Naoki Asakawa ,  Muneo Nonomura

    IPC分类号： A61K9/16 ,  A61K31/44 ,  A61K31/415 ,  A61K9/50 ,  A61K31/4439 ,  B01J2/00 ,  A61J3/00

    CPC分类号： A61K9/1682 ,  A61J3/005 ,  A61K9/167 ,  A61K9/1676 ,  A61K9/1694 ,  A61K9/5078 ,  A61K31/4439 ,  B01J2/003

    摘要： In a production process of granules containing a biologically active substance, variation in the elution profile of the biologically active substance is reduced by heating the temperature of granules to about 50° C. or higher and maintaining the temperature for about 1 minute or longer. By setting the spray speed to about 90 mg/min or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1.5 g/cm2 or more, the variation in the elution profile of the biologically active substance from the granules is reduced.

    摘要翻译： 在含有生物活性物质的颗粒的生产方法中，通过将颗粒的温度加热至约50℃或更高并保持约1分钟或更长时间来降低生物活性物质的洗脱曲线的变化。 当喷雾含有生物活性物质的主剂的喷雾剂，同时喷涂粘合液体至核心并设定每单位面积的总进料重量时，通过将喷雾速度设定为每1g核心约90mg / min或更高 对于离心流化床包衣造粒机至约1.5g / cm 2或更高，来自颗粒的生物活性物质的洗脱曲线的变化减小。

    Diffusion promoting apparatus for low flow velocity gradient high-speed liquid chromatography
    10.
    发明授权
    Diffusion promoting apparatus for low flow velocity gradient high-speed liquid chromatography 失效
    用于低流速梯度高速液相色谱的扩散促进装置

    公开(公告)号：US06780325B1

    公开(公告)日：2004-08-24

    申请号：US09831496

    申请日：2001-05-10

    申请人： Kaoru Murata ,  Nariyasu Mano ,  Naoki Asakawa

    发明人： Kaoru Murata ,  Nariyasu Mano ,  Naoki Asakawa

    IPC分类号： B01D1508

    CPC分类号： G01N30/34 ,  G01N2030/324 ,  G01N2030/347

    摘要： The present invention provides a device for improving detection sensitivity and a method for improving the detection sensitivity for use in a low flow velocity high performance liquid chromatographic apparatus. That is, the present invention is a diffusion promoting device connected at just before a separation column and having a function for improving detection sensitivity for use in a low flow velocity high performance liquid chromatographic apparatus.

    摘要翻译： 本发明提供一种用于提高检测灵敏度的装置以及用于提高用于低流速高效液相色谱仪的检测灵敏度的方法。 也就是说，本发明是在分离柱之前连接的扩散促进装置，具有提高用于低流速高效液相色谱仪的检测灵敏度的功能。