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公开(公告)号：US20210401734A1
公开(公告)日：2021-12-30
申请号：US17469958
申请日：2021-09-09
IPC分类号： A61K9/00 , A61K47/10 , A61K47/12 , A61K47/42 , A61K9/06 , A61K8/02 , A61K8/34 , A61K8/36 , A61K8/60 , A61K8/64 , A61K47/26 , A61Q19/00
摘要： A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; R3 is a —(CH2)n—X group; n is a number of 1 to 4; and X is amino group, guanidino group, —CONH2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.
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公开(公告)号：US20180000716A1
公开(公告)日：2018-01-04
申请号：US15547401
申请日：2016-01-27
IPC分类号： A61K8/64 , A61K8/55 , A61K8/39 , A61K8/37 , A61K8/365 , A61K8/362 , A61K8/34 , A61Q19/00 , A61K8/02
CPC分类号： A61K8/64 , A61K8/0229 , A61K8/34 , A61K8/345 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/37 , A61K8/39 , A61K8/55 , A61K8/553 , A61K8/67 , A61Q19/00
摘要： A moisturizing base material that contains a lipid peptide compound including at least one of compounds of Formula (1) below and simulated compounds thereof or pharmaceutically usable salts thereof, a surfactant, a specific polyhydric alcohol, a fatty acid, and water. (wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; and R3 is a —(CH2)n—X group; n is a number of 1 to 4; and X is amino group, guanidino group, —CONH2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.)
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公开(公告)号：US20170009201A1
公开(公告)日：2017-01-12
申请号：US15113762
申请日：2015-01-23
发明人： Hisato HAYASHI , Misayo OTANI , Koichiro SARUHASHI , Taito NISHINO , Takehisa IWAMA , Tatsuro KANAKI , Ayako AIHARA
IPC分类号： C12N5/00
CPC分类号： C12N5/0068 , C12N2533/70 , C12N2533/72 , C12N2533/78 , C12N2535/00
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition having an effect of preventing sedimentation of cells and/or tissues, which is afforded by substantially retaining the cells and/or tissues without substantially increasing the viscosity of the solution by nanofibers which have been added to the solution and uniformly dispersed in the liquid medium, and the like.
摘要翻译： 本发明通过使用具有抑制细胞和/或组织沉淀的作用的培养基组合来提供包含培养细胞和/或悬浮状态的组织的细胞和/或组织的培养方法，所述培养基组合物通过基本上保持细胞 和/或组织，而基本上不会增加已经加入到溶液中并均匀分散在液体介质中的纳米纤维的溶液粘度等。
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公开(公告)号：US20220306985A1
公开(公告)日：2022-09-29
申请号：US17750908
申请日：2022-05-23
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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5.发明申请CULTURE MEDIUM COMPOSITION AND METHOD OF CULTURING CELL OR TISSUE USING THEREOF 有权培养基组合物和使用其培养细胞或组织的方法公开(公告)号：US20140106348A1
公开(公告)日：2014-04-17
申请号：US13949310
申请日：2013-07-24
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
CPC分类号： C12N5/0043 , C12N5/005 , C12N5/067 , C12N5/0693 , C12N2500/14 , C12N2500/34 , C12N2531/00 , C12N2533/80 , G01N33/5011 , G01N33/5014 , G01N33/5044 , G01N33/5067
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like.
摘要翻译： 本发明通过使用在液体介质中形成不确定结构的介质组合物提供包含悬浮状态的培养细胞和/或组织的细胞和/或组织的培养方法，所述结构均匀地分散在溶液中并基本保持 细胞和/或组织，而基本上不增加溶液的粘度，从而提供防止沉淀的效果等。
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公开(公告)号：US20190380949A1
公开(公告)日：2019-12-19
申请号：US16554015
申请日：2019-08-28
IPC分类号： A61K9/00 , A61K47/10 , A61K47/12 , A61K47/42 , A61K8/02 , A61K8/34 , A61K8/36 , A61K8/60 , A61K8/64 , A61K47/26 , A61Q19/00
摘要： A transdermally absorbable base material including: a lipid peptide compound including at least one of compound of Formula (1) below and the similar compounds or pharmaceutically usable salts thereof; a surfactant; a specific polyhydric alcohol; a fatty acid; and water, wherein R1 is a C9-23 aliphatic group; R2 is a hydrogen atom or a C1-4 alkyl group that optionally has a branched chain having a carbon atom number of 1 or 2; R3 is a —(CH2)n—X group; n is a number of 1 to 4; and X is amino group, guanidino group, —CONH2 group, or a 5-membered cyclic group optionally having 1 to 3 nitrogen atoms, a 6-membered cyclic group optionally having 1 to 3 nitrogen atoms, or a condensed heterocyclic group constituted by a 5-membered cyclic group and a 6-membered cyclic group which optionally have 1 to 3 nitrogen atoms.
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公开(公告)号：US20180185414A1
公开(公告)日：2018-07-05
申请号：US15735401
申请日：2016-06-10
发明人： Osamu HIRATA , Takehisa IWAMA
IPC分类号： A61K33/42 , A61K9/10 , A61K47/38 , A61K47/36 , A61K47/02 , A61K47/24 , A61K47/22 , A61K47/18 , A61K8/04 , A61K8/24 , A61K8/73 , A61K8/55 , A61K8/49 , A61K8/44 , A61Q19/08 , A61Q19/02
CPC分类号： A61K33/42 , A61K8/0241 , A61K8/04 , A61K8/19 , A61K8/24 , A61K8/44 , A61K8/4973 , A61K8/55 , A61K8/676 , A61K8/73 , A61K8/731 , A61K8/733 , A61K8/735 , A61K9/0014 , A61K9/10 , A61K33/06 , A61K33/08 , A61K47/02 , A61K47/183 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40 , A61K47/42 , A61K2800/412 , A61Q19/007 , A61Q19/02 , A61Q19/08
摘要： The objective of the present invention is to provide a calcium salt composition with improved dispersity and preservation stability of calcium salt in an aqueous medium as well as with increased filaggrin production promoting action of calcium salt in addition. The present invention relates to a calcium salt composition comprising a calcium salt insoluble or poorly soluble to an aqueous medium and an anionic dispersant.
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公开(公告)号：US20140162318A1
公开(公告)日：2014-06-12
申请号：US13974820
申请日：2013-08-23
发明人： Misayo TOMURA , Takehisa IWAMA , Koichiro SARUHASHI , Taito NISHINO , Masato HORIKAWA , Hiroharu KAWAHARA
IPC分类号： C12P21/00
CPC分类号： C12P21/00 , C07K14/565 , C12N5/0018 , C12N2501/90 , C12N2511/00
摘要： [Summary] The present invention relates to a protein production accelerating agent that has enabled to largely increase the produced amount of a desired protein by adding polysaccharides to a medium for animal cells containing a serum or serum alternative, and a production method of a protein using a medium containing the protein production accelerating agent.
摘要翻译： 发明内容本发明涉及蛋白质生产促进剂，其能够通过向含有血清或血清替代物的动物细胞的培养基中添加多糖而大大增加所需蛋白质的产生量，以及使用 含有蛋白质生产促进剂的培养基。
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公开(公告)号：US20200208101A1
公开(公告)日：2020-07-02
申请号：US16801785
申请日：2020-02-26
发明人： Taito NISHINO , Tatsuro KANAKI , Ayako OTANI , Koichiro SARUHASHI , Misayo Tomura , Takehisa IWAMA , Masato HORIKAWA , Norio NAKATSUJI , Tomomi OTSUJI
摘要： The present invention provides a culture method of cells and/or tissues including culturing cells and/or tissues in a suspended state by using a medium composition wherein indeterminate structures are formed in a liquid medium, the structures are uniformly dispersed in the solution and substantially retain the cells and/or tissues without substantially increasing the viscosity of the solution, thus affording an effect of preventing sedimentation thereof, and the like
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公开(公告)号：US20190053988A1
公开(公告)日：2019-02-21
申请号：US16166942
申请日：2018-10-22
发明人： Hisato HAYASHI , Takehisa IWAMA
IPC分类号： A61K8/02 , A61K8/365 , A61K8/06 , A61K8/24 , A61K8/20 , A61K8/34 , A61K8/73 , A61K8/44 , A61L26/00 , A61K8/60 , A61K45/06 , A61K31/717 , A61K8/27 , A61K8/81 , A61K8/23 , A61K8/67 , A61K8/46 , A61Q19/00 , C08L1/02 , C08L5/14
摘要： Described are a method for producing cellulose fibers suitable for use in a thickening composition, a method for producing a thickening composition that contains the cellulose fibers, and a method for thickening a composition. The method for producing the cellulose fibers includes grinding a composition containing cellulose fibers and an aqueous solution to produce a dispersion containing cellulose fibers having an average fiber diameter (D) in a range of from 0.001 to 100 μm in the aqueous solution.
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