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公开(公告)号：US20230203369A1
公开(公告)日：2023-06-29
申请号：US17797181
申请日：2021-02-12
申请人： NORTHWESTERN UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , HOWARD HUGHES MEDICAL INSTITUTE
发明人： Nathan C. GIANNESCHI , Nanzhi ZANG , Massimo SCANZIANI , Dante S. BORTONE , Treffly B. DITRI , Anthony M. RUSH
CPC分类号： C09K11/06 , G01N33/587 , B82Y5/00 , B82Y30/00 , C09K2211/1466 , C09K2211/145
摘要： Disclosed is composition comprising: a first fluorophore moiety, and nanoparticles, wherein the nanoparticles comprise: a first plurality of a first nanoparticle, the first nanoparticle comprising: a first outer surface, a first interior bulk, and a first polymer, wherein the first polymer is covalently bonded to the first fluorophore moiety within the first interior bulk of the first nanoparticle. Also disclosed is a composition comprising: a chelate moiety, and nanoparticles, wherein the nanoparticles comprise: a plurality of a chelate nanoparticle, the chelate nanoparticle comprising: an outer surface, an interior bulk, and a polymer, wherein the polymer is covalently bonded to the chelate moiety within the interior bulk of the chelate nanoparticle. Also disclosed are methods of making such compositions and using such composition for brain mapping and tracing of axonal projections.
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公开(公告)号：US20240110004A1
公开(公告)日：2024-04-04
申请号：US18452059
申请日：2023-08-18
申请人： Northwestern University , The Regents of the University of California , Case Western Reserve University
发明人： Nathan C. GIANNESCHI , Mara A. FATTAH , Wonmin CHOI , Xin QI
IPC分类号： C08G61/08 , A61K31/787 , A61P25/28
CPC分类号： C08G61/08 , A61K31/787 , A61P25/28 , C08G2261/122 , C08G2261/149 , C08G2261/228 , C08G2261/3342 , C08G2261/418
摘要： Disclosed are protein-like polymers and uses thereof. The protein-like polymers generally comprise a polymer of formula (FX1) or (FX2). The polymer of formula (FX1) or (FX2) in some aspects inhibits the protein-protein interaction between VCP and mutant-type Huntingtin protein.
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公开(公告)号：US20210393673A1
公开(公告)日：2021-12-23
申请号：US17332704
申请日：2021-05-27
发明人： Nathan C. GIANNESCHI , Yuran HUANG , Yiwen LI
IPC分类号： A61K31/787 , A61K9/51
摘要： Provided, inter alia, are synthetic melanin nanoparticles (MelNPs) useful for protecting keratinocytes from UV-damage and for treating melanin-defective diseases.
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公开(公告)号：US20240325307A1
公开(公告)日：2024-10-03
申请号：US18423695
申请日：2024-01-26
CPC分类号： A61K9/1075 , A61K9/146 , A61K47/42 , A61K47/58 , C07K14/001 , C08G61/08 , C08G2261/126 , C08G2261/1424 , C08G2261/1432 , C08G2261/148 , C08G2261/164 , C08G2261/1644 , C08G2261/1646 , C08G2261/3324 , C08G2261/334 , C08G2261/418 , C08G2261/80 , C08G2261/90 , C08G2261/94
摘要： Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.
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公开(公告)号：US20210283054A1
公开(公告)日：2021-09-16
申请号：US17160588
申请日：2021-01-28
摘要： Described herein, inter alia, are peptide containing polymers, and methods of making and using the same.
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公开(公告)号：US20240216892A1
公开(公告)日：2024-07-04
申请号：US18269078
申请日：2021-12-22
CPC分类号： B01J20/3057 , B01D53/02 , B01J20/262 , B01J20/28069 , B01J20/3208 , B01J20/3272 , B01D2253/202 , B01D2256/245 , B01D2257/102 , B01D2257/108 , B01D2257/406 , B01D2257/504 , B01D2257/7025
摘要： Aspects of the invention include a method of capturing target compound(s) using a capture device, the method comprising: exposing the device to an environment comprising the target compound(s); wherein the device comprises: a porous artificial melanin material comprising: one or more melanin oligomers and/or polymers; wherein the melanin oligomers and/or polymers comprise a plurality of covalently-bonded melanin base units; wherein the melanin oligomers and/or polymers are arranged to form an internal structure having a plurality of pores; wherein the porous artificial melanin material is characterized by a pore volume per mass of material greater than or equal to 0.1 cm3/g and wherein at least a portion of said pores have at least one size dimension greater than or equal to 0.5 nm; and capturing the target compound(s) via an interaction between the porous artificial melanin material and the target compound(s).
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公开(公告)号：US20230181747A1
公开(公告)日：2023-06-15
申请号：US17921546
申请日：2021-04-29
CPC分类号： A61K47/595 , C08G69/48 , C08G69/08 , A61K47/641 , A61P35/00 , C08G61/08 , A61K47/59 , C08G2261/418 , C08G2261/3324 , C08G2261/1432 , C08G2261/1412 , C08G2261/1426 , C08G2261/1414
摘要： Aspects of the invention include a polymer comprising: a plurality of repeating units, each repeating unit comprising a polymer backbone group directly or indirectly covalently linked to one or two side chain moieties; wherein: each polymer backbone group is independently a ROMP-polymerized monomer; each one of the one or two side chain moieties independently comprises a peptide moiety or a non-peptide therapeutic moiety; wherein the polymer comprises a plurality of peptide moieties; each polymer backbone group is covalently attached to at least one other polymer backbone group; 100% of the ROMP-polymerized monomers are each individually attached to the one or two side chain moieties; and at least one side chain moiety of the polymer comprises a non-peptide therapeutic moiety, one polymer-terminating group comprises a non-peptide therapeutic moiety, and/or each of both polymer-terminating groups comprises a non-peptide therapeutic moiety.
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公开(公告)号：US20220389414A1
公开(公告)日：2022-12-08
申请号：US17772169
申请日：2020-10-28
申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , WISCONSIN ALUMNI RESEARCH FOUNDATION , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , NORTHWESTERN UNIVERSITY
发明人： Alan ASPURU-GUZIK , Si Yue GUO , Tony Chang-Chi WU , Pascal Thomas FRIEDERICH , Randall Howard GOLDSMITH , Leroy CRONIN , Abhishek SHARMA , Yudong CAO , Nathan C. GIANNESCHI , Christopher James FORMAN
摘要： Molecular computer techniques for solving a computational problem using an array of reaction sites, for example, droplets, are disclosed. The problem may be represented as a Hamiltonian in terms of problem variables and problem parameters. The reaction sites may have a physicochemical property mapping to discrete site states corresponding to possible values of the problem variables. In a purely molecular approach, the reaction sites have intra-site and inter-site couplings enforced thereon representing the problem parameters, and the array is allowed to evolve, subjected to the enforced couplings, to a final configuration conveying a solution to the problem. In a hybrid classical-molecular approach, an iterative procedure may be performed that involves feeding read-out site states into a digital computer, determining, based on the problem parameters, perturbations to be applied to the states, and allowing the array to evolve under the perturbations to a final configuration conveying a solution to the problem.
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公开(公告)号：US20240189385A1
公开(公告)日：2024-06-13
申请号：US18283749
申请日：2022-04-04
CPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C07K14/001
摘要： In an aspect, the invention provides therapeutic agents comprising brush polymers that address challenges associated with conventional administration of free therapeutic peptides. In an embodiment, for example, the invention provides brush polymers incorporating one or more therapeutic peptides comprising a sequence having 75% or greater sequence identity of SEQ ID NO: 1 (LDEETGEFL) as side chain moieties. Therapeutic agents of the invention comprising brush polymers include high-density brush polymers including cross-linked brush polymers, brush block copolymers, and brush random copolymers. In an embodiment, brush polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration. The invention also includes methods of making and using therapeutic agents comprising brush polymers.
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10.发明公开公开(公告)号：US20230193039A1
公开(公告)日：2023-06-22
申请号：US17770247
申请日：2020-10-29
发明人： Nathan C. GIANNESCHI , Wei CAO
CPC分类号： C09B69/104 , C07F11/00 , B82Y40/00
摘要： In an aspect, an artificial selenomelanin material comprises: one or more selenomelanin polymers; wherein the one or more selenomelanin polymers comprise a plurality of covalently bonded selenomelanin base units; and wherein a chemical formula of each of the one or more selenomelanin base units comprises at least one selenium atom. Optionally, each selenomelanin polymer is a pheomelanin. Preferably, the chemical formula of each of the one or more selenomelanin base units comprises at least one covalent bond with each of the at least one selenium atom.
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