利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

170 条记录 (耗时 0.041 秒)

    Method for obtaining stool samples for gastrointestinal cancer testing
    1.
    发明授权
    Method for obtaining stool samples for gastrointestinal cancer testing 失效
    获取胃肠癌检测粪便样本的方法

    公开(公告)号：US5331973A

    公开(公告)日：1994-07-26

    申请号：US31533

    申请日：1993-03-15

    申请人： Paul N. Fiedler ,  Robert A. Levine ,  Stephen C. Wardlaw

    发明人： Paul N. Fiedler ,  Robert A. Levine ,  Stephen C. Wardlaw

    IPC分类号： A61B10/00 ,  G01N33/483 ,  A61B5/00

    CPC分类号： A61B10/0038

    摘要： The specification discloses a method for enhancing the reliability of screening tests used for detecting the presence or absence of chemical markers associated with gastrointestinal cancer. The method comprises the steps of providing a laxative purge for administration to a patient, collecting a watery fecal sample and then applying the watery fecal sample to a test medium having an indicator to indicate the presence of chemical markers associated with gastrointestinal cancer, if there. Two alternative methods are suggested for obtaining a watery fecal sample. In a first embodiment, the purge is administered to the patient following a recent bowel movement and the first watery post-purge bowel movement is collected. In a second embodiment, the purge is administered to the patient, the first post-purge bowel movement is discarded and the second watery post-purge bowel movement is collected.

    摘要翻译： 该说明书公开了一种用于增强用于检测与胃肠癌相关的化学标记物的存在或不存在的筛选试验的可靠性的方法。 该方法包括以下步骤：向患者提供泻药吹扫，收集水样粪便样品，然后将含水粪便样品施用于具有指示剂的测试培养基，以指示与胃肠癌相关的化学标记的存在（如果有的话）。 建议采用两种替代方法来获得水样粪便样品。 在第一实施例中，在最近的肠运动之后向患者施用吹扫，并且收集第一次含水的后清除肠运动。 在第二实施例中，向患者施用吹扫，弃去第一次清除后肠道运动，并收集第二次含水的清洗后肠道运动。

    Method for in vitro detection of formed elements in biological samples
    2.
    发明授权
    Method for in vitro detection of formed elements in biological samples 失效
    体外检测生物样品中形成元素的方法

    公开(公告)号：US5403714A

    公开(公告)日：1995-04-04

    申请号：US5086

    申请日：1993-01-15

    申请人： Robert A. Levine ,  Stephen C. Wardlaw ,  Paul N. Fiedler

    发明人： Robert A. Levine ,  Stephen C. Wardlaw ,  Paul N. Fiedler

    IPC分类号： G01N33/569 ,  G01N33/574 ,  G01N33/536 ,  G01N33/558

    CPC分类号： G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/813 ,  Y10S436/824

    摘要： A biologic sample such as feces, sputum, cervical tissue, pleural fluids, exudates, cytologic specimens, or the like, is tested for the presence or absence of: ova; parasites; microorganisms; inflammatory, neoplastic tissue cells; or other target materials which are indicative of infestation, disease or infection. The sample is mixed with a buffer fluid and placed in a transparent tube which contains a volume-constricting cylindrical insert for gravimetric separation of components of the sample. The mixture is centrifuged, and the annular space between the insert and tube bore is examined under magnification for the presence of the target materials.

    摘要翻译： 对生物样品如粪便，痰液，宫颈组织，胸膜液，渗出液，细胞学标本等进行测试，以确定是否存在：ova; 寄生虫 微生物 炎性，肿瘤组织细胞; 或指示感染，疾病或感染的其他目标材料。 将样品与缓冲液混合并置于含有体积收缩的圆柱形插入物的透明管中，用于重量分离样品组分。 将混合物离心，并且在放大下检查插入件和管孔之间的环形空间以存在目标材料。

    In vitro detection of ova, parasites, and other formed elements in stool
    3.
    发明授权
    In vitro detection of ova, parasites, and other formed elements in stool 失效
    体外检测粪便中的卵，寄生虫和其他形成的元素

    公开(公告)号：US5252460A

    公开(公告)日：1993-10-12

    申请号：US783397

    申请日：1991-10-28

    申请人： Paul N. Fiedler ,  Stephen C. Wardlaw ,  Robert A. Levine

    发明人： Paul N. Fiedler ,  Stephen C. Wardlaw ,  Robert A. Levine

    IPC分类号： G01N33/569 ,  G01N33/574 ,  G01N33/537 ,  G01N33/538

    CPC分类号： G01N33/569 ,  G01N33/56966 ,  G01N33/574 ,  Y10S436/80 ,  Y10S436/805 ,  Y10S436/81 ,  Y10S436/813 ,  Y10S436/824

    摘要： A biologic sample such as feces, sputum, cervical tissue, pleural fluids, exudates, cytologic specimens, or the like, is tested for the presence or absence of: ova; parasites; microorganisms; inflammatory, neoplastic tissue cells; or other target materials which are indicative of infestation, disease or infection. The sample is mixed with a buffer fluid and placed in a transparent tube which contains a volume-constricting cylindrical insert for gravimetric separation of components of the sample. The mixture is centrifuged, and the annular space between the insert and tube bore is examined under magnification for the presence of the target materials.

    摘要翻译： 对生物样品如粪便，痰液，宫颈组织，胸膜液，渗出液，细胞学标本等进行测试，以确定是否存在：ova; 寄生虫 微生物 炎性，肿瘤组织细胞; 或指示感染，疾病或感染的其他目标材料。 将样品与缓冲液混合并置于含有体积收缩的圆柱形插入物的透明管中，用于重量分离样品组分。 将混合物离心，并且在放大下检查插入件和管孔之间的环形空间以存在目标材料。

    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
    8.
    发明授权
    Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells 有权
    利用红细胞内含有的血红蛋白的内在色素沉淀来测定血液样品的血细胞比容的方法和装置

    公开(公告)号：US08133738B2

    公开(公告)日：2012-03-13

    申请号：US13116837

    申请日：2011-05-26

    申请人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    发明人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn Unfricht ,  Niten V. Lalpuria

    IPC分类号： G01N33/48 ,  G01N33/86

    CPC分类号： G01N33/80 ,  A61B5/145 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/48 ,  G01N33/49 ,  G01N33/721 ,  G01N33/86

    摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.

    摘要翻译： 提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和 高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。

    METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE
    9.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING AT LEAST ONE HEMOGLOBIN RELATED PARAMETER OF A WHOLE BLOOD SAMPLE 有权
    用于确定至少一种HEMOGLOBIN相关参数的全血样品的方法和装置

    公开(公告)号：US20110256573A1

    公开(公告)日：2011-10-20

    申请号：US13051705

    申请日：2011-03-18

    申请人： Graham Davis ,  Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten Lalpuria ,  Paul G. Mitsis

    发明人： Graham Davis ,  Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten Lalpuria ,  Paul G. Mitsis

    IPC分类号： C12Q1/02 ,  C12M1/34

    CPC分类号： G01N33/726 ,  G01N15/1475 ,  G01N2015/0073

    摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.

    摘要翻译： 提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有 在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

    METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS
    10.
    发明申请
    METHOD AND APPARATUS FOR DETERMINING THE HEMATOCRIT OF A BLOOD SAMPLE UTILIZING THE INTRINSIC PIGMENTATION OF HEMOGLOBIN CONTAINED WITHIN THE RED BLOOD CELLS 有权
    用于确定使用红细胞中含有的HEMOGLOBIN的内在色素的血液样品的HEMATOCRIT的方法和装置

    公开(公告)号：US20110230740A1

    公开(公告)日：2011-09-22

    申请号：US13116837

    申请日：2011-05-26

    申请人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn W. Unfricht ,  Niten V. Lalpuria

    发明人： Robert A. Levine ,  Stephen C. Wardlaw ,  Darryn W. Unfricht ,  Niten V. Lalpuria

    IPC分类号： A61B5/1455

    CPC分类号： G01N33/80 ,  A61B5/145 ,  G01N15/1463 ,  G01N15/1475 ,  G01N33/48 ,  G01N33/49 ,  G01N33/721 ,  G01N33/86

    摘要： A method for determining the hematocrit of a blood sample is provided that includes the steps of: 1) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by the interior surfaces of first and second panels and a height extending there between, wherein both panels are transparent, and the height is such that at least some of the red blood cells within the sample contact both interior surfaces of the panels and one or more lacunae within the quiescent sample extend between the interior surfaces; 2) imaging at least a portion of the quiescent sample, which sample portion contains the red blood cells and one or more lacunae to determine an optical density of the imaged portion of the sample on a per image unit basis; 3) selecting and averaging the optical density values of the image units aligned with the red blood cells contacting the interior surfaces, and assigning an upper boundary value of 100% to the average optical density value of those image units; 4) selecting the optical density values of the image units aligned with the one or more lacunae, and assigning a lower boundary value of 0% to the optical density values of those image units; and 5) determining the hematocrit of the sample by assigning relative values to the optical density value of each image of the imaged sample portion as a function of the upper and lower boundary values, and averaging the relative values.

    摘要翻译： 提供了一种用于确定血液样本的血细胞比容的方法，其包括以下步骤：1）将样品沉积到适于静态保持样品进行分析的分析室中，由第一和第二面板的内表面限定的腔室和 高度在其间延伸，其中两个面板是透明的，并且高度使得样品中的至少一些红细胞接触面板的两个内表面，并且静止样品内的一个或多个空隙在内表面之间延伸; 2）对静止样品的至少一部分进行成像，该样品部分包含红细胞和一个或多个空隙，以基于每个图像单位确定样品的成像部分的光密度; 3）选择和平均与内表面接触的红细胞对准的图像单元的光密度值，并将上限边界值分配给这些图像单元的平均光密度值; 4）选择与一个或多个空白对齐的图像单元的光密度值，并为这些图像单元的光密度值分配0％的下边界值; 以及5）通过将所述成像样本部分的每个图像的光密度值分配相对值作为上边界值和下边界值的函数来确定样本的血细胞比容，并平均相对值。