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1.发明授权Methods and systems to prevent punch loss during automated sample processing 有权自动化样品处理过程中防止冲孔损失的方法和系统公开(公告)号：US08689649B2
公开(公告)日：2014-04-08
申请号：US12630899
申请日：2009-12-04
IPC分类号： G01N1/08
CPC分类号： G01N1/286 , G01N2001/288 , G01N2035/042
摘要： Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.
摘要翻译： 用于冲切用于生物样品的多孔基材片的自动方法和系统，包括：将所述多孔基材装载到包括模头和开口的支撑件上; 在至少z方向上移动容器支撑件以相对于支撑件定位容器，使得容器中的开口对齐并且基本上与支撑件中的开口齐平; 致动冲压头，使冲头通过冲模，从而从多孔基材上冲出一块; 并且致动顶针以将冲压件从多孔基底支撑件推出并进入与支撑件中的开口对准的容器中。
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2.发明申请METHODS AND SYSTEMS TO PREVENT PUNCH LOSS DURING AUTOMATED SAMPLE PROCESSING 有权在自动样品加工过程中防止冲击损失的方法和系统公开(公告)号：US20110132111A1
公开(公告)日：2011-06-09
申请号：US12630899
申请日：2009-12-04
IPC分类号： G01N1/04
CPC分类号： G01N1/286 , G01N2001/288 , G01N2035/042
摘要： Automated methods and systems for punching out pieces of a porous substrate for biological samples comprising: loading the porous substrate onto a support comprising a die and an opening; moving a receptacle support in at least a z-direction to position a receptacle relative to the support so that an opening in the receptacle is aligned and substantially flush with the opening in the support; actuating a punching head so that the punching head passes through the die, thereby punching a piece out of the porous substrate; and actuating an ejector pin to eject the punched piece from the porous substrate support and into the receptacle aligned with the opening in the support.
摘要翻译： 用于冲切用于生物样品的多孔基材片的自动方法和系统，包括：将所述多孔基材装载到包括模头和开口的支撑件上; 在至少z方向上移动容器支撑件以相对于支撑件定位容器，使得容器中的开口对齐并且基本上与支撑件中的开口齐平; 致动冲压头，使冲头通过冲模，从而从多孔基材上冲出一块; 并且致动顶针以将冲压件从多孔基底支撑件推出并进入与支撑件中的开口对准的容器中。
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公开(公告)号：US20110129863A1
公开(公告)日：2011-06-02
申请号：US12629088
申请日：2009-12-02
申请人： Philip Alexander Shoemaker , Weston Blaine Griffin , Erin Jean Finehout , Xuefeng Wang , Kashan Ali Shaikh , Greg Darryl Goddard
发明人： Philip Alexander Shoemaker , Weston Blaine Griffin , Erin Jean Finehout , Xuefeng Wang , Kashan Ali Shaikh , Greg Darryl Goddard
CPC分类号： G01N1/4055 , B01L3/5025 , B01L3/50255 , B01L2200/025 , B01L2200/0689 , B01L2300/0627 , B01L2300/0829 , B01L2300/0832 , G01N1/34 , G01N1/405 , G01N1/4077 , G01N30/7233 , G01N35/00029 , G01N35/1095 , G01N2001/4061 , G01N2001/4088 , G01N2030/009 , G01N2030/062 , G01N2035/00128 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
摘要翻译： 用于处理固定到多孔基材的样品的方法和系统通常包括限定一个或多个流体隔离区域的压缩机，用于多孔基材的支撑体，其具有对应于压缩机的一个或多个流体隔离区域的开口， 致动器，其使至少一部分压缩机压靠多孔基底，至少当压缩机被压靠在多孔基底上时，流体入口至少进入流体隔离区域，以及流体出口以接收流体，通过开口 在对应于压缩机的流体隔离区域的支撑件中，至少当压缩机被压靠在多孔基底上时。
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公开(公告)号：US08685749B2
公开(公告)日：2014-04-01
申请号：US12629088
申请日：2009-12-02
申请人： Philip Alexander Shoemaker , Weston Blaine Griffin , Erin Jean Finehout , Xuefeng Wang , Kashan Ali Shaikh , Greg Darryl Goddard
发明人： Philip Alexander Shoemaker , Weston Blaine Griffin , Erin Jean Finehout , Xuefeng Wang , Kashan Ali Shaikh , Greg Darryl Goddard
CPC分类号： G01N1/4055 , B01L3/5025 , B01L3/50255 , B01L2200/025 , B01L2200/0689 , B01L2300/0627 , B01L2300/0829 , B01L2300/0832 , G01N1/34 , G01N1/405 , G01N1/4077 , G01N30/7233 , G01N35/00029 , G01N35/1095 , G01N2001/4061 , G01N2001/4088 , G01N2030/009 , G01N2030/062 , G01N2035/00128 , Y10T436/24 , Y10T436/25 , Y10T436/25375 , Y10T436/255
摘要： Methods and systems for processing samples fixed to a porous substrate generally comprising, a compressor defining one or more fluid isolation areas, a support, for the porous substrate, having an opening corresponding to one or more of the fluid isolation areas of the compressor, an actuator that causes at least a portion of the compressor to press against the porous substrate, a fluid inlet having access to the fluid isolation area at least when the compressor is pressed against the porous substrate, and a fluid outlet to receive fluid, through the opening in the support corresponding to the fluid isolation area of the compressor, at least when the compressor is pressed against the porous substrate.
摘要翻译： 用于处理固定到多孔基材的样品的方法和系统通常包括限定一个或多个流体隔离区域的压缩机，用于多孔基材的支撑体，其具有对应于压缩机的一个或多个流体隔离区域的开口， 致动器，其使至少一部分压缩机压靠多孔基底，至少当压缩机被压靠在多孔基底上时，流体入口至少进入流体隔离区域，以及流体出口以接收流体，通过开口 在对应于压缩机的流体隔离区域的支撑件中，至少当压缩机被压靠在多孔基底上时。
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公开(公告)号：US08216409B2
公开(公告)日：2012-07-10
申请号：US12635231
申请日：2009-12-10
申请人： James Mitchell White , Nichole Lea Wood , Weston Blaine Griffin , Ryan Austin Hutchinson , Owen Scott Quirion , Philip Alexander Shoemaker , Eric Douglas Williams
发明人： James Mitchell White , Nichole Lea Wood , Weston Blaine Griffin , Ryan Austin Hutchinson , Owen Scott Quirion , Philip Alexander Shoemaker , Eric Douglas Williams
IPC分类号： B65H81/00
CPC分类号： B01D63/021 , A61M1/34 , A61M1/3403 , B01D63/022 , B01D63/024 , B01D2313/20 , B01D2313/21 , B01D2313/50
摘要： The invention provides a method of manufacturing a housingless hollow fiber filtration apparatus using batch, continuous, and semi-continuous processes. Also provided is manufacturing methods to increase rigidity of the apparatus.
摘要翻译： 本发明提供一种使用分批，连续和半连续方法制造无壳中空纤维过滤装置的方法。 还提供了增加设备刚度的制造方法。
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公开(公告)号：US10934519B2
公开(公告)日：2021-03-02
申请号：US13193925
申请日：2011-07-29
申请人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
发明人： Jaydeep Roy , Andrew Michael Leach , Weston Blaine Griffin , Stefan Rakuff , Philip Alexander Shoemaker
IPC分类号： C12M1/00
摘要： The methods of harvesting cells are provided, wherein the methods comprise introducing a processing material and a source material into a processing loop. The processing loop comprises a processing chamber and a filtering device. The processing material and the source material are circulating through the processing chamber and the filtering device, wherein the processing chamber has a mass; balancing an influx of the processing material into the processing chamber with a permeate flux of the filtering device to maintain the mass of the processing chamber at a constant value; and collecting the cells in a collection chamber. Cell harvesting devices are also provided for processing and harvesting cells using a control law to balance the mass of the processing chamber through the entire process.
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7.发明授权公开(公告)号：US08713775B2
公开(公告)日：2014-05-06
申请号：US13161579
申请日：2011-06-16
申请人： Zhipeng Zhang , Philip Alexander Shoemaker , Robert Jeffrey Pieciuk , Weston Blaine Griffin , Arvind Rangarajan , Diego Quinones , Prabhjot Singh
发明人： Zhipeng Zhang , Philip Alexander Shoemaker , Robert Jeffrey Pieciuk , Weston Blaine Griffin , Arvind Rangarajan , Diego Quinones , Prabhjot Singh
CPC分类号： F01D5/005 , B23P6/02 , F01D25/285 , F05D2230/80
摘要： An apparatus and method are provided for servicing a dynamoelectric machine component. The apparatus includes a tool delivery mechanism adapted for delivering a tool to a desired location in the dynamoelectric machine, and a tool support fixture adapted to be secured onto the body of the dynamoelectric machine, where the tool support fixture can be used for supporting and adjusting the tool delivery mechanism. A sleeve mechanism is attached to the tool support fixture, and the sleeve mechanism is disposed around a portion of the tool delivery mechanism. The apparatus is adapted to service the component of the dynamoelectric machine in-situ.
摘要翻译： 提供了一种用于维修电动机器部件的装置和方法。 该装置包括适于将工具传送到电动机中的期望位置的工具传送机构，以及适于固定在电动机的主体上的工具支撑夹具，其中工具支撑夹具可用于支撑和调节 工具传递机制。 套筒机构附接到工具支撑固定件，并且套筒机构设置在工具传送机构的一部分周围。 该装置适用于现场维修电动机组件。
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8.发明申请公开(公告)号：US20120317771A1
公开(公告)日：2012-12-20
申请号：US13161579
申请日：2011-06-16
申请人： Zhipeng Zhang , Philip Alexander Shoemaker , Robert Jeffrey Pieciuk , Weston Blaine Griffin , Arvind Rangarajan , Diego Quinones , Prabhjot Singh
发明人： Zhipeng Zhang , Philip Alexander Shoemaker , Robert Jeffrey Pieciuk , Weston Blaine Griffin , Arvind Rangarajan , Diego Quinones , Prabhjot Singh
CPC分类号： F01D5/005 , B23P6/02 , F01D25/285 , F05D2230/80
摘要： An apparatus and method are provided for servicing a dynamoelectric machine component. The apparatus includes a tool delivery mechanism adapted for delivering a tool to a desired location in the dynamoelectric machine, and a tool support fixture adapted to be secured onto the body of the dynamoelectric machine, where the tool support fixture can be used for supporting and adjusting the tool delivery mechanism. A sleeve mechanism is attached to the tool support fixture, and the sleeve mechanism is disposed around a portion of the tool delivery mechanism. The apparatus is adapted to service the component of the dynamoelectric machine in-situ.
摘要翻译： 提供了一种用于维修电动机器部件的装置和方法。 该装置包括适于将工具传送到电动机中的期望位置的工具传送机构，以及适于固定在电动机的主体上的工具支撑夹具，其中工具支撑夹具可用于支撑和调节 工具传递机制。 套筒机构附接到工具支撑固定件，并且套筒机构设置在工具传送机构的一部分周围。 该装置适用于现场维修电动机组件。
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9.发明授权Disposable fluid path systems and methods for processing complex biological materials 有权一次性流体路径系统和处理复杂生物材料的方法公开(公告)号：US08512566B2
公开(公告)日：2013-08-20
申请号：US12636112
申请日：2009-12-11
申请人： Weston Blaine Griffin , Jaydeep Roy , Eric Douglas Williams , Philip Alexander Shoemaker , James Mitchell White
发明人： Weston Blaine Griffin , Jaydeep Roy , Eric Douglas Williams , Philip Alexander Shoemaker , James Mitchell White
CPC分类号： A61M1/3633 , A61M1/0272 , A61M2202/0437 , A61M2202/0462 , B01D21/34
摘要： Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.
摘要翻译： 本文公开了用于处理复杂材料的一次性流体路径。 一次性流体路径包括重力辅助的一次性系统，用于通过沉降将生物样品分离成两个或更多个不同的子材料。 流体路径包括样品输送导管和袋组件，其中袋组包括管组件，分离组件和过滤器组件。 还公开了使用该系统的方法。
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10.发明申请DISPOSABLE FLUID PATH SYSTEMS AND METHODS FOR PROCESSING COMPLEX BIOLOGICAL MATERIALS 有权可处理的流体路径系统和处理复合生物材料的方法公开(公告)号：US20110139723A1
公开(公告)日：2011-06-16
申请号：US12636112
申请日：2009-12-11
申请人： Weston Blaine Griffin , Jaydeep Roy , Eric Douglas Williams , Philip Alexander Shoemaker , James Mitchell White
发明人： Weston Blaine Griffin , Jaydeep Roy , Eric Douglas Williams , Philip Alexander Shoemaker , James Mitchell White
CPC分类号： A61M1/3633 , A61M1/0272 , A61M2202/0437 , A61M2202/0462 , B01D21/34
摘要： Disclosed herein is a disposable fluid path for processing complex materials. The disposable fluid path comprises a gravity assisted disposable system for separating a biological sample into two or more distinct submaterials through sedimentation. The fluid path is comprised of a sample delivery conduit and bag-set wherein the bag set comprising a tubing assembly, a separation assembly, and a filter assembly. Methods of using the system are also disclosed.
摘要翻译： 本文公开了用于处理复杂材料的一次性流体路径。 一次性流体路径包括重力辅助的一次性系统，用于通过沉降将生物样品分离成两个或更多个不同的子材料。 流体路径包括样品输送导管和袋组件，其中袋组包括管组件，分离组件和过滤器组件。 还公开了使用该系统的方法。
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