摘要:
Novel disubstituted bicyclic heterocycles, of which the following are exemplary:(a) 1-methyl-2-[(4-amidinophenyl)-oxymethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(b) 1-methyl-2-[2-(4-amidinophenyl)-ethyl]-5-[N-(N-(hydroxycarbonylmethyl)-aminocarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole,(c) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-benzimidazole and(d) 1-methyl-2-[N-(4-amidinophenyl)-aminomethyl]-5-[N-(hydroxycarbonylmethyl)-quinoline-8-sulphonylamino]-indole.These are useful for the treatment of thrombotic disease.
摘要:
The present invention relates to 5-membered heterocyclic condensed benzoderivatives of formula ##STR1## wherein R.sub.a to R.sub.c, A, X and Y are defined as in claim 1, the tautomers, stereoisomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable properties.The compounds of the above formula I wherein R.sub.c denotes a cyano group are valuable intermediates for preparing the other compounds of formula I, and the compounds of the above formula I wherein R.sub.c denotes one of the following amidino groups and the tautomers and stereoisomers thereof have valuable pharmacological properties, particularly an antithrombotic activity.
摘要:
The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which have valuable pharmacological properties, particularly the effect of extending the thrombin time, a thrombin inhibiting effect and an inhibiting effect on related serine proteases such as trypsin, pharmaceutical compositions containing this compound and processes for the preparation thereof.
摘要:
The invention relates to a method and a device for the removal of a tube blank (3) located on a support core (2). The tube blank (3) is detached from the support core (2) by means of the introduction of a medium through a device (10), whereby a detachment may be alternatively or additionally achieved by the application of a vacuum to a sleeve (4) enclosing the tube blank (3).
摘要:
A spiraling arrangement (1) for applying a spirally-shaped filament layer to an elongated carrier (2) which is drivable in the direction of the carrier longitudinal axis (X). The arrangement has a rotor (3), which is rotatable about the carrier longitudinal axis (X), and a plurality of filament bobbin carrier shafts (5) which extend in the direction of the carrier longitudinal axis (X). The carrier shafts (5) are arranged distributed on a circumscribed circle radius of the rotor (3) and are each configured to take up a plurality of filament bobbins (7). On one end face (6a) of the rotor (3), filament brake elements (10) are arranged distributed over the periphery and can be driven synchronously with respect to each other. The filaments (8) are taken off the filament bobbins (7) and are guided by filament guide elements (9) via the filament brake elements (10) and an annular comb (12), which encloses the carrier (2), onto the carrier (2).
摘要:
A method for determining the storage state of an ammonia-storing SCR catalyst, the change in at least one physical property of the SCR catalyst material, changing with the NH3 storing process, being sensed, the measurement taking place on the SCR catalyst material itself by applying a measuring pickup to the SCR catalyst or bringing it into direct contact with the latter and determining the storage state on the basis of these results. In an alternative embodiment, a material identical or similar to the SCR catalyst material with regard to its physical properties is arranged in the exhaust-gas stream in addition to the SCR catalyst material, and the change in at least one physical property of this substitute material changing with the NH3 storing process, is sensed, the measurement taking place on the substitute material itself by applying the substitute material to the measuring pickup or bringing it into direct contact with the latter and determining the storage state of the SCR catalyst on the basis of these results.
摘要:
An exhaust-gas aftertreatment device with a nitrogen oxide storage catalytic converter for an internal combustion engine, and a method for operating an exhaust-gas aftertreatment device which is assigned to an internal combustion engine and has a nitrogen oxide storage catalytic converter. An SCR catalytic converter is arranged in the exhaust-gas aftertreatment device, it being possible for the exhaust gas which emerges from the nitrogen oxide storage catalytic converter to be fed to the SCR catalytic converter when the internal combustion engine is in a desulphating operating mode with a reducing exhaust-gas composition, in order for H2S which is formed during the desulphating to be removed. When the internal combustion engine is in a desulphating operating mode, the following steps are performed: establishing a reducing exhaust gas composition upstream of the nitrogen oxide storage catalytic converter; releasing the sulphur which is bound in the nitrogen oxide storage catalytic converter, to form hydrogen sulphide (H2S); feeding the hydrogen sulphide to an SCR catalytic converter which is arranged downstream of the nitrogen oxide storage catalytic converter in the exhaust-gas aftertreatment device; and reacting the hydrogen sulphide in the SCR catalytic converter to form sulphur dioxide under reducing exhaust-gas conditions. The method may be used in motor vehicles, e.g., passenger cars, with lean-burn internal combustion engines.
摘要:
A method for the production of curved thread-reinforced tubular structures composed of rubber layers and of strengthening layers and an accompanying device. In one aspect, the method includes the application of a first rubber layer to the circumference of mandrels driven forward in a feed direction (X) and winding on of a multiplicity of parallel reinforcing threads, having defined thread angles (α) with respect to the feed axis (x), by means of a bobbin creel, to form a first thread ply. The mandrels are led through a rotating deflection element surrounding the mandrels and the reinforcing threads are guided so as to be distributed on the inner circumference. An application of a covering rubber layer may be performed (after the optionally multiple execution of the previous steps, alone or in combination). The mandrels are led through the deflection element of the bobbin creel eccentrically in the region of the deflection element.
摘要:
An air spring rolling-lobe flexible member is made of elastomeric material and has at least two layers of intersecting reinforcement filaments. The reinforcement filaments are arranged in an essentially parallel manner to each other at an angle between 40° and 80° to the direction of the periphery of the rolling-lobe flexible member. At least one component quantity of the reinforcement filaments (1, 2) within one layer exhibits another strength compared to the remaining component quantity thereof.
摘要:
The invention relates to a method and a device for the removal of a tube blank (3) located on a support core (2). The tube blank (2) is detached from the support core (2) by means of the introduction of a medium through a device (10), whereby a detachment may be alternatively or additionally achieved by the application of a vacuum to a sleeve (4) enclosing the tube blank (3).