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公开(公告)号:US09487752B2
公开(公告)日:2016-11-08
申请号:US13435698
申请日:2012-03-30
申请人: Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
发明人: Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
CPC分类号: C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
摘要翻译: 提供了多能干细胞分化的方法和组成。 例如,在某些方面,包括在基本上不含生长因子如FGF和TGFβ的培养基中用于神经分化的引发干细胞的方法。 作为优点,神经细胞可以具有改善的一致性和纯度。
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公开(公告)号:US20120276063A1
公开(公告)日:2012-11-01
申请号:US13435698
申请日:2012-03-30
申请人: Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
发明人: Nathan Meyer , Matthew George , Casey Stankewicz , Deepika Rajesh
CPC分类号: C12N5/0619 , A61K35/12 , A61K35/30 , C12N5/0622 , C12N2501/119 , C12N2501/155 , C12N2506/45
摘要: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including priming stem cells for neural differentiation in a culture medium essentially free of growth factors such as FGF and TGFβ. As an advantage, the neural cells may be provided with improved consistency and purity.
摘要翻译: 提供了多能干细胞分化的方法和组成。 例如,在某些方面,包括在基本上不含生长因子例如FGF和TGF-bgr的培养基中用于神经分化的引发干细胞的方法。 作为优点,神经细胞可以具有改善的一致性和纯度。
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公开(公告)号:US09181529B2
公开(公告)日:2015-11-10
申请号:US13276832
申请日:2011-10-19
申请人: Steven Kattman , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
发明人: Steven Kattman , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
CPC分类号: C12N5/0696 , C12N5/0607 , C12N2503/00 , C12N2506/00
摘要: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.
摘要翻译: 提供了多能干细胞分化的方法和组成。 例如,在某些方面,包括筛选所选批次的培养基中所选干细胞克隆的最佳分化条件的方法,以及使用确定的最佳条件分化成特定细胞谱系。
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公开(公告)号:US20120129211A1
公开(公告)日:2012-05-24
申请号:US13276832
申请日:2011-10-19
申请人: STEVEN KATTMAN , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
发明人: STEVEN KATTMAN , Wen Bo Wang , Peter Fuhrken , Nathan Meyer , Matthew George , Casey Stankewicz
CPC分类号: C12N5/0696 , C12N5/0607 , C12N2503/00 , C12N2506/00
摘要: Methods and composition for differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including screening of optimal differentiation conditions for a selected stem cell clone in a selected batch of culture medium and use of the determined optimal condition for differentiation into a specific cell lineage.
摘要翻译: 提供了多能干细胞分化的方法和组成。 例如,在某些方面,包括筛选所选批次的培养基中所选干细胞克隆的最佳分化条件的方法,以及使用确定的最佳条件分化成特定细胞谱系。
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公开(公告)号:US08906034B2
公开(公告)日:2014-12-09
申请号:US13864012
申请日:2013-04-16
申请人: Garrett Gleeson , Thomas Perry , Nathan Meyer , Anand Parikh , Clark Hutton
发明人: Garrett Gleeson , Thomas Perry , Nathan Meyer , Anand Parikh , Clark Hutton
CPC分类号: A61B17/7074 , A61B17/708
摘要: An orthopedic instrument for compression and distraction of bone segments includes a first receiver, a second receiver, a positioner member, and a guide member. The first receiver includes a first receiver aperture that receives a first screw extender. The second receiver includes a second extender aperture that receives a second screw extender. The positioner member translates the second receiver relative to the first receiver to apply one of a compression and a distraction force on the screw extenders. The guide member parallel to the positioner member guides the second receiver relative to the first receiver.
摘要翻译: 用于骨段的压缩和牵引的矫形器械包括第一接收器,第二接收器,定位器构件和引导构件。 第一接收器包括接收第一螺旋延长器的第一接收器孔。 第二接收器包括接收第二螺旋延伸器的第二扩展器孔。 定位器构件相对于第一接收器转换第二接收器以将螺旋延伸器中的压缩和牵引力中的一个施加。 平行于定位器构件的引导构件相对于第一接收器引导第二接收器。
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公开(公告)号:US20110312090A1
公开(公告)日:2011-12-22
申请号:US13164461
申请日:2011-06-20
申请人: Nathan Meyer , Brad Swanson , Steve Fiene
发明人: Nathan Meyer , Brad Swanson , Steve Fiene
IPC分类号: C12N5/077
CPC分类号: C12N5/0657 , C12N2500/00 , C12N2501/999
摘要: Methods and composition for maintenance of cardiomyocytes are provided. For example, in certain aspects methods including culturing the cardiomyocytes in a medium essentially free of serum or containing dialyzed serum to maintain long-term purity. In further aspects, methods for modulation of cardiomyocytes may be provided.
摘要翻译: 提供了维持心肌细胞的方法和组成。 例如,在某些方面,包括在基本上不含血清或含有透析血清的培养基中培养心肌细胞以保持长期纯度的方法。 在另外的方面,可以提供用于调节心肌细胞的方法。
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公开(公告)号:US20050142357A1
公开(公告)日:2005-06-30
申请号:US11003407
申请日:2004-12-06
申请人: Michael Zajaczkowski , Kevin McKinney , Andy Hogan , Ben Wagner , Nathan Meyer , Barbara Stutzman Wilt
发明人: Michael Zajaczkowski , Kevin McKinney , Andy Hogan , Ben Wagner , Nathan Meyer , Barbara Stutzman Wilt
IPC分类号: B32B27/30 , C08L71/00 , C09J7/02 , C09J133/04
CPC分类号: C08G65/336 , C08L71/00 , C08L2312/08 , C08L2666/02 , C08L2666/08 , C09J7/385 , C09J133/04 , C09J171/02 , Y10T428/28
摘要: A pressure sensitive adhesive composition is provided comprised of a cross-linked multifunctional liquid polymer having a Tg
摘要翻译: 提供了一种压敏粘合剂组合物,其由具有Tg <20℃的交联多官能液体聚合物,与液体聚合物相容的至少一种增粘树脂和至少一种不兼容或至少部分的另外的树脂组成 与液体聚合物不相容。
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公开(公告)号:US20130289633A1
公开(公告)日:2013-10-31
申请号:US13864012
申请日:2013-04-16
申请人: Garrett GLEESON , Thomas Perry , Nathan Meyer , Anand Parikh , Clark Hutton
发明人: Garrett GLEESON , Thomas Perry , Nathan Meyer , Anand Parikh , Clark Hutton
IPC分类号: A61B17/70
CPC分类号: A61B17/7074 , A61B17/708
摘要: An orthopedic instrument for compression and distraction of bone segments includes a first receiver, a second receiver, a positioner member, and a guide member. The first receiver includes a first receiver aperture that receives a first screw extender. The second receiver includes a second extender aperture that receives a second screw extender. The positioner member translates the second receiver relative to the first receiver to apply one of a compression and a distraction force on the screw extenders. The guide member parallel to the positioner member guides the second receiver relative to the first receiver.
摘要翻译: 用于骨段的压缩和牵引的矫形器械包括第一接收器,第二接收器,定位器构件和引导构件。 第一接收器包括接收第一螺旋延长器的第一接收器孔。 第二接收器包括接收第二螺旋延伸器的第二扩展器孔。 定位器构件相对于第一接收器转换第二接收器以将螺旋延伸器中的压缩和牵引力中的一个施加。 平行于定位器构件的引导构件相对于第一接收器引导第二接收器。
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公开(公告)号:US08821502B2
公开(公告)日:2014-09-02
申请号:US13409711
申请日:2012-03-01
申请人: Garrett Gleeson , Clark Hutton , Nathan Meyer , Anand Parikh
发明人: Garrett Gleeson , Clark Hutton , Nathan Meyer , Anand Parikh
CPC分类号: A61B17/708
摘要: An instrument for multilevel compression and distraction of vertebrae in a spinal column includes a first arm, a second arm, a third arm, a linking member, and a coupler. The first arm includes a distal end with a first aperture for receiving a first screw extender that attaches to a first vertebra. The second arm includes a distal end with a second aperture for receiving a second screw extender that attaches to a second vertebra. The third arm includes a distal end with a third aperture for receiving a third screw extender that attaches to a third vertebra. The linking member pivotally links proximal ends of the first, second, and third arms. The coupler positions the distal ends of the first arm and the second arm relative to the third arm to compress and distract the first vertebra and the second vertebra relative to the third vertebra.
摘要翻译: 用于脊柱中椎骨多层压缩和牵引的仪器包括第一臂,第二臂,第三臂,连接构件和联接器。 第一臂包括具有第一孔的远端,用于接收附接到第一椎骨的第一螺钉延伸器。 第二臂包括具有第二孔的远端,用于接收附接到第二椎骨的第二螺钉延伸器。 第三臂包括具有第三孔的远端,用于接收连接到第三椎骨的第三螺钉延伸器。 连接构件枢转地连接第一,第二和第三臂的近端。 耦合器使第一臂和第二臂的远端相对于第三臂定位,以相对于第三椎骨压缩和分散第一椎骨和第二椎骨。
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公开(公告)号:US20110112586A1
公开(公告)日:2011-05-12
申请号:US12943210
申请日:2010-11-10
申请人: Jeffrey Allen Guyer , Thomas Purcell , Nathan Meyer , Ali Araghi , Javier Garcia-Bengochea , Carl Lauryssen , Moran Lorio
发明人: Jeffrey Allen Guyer , Thomas Purcell , Nathan Meyer , Ali Araghi , Javier Garcia-Bengochea , Carl Lauryssen , Moran Lorio
IPC分类号: A61B17/56
CPC分类号: A61F2/4611 , A61B17/0293 , A61B17/86 , A61B2017/0262
摘要: A method and device for attaching a curvilinear access device having a movable top and an expandable working portal to the spine, the attachment including a holding arm assembly, posterior tang, anterior tang and/or a portal fixation pin.
摘要翻译: 一种用于将具有可移动顶部和可扩展工作入口的曲线进入装置附接到脊柱的方法和装置,所述附件包括保持臂组件,后脚,前柄脚和/或入口固定销。
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