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公开(公告)号：US08685752B2
公开(公告)日：2014-04-01
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A Kularatne
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X, wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译： 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂， 并使用流式细胞术检测表达配体受体的致病细胞。
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公开(公告)号：US20100055735A1
公开(公告)日：2010-03-04
申请号：US12513028
申请日：2007-11-02
申请人： Philip Stewart Low , Wei He , Sumith A. Kularatne
发明人： Philip Stewart Low , Wei He , Sumith A. Kularatne
IPC分类号： C12Q1/06
CPC分类号： G01N33/582 , G01N15/1459 , G01N15/1463 , G01N33/5091 , G01N33/574 , G01N33/57434 , G01N2015/1006 , G01N2015/1438 , G01N2015/149 , G01N2458/00
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells. The method comprises the steps of combining with an ex vivo patient sample a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using flow cytometry.
摘要翻译： 本发明涉及诊断由致病细胞介导的疾病状态的方法。 该方法包括以下步骤：将离体患者样品与包含通式Ab-X的缀合物或复合物的组合物组合，其中组Ab包含与致病细胞结合的配体，X组包含成像剂，以及 使用流式细胞术检测表达配体受体的致病细胞。
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公开(公告)号：US20100324008A1
公开(公告)日：2010-12-23
申请号：US12673931
申请日：2008-08-15
IPC分类号： A61K31/555 , C07K2/00 , C07C275/00 , C07C237/00 , C07F3/10
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US09193763B2
公开(公告)日：2015-11-24
申请号：US12673931
申请日：2008-08-15
IPC分类号： C07K5/08 , C07D207/416 , C07C323/52 , A61K47/48 , A61K49/00 , A61K51/04
CPC分类号： A61K47/64 , A61K31/426 , A61K31/4745 , A61K31/475 , A61K47/54 , A61K47/542 , A61K47/547 , A61K47/548 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056 , A61K51/04 , A61K51/0402 , A61K51/0489 , A61K51/088 , C07C323/52 , C07D207/416 , C07K5/08
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical composition containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于递送治疗，诊断和成像剂的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的药物组合物和使用缀合物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US20110288152A1
公开(公告)日：2011-11-24
申请号：US13124448
申请日：2009-10-16
IPC分类号： A61K31/7088 , A61P35/00 , C07K2/00 , A61K31/713 , C07H21/04 , C07H21/02
CPC分类号： A61K51/088 , C12N15/111 , C12N2310/351 , C12N2320/32
摘要： Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for targeting prostate cancer cells. Also described herein are compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
摘要翻译： 本文描述了可用于靶向前列腺癌细胞的前列腺特异性膜抗原（PSMA）结合缀合物。 本文还描述了含有它们的组合物和使用共轭物和组合物的方法。 还描述了制备缀合物和含有它们的组合物的方法。
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公开(公告)号：US20220105205A1
公开(公告)日：2022-04-07
申请号：US17112497
申请日：2020-12-04
IPC分类号： A61K49/00 , G01N21/64 , C07K5/087 , C07K5/11 , C07K7/06 , C07K5/062 , C07D209/20 , C07K5/083 , G01N33/574 , C07K7/02 , C07K5/072 , C07K5/078 , C07K5/065 , C07K5/09 , G01N33/58
摘要： The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
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公开(公告)号：US08795633B2
公开(公告)日：2014-08-05
申请号：US12067734
申请日：2006-09-22
申请人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
发明人： Philip Stewart Low , Wei He , Walter Anthony Henne, Jr. , Derek David Doorneweerd , Ji-Xin Cheng
IPC分类号： A61B5/00
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译： 本发明涉及用于诊断致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式Ab-X的缀合物或复合物的组合物，其中组Ab包含与 致病细胞和组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。
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公开(公告)号：US20080254499A1
公开(公告)日：2008-10-16
申请号：US12067734
申请日：2006-09-22
CPC分类号： A61K49/0058 , A61K47/542 , A61K47/62 , A61K49/0041 , A61K49/0043 , A61K49/0052 , A61K49/0056
摘要： The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.
摘要翻译： 本发明涉及一种用于诊断由致病细胞介导的疾病状态的方法，所述方法包括以下步骤：向患者施用包含通式“π-in-line-formula description =”的共轭物或复合物的组合物 公式“end =”lead“？> Ab-X <？in-line-formula description =”In-line Formulas“end =”tail“？>其中A组包括配体 结合致病细胞，组X包含成像剂，并使用体内流式细胞术检测表达配体受体的致病细胞。
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公开(公告)号：US20110172254A1
公开(公告)日：2011-07-14
申请号：US13063889
申请日：2009-09-17
IPC分类号： A61K31/519 , A61K31/517 , C07D471/04 , C07D239/72 , A61P35/00
CPC分类号： A61K47/48338 , A61K31/475 , A61K31/517 , A61K47/55 , A61K47/551 , C07D487/04
摘要： Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating such diseases are also described.
摘要翻译： 描述了抗叶酸剂，可释放接头和药物的结合物，以及含有它们的药物组合物。 缀合物可用于治疗由致病细胞群体引起的疾病。 还描述了治疗这些疾病的方法。
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公开(公告)号：US5820847A
公开(公告)日：1998-10-13
申请号：US784019
申请日：1997-01-15
IPC分类号： A61K31/19 , A61K31/02 , A61K31/375 , A61K31/40 , A61K31/44 , A61K31/51 , A61K31/711 , A61K47/48 , A61K49/00 , A61K51/04 , C07B59/00 , C07F9/10 , C07H21/00 , C07K14/00 , C12N1/21 , C12N5/00 , C12N15/09 , C12N15/64 , C12N15/82 , C12N15/87 , C12Q1/68 , C12R1/19 , C12R1/91 , A61K9/127 , A61K51/02
CPC分类号： B82Y5/00 , A61K47/48107 , A61K47/48146 , A61K47/48353 , A61K49/001 , A61K51/0497 , C07B59/004 , C12N15/64 , C12N15/8206 , C12N15/87 , C12Q1/68
摘要： A method is provided for targeting a diagnostic agent for delivery to a folate receptor-bearing cell of an animal. The method comprises the step of administering to an animal a composition comprising a diagnostic agent complexed with a targeting ligand selected from the group consisting of folate, folate receptor-binding analogs of folate, or other folate receptor-binding ligands.
摘要翻译： 提供了一种靶向用于递送至动物的含叶酸受体的细胞的诊断剂的方法。 该方法包括向动物施用包含与选自叶酸，叶酸的叶酸受体结合类似物或其它叶酸受体结合配体的靶向配体复合的诊断剂的组合物的步骤。
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