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    Eye-fatigue examining device and eye-fatigue examining method
    1.
    发明授权
    Eye-fatigue examining device and eye-fatigue examining method 有权

    公开(公告)号：US10959615B2

    公开(公告)日：2021-03-30

    申请号：US16085595

    申请日：2017-02-20

    Applicant: OSAKA UNIVERSITY ,  TOPCON CORPORATION

    Inventor： Takashi Fujikado ,  Masakazu Hirota ,  Kohji Nishida ,  Makoto Saika ,  Tatsuo Yamaguchi ,  Suguru Miyagawa

    IPC: A61B3/113 ,  A61B3/10 ,  A61B3/08 ,  A61B3/00

    Abstract: An eye-fatigue examining device and an eye-fatigue examining method capable of examining eye fatigue of a subject's eye regardless of an age of a patient are provided. The eye-fatigue examining device includes: a light quantity difference adjusting unit that increases a light quantity difference between lights respectively incident on right and left subject's eyes; a gaze direction detecting unit that detects gaze directions of the respective subject's eyes while the light quantity difference adjusting unit increases the light quantity difference; and a light quantity difference deciding unit that decides a specific light quantity difference at which a change in the gaze directions due to the increase in the light quantity difference occurs, based on the detection result of the gaze direction detecting unit.

    Therapeutic instrument
    4.
    发明授权
    Therapeutic instrument 有权

    公开(公告)号：US10232153B2

    公开(公告)日：2019-03-19

    申请号：US15126553

    申请日：2015-02-26

    Applicant: OSAKA UNIVERSITY ,  HOYA CORPORATION

    Inventor： Kohji Nishida ,  Takeshi Soma ,  Yusuke Goto ,  Kikuo Mitomo

    IPC: A61M31/00 ,  A61F2/00 ,  A61F2/14 ,  A61F9/007 ,  A61F9/00

    Abstract: A therapeutic instrument (20), includes: a support member (25) having a tongue-shaped supporting portion (50) for supporting a sheet-like therapeutic agent; a nozzle member (23) having a cylindrical portion (30) in which the supporting portion (50) supporting the therapeutic agent can be housed, and having an opening (34) through which the supporting portion (50) can be loaded and unloaded in/from a tip of the cylindrical portion (30); a syringe unit (22) that acts a positive pressure in the cylindrical portion (30) for pushing-out the therapeutic agent housed in the cylindrical portion (30) together with the supporting portion (50) to outside the cylindrical portion (30) through the opening (34); and a water flow forming part including a plurality of protrusions (53) formed on a surface of the supporting portion (50) so as to form a water flow at a place where the supporting portion (50) and the therapeutic agent are facing each other, when a medical water is fed into the cylindrical portion (30) in a state in which the therapeutic agent is housed in the cylindrical portion (30) together with the supporting portion (50).

    TISSUE-PRESERVING LIQUID AND TISSUE-PRESERVING METHOD
    5.
    发明申请
    TISSUE-PRESERVING LIQUID AND TISSUE-PRESERVING METHOD 审中-公开
    组织保存液体和组织保存方法

    公开(公告)号：US20150351380A1

    公开(公告)日：2015-12-10

    申请号：US14416148

    申请日：2013-07-03

    Applicant: OSAKA UNIVERSITY

    Inventor： Ryuhei Hayashi ,  Kohji Nishida ,  Ryosuke Katori

    IPC: A01N1/02

    CPC classification number: A01N1/0226

    Abstract: The present invention provides a tissue preservation solution that has good quality for preservation of tissues, organs and cells, and is useful in the fields of regenerative medicine, transplantation medicine, etc. The tissue preservation solution of the present invention comprises a compound having a Nrf2 activating effect. Preferable compounds having a Nrf2 activating effect are electrophiles, and in particular, ebselen and tert-butylhydroquinone. A preferable basal solution of the tissue preservation solution is Hank's balanced salt solution.

    Abstract translation: 本发明提供一种保存组织，器官和细胞的良好质量的组织保存液，可用于再生医学，移植药物等领域。本发明的组织保存液含有具有Nrf2 激活效果。 具有Nrf2活化作用的优选化合物是亲电子试剂，尤其是依普硒和叔丁基氢醌。 组织保存液的优选基础溶液是汉克平衡盐溶液。

    METHOD FOR PRODUCING AN AQUEOUS DISPERSION OF DRUG NANOPARTICLES AND USE THEREOF
    6.
    发明申请
    METHOD FOR PRODUCING AN AQUEOUS DISPERSION OF DRUG NANOPARTICLES AND USE THEREOF 审中-公开
    用于生产药物纳米颗粒的水性分散体的方法及其用途

    公开(公告)号：US20150087624A1

    公开(公告)日：2015-03-26

    申请号：US14395952

    申请日：2013-04-23

    Applicant: OSAKA UNIVERSITY

    Inventor： Koichi Baba ,  Kohji Nishida ,  Noriyasu Hashida

    IPC: A61K9/10 ,  A61K31/57 ,  A61K9/00 ,  A61K31/27

    CPC classification number: A61K9/10 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/19 ,  A61K31/27 ,  A61K31/57 ,  A61K47/44 ,  A61K51/082 ,  B82Y5/00 ,  B82Y40/00

    Abstract: A nanoparticle aqueous dispersion in which nanoparticles are dispersed in water is produced through a method including a step of freeze-drying a frozen sample of a liquid mixture of a first solution and a second solution and a step of dispersing the freeze-dried sample in water. In this method, the liquid mixture contains an active ingredient and an ointment base, the first solution includes contains an organic solvent as its solvent, and the second solution contains water as its solvent. The method, which is arranged as such, can provide an aqueous composition containing nanoparticles dispersed therein and usable stably as an aqueous dispersion preparation.

    Abstract translation: 通过包括冷冻干燥第一溶液和第二溶液的液体混合物的冷冻样品的步骤的方法制备纳米颗粒分散在水中的纳米颗粒水分散体，以及将冷冻干燥样品分散在水中的步骤 。 在该方法中，液体混合物含有活性成分和软膏基质，第一溶液包含有机溶剂作为溶剂，第二溶液含有水作为溶​​剂。 这样布置的方法可以提供含有分散在其中的纳米颗粒的水性组合物，并可稳定地用作水分散体制剂。

    METHOD FOR PRODUCING STEM CELL-DERIVED LACRIMAL GLAND TISSUE
    8.
    发明申请
    METHOD FOR PRODUCING STEM CELL-DERIVED LACRIMAL GLAND TISSUE 有权

    公开(公告)号：US20210024896A1

    公开(公告)日：2021-01-28

    申请号：US16981455

    申请日：2019-03-28

    Applicant: Osaka University

    Inventor： Kohji Nishida ,  Ryuhei Hayashi ,  Toru Okubo ,  Yoichi Honma

    IPC: C12N5/074 ,  A61K35/55

    Abstract: Provided is a method for producing a stem cell-derived lacrimal gland tissue, the method comprising isolating SSEA4 and CD104 double positive cells from a self-formed ectodermal autonomous multi-zone (SEAM) cell population derived from pluripotent stem cells and three-dimensionally culturing the isolated cells in a medium with epidermal growth factor (EGF) and a ROCK inhibitor to produce a cell population expressing a lacrimal gland-related protein. The present invention provides a lacrimal gland organoid produced from pluripotent stem cells including iPS cells and thus is very useful for cell-based regenerative therapy for lacrimal gland-related diseases and cell-based research on the diseases.

    METHOD FOR CONTROLLING DIFFERENTIATION OF PLURIPOTENT STEM CELLS
    9.
    发明申请
    METHOD FOR CONTROLLING DIFFERENTIATION OF PLURIPOTENT STEM CELLS 审中-公开

    公开(公告)号：US20200010800A1

    公开(公告)日：2020-01-09

    申请号：US16482160

    申请日：2018-01-31

    Applicant: Osaka University

    Inventor： Kohji Nishida ,  Kiyotoshi Sekiguchi ,  Ryuhei Hayashi ,  Shun Shibata

    IPC: C12N5/079

    Abstract: The present invention relates to a method for controlling differentiation of pluripotent stem cells, which method comprises selecting a laminin or a fragment thereof based on binding affinity for the pluripotent stem cells and inducing differentiation of the pluripotent stem cells in the presence of the laminin or a fragment thereof. Here, the binding affinity for cells can be assessed by time-course observation of the survival rate and motility of the cells. According to the present invention, a cell population containing any desired proportion of differentiated cells can be produced from pluripotent stem cells in a simple manner. The cell population obtained by this production method is very useful for cell therapy-based treatment strategies for diseases.

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