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公开(公告)号:US20150024488A1
公开(公告)日:2015-01-22
申请号:US14129249
申请日:2012-06-28
申请人: Pathiraja Arachchillage Gunatillake , Carlos Gurrero-Sanchez , Tracey Michelle Hinton , San Hoa Thang , Mark Leslie Tizard
发明人: Pathiraja Arachchillage Gunatillake , Carlos Gurrero-Sanchez , Tracey Michelle Hinton , San Hoa Thang , Mark Leslie Tizard
IPC分类号: A61K48/00 , C08F293/00 , C12N15/113
CPC分类号: A61K48/0041 , A61K47/543 , A61K47/58 , A61K47/60 , A61K47/6921 , C08F293/00 , C08F293/005 , C08F2438/01 , C12N15/113 , C12N15/87 , C12N2760/16111
摘要: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.
摘要翻译: 本发明涉及包含阳离子嵌段共聚物和核酸的配合物,所述阳离子嵌段共聚物至少具有包含阳离子嵌段和两个亲水嵌段的三嵌段结构,或亲水嵌段和两个阳离子嵌段。
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公开(公告)号:US08357767B2
公开(公告)日:2013-01-22
申请号:US12245491
申请日:2008-10-03
CPC分类号: C08G18/428 , A61L27/18 , A61L31/06 , B33Y70/00 , B33Y80/00 , C08G18/4283 , C08G18/664 , C08G18/722 , C08G2230/00 , C08L75/04
摘要: The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%. The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopedic implant, a drug delivery coating or in tissue engineering.
摘要翻译: 本发明提供一种聚氨酯/聚氨酯/尿素组合物,其在0℃至60℃的温度下具有大于10MPa的拉伸强度,大于400MPa的弹性模量和断裂伸长率大于30% 且相对湿度在0%至100%之间。 本发明还提供本发明组合物在生物医学血管支架,矫形植入物,药物递送涂层或组织工程中的用途。
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公开(公告)号:US20090175921A1
公开(公告)日:2009-07-09
申请号:US11992340
申请日:2006-09-20
IPC分类号: A61L27/54 , C07C69/675 , C07C69/732 , C09K3/00 , C08G18/67 , C08G18/32
CPC分类号: C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula (I)
摘要翻译: 本发明涉及扩链剂,其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲(例如支架,用于组织工程的支架)中的用途。 扩链剂包括式(I)化合物,
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公开(公告)号:US20130121969A1
公开(公告)日:2013-05-16
申请号:US13665531
申请日:2012-10-31
CPC分类号: A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
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公开(公告)号:US20090099600A1
公开(公告)日:2009-04-16
申请号:US12245491
申请日:2008-10-03
CPC分类号: C08G18/428 , A61L27/18 , A61L31/06 , B33Y70/00 , B33Y80/00 , C08G18/4283 , C08G18/664 , C08G18/722 , C08G2230/00 , C08L75/04
摘要: The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%.The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopaedic implant, a drug delivery coating or in tissue engineering.
摘要翻译: 本发明提供一种聚氨酯/聚氨酯/尿素组合物,其在0℃至60℃的温度下具有大于10MPa的拉伸强度,大于400MPa的弹性模量和断裂伸长率大于30% 且相对湿度在0%至100%之间。 本发明还提供本发明组合物在生物医学血管支架,矫形植入物,药物递送涂层或组织工程中的用途。
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公开(公告)号:US08962786B2
公开(公告)日:2015-02-24
申请号:US13164316
申请日:2011-06-20
IPC分类号: C08G18/00 , C07C69/675 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C08G18/10 , C08G18/32 , C08G18/42 , C08G18/66 , C08G18/77
CPC分类号: C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula(I)
摘要翻译: 本发明涉及扩链剂,其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲(例如支架,用于组织工程的支架)中的用途。 扩链剂包括式(I)化合物,
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公开(公告)号:US20110287102A1
公开(公告)日:2011-11-24
申请号:US13164316
申请日:2011-06-20
IPC分类号: A61K9/14 , C07C69/732 , A61K47/34 , C12N5/071 , C08G18/68 , C08G18/66 , A61L27/34 , A61L27/18 , C07C69/675 , A61P43/00
CPC分类号: C08G18/3221 , A61L27/18 , A61L31/06 , C07C69/40 , C07C69/60 , C07C69/675 , C08G18/10 , C08G18/4277 , C08G18/6603 , C08G18/664 , C08G18/6674 , C08G18/73 , C08G18/771 , C08L75/04
摘要: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.The chain extenders comprise a compound of formula.(I)
摘要翻译: 本发明涉及扩链剂,其制备方法及其在制备用于生物相容的可生物降解的聚氨酯和用于生物医学应用的聚氨酯脲(例如支架,用于组织工程的支架)中的用途。 扩链剂包括式(I)化合物:
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公开(公告)号:US06313254B1
公开(公告)日:2001-11-06
申请号:US09147971
申请日:1999-05-17
IPC分类号: C08G77458
CPC分类号: C08G18/6511 , A61L15/26 , A61L27/18 , A61L29/06 , A61L31/06 , C08G18/44 , C08G18/4854 , C08G18/4858 , C08G18/61 , Y10S428/904 , Y10T428/31551 , C08L75/04 , C08L83/04
摘要: The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissues or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from about 60 to 98 wt % of at least one polysiloxane macrodiol and about 2 to 40 wt % of at least one polyether and/or polycarbonate macrodiol and processes for its preparation.
摘要翻译: 本发明涉及具有改进的机械性能,透明度,加工性和/或耐降解性的材料,其包含聚氨酯弹性体组合物,其包含衍生自至少一种聚硅氧烷大分子二醇和至少一种聚醚和/或聚碳酸酯聚二醇的软链段。 该材料可用作抗降解材料或生物材料,并且特别可用于制造接触生物体组织或体液的医疗器械,制品或植入物。 本发明还提供了一种聚氨酯弹性体组合物,其包含衍生自约60至98重量%的至少一种聚硅氧烷大二醇和约2至40重量%的至少一种聚醚和/或聚碳酸酯大二醇的软链段及其制备方法 。
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9.
公开(公告)号:US08729202B2
公开(公告)日:2014-05-20
申请号:US11070217
申请日:2005-03-03
IPC分类号: C08F10/00
CPC分类号: C08G18/10 , C08G18/3206 , C08G18/4277 , C08G18/428 , C08G18/4854 , C08G18/7671 , C08G18/771 , C08G18/8116 , C08L75/16 , C08L101/16
摘要: The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.
摘要翻译: 本发明提供了用于生物医学应用的生物相容性聚合物组合物,其包含基础分子,连接分子和至少一种引发剂化合物,所述碱基分子具有至少两个不同的官能团,并且所述连接分子具有与至少一个 所述碱基分子的功能性,所述碱基分子的所述至少两个官能团中的第一个能够通过与所述连接分子的反应来实现所述聚合物组合物的第一固化阶段,并且所述碱基分子的第二和任何其它官能团能够进行第二次和进一步固化 所述聚合物组合物的阶段,所述第一,第二和任何其它固化阶段能够根据需要同时或彼此独立地活化。
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公开(公告)号:US08529880B2
公开(公告)日:2013-09-10
申请号:US13665531
申请日:2012-10-31
IPC分类号: A61K31/74
CPC分类号: A61K47/482 , A61F2/30 , A61F2/30756 , A61K31/74 , A61L27/18 , A61L27/3817 , A61L27/3834 , A61L27/50 , A61L27/58 , C08G18/3206 , C08G18/8022 , C08L75/04
摘要: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
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