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公开(公告)号：US06638310B2
公开(公告)日：2003-10-28
申请号：US09734860
申请日：2000-12-12
申请人： Jo-Wen Lin , Nelson L. Scarborough , Lawrence Shimp , David Kaes
发明人： Jo-Wen Lin , Nelson L. Scarborough , Lawrence Shimp , David Kaes
IPC分类号： A61F244
CPC分类号： A61F2/4684 , A61F2/28 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2/4611 , A61F2002/2825 , A61F2002/2853 , A61F2002/2892 , A61F2002/30057 , A61F2002/30131 , A61F2002/30492 , A61F2002/30616 , A61F2002/4622 , A61F2002/4628 , A61F2220/0025 , A61F2230/0013 , A61F2310/00017
摘要： An intervertebral spacer formed of dense cancellous human or animal bone is provided. In one preferred embodiment, the intervertebral spacer includes at least one bore which is dimensioned to receive a plug formed from cortical bone tissue. The cortical bone plug provides increased mechanical strength to the intervertebral spacer. Instrumentation for gauging the size of an intervertebral receiving bed and for grasping and inserting an intervertebral spacer or implant into an intervertebral receiving bed are also provided. These instruments include a spacer trial or set of spacer trials for determining the appropriate size spacer required for a particular surgical procedure, a spacer introducer for grasping and positioning a spacer at least partially within a receiving bed formed in the intervertebral space, and a bone tamp for driving a spacer into the receiving bed. Any one or all of these instruments may be provided in a kit for inserting an implant into the intervertebral space. The kit may also include one or more intervertebral spacers or implants.
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公开(公告)号：US20100111906A1
公开(公告)日：2010-05-06
申请号：US12548029
申请日：2009-08-26
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译： 由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素 体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。 还提供了使用该组合物修复骨缺损部位的方法。
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公开(公告)号：US06863694B1
公开(公告)日：2005-03-08
申请号：US09610026
申请日：2000-07-03
申请人： Todd M. Boyce , David Kaes , Nelson L. Scarborough
发明人： Todd M. Boyce , David Kaes , Nelson L. Scarborough
CPC分类号： A61L27/3645 , A61B17/60 , A61B17/68 , A61B17/70 , A61B17/80 , A61B17/8071 , A61B17/8085 , A61B17/809 , A61C8/0012 , A61F2/28 , A61F2/2803 , A61F2/3099 , A61F2/34 , A61F2/36 , A61F2/3877 , A61F2/40 , A61F2/44 , A61F2/4455 , A61F2002/2817 , A61F2002/2853 , A61F2002/2871 , A61F2002/2882 , A61F2002/2892 , A61F2002/2896 , A61F2002/30004 , A61F2002/30059 , A61F2002/30153 , A61F2002/30166 , A61F2002/30172 , A61F2002/30205 , A61F2002/3021 , A61F2002/30217 , A61F2002/30225 , A61F2002/30235 , A61F2002/30238 , A61F2002/30785 , A61F2002/30971 , A61F2002/4212 , A61F2002/4271 , A61F2230/0019 , A61F2230/0028 , A61F2230/0052 , A61F2230/0067 , A61F2230/0069 , A61F2250/0014 , A61L27/3608 , A61L27/3683 , A61L2430/02
摘要： An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
摘要翻译： 以柔软片形式的成骨性骨植入物，其包含骨源性颗粒的相干质量，所述骨质疏植体具有不大于约32％的空隙体积，以及使成骨植入物具有不大于约32％空隙体积的方法， 该方法包括：提供骨源颗粒的连贯质量; 并且机械地成形骨衍生的颗粒的相干团块以形成柔性片形式的成骨植骨。
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公开(公告)号：US06808585B2
公开(公告)日：2004-10-26
申请号：US09973597
申请日：2001-10-09
申请人： Todd M. Boyce , David Kaes , Nelson L. Scarborough
发明人： Todd M. Boyce , David Kaes , Nelson L. Scarborough
IPC分类号： A61F228
CPC分类号： A61F2/28 , A61F2002/30535 , A61F2250/0058 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L2430/02
摘要： An osteogenic osteoimplant in the form of a flexible sheet comprising a coherent mass of bone-derived particles, the osteoimplant having a void volume not greater than about 32% and a method of making an osteogenic osteoimplant having not greater than about 32% void volume, the method comprising: providing a coherent mass of bone-derived particles; and, mechanically shaping the coherent mass of bone-derived particles to form an osteogenic osteoimplant in the form of a flexible sheet.
摘要翻译： 以柔软片形式的成骨性骨植入物，其包含骨源性颗粒的相干质量，所述骨质疏植体具有不大于约32％的空隙体积，以及使成骨植入物具有不大于约32％空隙体积的方法， 所述方法包括：提供骨源颗粒的连贯质量; 并且机械地成形骨衍生的颗粒的相干团块以形成柔性片形式的成骨植骨。
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公开(公告)号：US20110274668A1
公开(公告)日：2011-11-10
申请号：US13185553
申请日：2011-07-19
CPC分类号： A61K35/32 , Y10S606/909
摘要： An osteoinductive/osteoconductive composition prepared from a quantity, of demineralized fibrous bone elements possessing an average surface area to volume ratio of about 100:1 to about 20:1, a quantity of mostly shaped regular non-fibrous bone elements possessing an average surface area to volume ratio of about 10:1 or less and a sufficient quantity of biocompatible fluid carrier sufficient to provide the composition as a deformable mass is provided herein. Also provided is a method of using the composition to repair a bone defect site.
摘要翻译： 由一定数量的具有约100:1至约20:1的平均表面积与体积比的软化纤维骨元素制备的骨诱导/骨传导组合物，具有平均表面积的大多数成形的规则非纤维骨元素 体积比为约10:1或更低，并且足够量的足以提供组合物作为可变形物质的生物相容性流体载体在本文中提供。 还提供了使用该组合物修复骨缺损部位的方法。
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公开(公告)号：US06332779B1
公开(公告)日：2001-12-25
申请号：US09609982
申请日：2000-07-03
IPC分类号： A61C500
CPC分类号： A61F2/28 , A61F2/2803 , A61F2/2875 , A61L27/3608 , A61L27/3645
摘要： A method for promoting the growth of bone, periodontium, or ligament in a warm-blooded vertebrate, the method comprising: producing a surgical flap to expose the bone, periodontium or ligament; debriding the bone, periodontium or ligament to remove organic matter from the bone, periodontium or ligament; implanting an effective amount of an osteogenic bone graft material, the bone graft material consisting of an osteoimplant having not greater than about 32% void volume formed at least in part from elongate bone-derived elements optionally in combination with bone powder; replacing the flap; and, allowing the bone, periodontium or ligament to regrow.
摘要翻译： 一种用于促进温血脊椎动物中骨，牙周或韧带生长的方法，所述方法包括：产生外科皮瓣以暴露骨，牙周组织或韧带; 清除骨骼，牙周组织或韧带以从骨，牙周组织或韧带中去除有机物质; 植入有效量的成骨骨移植材料，所述骨移植物材料由不超过约32％空隙体积的骨植入材料组成，所述骨植入物至少部分地由细长骨衍生的元素任选地与骨粉末组合形成; 更换皮瓣 并允许骨，牙周组织或韧带重新生长。
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公开(公告)号：US09364582B2
公开(公告)日：2016-06-14
申请号：US13238844
申请日：2011-09-21
CPC分类号： A61L27/20 , A61F2/28 , A61L27/24 , A61L27/3608 , A61L27/365 , A61L27/48
摘要： Described are malleable medical compositions such as pastes or putties that include solids combined with a liquid carrier. The solids can include particulate collagen and particulate demineralized bone matrix. The liquid carrier includes an aqueous medium comprising one or more polysaccharides. Also described are methods for making and using such medical compositions.
摘要翻译： 描述的是可延展的药物组合物，例如包括与液体载体结合的固体的糊剂或油灰。 固体可以包括颗粒胶原和颗粒脱矿质骨基质。 液体载体包括含有一种或多种多糖的水性介质。 还描述了制备和使用这种医药组合物的方法。
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公开(公告)号：US08663672B2
公开(公告)日：2014-03-04
申请号：US11231954
申请日：2005-09-21
申请人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人： Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
CPC分类号： A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要： An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
摘要翻译： 提供了一种骨植入物，其包括细长骨颗粒的相干团聚体，所述骨植入物具有预定的尺寸和形状。 骨质植入物具有高吸收性和海绵状。 本文还提供了一种制造骨样植入物的方法以及利用骨植入物修复和/或治疗骨缺损的方法。
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9.发明授权Process for producing flexible sheets from demineralized, elongate, bone particles 有权从软化细长的骨颗粒生产柔性片的方法公开(公告)号：US06436138B1
公开(公告)日：2002-08-20
申请号：US09155064
申请日：1998-09-18
IPC分类号： A61F228
CPC分类号： A61L27/3691 , A61F2/28 , A61F2/3094 , A61F2/4644 , A61F2002/30957 , A61F2002/4649 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L2430/40 , Y10S623/901 , Y10S623/919
摘要： A process for fabricating shaped material from demineralized bone particles includes the steps of applying a liquid slurry of demineralized bone particles to a support, removing excess liquid form the demineralized bone particles to provide a cohering shaped mass of demineralized bone particles, and warming the shaped mass of demineralized bone particles at a predetermined temperature and for a predetermined time period. The resultant bone mass exhibits enhanced tensile strength and minimal bone particle disassociation upon rehydration thereby improving product handling and application at the operative site.
摘要翻译： 从软化骨粒子制造成形材料的方法包括以下步骤：将软化骨颗粒的液体浆料施加到支撑体上，从脱矿骨粒子中除去多余的液体，以提供凝固成型的脱矿质骨粒子，并加热成形质量 的软化骨颗粒在预定温度和预定时间段内。 所得骨量在再水化时表现出增强的拉伸强度和最小的骨粒子分离，从而改善在手术部位的产品处理和应用。
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10.发明授权Surgical implant containing a resorbable radiopaque marker and method of locating such within a body 失效包含可再吸收的不透射线标记的外科植入物和在体内定位的方法
公开(公告)号：US5676146A
公开(公告)日：1997-10-14
申请号：US713694
申请日：1996-09-13
IPC分类号： A61L27/00 , A61B6/00 , A61B6/12 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/10 , A61F2/28 , A61F2/30 , A61K35/32 , A61L27/02 , A61L27/24 , A61L27/36 , A61L27/58
CPC分类号： A61B6/583 , A61B6/12 , A61F2/28 , A61B90/39 , A61F2002/30059 , A61F2002/30062 , A61F2002/3008 , A61F2002/30153 , A61F2002/30235 , A61F2002/30242 , A61F2002/30263 , A61F2002/30291 , A61F2210/0004 , A61F2230/0019 , A61F2230/0069 , A61F2230/0071 , A61F2230/0084 , A61F2230/0091 , A61F2250/0098 , A61F2310/00293 , A61F2310/00365
摘要： A surgical implant containing a resorbable radiopaque marker enables the position and/or orientation of the implant to be readily determined by x-ray or other radiographic technique following its surgical implantation in the body.
摘要翻译： 包含可再吸收的不透射线标记的手术植入物使得通过其在体内的手术植入后的X射线或其它放射照相技术容易地确定植入物的位置和/或取向。
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