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1.发明申请ANTI-CROSS-LINKING AGENTS AND METHODS FOR INHIBITING CROSS-LINKING OF INJECTABLE HYDROGEL FORMULATIONS 审中-公开用于抑制可注射水凝胶制剂交联的反交联剂和方法公开(公告)号：US20070275030A1
公开(公告)日：2007-11-29
申请号：US11754003
申请日：2007-05-25
IPC分类号： A61K9/14
CPC分类号： A61K9/0024 , A61K47/32 , C08F8/00 , C08F2810/20 , C08J3/075 , C08J3/28 , C08F16/06
摘要： The invention relates to cross-link-resistant injectable hydrogel formulations and methods of partially or practically wholly inhibiting injectable hydrogel formulations from cross-linking, for example, during irradiation, using anti-cross-linking agents, which facilitates injectability of the hydrogel formulation. The invention also relates to methods of making the cross-link-resistant, for example, irradiation cross-link resistant, injectable hydrogel formulations, and methods of administering the same in treating a subject in need.
摘要翻译： 本发明涉及交联耐药性可注射水凝胶制剂以及使用抗交联剂部分或几乎完全抑制可交联水凝胶制剂的方法，例如在辐照期间，这促进了水凝胶制剂的注射。 本发明还涉及使抗交联性的方法，例如，辐射交联抗性，可注射的水凝胶制剂及其用于治疗所需受试者的方法。
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2.发明申请公开(公告)号：US20170049934A1
公开(公告)日：2017-02-23
申请号：US15191857
申请日：2016-06-24
申请人： Orhun K. MURATOGLU , Edward T. KOPESKY , Ebru ORAL
发明人： Orhun K. MURATOGLU , Edward T. KOPESKY , Ebru ORAL
CPC分类号： A61L27/505 , A61L27/16 , B29C43/003 , B29C43/18 , B29C71/04 , B29K2023/0683 , B29K2105/20 , B29K2995/0056 , B29L2031/753 , C08F10/02 , C08F110/02 , C08J3/24 , C08J3/28 , C08J2323/06 , C08K5/1545 , C08K2201/012 , C08F2/46 , C08F2500/01
摘要： The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface regions of antioxidant-containing polymeric materials, and materials used therewith also are provided.
摘要翻译： 本发明涉及制备交联抗氧化聚合物材料并防止或最小化抗氧化剂的聚合物材料中的抗氧化剂体内洗脱的方法。 本发明还提供了掺杂具有交联和抗氧化分布的空间控制的聚合材料的方法，例如维生素E（α-生育酚），以及用于提取/洗脱抗氧化剂的方法，例如维生素E（α-生育酚 ），来自含抗氧化剂的聚合物材料的表面区域，以及与其一起使用的材料。
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公开(公告)号：US20140183794A1
公开(公告)日：2014-07-03
申请号：US14202395
申请日：2014-03-10
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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4.发明申请HIGH MODULUS CROSSLINKED POLYETHYLENE WITH REDUCED RESIDUAL FREE RADICAL CONCENTRATION PREPARED BELOW THE MELT 审中-公开高密度交联聚乙烯，具有降低残留自由度的浓度公开(公告)号：US20090326659A1
公开(公告)日：2009-12-31
申请号：US12492323
申请日：2009-06-26
IPC分类号： A61F2/30 , B29C35/08 , C08F110/02
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译： 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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公开(公告)号：US20170259467A1
公开(公告)日：2017-09-14
申请号：US15596318
申请日：2017-05-16
IPC分类号： B29C35/08 , A61L27/16 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , B29C43/00 , C08J3/28 , C08K5/00 , C08K5/1545 , C08L23/06
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：US20140275318A1
公开(公告)日：2014-09-18
申请号：US14287723
申请日：2014-05-27
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散和其中使用的材料掺杂含有与维生素E的交联UHMWPE的医疗装置。
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公开(公告)号：US20080262120A1
公开(公告)日：2008-10-23
申请号：US12111489
申请日：2008-04-29
申请人： Orhun K. MURATOGLU
发明人： Orhun K. MURATOGLU
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61F2/34 , A61F2/38 , A61F2/3868 , A61F2/3872 , A61F2/389 , A61F2/4081 , A61F2/4241 , A61F2002/30014 , A61F2002/30133 , A61F2002/30685 , A61F2002/4243 , A61F2230/0015 , A61F2250/0018 , A61L27/50 , B29B13/08 , B29C35/0266 , B29C71/04 , B29C2035/0877 , B29K2023/0675 , B29K2023/0683 , B29K2105/243 , B29K2105/255 , B29L2031/7532 , C08L23/06
摘要： The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
摘要翻译： 本发明提供部分和完全的屏蔽方法来改变辐照聚合物如聚乙烯的交联特性。 也提供包含辐照聚合物的辐射聚合物和制造制品，例如医用前列腺。
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公开(公告)号：US20160296661A1
公开(公告)日：2016-10-13
申请号：US15184228
申请日：2016-06-16
CPC分类号： A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
摘要翻译： 本发明涉及制备交联的，氧化稳定的和高度结晶的聚合物材料的方法。 本发明还提供了处理照射交联的含抗氧化剂的聚合物和与其一起使用的材料的方法。
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公开(公告)号：US20130062817A1
公开(公告)日：2013-03-14
申请号：US13606457
申请日：2012-09-07
IPC分类号： B29C35/08
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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公开(公告)号：US20110004315A1
公开(公告)日：2011-01-06
申请号：US12882481
申请日：2010-09-15
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散和其中使用的材料掺杂含有与维生素E的交联UHMWPE的医疗装置。
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