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    Polyunsaturated compounds, method for preparing same and compositions containing the same
    5.
    发明授权
    Polyunsaturated compounds, method for preparing same and compositions containing the same 失效
    多不饱和化合物，其制备方法和含有它们的组合物

    公开(公告)号：US08420610B2

    公开(公告)日：2013-04-16

    申请号：US12086625

    申请日：2006-12-14

    申请人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    发明人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    IPC分类号： A01N43/04 ,  A01N37/00 ,  A61K31/70 ,  A61K31/19 ,  C07H15/00 ,  C07C59/00

    CPC分类号： C07D339/04 ,  A61K8/33 ,  A61K8/37 ,  A61K8/4986 ,  A61K8/585 ,  A61K8/602 ,  A61Q19/02 ,  C07B2200/09 ,  C07C403/08 ,  C07C403/10 ,  C07C403/14 ,  C07C403/20 ,  C07C2601/16 ,  C07F7/081 ,  C07F7/0812 ,  C07H15/203

    摘要： The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R′1, -A-R′1 group, R′1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3 R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC —(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′2—O—R6 group, wherein R′2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C 1-C 16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

    摘要翻译： 本发明涉及式（I）的新型多不饱和化合物，其中：R1表示R'1，-AR'1基团，R'1选自-COOH，-COOR3，-CONH2，-CONHR3，-CONR3R4，-CHO ，-CH 2 OH，-CH 2 OR 5，A表示C 2 -C 16亚烷基，亚烯基或亚炔基; R2表示：任选取代的芳基或任选取代的杂芳基; 糖残基或脂肪酸残基，优选在链末端，特别是通过羟基，乙酰氧基或任选被保护的氨基部分支化和/或取代; a -OC-（CH 2）n CO-生育酚（α，β或γ或δ）组，其中2 $ m（F）n $ m（F）10; -R'2-O-R6基团，其中R'2是任选取代的亚芳基或任选取代的亚杂芳基，R 6表示氢原子，直链或支链任选取代的C 1 -C 16烷基，直链 或支链任选取代的C 2 -C 16烯基，或直链或支链C 2 -C 16炔基，任选取代的生育酚基等，氨基酸残基或糖残基。 本发明还涉及组合物，特别是包含至少一种式（I）化合物的化妆品和/或皮肤病学组合物，以及它们作为增白剂和/或脱色素剂的用途，以及使用所述组合物的美容方法。

    UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY
    6.
    发明申请
    UNSATURATED FATTY AMINO ACID DERIVATIVES AND USE THEREOF IN DERMAL COSMETOLOGY 审中-公开
    不饱和脂肪氨基酸衍生物及其在真菌学中的应用

    公开(公告)号：US20100240754A1

    公开(公告)日：2010-09-23

    申请号：US12523231

    申请日：2008-01-16

    申请人： Roger Tarroux ,  Marie Charveron ,  Sylvie Daunes-Marion ,  Natacha Frison ,  Benôit Folleas ,  Jean-Louis Brayer

    发明人： Roger Tarroux ,  Marie Charveron ,  Sylvie Daunes-Marion ,  Natacha Frison ,  Benôit Folleas ,  Jean-Louis Brayer

    IPC分类号： C07C229/30 ,  C07C227/00 ,  A61K31/197 ,  A61K8/44 ,  A61Q19/08 ,  A61P17/00

    CPC分类号： C07C229/30 ,  C07C227/00 ,  C07C237/16

    摘要： The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C1-C6)alkyl optionally substituted by halogen; R1 is hydrogen, fluorine, chlorine or bromine, or a CF3 or CHF2 or a (C1-C6)alkyl, (C1-C6)alkenyl or (C1-C6)alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C1-C6)alkyl or (C3-C6)cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C1-C6)alkyl or (C1-C6)acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.

    摘要翻译： 本发明涉及由通式（I）的不饱和脂肪氨基酸衍生物及其药学上可接受的酸加成盐组成的药物，其中：X为氧或NH，R n独立地为氢或（C 1 -C 6 ）烷基任选被卤素取代; R 1是任选被一个或多个卤素原子取代的氢，氟，氯或溴，或CF 3或CHF 2或（C 1 -C 6）烷基，（C 1 -C 6）烯基或（C 1 -C 6） R是氢或任选被一个或多个卤素原子取代的（C 1 -C 6）烷基或（C 3 -C 6）环烷基; Ra和Rb独立地是氢（C1-C6）烷基或（C1-C6）酰基，Ra和Rb是含有4-6个碳原子的烃基; n为2〜14的整数。

    Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same
    7.
    发明申请
    Novel Polyunsaturated Compounds, Method for Preparing Same and Compositions Containing the Same 失效
    新型多不饱和化合物，其制备方法及其组合物

    公开(公告)号：US20100168045A1

    公开(公告)日：2010-07-01

    申请号：US12086625

    申请日：2006-12-14

    申请人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    发明人： Pascal Bordat ,  Roger Tarroux ,  Jean-Hilaire Saurat ,  Olivier Sorg ,  Jean-Louis Brayer ,  Natacha Frison

    IPC分类号： A61K8/37 ,  C07H15/207 ,  A61K8/60 ,  C07C69/736 ,  C07C47/277 ,  C07C69/587 ,  C07D339/04 ,  A61K8/49 ,  C07D311/72 ,  A61K8/67 ,  C07C69/738 ,  A61K8/34 ,  A61K8/33 ,  A61Q5/00 ,  A61Q19/02

    CPC分类号： C07D339/04 ,  A61K8/33 ,  A61K8/37 ,  A61K8/4986 ,  A61K8/585 ,  A61K8/602 ,  A61Q19/02 ,  C07B2200/09 ,  C07C403/08 ,  C07C403/10 ,  C07C403/14 ,  C07C403/20 ,  C07C2601/16 ,  C07F7/081 ,  C07F7/0812 ,  C07H15/203

    摘要： The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R′1, -A-R′1 group, R′1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3, R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R′2—O—R6 group, wherein R′2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C1-C16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheryl radical or the like, an amino acid residue, or a sugar residue. The invention also concerns the compositions, in particular cosmetic and/or dermatological compositions containing at least one compound of formula (I) as well as their use as whitening and/or depigmenting agent, and the cosmetic method using said compositions.

    摘要翻译： 本发明涉及式（I）的新型多不饱和化合物，其中：R1表示R'1，-AR'1基团，R'1选自-COOH，-COOR3，-CONH2，-CONHR3，-CONR3，R4， - CHO，-CH2OH，-CH2OR5和A表示C2-C16亚烷基，亚烯基或亚炔基; R2表示：任选取代的芳基或任选取代的杂芳基; 糖残基或脂肪酸残基，优选在链末端，特别是羟基，乙酰氧基或任选被保护的氨基上任选地支链和/或取代; a -OC-（CH 2）n CO-生育酚（α，β或γ或δ）组，其中2 $ m（F）n $ m（F）10; -R'2-O-R6基团，其中R'2是任选取代的亚芳基或任选取代的亚杂芳基，R 6表示氢原子，直链或支链任选取代的C 1 -C 16烷基，直链或支链 任选取代的C 2 -C 16烯基，或直链或支链C 2 -C 16炔基，任选取代的生育酚基等，氨基酸残基或糖残基。 本发明还涉及组合物，特别是包含至少一种式（I）化合物的化妆品和/或皮肤病学组合物，以及它们作为增白剂和/或脱色素剂的用途，以及使用所述组合物的美容方法。