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公开(公告)号：US06436637B1
公开(公告)日：2002-08-20
申请号：US09206646
申请日：1998-12-07
申请人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
发明人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
IPC分类号： C12N916
摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.
摘要翻译： 本发明提供了人蛋白磷酸酶（PROPHO）和识别和编码PROPHO的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与PROPHO表达相关的疾病的方法。
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公开(公告)号：US5853997A
公开(公告)日：1998-12-29
申请号：US873093
申请日：1997-06-11
申请人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
发明人： Olga Bandman , Surya K. Goli , Preeti Lal , Neil C. Corley , Hong Zhang
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61K45/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07K16/40 , C12N9/16 , C12N15/55 , C12Q1/68 , C07H21/04 , C12N1/20
摘要： The invention provides a human protein phosphatase (PROPHO) and polynucleotides which identify and encode PROPHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PROPHO.
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公开(公告)号：US5885803A
公开(公告)日：1999-03-23
申请号：US878989
申请日：1997-06-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
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公开(公告)号：US06207148B1
公开(公告)日：2001-03-27
申请号：US09272796
申请日：1999-03-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
IPC分类号： A61K3843
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
摘要翻译： 本发明提供了识别和编码它们的人类疾病相关蛋白激酶和多核苷酸（统称为DAPK）。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供用于诊断和治疗与人类疾病相关蛋白激酶的表达相关的疾病的方法。
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公开(公告)号：US5922566A
公开(公告)日：1999-07-13
申请号：US855261
申请日：1997-05-13
申请人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley
发明人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K45/00 , A61P29/00 , A61P35/00 , C07K14/705 , C07K16/30 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/02 , C12N5/10 , C12P21/02 , C12Q1/68 , C12N15/00 , C07H21/04 , C12N15/63 , C12N15/85
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The present invention provides a human tumor-associated antigen (TUAN) and polynucleotides which identify and encode TUAN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TUAN and for treating or preventing disorders associated with expression of TUAN.
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公开(公告)号：US6156523A
公开(公告)日：2000-12-05
申请号：US153939
申请日：1998-09-16
申请人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人： Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号： C12N9/1205 , C12Y207/01037 , A61K38/00
摘要： The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译： 本发明提供人丝氨酸/苏氨酸蛋白激酶（HSTK）和识别和编码HSTK的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供用于诊断，治疗或预防与HSTK表达相关的病症的方法。
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公开(公告)号：US06632617B1
公开(公告)日：2003-10-14
申请号：US09855288
申请日：2001-05-14
申请人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley , David G. Streeter
发明人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley , David G. Streeter
IPC分类号： C07K1600
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The invention provides a cDNA which encodes a TUAN. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of inflammatory and cell proliferative disorders, in particular, Crohn's disease and colon cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
摘要翻译： 本发明提供编码TAN的cDNA。 它还提供了cDNA，片段，补体及其变体以及编码的蛋白质，其部分及其抗体用于诊断和治疗炎症和细胞增殖性疾病，特别是克罗恩病和结肠癌的用途。 本发明另外提供用于产生蛋白质的表达载体和宿主细胞和转基因模型系统
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公开(公告)号：US06350581B1
公开(公告)日：2002-02-26
申请号：US09227224
申请日：1999-01-08
申请人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley
发明人： Olga Bandman , Surya K. Goli , Purvi Shah , Neil C. Corley
IPC分类号： C07K1400
CPC分类号： C07K14/705 , A61K38/00 , A61K39/00
摘要： The present invention provides a human tumor-associated antigen (TUAN) and polynucleotides which identify and encode TUAN. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TUAN and for treating or preventing disorders associated with expression of TUAN.
摘要翻译： 本发明提供了一种人肿瘤相关抗原（TUAN）和识别和编码TUAN的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了用于制备TAN并用于治疗或预防与TUAN表达相关的疾病的方法。
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公开(公告)号：US06379913B1
公开(公告)日：2002-04-30
申请号：US09299689
申请日：1999-04-26
IPC分类号： C12N948
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
摘要翻译： 本发明提供了人丝氨酸羧肽酶（CPEPT）和识别和编码CPEPT的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 本发明还提供了治疗与CPEPT表达相关的疾病的方法。
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公开(公告)号：US5925521A
公开(公告)日：1999-07-20
申请号：US828488
申请日：1997-03-31
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/10 , A61P9/10 , A61P9/12 , A61P13/12 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , A61P39/02 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/48 , C12N9/64 , C12N15/57 , C12Q1/68 , C12N15/63
摘要： The present invention provides a human serine carboxypeptidase (CPEPT) and polynucleotides which identify and encode CPEPT. The invention also provides expression vectors, host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with expression of CPEPT.
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