公开(公告)号：US20060141592A1

公开(公告)日：2006-06-29

申请号：US10527703

申请日：2003-09-12

申请人： Motoo Sumida ,  Kenichi Higashiyama

发明人： Motoo Sumida ,  Kenichi Higashiyama

IPC分类号： C12P7/64

CPC分类号： C12P7/6472 ,  A23D9/00 ,  A23K20/158 ,  A23L33/115 ,  A23V2002/00 ,  C11C3/10 ,  A23V2250/1862

摘要： There are provided polyunsaturated fatty acids-containing oils/fats or triglycerides with high digestion and absorption properties and resistance to oxidative damage, which are suitable for applications in fields such as modified milk for infants, food products and healthy foods and/or supplements, produced by transesterification of polyunsaturated fatty acids-containing oils/fats or triglycerides with vegetable oils/fats or triglycerides using 1,3-position specific type lipases.

摘要翻译： 提供了含有不饱和脂肪酸的油/脂肪或甘油三酸酯，具有高消化吸收性能和抗氧化损伤性，适用于婴幼儿改良牛奶，食品和健康食品和/或补品等领域。 通过使用1,3位特异性脂肪酶将多不饱和脂肪酸的油/脂肪或甘油三酯与植物油/脂肪或甘油三酸酯进行酯交换。

公开(公告)号：US07998712B2

公开(公告)日：2011-08-16

申请号：US10527703

申请日：2003-09-12

申请人： Motoo Sumida ,  Kenichi Higashiyama

发明人： Motoo Sumida ,  Kenichi Higashiyama

IPC分类号： C12P7/64 ,  A61K1/17

CPC分类号： C12P7/6472 ,  A23D9/00 ,  A23K20/158 ,  A23L33/115 ,  A23V2002/00 ,  C11C3/10 ,  A23V2250/1862

摘要： There are provided polyunsaturated fatty acids-containing oils/fats or triglycerides with high digestion and absorption properties and resistance to oxidative damage, which are suitable for applications in fields such as modified milk for infants, food products and healthy foods and/or supplements, produced by transesterification of polyunsaturated fatty acids-containing oils/fats or triglycerides with vegetable oils/fats or triglycerides using 1,3-position specific type lipases.

摘要翻译： 提供了含有不饱和脂肪酸的油/脂肪或甘油三酸酯，具有高消化吸收性能和抗氧化损伤性，适用于婴幼儿改良牛奶，食品和健康食品和/或补品等领域。 通过使用1,3位特异性脂肪酶将多不饱和脂肪酸的油/脂肪或甘油三酯与植物油/脂肪或甘油三酸酯进行酯交换。

公开(公告)号：US07538238B2

公开(公告)日：2009-05-26

申请号：US10482373

申请日：2002-07-02

申请人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

发明人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

IPC分类号： A23D9/00

CPC分类号： C12P7/6472 ,  A23C9/1528 ,  A23C11/04 ,  A23K20/158 ,  A23L33/115 ,  A23L33/12 ,  C11C3/08 ,  C11C3/10

摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.

摘要翻译： 本发明涉及含有甘油三酯的油的制备方法，其中中链脂肪酸与甘油三酯的1位和3位结合，多不饱和脂肪酸通过使脂肪酶特异性地作用于2位而结合到2位上 在固定在孔径为约100埃以上的多孔离子交换树脂载体上的1-位和3-位的酯键作用于中链脂肪酸和至少含有至少 一种选自具有18个或更多个碳原子的ω-6系多不饱和脂肪酸和3个或更多个双键的多不饱和脂肪酸和具有18个或更多个碳原子和2个或更多个双键但不含ω3的ω-系列多不饱和脂肪酸 系列多不饱和脂肪酸，通过该方法获得的油和脂肪或甘油三酯，以及在食品，饮料或药物中使用油和脂肪或甘油三酸酯 l组成。

公开(公告)号：US20050287651A1

公开(公告)日：2005-12-29

申请号：US10530747

申请日：2003-10-09

申请人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

发明人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

IPC分类号： A23D9/02 ,  C12P7/64

CPC分类号： C12P7/6472 ,  A23D9/02

摘要： A process for producing a crude oil having lowered unsaponifiable matter content and/or ester-type sterol content and comprising a highly unsaturated fatty acid as a constituent fatty acid, characterized in that a microorganism capable of producing a fat or oil comprising an unsaturated fatty acid as a constituent fatty acid is cultured in a medium containing a nitrogen source concentration of 2 to 15% within a culture tank equipped with an agitation impeller satisfying the requirement that the ratio of the diameter of agitation impeller (=d) to the inner diameter of the culture tank (=D) is d/D=0.30 to 0.6.

摘要翻译： 一种生产具有降低的不皂化物质含量和/或酯类固醇含量并含有高度不饱和脂肪酸作为构成脂肪酸的原油的方法，其特征在于，能够生产包含不饱和脂肪酸的脂肪或油的微生物 作为构成脂肪酸，在含有浓度为2〜15％的氮源的培养基中培养，在配备有搅拌叶轮的培养槽中，搅拌叶轮满足搅拌叶轮直径（= d）与内径 培养罐（= D）为d / D = 0.30〜0.6。

公开(公告)号：US07709236B2

公开(公告)日：2010-05-04

申请号：US10530747

申请日：2003-10-09

申请人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

发明人： Kengo Akimoto ,  Kenichi Higashiyama ,  Hiroshi Kawashima ,  Motoo Sumida

IPC分类号： C12P7/64

CPC分类号： C12P7/6472 ,  A23D9/02

摘要： A process for producing a crude oil having lowered unsaponifiable matter content and/or ester-type sterol content and comprising a highly unsaturated fatty acid as a constituent fatty acid, characterized in that a microorganism capable of producing a fat or oil comprising an unsaturated fatty acid as a constituent fatty acid is cultured in a medium containing a nitrogen source concentration of 2 to 15% within a culture tank equipped with an agitation impeller satisfying the requirement that the ratio of the diameter of agitation impeller (=d) to the inner diameter of the culture tank (=D) is d/D=0.30 to 0.6.

摘要翻译： 一种生产具有降低的不皂化物质含量和/或酯类固醇含量并含有高度不饱和脂肪酸作为构成脂肪酸的原油的方法，其特征在于，能够生产包含不饱和脂肪酸的脂肪或油的微生物 作为构成脂肪酸，在含有浓度为2〜15％的氮源的培养基中培养，在配备有搅拌叶轮的培养槽中，搅拌叶轮满足搅拌叶轮直径（= d）与内径 培养罐（= D）为d / D = 0.30〜0.6。

公开(公告)号：US07767427B2

公开(公告)日：2010-08-03

申请号：US12232851

申请日：2008-09-25

申请人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

发明人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

IPC分类号： C12P7/64

CPC分类号： C12P7/6472 ,  A23C9/1528 ,  A23C11/04 ,  A23K20/158 ,  A23L33/115 ,  A23L33/12 ,  C11C3/08 ,  C11C3/10

摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.

摘要翻译： 本发明涉及含有甘油三酯的油的制备方法，其中中链脂肪酸与甘油三酯的1位和3位结合，多不饱和脂肪酸通过使脂肪酶特异性地作用于2位而结合到2位上 在已经固定在孔径为约100埃以上的多孔离子交换树脂载体上的1-位和3-位的酯键作用于至少含有至少含有中链脂肪酸和原料油的混合物 一种选自具有18个或更多个碳原子的ω6系多不饱和脂肪酸和3个或更多个双键的多不饱和脂肪酸和具有18个以上碳原子和2个以上双键但不含ω3的ω9系多不饱和脂肪酸 系列多不饱和脂肪酸，通过该方法获得的油和脂肪或甘油三酯，以及在食品，饮料或药物组合物中使用油和脂肪或甘油三酸酯 。

公开(公告)号：US20090076149A1

公开(公告)日：2009-03-19

申请号：US12232851

申请日：2008-09-25

申请人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

发明人： Kengo Akimoto ,  Motoo Sumida ,  Kenichi Higashiyama ,  Shigeaki Fujikawa

IPC分类号： A61K31/20 ,  C12P7/64 ,  C07C53/00 ,  A23D9/00 ,  A23K1/00

CPC分类号： C12P7/6472 ,  A23C9/1528 ,  A23C11/04 ,  A23K20/158 ,  A23L33/115 ,  A23L33/12 ,  C11C3/08 ,  C11C3/10

摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.

公开(公告)号：US20050228188A1

公开(公告)日：2005-10-13

申请号：US10511829

申请日：2003-04-28

申请人： Motoo Sumida ,  Masahiro Nakao ,  Namino Tomimori ,  Koshi Namikawa ,  Harukazu Fukami

发明人： Motoo Sumida ,  Masahiro Nakao ,  Namino Tomimori ,  Koshi Namikawa ,  Harukazu Fukami

IPC分类号： A23L1/29 ,  A23L1/30 ,  A61K8/37 ,  A61Q1/06 ,  C07C403/24 ,  C12P7/62 ,  C12P7/64 ,  C12P23/00 ,  C07C57/26

CPC分类号： C07C403/24 ,  A23L33/10 ,  A23L33/115 ,  A61K8/37 ,  A61Q1/06 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/6454 ,  C12P23/00

摘要： The present invention provides an astaxanthin medium-chain fatty acid ester, which is expected to be applied in the fields of food, cosmetics and pharmaceuticals, and has higher digestibility and tissue penetration than long chain fatty acid ester form astaxanthins. When the synthesis of an astaxanthin medium-chain fatty acid ester is attempted using the catalytic action of lipase by conventional methods, ester cannot be formed. However, according to the present invention, a composition comprising an astaxanthin medium-chain fatty acid monoester and/or diester is produced by adding a certain amount of water into a reaction system and reacting an astaxanthin or a long chain fatty acid ester thereof with a medium-chain fatty acid, a triglyceride thereof or a suitable ester. Moreover, these monoesters and/or diesters are isolated, as necessary. The present invention further provides food or cosmetics comprising the composition of the present invention.

摘要翻译： 本发明提供了一种预期用于食品，化妆品和药物领域的虾青素中链脂肪酸酯，并且比长链脂肪酸酯形式的虾青素具有更高的消化率和组织穿透性。 当通过常规方法尝试使用脂肪酶的催化作用来合成虾青素中链脂肪酸酯时，不能形成酯。 然而，根据本发明，通过向反应体系中加入一定量的水并使虾青素或其长链脂肪酸酯与一种虾青素或其长链脂肪酸酯反应而制备包含虾青素中链脂肪酸单酯和/或二酯的组合物 中链脂肪酸，其甘油三酯或合适的酯。 此外，根据需要分离这些单酯和/或二酯。 本发明还提供包含本发明组合物的食品或化妆品。

公开(公告)号：US5081284A

公开(公告)日：1992-01-14

申请号：US373811

申请日：1989-06-29

申请人： Naoki Higuchi ,  Masayuki Saitoh ,  Norio Iwasawa ,  Motoo Sumida ,  Hiroshi Shibata

发明人： Naoki Higuchi ,  Masayuki Saitoh ,  Norio Iwasawa ,  Motoo Sumida ,  Hiroshi Shibata

IPC分类号： C12N9/99 ,  A61K31/16 ,  A61K31/165 ,  A61K31/695 ,  A61K38/00 ,  A61K38/55 ,  A61P17/00 ,  A61P27/02 ,  A61P27/12 ,  A61P29/00 ,  A61P43/00 ,  C07C237/04 ,  C07C237/06 ,  C07C237/22 ,  C07C271/22 ,  C07C271/34 ,  C07C271/54 ,  C07C311/21 ,  C07C313/24 ,  C07D209/48 ,  C07F7/08 ,  C07F7/10 ,  C07F9/24 ,  C07F9/36 ,  C07F9/44 ,  C07K5/06

CPC分类号： C07D209/48 ,  C07C237/06 ,  C07C237/22 ,  C07C271/22 ,  C07C271/34 ,  C07F7/0818 ,  C07F9/2458 ,  C07K5/06043 ,  C07K5/06191 ,  A61K38/00 ,  C07C2103/74

摘要： A novel N-substituted peptidyl compound represented by the general formula (1): ##STR1## where R.sub.1 is a straight-chained or branched acyl group having 2-10 carbon atoms, a branched, cyclic or partly branched cyclic alkyloxycarbonyl group having 4-15 carbon atoms, a substituted or unsubstituted benzyloxycarbonyl group, a 2,2,2-trichloroethyloxycarbonyl group, a 2-(trimethylsilyl)ethyloxycarbonyl group, a p-toluensulfonyl group, an o-nitrophenylsulfenyl group, a diphenylphosphonothioyl group, a triphenylmethyl group, a 2-benzoyl-1-methylvinyl group or a 4-phenylbutyryl group; R.sub.2 is a hydrogen atom or when taken together with R.sub.1, may form a phthaloyl group; R.sub.3 is an isobutyl group, a n-butyl group or an isopropyl group; R.sub.4 is a butyl group, a benzyl group or a methylthioethyl group; and R.sub.5 is a hydrogen atom or a chloromethyl group, which inhibits the activity of cysteine proteinases.

公开(公告)号：US5814631A

公开(公告)日：1998-09-29

申请号：US849114

申请日：1997-05-28

申请人： Harukazu Fukami ,  Akiko Ito ,  Shinjiro Niwata ,  Saki Kakutani ,  Motoo Sumida ,  Yoshinobu Kiso

发明人： Harukazu Fukami ,  Akiko Ito ,  Shinjiro Niwata ,  Saki Kakutani ,  Motoo Sumida ,  Yoshinobu Kiso

IPC分类号： C07D239/96 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07F9/6512 ,  A61K31/495 ,  A61K31/505 ,  C07D239/72 ,  C07D403/02

CPC分类号： C07D401/06 ,  C07D239/96 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07F9/65128

摘要： A chymase inhibitor containing as its effective ingredient a quinazoline derivative, or a pharmaceutically acceptable salt thereof, having the formula (1): ##STR1## and a pharmaceutical preparation for the prevention of cardiac and circulatory system diseases derived from abnormal exacerbation of Ang II production containing the same as its effective ingredient.

摘要翻译： PCT No.PCT / JP96 / 02830 Sec。 371日期：1997年5月8日 102（e）日期1997年5月8日PCT提交1996年9月27日PCT公布。 公开号WO97 / 11941 日期1997年3月4日含有具有式（1）的喹唑啉衍生物或其药学上可接受的盐作为其有效成分的胃促胰酶抑制剂：（1）和用于预防心脏和循环系统疾病的药物制剂 衍生自与其有效成分相同的Ang II产生异常恶化。