-
公开(公告)号：US10689425B2
公开(公告)日：2020-06-23
申请号：US15369489
申请日：2016-12-05
Applicant: Purdue Research Foundation
Inventor： Alyssa Panitch , John Eric Paderi , Kinam Park , Katherine Allison Stuart , Steve Higbee
IPC: C07K14/00 , A61L27/24 , C07K9/00 , C07K14/47 , A61L27/38 , A61L27/54 , C07K14/78 , A61L27/22 , A61K38/00
Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.
-
公开(公告)号：US20170196481A1
公开(公告)日：2017-07-13
申请号：US15316691
申请日：2015-06-16
Applicant: Purdue Research Foundation
Inventor： Ann Elizabeth Rundell , Kinam Park , Laurent L. Couetil , Michael Sean Pargett , Pamidipani Arun Mohan , Mark Hamilton , Ryan James Miller
CPC classification number: A61B5/082 , A61B5/14532
Abstract: The invention generally relates to systems and methods for determining a concentration of glucose in exhaled breadth. In certain aspects, the invention provides a system including a sample collection module configured to collect a condensate sample produced from a mixture of exhaled breadth from a subject and ambient air. The condensate sample includes exhaled breadth glucose and ambient air glucose. The system also includes an assay module configured to assay the condensate sample for total glucose. The system also includes an analysis module that includes a processor that is configured to determine a total glucose concentration in the condensate sample, and adjust the total glucose concentration based upon a concentration of the ambient air glucose in the condensate sample, thereby determining a concentration of the exhaled breadth glucose in the exhaled breadth from the subject.
-
公开(公告)号：US10828370B2
公开(公告)日：2020-11-10
申请号：US15310416
申请日：2015-05-12
Applicant: Purdue Research Foundation
Inventor： Alyssa Panitch , Rebecca Scott , Kinam Park , James Wodicka
IPC: A61K38/08 , A61K47/42 , C07D487/04 , C08B37/02 , C08B37/00 , C08B37/08 , A61K47/61 , A61K47/54 , A61P9/10 , A61P29/00 , A61P9/14 , C07K14/47
Abstract: The invention relates to peptide conjugates that can bind to endothelial cells, and that are useful for reducing the incidence and severity of endothelial dysfunction in mammals.
-
4.发明授权公开(公告)号：US09512192B2
公开(公告)日：2016-12-06
申请号：US15078885
申请日：2016-03-23
Applicant: Purdue Research Foundation
Inventor： Alyssa Panitch , John Eric Paderi , Kinam Park , Katherine Allison Stuart , Steve Higbee
IPC: C07K9/00 , A61K38/14 , A61K31/726 , C07K14/47 , A61L27/24 , A61L27/38 , A61L27/54 , C07K14/78 , C07K14/00 , A61L27/22 , A61K38/00
CPC classification number: C07K14/4725 , A61K38/00 , A61L27/227 , A61L27/24 , A61L27/3804 , A61L27/54 , A61L2300/25 , A61L2300/42 , C07K9/00 , C07K9/001 , C07K14/00 , C07K14/78
Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.
Abstract translation: 本发明涉及胶原结合合成肽聚糖和包含胶原基质和胶原结合合成肽聚糖的工程胶原基质，其中胶原结合合成肽聚糖可以是异常的，或者可以与氨基酸序列的一部分具有氨基酸同源性 蛋白质或调节胶原纤维发生的蛋白多糖。 本发明还涉及包含这种胶原结合合成肽聚糖或工程化胶原基质的试剂盒，化合物，组合物和工程化移植物构建体及其制备和使用方法。
-
公开(公告)号：US20240207171A1
公开(公告)日：2024-06-27
申请号：US18538022
申请日：2023-12-13
Applicant: Purdue Research Foundation
Inventor： Andrew David Otte , Kinam Park
IPC: A61K9/00 , A61K31/485
CPC classification number: A61K9/0024 , A61K31/485
Abstract: The present invention generally relates to formulations comprising a drug and biodegradable polymers that are compacted mechanically from a physical mixture to disrupt interconnected open channels for substantially longer drug release than non-compacted counterpart formulations and methods of use and manufacture thereof.
-
Patent Agency Ranking
公开(公告)号：US20170275345A1
公开(公告)日：2017-09-28
申请号：US15369489
申请日：2016-12-05
Applicant: Purdue Research Foundation
Inventor： Alyssa Panitch , John Eric Paderi , Kinam Park , Katherine Allison Stuart , Steve Higbee
IPC: C07K14/47 , A61L27/22 , A61L27/24 , A61L27/38 , A61L27/54 , C07K14/00 , C07K14/78 , C07K9/00 , A61K38/00
Abstract: This invention relates to collagen-binding synthetic peptidoglycans and engineered collagen matrices comprising a collagen matrix and a collagen-binding synthetic peptidoglycan where the collagen-binding synthetic peptidoglycan can be aberrant or can have amino acid homology with a portion of the amino acid sequence of a protein or a proteoglycan that regulates collagen fibrillogenesis. The invention also relates to kits, compounds, compositions, and engineered graft constructs comprising such collagen-binding synthetic peptidoglycans or engineered collagen matrices and methods for their preparation and use.
-
公开(公告)号：US11000479B2
公开(公告)日：2021-05-11
申请号：US16653707
申请日：2019-10-15
Inventor： Gwangheum Yoon , Bong Kwan Soh , Andrew David Otte , Kinam Park
IPC: A61K9/16 , A61K9/00 , A61K31/485
Abstract: The present disclosure relates to naltrexone sustained release microparticle delivery systems for the treatment of diseases ameliorated by naltrexone. The injectable microparticle delivery system includes naltrexone encapsulated in biodegradable microparticles administered in a pharmaceutically acceptable vehicle.
-
公开(公告)号：US20180326077A1
公开(公告)日：2018-11-15
申请号：US15310416
申请日：2015-05-12
Applicant: Purdue Research Foundation
Inventor： Alyssa Panitch , Rebecca Scott , Kinam Park , James Wodicka
IPC: A61K47/42 , A61K47/61 , C08B37/02 , C07K14/47 , A61K47/54 , C08B37/00 , C08B37/08 , A61P9/14 , A61P9/10 , A61P29/00 , C07D487/04
CPC classification number: A61K47/42 , A61K47/545 , A61K47/61 , A61P9/10 , A61P9/14 , A61P29/00 , C07D487/04 , C07K14/4725 , C08B37/0021 , C08B37/0069 , C08B37/0072
Abstract: The invention relates to peptide conjugates that can bind to endothelial cells, and that are useful for reducing the incidence and severity of endothelial dysfunction in mammals.
-
公开(公告)号：US20180030091A1
公开(公告)日：2018-02-01
申请号：US15713530
申请日：2017-09-22
Applicant: Purdue Research Foundation
Inventor： John Eric Paderi , Alyssa Panitch , Kinam Park , Katherine Allison Stuart
CPC classification number: C07K7/08 , A61K31/726 , A61K31/727 , A61K38/00 , A61K38/14 , C07K7/06 , C07K9/00
Abstract: This invention relates to collagen-binding synthetic peptidoglycans. More particularly, this invention relates to collagen-binding synthetic peptidoglycans for use in vascular intervention procedures. The invention also relates to kits comprising such collagen-binding synthetic peptidoglycans and catheters or stents.
-
公开(公告)号：US09081003B2
公开(公告)日：2015-07-14
申请号：US13886810
申请日：2013-05-03
Applicant: Purdue Research Foundation
Inventor： Kinam Park , Bumsoo Han , Bongseop Kwak , Crystal Soo Jung Shin
CPC classification number: G01N33/5011 , B01L3/5027 , B01L2300/0877 , B01L2300/0887 , B01L2300/163 , C12M21/08 , C12M25/04 , G01N33/5026 , G01N33/5088 , G01N33/5091
Abstract: A system is provided that simulates the in vivo micro-environment of three-dimensional cellular structures or bodies, such as tumors. The system simulates the pressure gradients and fluid flows of the vascular and lymphatic systems as well as the interstitial and capillary transport mechanisms between the 3D cellular structure and the vascular and lymphatic systems. The system can be used to introduce drugs or drug delivery carriers to a tumor, for example, to assess the uptake capability and effect on the tumor. The system maintains the viability of the tumor cells for a sufficiently long period of time to permit testing of several different drugs and/or delivery carriers.
Abstract translation: 提供了一种模拟三维细胞结构或体内诸如肿瘤的体内微环境的系统。 该系统模拟血管和淋巴系统的压力梯度和流体流动以及3D细胞结构与血管和淋巴系统之间的间质和毛细血管转运机制。 该系统可用于将药物或药物递送载体引入肿瘤，例如以评估对肿瘤的摄取能力和作用。 该系统维持肿瘤细胞的活力足够长的时间以允许测试几种不同的药物和/或递送载体。
-
-
-
-
-
-
-
-
-
Search Results
11
records
(took 0.015 seconds)
