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公开(公告)号：US09487752B2
公开(公告)日：2016-11-08
申请号：US13435698
申请日：2012-03-30
申请人： Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
发明人： Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
CPC分类号： C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
摘要翻译： 提供了多能干细胞分化的方法和组成。 例如，在某些方面，包括在基本上不含生长因子如FGF和TGFβ的培养基中用于神经分化的引发干细胞的方法。 作为优点，神经细胞可以具有改善的一致性和纯度。
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2.发明申请公开(公告)号：US20120276063A1
公开(公告)日：2012-11-01
申请号：US13435698
申请日：2012-03-30
申请人： Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
发明人： Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
CPC分类号： C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要： Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
摘要翻译： 提供了多能干细胞分化的方法和组成。 例如，在某些方面，包括在基本上不含生长因子例如FGF和TGF-bgr的培养基中用于神经分化的引发干细胞的方法。 作为优点，神经细胞可以具有改善的一致性和纯度。
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公开(公告)号：US20090275131A1
公开(公告)日：2009-11-05
申请号：US12435123
申请日：2009-05-04
申请人： Christine Daigh , Deepika Rajesh
发明人： Christine Daigh , Deepika Rajesh
IPC分类号： C12N5/08
CPC分类号： C12N5/0642 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2502/1394 , C12N2506/02 , C12N2509/00
摘要： Provided are methods for generating mast cells from pluripotent stem cells in vitro. Methods are disclosed for the differentiation of pluripotent cells, such as iPS cells and/or human embryonic stem cells, into mast cells. The resulting mast cells may be used for various purposes including screening cells for drug development and research. Growth factors which may be included in culture media according to the present invention include stem cell factor (SCF), FLT-3 ligand, thrombopoietin (TPO), interleukin-3 (IL-3), and/or interleukin-6 (IL-6).
摘要翻译： 提供了在体外从多能干细胞产生肥大细胞的方法。 公开了将多能细胞如iPS细胞和/或人胚胎干细胞分化为肥大细胞的方法。 所得的肥大细胞可用于各种目的，包括用于药物开发和研究的筛选细胞。 根据本发明可以包括在培养基中的生长因子包括干细胞因子（SCF），FLT-3配体，血小板生成素（TPO），白细胞介素-3（IL-3）和/或白细胞介素-6（IL- 6）。
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4.发明授权公开(公告)号：US07056491B2
公开(公告)日：2006-06-06
申请号：US10014724
申请日：2001-11-07
IPC分类号： A61K49/00
CPC分类号： A61K41/0038 , A61K31/01 , A61K31/045 , A61K31/11 , A61K31/12
摘要： A method of sensitizing tumor cells to radiation thereapy, chemotherapy and immunomodulatory thereapy, comprising the step of exposing the tumor cell to an effective amount of at least one monoterpene or sesquiterpene and treating the tumor cell is disclosed.
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公开(公告)号：US08765470B2
公开(公告)日：2014-07-01
申请号：US13197529
申请日：2011-08-03
CPC分类号： C12N5/0696 , C12N15/63 , C12N15/85 , C12N2501/06 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2510/00 , C12N2510/04 , C12N2710/16243 , C12N2800/108
摘要： Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
摘要翻译： 提供了用于提供诱导性多能干（iPS）细胞的方法和组合物。 例如，在某些方面，描述了包括通过附加型载体转化的B淋巴细胞重新编程的方法，例如基于Epstein-Barr病毒的载体。 此外，本发明提供基本上不含外源元件并具有B细胞免疫球蛋白可变区重排的诱导多能干细胞。
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公开(公告)号：US08513012B2
公开(公告)日：2013-08-20
申请号：US12435123
申请日：2009-05-04
申请人： Christine Daigh , Deepika Rajesh
发明人： Christine Daigh , Deepika Rajesh
CPC分类号： C12N5/0642 , C12N2501/125 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2502/1394 , C12N2506/02 , C12N2509/00
摘要： Provided are methods for generating mast cells from pluripotent stem cells in vitro. Methods are disclosed for the differentiation of pluripotent cells, such as iPS cells and/or human embryonic stem cells, into mast cells. The resulting mast cells may be used for various purposes including screening cells for drug development and research. Growth factors which may be included in culture media according to the present invention include stem cell factor (SCF), FLT-3 ligand, thrombopoietin (TPO), interleukin-3 (IL-3), and/or interleukin-6 (IL-6).
摘要翻译： 提供了在体外从多能干细胞产生肥大细胞的方法。 公开了将多能细胞如iPS细胞和/或人胚胎干细胞分化为肥大细胞的方法。 所得的肥大细胞可用于各种目的，包括用于药物开发和研究的筛选细胞。 根据本发明可以包括在培养基中的生长因子包括干细胞因子（SCF），FLT-3配体，血小板生成素（TPO），白细胞介素-3（IL-3）和/或白细胞介素-6（IL- 6）。
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公开(公告)号：US08372642B2
公开(公告)日：2013-02-12
申请号：US12715136
申请日：2010-03-01
申请人： Deepika Rajesh , Rachel Lewis
发明人： Deepika Rajesh , Rachel Lewis
CPC分类号： C12N5/0647 , C12N5/0692 , C12N2500/02 , C12N2501/115 , C12N2501/125 , C12N2501/14 , C12N2501/145 , C12N2501/155 , C12N2501/165 , C12N2501/22 , C12N2501/23 , C12N2501/26 , C12N2506/03 , C12N2506/45
摘要： Provided herein are methods for the in vitro maintenance, expansion, culture, and/or differentiation of pluripotent cells, such as human embryonic stem cells (hESC) or induced pluripotent cells (iPSC), into hematopoietic precursor cells or endothelial cells. The pluripotent cells may be maintained and differentiated under defined conditions; thus, the use of mouse feeder cells or serum is not required in certain embodiments for the differentiation of the pluripotent cells into hematopoietic precursor cells or endothelial cells. The resulting hematopoietic precursor cells may be further differentiated into various myeloid or lymphoid lineages.
摘要翻译： 本文提供了将多能细胞如人胚胎干细胞（hESC）或诱导的多能细胞（iPSC）体外维持，扩增，培养和/或分化到造血前体细胞或内皮细胞中的方法。 可以在限定的条件下维持和分化多能细胞; 因此，在某些实施方案中，为了将多能细胞分化成造血前体细胞或内皮细胞，不需要使用小鼠饲养细胞或血清。 所得到的造血前体细胞可进一步分化成各种骨髓或淋巴系。
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公开(公告)号：US20120135525A1
公开(公告)日：2012-05-31
申请号：US13376361
申请日：2010-06-04
申请人： Matthew Brown , Elizabeth Rondon Dominguez , Randy Learish , Emile Nuwaysir , Deepika Rajesh , Amanda Mack
发明人： Matthew Brown , Elizabeth Rondon Dominguez , Randy Learish , Emile Nuwaysir , Deepika Rajesh , Amanda Mack
CPC分类号： C12N5/0696 , C12N5/0637 , C12N15/85 , C12N2501/2302 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2502/1114 , C12N2506/11 , C12N2510/00 , C12N2800/108
摘要： Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
摘要翻译： 公开了与诱导性多能干细胞（iPS细胞）的产生有关的方法和组合物。 例如，可以从CD34 +造血细胞例如人CD34 +血液祖细胞或T细胞产生诱导的多能干细胞。 还提供了各种iPS细胞系。 在某些实施方案中，本发明提供具有包含T细胞受体的遗传重排的基因组的新型诱导多能干细胞。
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公开(公告)号：US08741648B2
公开(公告)日：2014-06-03
申请号：US13376361
申请日：2010-06-04
申请人： Deepika Rajesh , Amanda Mack
发明人： Deepika Rajesh , Amanda Mack
CPC分类号： C12N5/0696 , C12N5/0637 , C12N15/85 , C12N2501/2302 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2502/1114 , C12N2506/11 , C12N2510/00 , C12N2800/108
摘要： Methods and compositions relating to the production of induced pluripotent stem cells (iPS cells) are disclosed. For example, induced pluripotent stem cells may be generated from CD34+ hematopoietic cells, such as human CD34+ blood progenitor cells, or T cells. Various iPS cell lines are also provided. In certain embodiments, the invention provides novel induced pluripotent stem cells with a genome comprising genetic rearrangement of T cell receptors.
摘要翻译： 公开了与诱导性多能干细胞（iPS细胞）的产生有关的方法和组合物。 例如，可以从CD34 +造血细胞例如人CD34 +血液祖细胞或T细胞产生诱导的多能干细胞。 还提供了各种iPS细胞系。 在某些实施方案中，本发明提供具有包含T细胞受体的遗传重排的基因组的新型诱导多能干细胞。
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公开(公告)号：US20120058562A1
公开(公告)日：2012-03-08
申请号：US13197529
申请日：2011-08-03
CPC分类号： C12N5/0696 , C12N15/63 , C12N15/85 , C12N2501/06 , C12N2501/115 , C12N2501/15 , C12N2501/235 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2501/727 , C12N2506/11 , C12N2510/00 , C12N2510/04 , C12N2710/16243 , C12N2800/108
摘要： Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.
摘要翻译： 提供了用于提供诱导性多能干（iPS）细胞的方法和组合物。 例如，在某些方面，描述了包括通过附加型载体转化的B淋巴细胞重新编程的方法，例如基于Epstein-Barr病毒的载体。 此外，本发明提供基本上不含外源元件并具有B细胞免疫球蛋白可变区重排的诱导多能干细胞。
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