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1.发明授权
公开(公告)号：US5756529A
公开(公告)日：1998-05-26
申请号：US536318
申请日：1995-09-29
申请人： Peter C. Isakson , John J. Talley
发明人： Peter C. Isakson , John J. Talley
IPC分类号： C07D231/12 , A61K31/00 , A61K31/415 , A61K31/4162 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/635 , A61P29/00 , C07D401/04 , C07D405/04 , C07D409/04 , C07D495/04 , A61K31/495 , A61K31/535
CPC分类号： A61K31/635 , A61K31/415
摘要： A method of using pyrazolyl benzenesulfonamide compounds in treating inflammation and inflammation-related disorders in companion animals is disclosed.
摘要翻译： 公开了使用吡唑基苯磺酰胺化合物治疗伴侣动物的炎症和炎症相关疾病的方法。
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公开(公告)号：US09226983B2
公开(公告)日：2016-01-05
申请号：US13081212
申请日：2011-04-06
CPC分类号： C07K16/241 , A61K47/6845 , A61K51/1021 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , G01N33/6863 , G01N2333/7151 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
摘要： Isolated binding proteins, e.g., antibodies or antigen binding portions thereof, which bind to tumor necrosis factor-alpha (TNF-α), e.g., human TNF-α, and related antibody-based compositions and molecules are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, as well as therapeutic and diagnostic methods for using the antibodies.
摘要翻译： 公开了与肿瘤坏死因子-α（TNF-α）结合的分离的结合蛋白，例如结合肿瘤坏死因子-α（TNF-α）的抗体或其抗原结合部分以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物，以及使用抗体的治疗和诊断方法。
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公开(公告)号：US20120034160A1
公开(公告)日：2012-02-09
申请号：US13196138
申请日：2011-08-02
申请人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
IPC分类号： A61K51/10 , A61P41/00 , A61P17/06 , A61K39/395 , C12N5/10 , A61P3/10 , A61P9/10 , A61P13/12 , A61P33/00 , A61P11/06 , C12N1/21 , C12N1/15 , C12N1/19 , A61P25/16 , C12N1/11 , C12N15/63 , A61P37/08 , C07K16/24 , A61P1/00 , C07H21/04 , A61P31/16 , A61P25/06 , A61P19/10 , A61P17/00 , A61P25/00 , A61P25/18 , G01N33/566 , A61P31/00 , A61P25/28 , A61P9/00 , A61P15/00 , A61P37/02 , A61P35/02 , A61P35/00 , A61P31/04 , A61P29/00 , A61P17/02 , A61P31/18 , A61K49/00
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K49/00 , A61K51/1021 , C07K16/241 , C07K16/245 , C07K16/468 , C07K2317/35 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/53 , G01N33/56966 , G01N33/6857 , G01N33/6869 , G01N2333/54 , G01N2333/545 , G01N2800/24 , G01N2800/7028
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
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公开(公告)号：US20110212094A1
公开(公告)日：2011-09-01
申请号：US12914614
申请日：2010-10-28
申请人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
发明人： Tariq Ghayur , Jochen G. Salfeld , Michael J. McPherson , Maria C. Harris , Junjian Liu , Peter C. Isakson , Jijie Gu
IPC分类号： A61K39/395 , C07K16/46 , C12N9/96 , C07H21/04 , C12N15/63 , C12N1/00 , C12N1/21 , C12N5/10 , C12N1/15 , C12N1/19 , C12P21/08 , A61P29/00 , A61P19/06 , A61P19/02 , A61P17/00 , A61P37/06 , A61P1/16 , A61P13/12 , A61P31/12 , A61P11/00 , A61P37/08 , A61P25/00 , A61P31/00 , A61P35/00 , A61P5/00 , A61P5/14 , A61P9/00 , A61P3/00 , A61P7/00
CPC分类号： C07K16/241 , C07K16/22 , C07K16/2803 , C07K16/2875 , C07K16/44 , C07K16/468 , C07K2317/31 , C07K2317/73
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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5.发明授权Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A.sub.4 hydrolase inhibitor 失效用环氧合酶-2抑制剂和白三烯A4水解酶抑制剂的组合治疗炎症和炎症相关疾病
公开(公告)号：US5990148A
公开(公告)日：1999-11-23
申请号：US661674
申请日：1996-06-11
IPC分类号： C07D231/12 , A61K31/10 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K45/00 , A61K45/06 , A61P1/00 , A61P7/06 , A61P11/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D213/64 , C07D213/85 , C07D261/08 , C07D263/32 , C07D401/04 , C07D409/04 , A01N43/40 , A01N37/10 , A01N43/56 , A01N43/78
CPC分类号： A61K45/06
摘要： Combinations of a cyclooxygenase-2 inhibitor and a leukotriene A.sub.4 hydrolase inhibitor are described for treatment of inflammation and inflammation-related disorders.
摘要翻译： 描述了环氧合酶-2抑制剂和白三烯A4水解酶抑制剂的组合用于治疗炎症和炎症相关疾病。
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6.发明授权Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A.sub.4 hydrolase inhibitor 失效用环氧合酶-2抑制剂和白三烯A4水解酶抑制剂的组合治疗炎症和炎症相关疾病
公开(公告)号：US5700816A
公开(公告)日：1997-12-23
申请号：US489468
申请日：1995-06-12
IPC分类号： C07D231/12 , A61K31/10 , A61K31/165 , A61K31/18 , A61K31/195 , A61K31/38 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K45/00 , A61K45/06 , A61P1/00 , A61P7/06 , A61P11/00 , A61P25/04 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D213/64 , C07D213/85 , C07D261/08 , C07D263/32 , C07D401/04 , C07D409/04 , A61K31/445 , A61K31/135 , A61K31/20 , A61K31/40
CPC分类号： A61K45/06
摘要： Combinations of a cyclooxygenase-2 inhibitor and a leukotriene A.sub.4 hydrolase inhibitor are described for treatment of inflammation and inflammation-related disorders.
摘要翻译： 描述了环氧合酶-2抑制剂和白三烯A4水解酶抑制剂的组合用于治疗炎症和炎症相关疾病。
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公开(公告)号：US09035027B2
公开(公告)日：2015-05-19
申请号：US12477711
申请日：2009-06-03
申请人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
发明人： Tariq Ghayur , Peter C. Isakson , Lisa M. Olson , Chengbin Wu , Margaret Hugunin , Rajesh V. Kamath , Carolyn A. Cuff , Hamish J. Allen
IPC分类号： A61K39/395 , C07K16/46 , C07K16/22 , C07K16/24 , A61K45/06 , A61K47/48 , G01N33/68 , A61K39/00
CPC分类号： C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：US20120263722A1
公开(公告)日：2012-10-18
申请号：US13288185
申请日：2011-11-03
申请人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
发明人： Tariq Ghayur , Junjian Liu , Peter C. Isakson
IPC分类号： C07K16/46 , A61K39/395 , A61P29/00 , A61P35/00 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/02 , G01N33/53 , G01N21/64 , G01N21/76 , C40B30/04 , G01N27/62 , C12N15/13
CPC分类号： C07K16/468 , C07K16/22 , C07K16/247 , C07K16/248 , C07K16/2803 , C07K16/2809 , C07K16/2827 , C07K16/2851 , C07K16/2863 , C07K16/2878 , C07K16/2887 , C07K16/32 , C07K16/34 , C07K16/44 , C07K2317/31
摘要： Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
摘要翻译： 提供了工程化的多价和多特异性结合蛋白，制备方法及其在预防，诊断和/或治疗疾病中的用途。
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9.发明授权Immunosuppressive effects of administration of a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor 失效施用环氧合酶-2抑制剂和5-脂肪氧合酶抑制剂的免疫抑制作用公开(公告)号：US07132441B2
公开(公告)日：2006-11-07
申请号：US10098644
申请日：2002-03-15
IPC分类号： A61K31/415 , A61K31/34
摘要： This invention is in the field of a combination comprising a therapeutically-effective amount of a cyclooxygenase-2 inhibitor, a 5-lipoxygenase inhibitor and an immunosuppressive drug selected from antiproliferative agents, antiinflammatory-acting compounds and inhibitors of leukocyte activation. This combination may be used, for example, to suppress the immune response associated with organ transplantation, graft versus host disease, and conditions with underlying autoimmune or inflammatory reactivities or responses.
摘要翻译： 本发明涉及包含治疗有效量的环加氧酶-2抑制剂，5-脂氧合酶抑制剂和选自抗增生剂，抗炎作用化合物和白细胞活化抑制剂的免疫抑制药物的组合领域。 这种组合可以用于例如抑制与器官移植相关的免疫应答，移植物抗宿主病和具有潜在的自身免疫或炎性反应性或反应的病症。
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10.发明授权公开(公告)号：US08822645B2
公开(公告)日：2014-09-02
申请号：US12499652
申请日：2009-07-08
申请人： Tariq Ghayur , Jijie Gu , Peter C. Isakson
发明人： Tariq Ghayur , Jijie Gu , Peter C. Isakson
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07H21/04 , G01N33/53 , C12P21/06 , C12N1/20 , C12N15/00 , C12N5/00 , C12N5/16 , C07K1/00
CPC分类号： C07K16/468 , A61K38/00 , A61K45/06 , A61K47/6879 , A61K51/109 , C07K16/22 , C07K16/24 , C07K16/26 , C07K16/2863 , C07K16/2866 , C07K16/44 , C07K2317/31 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/6869 , G01N33/74 , G01N33/88 , G01N2333/4709 , G01N2333/48 , G01N2333/525 , G01N2333/5443 , G01N2333/545 , G01N2333/7155 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/478 , Y02A50/481
摘要： The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
摘要翻译： 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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