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公开(公告)号:US20080154386A1
公开(公告)日:2008-06-26
申请号:US11951084
申请日:2007-12-05
申请人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
发明人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
CPC分类号: A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译: 通过使整个骨骼软化,然后再次分解脱矿质骨以提供脱矿质骨颗粒,获得脱矿质骨颗粒。
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公开(公告)号:US20110108644A1
公开(公告)日:2011-05-12
申请号:US13010084
申请日:2011-01-20
申请人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
发明人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
IPC分类号: B02C19/00
CPC分类号: A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译: 通过使整个骨骼软化,然后再次分解脱矿质骨以提供脱矿质骨颗粒,获得脱矿质骨颗粒。
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公开(公告)号:US07939108B2
公开(公告)日:2011-05-10
申请号:US11951084
申请日:2007-12-05
申请人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
发明人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
IPC分类号: A61K35/32
CPC分类号: A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译: 通过使整个骨骼软化,然后再次分解脱矿质骨以提供脱矿质骨颗粒,获得脱矿质骨颗粒。
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公开(公告)号:US08529962B2
公开(公告)日:2013-09-10
申请号:US13010084
申请日:2011-01-20
申请人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
发明人: John W. Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
IPC分类号: A61K35/32
CPC分类号: A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译: 通过使整个骨骼软化,然后再次分解脱矿质骨以提供脱矿质骨颗粒,获得脱矿质骨颗粒。
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公开(公告)号:US07323193B2
公开(公告)日:2008-01-29
申请号:US10433588
申请日:2001-12-14
申请人: John Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
发明人: John Morris , Lawrence A. Shimp , Kenneth C. Petersen , Albert Manrique , David Kaes , Nelson Scarborough , Michael Dowd
IPC分类号: A61K35/32
CPC分类号: A61K35/32 , A61F2/4644 , A61F2002/4645 , A61K45/06 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L27/3695 , A61L2430/40 , C07K14/78
摘要: Demineralized bone particles are obtained by demineralizing whole bone and thereafter subdividing the demineralized bone to provide the demineralized bone particles.
摘要翻译: 通过使整个骨骼软化,然后再次分解脱矿质骨以提供脱矿质骨颗粒,获得脱矿质骨颗粒。
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公开(公告)号:US08323700B2
公开(公告)日:2012-12-04
申请号:US10509585
申请日:2003-03-31
CPC分类号: A61L27/3683 , A01N1/00 , A61F2/4644 , A61F2002/2835 , A61F2002/4645 , A61F2002/4649 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L2430/02 , A61L2430/40
摘要: The present invention relates to a method for making bone particles from bone of a variety of sizes and a workpiece forming and holding device for use with the method. The workpiece forming device includes a base and a base frame attached to the surface of the base. An apparatus for forming a solidified mass of bone and immobilization medium is also provided which includes the workpiece forming device and a detachable former member enclosing the base frame. Bone is immersed in an immobilization medium within such workpiece forming device, which is solidified to form a solidified mass of bone and immobilization medium and then subdivided to provide particles of bone in association to with immobilization medium. The immobilization medium may be optionally removed to leave bone particles suitable for use in orthopedic applications including implants.
摘要翻译: 本发明涉及一种用于制造各种尺寸的骨的骨颗粒的方法和用于该方法的工件形成和保持装置。 工件形成装置包括底座和附接到基座表面的底座。 还提供了一种用于形成固化骨和固定介质的装置,其包括工件形成装置和包围基架的可拆卸的成形构件。 将骨浸入这种工件形成装置内的固定介质中,固化介质被固化以形成骨和固定介质的固化块,然后细分以提供与固定介质相关联的骨颗粒。 可以任选地除去固定介质以留下适合用于矫形应用的骨颗粒,包括植入物。
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7.
公开(公告)号:US06440444B2
公开(公告)日:2002-08-27
申请号:US09911562
申请日:2001-07-24
IPC分类号: A61F1300
CPC分类号: A61F2/28 , A61F2/32 , A61F2/4644 , A61F2002/30535 , A61F2250/0058 , A61L27/3608 , A61L27/3645 , A61L27/3683 , A61L27/3691 , A61L27/3847 , A61L31/005 , A61L2430/02
摘要: A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.
摘要翻译: 提供了一种承重骨植入物,制造骨盆的方法和使用骨植入物修复骨的方法。 骨植入物包括成形的,压缩的骨颗粒组合物。 骨植入物具有大于约0.7g / cm 3的堆积密度和至少约3MPa的湿抗压强度。
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公开(公告)号:US08133421B2
公开(公告)日:2012-03-13
申请号:US10736799
申请日:2003-12-16
IPC分类号: A61B17/56
CPC分类号: A61B17/0401 , A61B17/72 , A61B17/742 , A61B17/80 , A61B17/86 , A61B2017/0409 , A61B2017/0414 , A61B2017/044 , A61C8/0012 , A61C8/0036 , A61F2/28 , A61F2/2803 , A61F2/2875 , A61F2/30965 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/442 , A61F2/446 , A61F2/4611 , A61F2/4644 , A61F2002/2817 , A61F2002/2825 , A61F2002/2835 , A61F2002/2871 , A61F2002/2892 , A61F2002/30004 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30125 , A61F2002/30143 , A61F2002/30146 , A61F2002/30148 , A61F2002/30153 , A61F2002/30154 , A61F2002/30158 , A61F2002/30225 , A61F2002/30237 , A61F2002/30238 , A61F2002/30261 , A61F2002/30266 , A61F2002/30433 , A61F2002/30535 , A61F2002/30561 , A61F2002/30622 , A61F2002/30678 , A61F2002/30785 , A61F2002/3085 , A61F2002/3092 , A61F2002/3095 , A61F2002/30952 , A61F2002/30957 , A61F2002/30962 , A61F2002/30968 , A61F2002/3611 , A61F2002/365 , A61F2002/3686 , A61F2210/0004 , A61F2220/0041 , A61F2230/0006 , A61F2230/0008 , A61F2230/0017 , A61F2230/0019 , A61F2230/0021 , A61F2230/0026 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2250/0058 , A61F2250/0071 , A61F2310/00011 , A61F2310/00161 , A61F2310/00173 , A61F2310/00293 , A61F2310/00347 , A61F2310/00365 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3691 , A61L27/3839 , A61L27/3847 , A61L31/005 , A61L2430/02 , B33Y80/00
摘要: A load-bearing osteoimplant which comprises a shaped, coherent aggregate of bone particles.
摘要翻译: 一种承重骨植入物,其包括骨形成的,相干的骨颗粒聚集体。
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公开(公告)号:US09387094B2
公开(公告)日:2016-07-12
申请号:US10137862
申请日:2002-05-02
申请人: Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
发明人: Albert Manrique , Jean T. Edwards , Nelson L. Scarborough , Scott D. Boden , Kathy Traianedes , Lawrence A. Shimp , James L. Russell
CPC分类号: A61F2/4644 , A61B17/866 , A61F2/28 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30059 , A61F2002/30075 , A61F2002/30113 , A61F2002/30131 , A61F2002/30153 , A61F2002/30154 , A61F2002/30156 , A61F2002/30158 , A61F2002/302 , A61F2002/30205 , A61F2002/30224 , A61F2002/30225 , A61F2002/30238 , A61F2002/30261 , A61F2002/3028 , A61F2002/30733 , A61F2002/30879 , A61F2002/30891 , A61F2002/30892 , A61F2002/30957 , A61F2002/30971 , A61F2002/4649 , A61F2210/0061 , A61F2230/0006 , A61F2230/0013 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0063 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0082 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L27/3691 , A61L31/005 , A61L2430/02 , B29C41/22 , B29C41/46 , B29K2105/16 , B29K2511/06 , B29L2031/7532
摘要: An osteoimplant is provided which comprises a coherent aggregate of elongate bone particles, the osteoimplant possessing predetermined dimensions and shape. The osteoimplant is highly absorbent and sponge-like in nature. Also provided herein are a method of fabricating the osteoimplant and a method of repairing and/or treating bone defects utilizing the osteoimplant.
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10.
公开(公告)号:US06294187B1
公开(公告)日:2001-09-25
申请号:US09256447
申请日:1999-02-23
IPC分类号: A61F1300
CPC分类号: A61F2/28 , A61F2/32 , A61F2/4644 , A61F2002/30535 , A61F2250/0058 , A61L27/3608 , A61L27/3645 , A61L27/3683 , A61L27/3691 , A61L27/3847 , A61L31/005 , A61L2430/02
摘要: A load-bearing osteoimplant, method of making the osteoimplant and method for repairing bone using the osteoimplant are provided. The osteoimplant comprises a shaped, compressed composition of bone particles. The osteoimplant possesses a bulk density of greater than about 0.7 g/cm3 and a wet compressive strength of at least about 3 MPa.
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