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公开(公告)号：US5922597A
公开(公告)日：1999-07-13
申请号：US860866
申请日：1997-07-14
IPC分类号： A61K35/12 , C12N5/02 , C12N5/0783 , C12N5/0789 , C12N5/08
CPC分类号： C12N5/0646 , C12N5/0647 , A61K2035/124 , C12N2500/38 , C12N2501/125 , C12N2501/21 , C12N2501/23 , C12N2501/39 , C12N2502/1394
摘要： A method for the culture of hematopoietic cells is provided comprising culturing said cells in stromal conditioned medium comprising one or more cytokines selected from the group consisting of MIP-1.alpha., IL-3, SCF, BB10010 and PF-4, so that the ability of the stem cells to self-replicate and differentiate is maintained or the ability of the committed progenitors to expand and differentiate is maintained.
摘要翻译： PCT No.PCT / US96 / 18222 Sec。 371日期1997年7月14日 102（e）日期1997年7月14日PCT 1996年11月13日PCT公布。 出版物WO97 / 18298 日期1997年5月22日提供造血细胞培养方法，包括在基质条件培养基中培养所述细胞，所述基质条件培养基包含一种或多种选自MIP-1α，IL-3，SCF，BB10010和PF-4的细胞因子， 使得维持干细胞自我复制和分化的能力，或保持所确定的祖细胞扩增和分化的能力。
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公开(公告)号：US5460964A
公开(公告)日：1995-10-24
申请号：US32670
申请日：1993-03-17
IPC分类号： C12N5/0789 , C12N5/02 , C12N5/06 , C12N5/08
CPC分类号： C12N5/0647 , C12N2501/21 , C12N2501/23 , C12N2501/39 , C12N2502/1394
摘要： A method for culturing mammalian hematopoietic, preferably stem cells, is provided comprising maintaining a population of human hematopoietic cells in a non-contacting relationship to a population of cultured stromal cells, which populations are in preferably liquid stromal growth medium connection, so that the ability of the stem cells in said population to differentiate and self-replicate is maintained during an extended culture period.
摘要翻译： 提供了一种用于培养哺乳动物造血干细胞的方法，优选干细胞包括维持人体造血细胞群与培养基质细胞群的非接触关系，所述群体优选为液体基质生长培养基连接， 的干细胞在所述群体中进行分化和自我复制是在延长的培养期间保持的。
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3.发明授权
公开(公告)号：US5523286A
公开(公告)日：1996-06-04
申请号：US152051
申请日：1993-11-12
IPC分类号： C07K14/47 , C07K14/77 , C12N5/0789 , A61K38/16 , A61K38/00 , C08B37/08 , C08B37/10 , C12N5/00
CPC分类号： C07K14/4725 , C07K14/77 , C12N5/0647 , C12N2501/125 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/90 , C12N2501/998 , C12N2502/1394
摘要： An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
摘要翻译： 公开了一种含阴离子大分子的组合物，其能够支持培养的哺乳动物造血细胞中长期骨髓培养起始细胞的保守和分化。 所公开的组合物是分子量大于200kD的糖蛋白，更特别是蛋白聚糖的混合物。
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公开(公告)号：US5436151A
公开(公告)日：1995-07-25
申请号：US862814
申请日：1992-04-03
IPC分类号： C12N5/0789 , C12N5/02 , C12N5/08
CPC分类号： C12N5/0647 , C12N2501/21 , C12N2501/23 , C12N2501/39 , C12N2502/1394
摘要： A method for culturing mammalian hematopoietic stem cells is provided comprising maintaining a population of human stem cells in fixed, non-contacting relationship to a population of cultured stromal cells, which populations are in liquid stromal growth medium connection, so that the ability of the stem cells to differentiate and self-replicate is maintained during an extended culture period.
摘要翻译： 提供了一种用于培养哺乳动物造血干细胞的方法，其包括将人类干细胞群与培养基质细胞群体固定，非接触的关系保持在一起，所述群体处于液体基质生长培养基连接中，使得茎干能力 在延长的培养期间维持细胞分化和自我复制。
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公开(公告)号：US5605829A
公开(公告)日：1997-02-25
申请号：US346893
申请日：1994-11-30
IPC分类号： C07K14/47 , C07K14/77 , C12N5/0789 , C12N5/00 , A61K38/16 , C07K14/475
CPC分类号： C07K14/4725 , C07K14/77 , C12N5/0647 , C12N2501/125 , C12N2501/22 , C12N2501/2306 , C12N2501/235 , C12N2501/90 , C12N2501/998 , C12N2502/1394
摘要： An anionic macromolecular containing composition is disclosed that is capable of supporting conservation and differentiation of long-term bone marrow culture initiating cells in cultured mammalian hematopoietic cells. The composition disclosed is a mixture of glycoproteins, more specifically proteoglycans, which are of a molecular weight greater than 200 kD.
摘要翻译： 公开了一种含阴离子大分子的组合物，其能够支持培养的哺乳动物造血细胞中长期骨髓培养起始细胞的保守和分化。 所公开的组合物是分子量大于200kD的糖蛋白，更特别是蛋白聚糖的混合物。
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公开(公告)号：US09974811B2
公开(公告)日：2018-05-22
申请号：US12416700
申请日：2009-04-01
CPC分类号： A61K35/28 , A61K48/00 , A61K2035/124 , A61K2039/5156 , C12N5/0607 , C12N2501/105 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2503/00 , C12N2510/00 , C12Y207/07049
摘要： The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells.
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7.发明申请Use of Multipotent Adult Stem Cells in Treatment of Myocardial Infarction and Congestive Heart Failure 审中-公开使用多能成人干细胞治疗心肌梗死和充血性心力衰竭公开(公告)号：US20120064047A1
公开(公告)日：2012-03-15
申请号：US13301186
申请日：2011-11-21
CPC分类号： A61K35/34 , A61K2035/124 , C12N5/0607 , C12N2500/36 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2501/33 , C12N2501/39 , C12N2533/52
摘要： The invention provides isolated stem cells of non-embryonic origin that can be maintained in culture in the undifferentiated state or differentiated to form cells of multiple tissue types. Also provided are methods of isolation and culture, as well as therapeutic uses for the isolated cells in cardiac indications.
摘要翻译： 本发明提供了非胚胎来源的分离的干细胞，其可以保持在未分化状态的培养物中或分化成多种组织类型的细胞。 还提供了分离和培养的方法，以及在心脏适应症中分离的细胞的治疗用途。
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公开(公告)号：US20110111492A1
公开(公告)日：2011-05-12
申请号：US12863015
申请日：2009-01-21
IPC分类号： C12N5/00
CPC分类号： C12N5/067 , A61K35/12 , C12N5/0607 , C12N5/0671 , C12N2500/02 , C12N2501/11 , C12N2501/135 , C12N2501/235 , C12N2503/02 , C12N2506/03
摘要： The invention is directed to compositions of cell aggregates and methods for making and using the cell aggregates where the aggregates comprise cells that are not embryonic stern cells but can differentiate into cell types of at least two of ectodermal, undo dermal, and mesodermal embryonic germ layers, e.g., stem cells.
摘要翻译： 本发明涉及细胞聚集体的组合物和用于制备和使用细胞聚集体的方法，其中聚集体包含不是胚胎细胞但可分化为外胚层，去皮肤和中胚层胚胎胚层中至少两种的细胞类型 ，例如干细胞。
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公开(公告)号：US07838289B2
公开(公告)日：2010-11-23
申请号：US10467963
申请日：2002-02-14
IPC分类号： C12N5/00
CPC分类号： A61K39/001 , A01K67/0271 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/106 , A61K35/12 , A61K48/00 , C12N5/0607 , C12N5/0619 , C12N5/0622 , C12N5/067 , C12N15/873 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/117 , C12N2501/119 , C12N2501/12 , C12N2501/135 , C12N2501/235 , C12N2501/237 , C12N2502/08 , C12N2502/30 , C12N2503/00 , C12N2506/03 , C12N2517/02
摘要： The present invention relates generally to mammalian multipotent adult stem cells (MASC), and more specifically to methods for obtaining, maintaining and differentiating MASC to cells of multiple tissue types. Uses of MASC in the therapeutic treatment of disease are also provided.
摘要翻译： 本发明一般涉及哺乳动物多潜能成体干细胞（MASC），更具体地涉及用于获得，维持和分化MASC至多种组织类型的细胞的方法。 还提供了MASC在治疗疾病中的用途。
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10.发明申请DIFFERENTIATION OF NON-EMBRYONIC STEM CELLS TO CELLS HAVING A PANCREATIC PHENOTYPE 有权非胚胎干细胞对具有胰腺癌细胞的细胞的分化公开(公告)号：US20090092586A1
公开(公告)日：2009-04-09
申请号：US12089868
申请日：2006-10-16
CPC分类号： C12N5/0607 , A61K35/12 , C12N5/0676 , C12N2500/38 , C12N2501/11 , C12N2501/12 , C12N2501/155 , C12N2501/16 , C12N2501/19 , C12N2501/41 , C12N2506/03 , C12N2510/00
摘要： The invention provides methods for differentiating non-embryonic multipotent stem cells along the pancreatic lineage. The present invention further provides non-embryonic multipotent stem cells and progeny derived therefrom to provide pancreatic cells to a subject.
摘要翻译： 本发明提供了沿着胰腺谱系分化非胚胎多潜能干细胞的方法。 本发明进一步提供非胚胎多能干细胞及其衍生的后代以向受试者提供胰腺细胞。
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