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1.发明授权
公开(公告)号：US4370417A
公开(公告)日：1983-01-25
申请号：US137032
申请日：1980-04-03
申请人： Paul P. Hung , Shaw-Guang Lee , Ranajit Roychoudhury , Barry J. Ratzkin , W. Jurgen Schrenk , Michael C. Chen
发明人： Paul P. Hung , Shaw-Guang Lee , Ranajit Roychoudhury , Barry J. Ratzkin , W. Jurgen Schrenk , Michael C. Chen
IPC分类号： A61K38/04 , A61K38/46 , A61P7/02 , C07H21/00 , C07H21/04 , C07K14/745 , C12N1/14 , C12N1/18 , C12N1/20 , C12N1/21 , C12N9/64 , C12N9/72 , C12N15/00 , C12N15/09 , C12P21/00 , C12R1/19 , C12R1/91
CPC分类号： C12N9/6462 , C12Y304/21073 , Y10S530/808
摘要： The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
摘要翻译： 本发明提供与人纤溶酶原激活物基因相关的脱氧核糖核酸（DNA）片段。 将片段插入质粒载体，其又可以并入细菌或其他微生物中。 然后可以培养细菌以产生具有人尿激酶特性的纤溶酶原激活物蛋白。
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公开(公告)号：US5643579A
公开(公告)日：1997-07-01
申请号：US283231
申请日：1994-07-29
申请人： Paul P. Hung , Alan R. Davis
发明人： Paul P. Hung , Alan R. Davis
IPC分类号： A61K39/00 , C07K14/02 , C07K14/14 , C07K14/16 , A61K39/29 , A61K39/12 , A61K39/23 , C12P21/06
CPC分类号： C07K14/005 , A61K39/00 , C12N2720/12322 , C12N2730/10122 , C12N2740/16222
摘要： Methods and vaccines for the production of antibodies to infectious organisms are described. Live recombinant adenovirus containing a foreign gene coding for an antigen produced by another infectious organism is delivered to the intestine of a warm-blooded animal in an enteric-coated dosage form, whereupon the virus infects the gut wall and induces the production of antibodies or cell mediated immunity to both adenovirus and the other infectious organism.
摘要翻译： 描述了用于产生感染性生物体的抗体的方法和疫苗。 含有编码另一感染性生物体产生的抗原的外源基因的活重组腺病毒以肠溶包被的剂型递送至温血动物的肠道，于是病毒感染肠壁并诱导产生抗体或细胞 介导的对腺病毒和其他感染性生物体的免疫。
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公开(公告)号：US4631290A
公开(公告)日：1986-12-23
申请号：US770807
申请日：1985-08-29
申请人： Paul P. Hung
发明人： Paul P. Hung
IPC分类号： A61K31/395 , C07D498/00 , C07D498/08
CPC分类号： C07D498/08 , A61K31/395
摘要： The invention disclosed herein provides a method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected from a group consisting of(a) 3-amino-4-deoxo-4-imino-rifamycin S,(b) 3-amino-4-deoxo-4-[(4-aminophenyl)sulphonyl]amino-rifamycin SV,(c) 4-O-n-butylsulphonyl-3-[(1-piperidinylimino)methyl]-rifamycin SV,(d) 4-O-n-butylsulfonyl-3-[(4-morpholinylimino)methyl]-rifamycin SV,(e) 3-[(dimethylhydrazono)methyl]-4-O-[(3-phenylpropyl)sulfonyl]-rifamycin SV said amount being effective to alleviate the effects of said hepatitis B virus. Also disclosed is a method of inhibiting the viral polymerase of hepatitis B virus by subjecting said polymerase to an amount of one of the rifamycin derivatives (a)-(e) above, said amount being effective to prevent the synthesis of hepatitis B virus by said viral polymerase.
摘要翻译： 本文公开的本发明提供了一种治疗由乙型肝炎病毒感染的动物的方法，包括向这种感染动物施用一定量的选自（a）3-氨基-4-脱氧-4-亚氨基 - 利福霉素 S，（b）3-氨基-4-脱氧-4 - [（4-氨基苯基）磺酰基]氨基 - 利福霉素SV，（c）4-叔丁基磺酰基-3 - [（1-哌啶基亚氨基）甲基] ，（d）4-对 - 丁基磺酰基-3 - [（4-吗啉基亚氨基）甲基] - 三叶霉素SV，（e）3 - [（二甲基亚肼基）甲基] -4-O - [（3-苯基丙基）磺酰基] SV表示该量有效减轻所述乙型肝炎病毒的作用。 还公开了一种通过使所述聚合酶经受一定量的上述利福霉素衍生物（a） - （e）之一来抑制乙型肝炎病毒的病毒聚合酶的方法，所述量有效地防止乙型肝炎病毒的合成由所述 病毒聚合酶。
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公开(公告)号：US4743619A
公开(公告)日：1988-05-10
申请号：US900012
申请日：1986-08-25
申请人： Paul P. Hung
发明人： Paul P. Hung
IPC分类号： A61K31/395 , C07D498/08 , A61K39/12 , A61K39/29
CPC分类号： C07D498/08 , A61K31/395 , Y10S514/894
摘要： The invention disclosed herein provides a method of treating an animal infected by hepatitis B virus comprising administering to such infected animal an amount of a rifamycin derivative selected from a group consisting of(a) 3-amino-4-deoxo-4-imino-rifamycin S,(b) 3-amino-4-deoxo-4-[(4-aminophenyl)sulfonyl]amino-rifamycin SV,(c) 4-O-(n-butylsulfonyl)-3-[(1-piperidinylimino)methyl]-rifamycin SV,(d) 4-O-(n-butylsulfonyl)-3-[(4-morpholinylimino)methyl]-rifamycin SV,(e) 3-[(dimethylhydrazono)methyl]-4-O-[(3-phenylpropyl)sulfonyl]-rifamycin SV, and(f) 4-deoxo-N,3-ethylidenimino-4-(methylsulfonyl)amino-rifamycin SV, said amount being effective to alleviate the effects of said hepatitis B virus. Also disclosed is a method of inhibiting the viral polymerase of hepatitis B virus by subjecting said polymerase to an amount of one of the rifamycin derivatives (a)-(f) above, said amount being effective to prevent the synthesis of hepatitis B virus by said viral polymerase. Compounds (b)-(f) described above are novel compounds.
摘要翻译： 本文公开的本发明提供了一种治疗由乙型肝炎病毒感染的动物的方法，包括向这种感染动物施用一定量的选自（a）3-氨基-4-脱氧-4-亚氨基 - 利福霉素 S，（b）3-氨基-4-脱氧-4 - [（4-氨基苯基）磺酰基]氨基 - 利福霉素SV，（c）4-O-（正丁基磺酰基）-3 - [（1-哌啶基亚氨基）甲基 ] - 哒嗪基-S-脯氨酸SV，（d）4-O-（正丁基磺酰基）-3 - [（4-吗啉代亚氨基）甲基] - 三叶霉素SV，（e）3 - [（二甲基亚肼基）甲基] -4-O - [ 3-苯基丙基）磺酰基] - 硫霉素SV和（f）4-脱氧-N，3-亚乙基亚氨基-4-（甲基磺酰基）氨基 - 利福霉素SV，所述量有效地减轻所述乙型肝炎病毒的作用。 还公开了通过使所述聚合酶以一定量的上述利福霉素衍生物（a） - （f）之一来抑制乙型肝炎病毒的病毒聚合酶的方法，所述量有效地防止乙型肝炎病毒的合成由所述 病毒聚合酶。 上述化合物（b） - （f）是新化合物。
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5.发明授权Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom 失效编码纤溶酶原激活物的重组脱氧核糖核酸及其制备纤溶酶原激活蛋白的方法
公开(公告)号：US4558010A
公开(公告)日：1985-12-10
申请号：US415491
申请日：1982-09-07
摘要： The present invention provides a deoxyribonucleic acid (DNA) segment related to a human plasminogen activator gene. The segment is inserted into a plasmid vector which in turn can be incorporated into a bacterium or other microorganism. The bacterium can then be cultured to produce a plasminogen activator protein having properties of human urokinase.
摘要翻译： 本发明提供与人纤溶酶原激活物基因相关的脱氧核糖核酸（DNA）片段。 将片段插入质粒载体，其又可以并入细菌或其他微生物中。 然后可以培养细菌以产生具有人尿激酶特性的纤溶酶原激活物蛋白。
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公开(公告)号：US4326033A
公开(公告)日：1982-04-20
申请号：US146823
申请日：1980-05-05
CPC分类号： C12N9/6462 , C12N9/00 , C12Y304/21073 , A61K38/00
摘要： Described is a structurally modified urokinase which is biologically active over an extended time period in comparison to native urokinase. The extended activity permits the administration of lower doses of urokinase when it is used in the treatment of thromboembolic diseases. Methods of appropriately modifying the structure of urokinase are described.
摘要翻译： 描述了与天然尿激酶相比在延长的时间段内具有生物活性的结构修饰的尿激酶。 延长的活性允许在用于治疗血栓栓塞性疾病时施用较低剂量的尿激酶。 描述适当改变尿激酶结构的方法。
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公开(公告)号：US4224408A
公开(公告)日：1980-09-23
申请号：US963245
申请日：1978-11-22
申请人： Paul P. Hung , Shaw-guang Lee
发明人： Paul P. Hung , Shaw-guang Lee
CPC分类号： C12P19/34 , C12N15/1096
摘要： Described is a method of obtaining complete copying of the entire length of single stranded ribonucleic acid (RNA) into its complementary deoxyribonucleic acid (cDNA) by reverse transcription using binding protein. The method can be used in recombinant DNA research to copy total messenger RNA into DNA.
摘要翻译： 描述了通过使用结合蛋白的逆转录获得将全长的单链核糖核酸（RNA）完全复制到其互补的脱氧核糖核酸（cDNA）中的方法。 该方法可用于重组DNA研究，将总信使RNA复制到DNA中。
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公开(公告)号：US06511845B1
公开(公告)日：2003-01-28
申请号：US09618360
申请日：2000-07-18
申请人： Alan R. Davis , Paul P. Hung , Michael D. Lubeck , Robert J. Natuk , Pranab K. Chanda , Shridhara C. S. Murthy , Shaw-Guang L. Lee
发明人： Alan R. Davis , Paul P. Hung , Michael D. Lubeck , Robert J. Natuk , Pranab K. Chanda , Shridhara C. S. Murthy , Shaw-Guang L. Lee
IPC分类号： A61K3921
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/10343 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , Y02A50/464 , Y02A50/472
摘要： This invention provides a method of protecting a primate from an infectious organism by stimulating the production of antibodies or cell mediated immunity to the infectious organism which comprises administering to said primate intranasally, intramuscularly, or subcutaneously, live recombinant adenoviruses in which the virion structural protein is unchanged from that in the native adenovirus from which the recombinant adenovirus is produced, and which contain the gene coding for the antigen corresponding to said antibodies or inducing said cell mediated immunity. Preferably, the infectious organism is HIV and the primate is a human.
摘要翻译： 本发明提供了通过刺激产生抗体或细胞介导的对感染性生物的免疫来保护灵长类从感染性生物体的方法，其包括向所述灵长类动物鼻内，肌内或皮下施用病毒结构蛋白质的活重组腺病毒 与从其产生重组腺病毒的天然腺病毒中不同，并且其含有编码对应于所述抗体的抗原的基因或诱导所述细胞介导的免疫。 优选地，感染性生物是HIV，灵长类是人。
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公开(公告)号：US5591823A
公开(公告)日：1997-01-07
申请号：US169813
申请日：1993-12-17
IPC分类号： A61K39/21 , A61K39/00 , A61P31/12 , A61P31/16 , A61P37/08 , C07H21/00 , C07K14/11 , C07K14/16 , C12N7/01 , C12N15/08 , C12N15/09 , C12N15/11 , C12N15/32 , C12N15/34 , C12N15/44 , C12P21/02 , G01N33/53 , G01N33/569 , C07K1/00 , A61K39/145 , C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/40 , C12N2740/16022 , C12N2760/16122
摘要： Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigenic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immunotherapy.
摘要翻译： 提供了嵌合DNA片段，其包括与编码具有5个免疫显性抗原位点的甲型流感病毒的HA表面蛋白基本上相同的核苷酸序列，其中插入与编码外源表位的碱基序列基本相同的核苷酸序列 进入抗原位点的核苷酸序列。 也提供相应的嵌合肽，表达载体和转化的宿主。 这些肽可用于提供针对相应抗原和测试试剂盒的疫苗以检测对这些抗原的暴露。 此外，这些肽或其相应的抗体可用于治疗和预防暴露于这些抗原的表现的方法，包括免疫治疗。
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公开(公告)号：US5376547A
公开(公告)日：1994-12-27
申请号：US150267
申请日：1988-01-29
IPC分类号： C12N9/64 , A61K31/00 , A61K38/00 , A61K38/46 , A61P7/00 , A61P7/02 , C12N9/72 , C12N15/09 , C12N9/48 , A61K37/547
CPC分类号： C12N9/6456
摘要： Des-epidermal growth factor homologous--plasminogen activators with greatly diminished affinity for liver membranes.
摘要翻译： 去皮表皮生长因子同源纤溶酶原激活剂，对肝膜的亲和力大大降低。
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