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公开(公告)号：US20130190206A1
公开(公告)日：2013-07-25
申请号：US13809833
申请日：2011-07-13
IPC分类号： G01N33/68
CPC分类号： G01N33/54306 , B01L3/5085 , B01L3/50857 , B01L2300/0636 , B01L2300/0819 , B01L2300/12 , B01L2300/16 , C12Q1/6818 , C12Q1/6837 , G01N33/53 , G01N33/5302 , G01N33/545 , G01N33/569 , G01N33/68
摘要： The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.
摘要翻译： 本发明描述了使用非常高密度的微孔阵列进行生物相互作用的高通量筛选的空间寻址技术。 讨论了能够识别，选择和表征特定蛋白质蛋白质，蛋白质DNA和/或蛋白质 - 碳水化合物相互作用的治疗，诊断和药物发现影响，从数百万（至数十亿）细胞的异质群体。 重要的是，该技术具有当前基于显示屏的筛选系统（即数百万亿）的筛选和选择能力，但具有更高的效率和更短的时间。
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公开(公告)号：US09291628B2
公开(公告)日：2016-03-22
申请号：US13809833
申请日：2011-07-13
CPC分类号： G01N33/54306 , B01L3/5085 , B01L3/50857 , B01L2300/0636 , B01L2300/0819 , B01L2300/12 , B01L2300/16 , C12Q1/6818 , C12Q1/6837 , G01N33/53 , G01N33/5302 , G01N33/545 , G01N33/569 , G01N33/68
摘要： The present invention describes a spatial addressing technique that uses a very high-density micro-pore array for high-throughput screening of biological interactions. The therapeutic, diagnostic and drug-discovery implications of being able to identify, select and characterize specific protein-protein, protein-DNA and/or protein-carbohydrate interactions from heterogeneous populations of millions (to billions) of cells is discussed. Importantly, this technique possesses the screening and selection capacity of current display-based screening systems (i.e., millions-billions) but with greater efficiency and shorter time.
摘要翻译： 本发明描述了使用非常高密度的微孔阵列进行生物相互作用的高通量筛选的空间寻址技术。 讨论了能够识别，选择和表征特定蛋白质蛋白质，蛋白质DNA和/或蛋白质 - 碳水化合物相互作用的治疗，诊断和药物发现影响，从数百万（至数十亿）细胞的异质群体。 重要的是，该技术具有当前基于显示屏的筛选系统（即数百万亿）的筛选和选择能力，但具有更高的效率和更短的时间。
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3.发明授权公开(公告)号：US08906669B2
公开(公告)日：2014-12-09
申请号：US13123491
申请日：2009-10-09
申请人： Ivan Dimov , Jens Ducree , Luke Lee , Gregor Kijanka
发明人： Ivan Dimov , Jens Ducree , Luke Lee , Gregor Kijanka
CPC分类号： B01L3/50273 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0887 , B01L2400/0457 , B01L2400/0472 , Y10T436/25
摘要： A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.
摘要翻译： 描述了包括具有在输入和输出之间的衬底内限定的流体路径的微流体装置的顺序流分析工具。 该装置包括设置在流体路径内但偏离流体路径的捕获室，捕获室沿着基本上垂直于流体路径的方向延伸到基板中，使得设置在流体流体内流动的流体内的可操作的颗粒将优先地在捕获 房间。
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公开(公告)号：US20120219727A1
公开(公告)日：2012-08-30
申请号：US13379324
申请日：2010-06-18
申请人： Ram Prasad Gandhiraman , Lourdes Basabe-Desmonts , Asif Riaz , Luke Lee , Ivan Dimov , Jens Ducree , Stephen Michael Daniels
发明人： Ram Prasad Gandhiraman , Lourdes Basabe-Desmonts , Asif Riaz , Luke Lee , Ivan Dimov , Jens Ducree , Stephen Michael Daniels
IPC分类号： C23C16/40 , C23C16/50 , C23C16/448
CPC分类号： C23C16/045 , B01L3/502707 , B01L2300/161 , B05D1/62 , B05D5/08 , B05D7/22 , B05D2201/00 , C23C16/505
摘要： The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities.
摘要翻译： 描述了在微流体装置的各个通道或空腔内形成阻挡层。 阻挡层通过气相沉积工艺实现，期望地在使用气体等离子体反应器的等离子体环境中实现。 在气体等离子体反应器中使用的前体化合物的合理选择可以提供在各个表面上产生层。 理想地，通过在各个通道或空腔的表面上化学吸附诸如氧化硅层的类金属氧化物来产生表面或阻挡层。
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5.发明申请公开(公告)号：US20110262906A1
公开(公告)日：2011-10-27
申请号：US13123491
申请日：2009-10-09
申请人： Ivan Dimov , Jens Ducree , Luke Lee , Gregor Kijanka
发明人： Ivan Dimov , Jens Ducree , Luke Lee , Gregor Kijanka
IPC分类号： C12Q1/68 , C12M1/40 , G01N1/28 , G01N33/00 , G01N33/68 , G01N21/75 , G01N33/50 , B01L3/00 , C12M1/00 , C12Q1/02
CPC分类号： B01L3/50273 , B01L3/502761 , B01L2200/027 , B01L2200/0647 , B01L2200/0668 , B01L2200/10 , B01L2300/0816 , B01L2300/0851 , B01L2300/0887 , B01L2400/0457 , B01L2400/0472 , Y10T436/25
摘要： A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.
摘要翻译： 描述了一种顺序流分析工具，其包括具有在输入和输出之间的衬底内限定的流体路径的微型虹膜装置。 该装置包括设置在流体路径内但偏离流体路径的捕获室，捕获室沿着基本上垂直于流体路径的方向延伸到基板中，使得设置在流体流体内流动的流体内的可操作的颗粒将优先地在捕获 房间。
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公开(公告)号：US20120276641A1
公开(公告)日：2012-11-01
申请号：US13504108
申请日：2010-10-28
CPC分类号： B01L3/50273 , B01L3/502753 , B01L2200/0631 , B01L2300/10 , B01L2300/14 , B01L2400/049 , F04B19/006 , Y10T29/494
摘要： A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 μL, (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms.
摘要翻译： 描述了用于血浆分离和基于血浆的血液分析的装置。 该装置使用小于5μL的血液样品（直接从手指），并且通过脱气驱动的流动技术实现流动，其使得血液自发地流入充满空气的死端通道而没有外部泵送机构。
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公开(公告)号：US20050105265A1
公开(公告)日：2005-05-19
申请号：US10714136
申请日：2003-11-13
申请人： Peter Petrov , Stefan Kalintchev , Ivan Parushev , Ivan Dimov , Lubomir Dimitrov
发明人： Peter Petrov , Stefan Kalintchev , Ivan Parushev , Ivan Dimov , Lubomir Dimitrov
CPC分类号： G11B33/126 , G11B33/128 , G11B33/1493
摘要： A docking module for conventional small form factor disk drives provides, in one embodiment, space for two such disk drives embedded in tray loaders, within a standard 3.5 inches halve height floppy bay. The docking module provides hot swappable insertion and removal of tray loaders together with disk drives. The bay is provided within a housing member. A button attached to a lever mechanism disconnects the docking module connector from the tray loader connector and partially pull out the loader when the button is pushed; An EMI shield fixedly coupled to the tray loaders each provide a barrier to electromagnetic interference.
摘要翻译： 在一个实施例中，用于传统小尺寸盘驱动器的对接模块在标准3.5英寸半高度软盘架内提供嵌入托盘装载机中的两个这样的盘驱动器的空间。 对接模块提供托盘装载机与磁盘驱动器的热插拔插拔。 海湾设置在壳体内。 连接到杠杆机构的按钮将对接模块连接器与托盘加载器连接器断开，并且当按下按钮时部分地拉出装载器; 固定地联接到托盘装载机的EMI屏蔽每个都提供对电磁干扰的屏障。
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