摘要:
Novel disubstituted bicyclic heterocycles, of which the following are exemplary:(a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-aminocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole and(d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-indole.These are useful for the treatment of thrombotic disease.
摘要:
The invention relates to new 2-hydroxy-n-propylamines of the formulaR.sub.1 --O--CH.sub.2 --CHOH--CH.sub.2 --NH--A--R.sub.2 (I)whereinR.sub.1, R.sub.2 and A are defined as in claim 1, the tautomers, enantiomers and acid addition salts thereof, particularly for pharmaceutical use the physiologically acceptable acid addition salts thereof with inorganic or organic acids, which have valuable pharmacological properties, more particularly a simultaneous cardiotonic and .beta.-blocking activity, and the use thereof as pharmaceutical compositions and processes for preparing them.
摘要:
The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which have valuable pharmacological properties, particularly the effect of extending the thrombin time, a thrombin inhibiting effect and an inhibiting effect on related serine proteases such as trypsin, pharmaceutical compositions containing this compound and processes for the preparation thereof.
摘要:
The invention relates to a method for operating a navigation system for a motor vehicle in a road network, and to a navigation system. To this end, first a zone of the road network is provided with an emissions class-dependent drive-through restriction, wherein the motor vehicle is associated with at least one emissions class. First, information about the geographical location of the zone and about the emissions class at least required there is stored in the navigation system. Then, information about the at least one emissions class of the motor vehicle is entered into the navigation system. Thereafter, the information entered is considered in the destination guidance process, wherein destination guidance into or through the zone is avoided if the at least one emissions class of the motor vehicle is affected by emissions class-dependent drive-through restrictions in the zone.
摘要:
In one aspect, a method for realizing a presence service with a buddy list that can be displayed on a display device of a terminal is provided. In an activated state, the buddy list itself is displayed, and in a deactivated state, the buddy list itself is not visible. The buddy list is updated by a control device during a change in state of at lest one subscriber to be monitored and/or of at least one device assigned to the subscriber. According to the invention, the updating of the buddy list ensues in the deactivated state by means of the control device while using a method other than one used in the activated state.
摘要:
The use of licenses is monitored in a computer or communication system which has a plurality of terminals and in which at least one license is associated with at least one user. The use of the license or licenses by each user is recorded during a defined period after the license starts to run. Based on the recording result, a message is generated and sent to the user's terminal at least if the scope of use falls short of a predeterminable value.
摘要:
The method of using compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano,R.sub.2 is fluorine, cyano, trifluoromethyl, nitro or alkyl of 1 to 4 carbon atoms,R.sub.3 is cycloalkyl or alkyl, each of 3 to 5 carbon atoms, andR.sub.4 is hydrogen or --CO--R.sub.5, whereR.sub.5 is alkoxy of 1 to 5 carbon atoms, alkenyloxy of 2 to 5 carbon atoms, aryloxy of 6 to 10 carbon atoms, aralkoxy of 7 to 11 carbon atoms, or amino which may be mono- or di-substituted by alkyl of 1 to 5 carbon atoms, alkenyl of 2 to 5 carbon atoms, aryl of 6 to 10 carbon atoms and/or aralkyl of 7 to 11 carbon atoms,and non-toxic, pharmacologically acceptable acid addition salts thereof as antirheumatics and antiphlogistics.
摘要:
In one aspect, a method for managing documents or partial documents in an electronic document folder is provided. A validity indication, which is individual to the document or partial document and specifies a validity expiry time is assigned to a respective document, e.g. an e-mail, or a partial document, e.g. an e-mail attachment and is stored, the indication being assigned to an executable validity program. Once the validity expiry time has been reached, the executable validity program, assigned to the validity indication, is executed for the document or partial document with an assigned validity indication. The executable validity program comprises a deletion routine for deleting the document or partial document with the assigned validity indication in the electronic document folder.
摘要:
The invention relates to an improved method for producing foamed material, especially poly(meth)acrylimide foams, which are foamed from polymer plates produced according to the casting method. The two-step method consists of a pre-heating step and at least one foaming step. The product obtained has a significantly smaller compressive strain, measured according to DIN 53425(ASMD 621), than prior art products.
摘要:
The invention relates to a method, whereby the decision as to whether a protocol conversion is required or not is made according to a target datum contained in a signaling message, it is decided whether. The generation of a signaling message according to another signaling protocol is only then carried out if it is absolutely necessary. Said measures enable data losses to be limited as a result of the protocol conversion. Furthermore, for example, the load on the protocol conversion unit is reduced.