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公开(公告)号：US09364582B2
公开(公告)日：2016-06-14
申请号：US13238844
申请日：2011-09-21
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions.
摘要翻译： 描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。 固体可以包括颗粒胶原和颗粒脱矿质骨基质。 液体载体包括含有一种或多种多糖的水性介质。 还描述了制备和使用这种医药组合物的方法。
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公开(公告)号：US08663672B2
公开(公告)日：2014-03-04
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
摘要翻译： 提供了一种骨植入物，其包括细长骨颗粒的相干团聚体，所述骨植入物具有预定的尺寸和形状。 骨质植入物具有高吸收性和海绵状。 本文还提供了一种制造骨样植入物的方法以及利用骨植入物修复和/或治疗骨缺损的方法。
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公开(公告)号：US06638310B2
公开(公告)日：2003-10-28
申请号：US09734860
申请日：2000-12-12
申请人： Jo-Wen Lin , Nelson L. Scarborough , Lawrence Shimp , David Kaes
发明人： Jo-Wen Lin , Nelson L. Scarborough , Lawrence Shimp , David Kaes
IPC分类号： A61F244
CPC分类号： A61F2/4684 , A61F2/28 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2002/2825 , A61F2002/2853 , A61F2002/2892 , A61F2002/30057 , A61F2002/30131 , A61F2002/30492 , A61F2002/30616 , A61F2002/4622 , A61F2002/4628 , A61F2220/0025 , A61F2230/0013 , A61F2310/00017
摘要： An intervertebral spacer formed of dense cancellous human or animal bone is provided. In one preferred embodiment, the intervertebral spacer includes at least one bore which is dimensioned to receive a plug formed from cortical bone tissue. The cortical bone plug provides increased mechanical strength to the intervertebral spacer. Instrumentation for gauging the size of an intervertebral receiving bed and for grasping and inserting an intervertebral spacer or implant into an intervertebral receiving bed are also provided. These instruments include a spacer trial or set of spacer trials for determining the appropriate size spacer required for a particular surgical procedure, a spacer introducer for grasping and positioning a spacer at least partially within a receiving bed formed in the intervertebral space, and a bone tamp for driving a spacer into the receiving bed. Any one or all of these instruments may be provided in a kit for inserting an implant into the intervertebral space. The kit may also include one or more intervertebral spacers or implants.
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4.发明授权Process for producing flexible sheets from demineralized, elongate, bone particles 有权从软化细长的骨颗粒生产柔性片的方法公开(公告)号：US06436138B1
公开(公告)日：2002-08-20
申请号：US09155064
申请日：1998-09-18
IPC分类号： A61F228
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61F2002/30957 , A61F2002/4649 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L2430/40 , Y10S623/901 , Y10S623/919
摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid form the demineralized bone particles to provide a cohering shaped mass of demineralized bone particles, and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period. The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.
摘要翻译： 从软化骨粒子制造成形材料的方法包括以下步骤：将软化骨颗粒的液体浆料施加到支撑体上，从脱矿骨粒子中除去多余的液体，以提供凝固成型的脱矿质骨粒子，并加热成形质量 的软化骨颗粒在预定温度和预定时间段内。 所得骨量在再水化时表现出增强的拉伸强度和最小的骨粒子分离，从而改善在手术部位的产品处理和应用。
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5.发明授权Surgical implant containing a resorbable radiopaque marker and method of locating such within a body 失效包含可再吸收的不透射线标记的外科植入物和在体内定位的方法
公开(公告)号：US5676146A
公开(公告)日：1997-10-14
申请号：US713694
申请日：1996-09-13
IPC分类号： A61L27/00 , A61B6/00 , A61B6/12 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/10 , A61F2/28 , A61F2/30 , A61K35/32 , A61L27/02 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61B6/583 , A61B6/12 , A61F2/28 , A61B90/39 , A61F2002/30059 , A61F2002/30062 , A61F2002/3008 , A61F2002/30153 , A61F2002/30235 , A61F2002/30242 , A61F2002/30263 , A61F2002/30291 , A61F2210/0004 , A61F2230/0019 , A61F2230/0069 , A61F2230/0071 , A61F2230/0084 , A61F2230/0091 , A61F2250/0098 , A61F2310/00293 , A61F2310/00365
摘要： A surgical implant containing a resorbable radiopaque marker enables the position and/or orientation of the implant to be readily determined by x-ray or other radiographic technique following its surgical implantation in the body.
摘要翻译： 包含可再吸收的不透射线标记的手术植入物使得通过其在体内的手术植入后的X射线或其它放射照相技术容易地确定植入物的位置和/或取向。
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公开(公告)号：US08197474B2
公开(公告)日：2012-06-12
申请号：US13185553
申请日：2011-07-19
IPC分类号： A61F2/28
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译： 由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素 体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。 还提供了使用该组合物修复骨缺损部位的方法。
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公开(公告)号：US20110274668A1
公开(公告)日：2011-11-10
申请号：US13185553
申请日：2011-07-19
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译： 由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素 体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。 还提供了使用该组合物修复骨缺损部位的方法。
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公开(公告)号：US08002813B2
公开(公告)日：2011-08-23
申请号：US12548029
申请日：2009-08-26
IPC分类号： A61F2/28
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译： 由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素 体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。 还提供了使用该组合物修复骨缺损部位的方法。
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公开(公告)号：US07179299B2
公开(公告)日：2007-02-20
申请号：US10285715
申请日：2002-11-01
申请人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
发明人： Jean T. Edwards , Lawrence A. Shimp , Michele Diegmann , Todd M. Boyce , Nelson L. Scarborough , James L. Russell
IPC分类号： A61F2/28
CPC分类号： A61L27/3683 , A61L27/3608 , A61L27/365 , A61L2430/02
摘要： A method of manufacturing an osteoinductive osteoimplant is provided which comprises the steps of: demineralizing part or all of at least one surface of a monolithic section of cortical bone to a depth of at least about 100 microns; and, configuring the monolithic section of cortical bone to provide an osteoimplant possessing an outer surface possessing at least one demineralized zone and a non-demineralized zone. An implant produced according to the above method demonstrates improved osteoinduction without producing any clinically significant reduction of strength in critical regions of the osteoimplant.
摘要翻译： 提供了一种制造骨诱导性骨植入物的方法，其包括以下步骤：将至少一个皮质骨整体部分的至少一个表面的部分或全部软化至至少约100微米的深度; 以及配置皮质骨的整体部分以提供具有外表面的骨植入物，所述外表面具有至少一个脱矿质区和非脱矿质区。 根据上述方法制备的植入物表现出改善的骨诱导，而不会在骨植入物的临界区域中产生任何临床显着的强度降低。
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公开(公告)号：US06383221B1
公开(公告)日：2002-05-07
申请号：US09924499
申请日：2001-08-08
IPC分类号： A61F244
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/30771 , A61F2/3094 , A61F2/30965 , A61F2/442 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2839 , A61F2002/30153 , A61F2002/30158 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/3023 , A61F2002/30266 , A61F2002/30772 , A61F2002/30774 , A61F2002/30785 , A61F2002/30789 , A61F2002/3079 , A61F2002/30879 , A61F2002/30884 , A61F2002/30892 , A61F2002/30902 , A61F2002/30904 , A61F2002/30971 , A61F2002/448 , A61F2002/4649 , A61F2230/0019 , A61F2230/0026 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2240/001 , A61F2310/00017 , A61F2310/00131 , A61F2310/00293 , A61F2310/00359 , Y10S623/901
摘要： An intervertebral implant having a composite wedge/dowel configuration is provided. The intervertebral implant includes a central body portion and a pair of radially extending wings. The radially extending wings can be tapered from a first end of the implant to the second end of the implant along an axis parallel to the longitudinal axis of the central body portion. Alternately, the radially extending wings can be tapered along an axis transverse to the longitudinal axis of the cylindrical body portion or along any other axis between parallel and transverse to the longitudinal axis. A throughbore or plurality of throughbores extend from a top surface of the implant through the implant to a bottom surface of the implant. The implant may be formed from a cortical ring cut from the diaphysis of a long bone by milling the top and bottom surfaces of the cortical ring to form the substantially central body portion and the tapered radially extending wings. The cortical ring is milled such that the intramedullary canal of the cortical ring defines a throughbore in the central body portion of the implant. The sidewalls of the implant may be machined to form a substantially rectangular shape or the implant can be left to have a substantially circular configuration. Alternately, the implant may be formed of any biocompatible material having the requisite strength requirements via any known process, i.e., molding.
摘要翻译： 提供具有复合楔形/定位销构造的椎间植入物。 椎间植入物包括中心主体部分和一对径向延伸的翼部。 径向延伸的翼可以沿着平行于中心主体部分的纵向轴线的轴线从植入物的第一端到植入物的第二端渐缩。 或者，径向延伸的翼可以沿着与圆柱形主体部分的纵向轴线相垂直的轴线或沿着与纵向轴线平行和横向的任何其它轴线成锥形。 通孔或多个通孔从植入物的顶表面通过植入物延伸到植入物的底表面。 植入物可以由通过研磨皮质环的顶部和底部表面的长骨骨干切割的皮质环形成，以形成基本中心的主体部分和锥形径向延伸的翼。 皮质环被研磨成使得皮质环的髓内管在植入物的中心体部分中形成通孔。 植入物的侧壁可以被机加工以形成基本上矩形的形状，或者植入物可以留下具有大致圆形的构型。 或者，植入物可以通过任何已知的方法即成型具有必要的强度要求的任何生物相容性材料形成。
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