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公开(公告)号：US20130114868A1
公开(公告)日：2013-05-09
申请号：US13626301
申请日：2012-09-25
申请人： Philippe M. Burlina , Amit Banerjee , Saurabh Vyas , Luis Garza
发明人： Philippe M. Burlina , Amit Banerjee , Saurabh Vyas , Luis Garza
IPC分类号： G06K9/78
CPC分类号： A61B5/0075 , A61B5/444 , G06K2009/4657 , G06T7/0012 , G06T2207/10048 , G06T2207/20081 , G06T2207/30088
摘要： A method of detecting a skin condition may include employing a multiband hyperspectral sensor to obtain multi-spectral data, employing the multi-spectral data to map constitutive skin parameters to corresponding spectral signatures via a forward model that enables generation of a set of samples including a plurality of parameters mapped to a plurality of spectral signatures, utilizing the set of samples to employ machine learning to generate an inverse model to enable mapping of a spectral signature of skin of a patient to corresponding skin parameters, estimatingconstitutive skin parameters of the skin of the patient based on the inverse model, and determining a distribution of the constitutive parameters for one or more skin locations.
摘要翻译： 检测皮肤状况的方法可以包括采用多频带高光谱传感器来获得多光谱数据，采用多光谱数据通过正向模型将组成型皮肤参数映射到相应的光谱特征，所述前向模型能够生成一组样本，包括 多个参数映射到多个光谱特征，利用该组样本来采用机器学习来生成逆模型，以使得能够将患者的皮肤的光谱特征映射到相应的皮肤参数，估计皮肤的皮肤组织的皮肤参数 基于逆模型的患者，以及确定一个或多个皮肤位置的本构参数的分布。
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2.发明申请Methods for the stereospecific and enantiomeric enrichment of beta-amino acids 审中-公开β-氨基酸立体定向和对映体富集的方法公开(公告)号：US20050009151A1
公开(公告)日：2005-01-13
申请号：US10875161
申请日：2004-06-22
申请人： Matthew Chase , Robert Clayton , Bryan Landis , Amit Banerjee
发明人： Matthew Chase , Robert Clayton , Bryan Landis , Amit Banerjee
CPC分类号： C12P13/04 , C12N9/1096 , C12P13/22 , C12P41/006
摘要： The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus. A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus. The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.
摘要翻译： 本发明涉及立体有择合成和β-氨基酸对映异构体富集的方法。 从新分离的Variouorax paradoxus菌株中纯化出具有D-β-苯丙氨酸立体选择性的新型D-β-氨基转移酶（D-3氨基-3-苯丙酸）。 从新分离的产碱杆菌菌株纯化出新的L-β-氨基转移酶。 D-和L--β-氨基转移酶可用于促进分别由L-谷氨酸或L-丙氨酸的混合物和3-酮基 - 苯丙氨酸的β-苯丙氨酸或β-L-苯丙氨酸的立体选择性生物合成， 在辅因子吡哆醛磷酸盐存在下，加入3-苯基丙酸。
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公开(公告)号：US06261810B1
公开(公告)日：2001-07-17
申请号：US09386588
申请日：1999-08-31
申请人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , David A. Lust , Sushil K. Srivastava
发明人： Ramesh N. Patel , Amit Banerjee , Venkata B. Nanduri , Laszlo J. Szarka , Shankar Swaminathan , John J. Venit , Jerome L. Moniot , David A. Lust , Sushil K. Srivastava
IPC分类号： C12P1718
CPC分类号： C07K5/06139 , A61K38/00 , C07K14/8103 , C12N9/1096
摘要： The present invention concerns an enzymatic oxidative deamination process of a dipeptide monomer to prepare an intermediate useful to prepare compounds having endopeptidase and angiotensin converting enzyme inhibition activity.
摘要翻译： 本发明涉及二肽单体的酶氧化脱氨过程，以制备可用于制备具有内肽酶和血管紧张素转化酶抑制活性的化合物的中间体。
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4.发明授权Enzymatic reduction method for the preparation of compounds useful for preparing taxanes 失效用于制备可用于制备紫杉烷类的化合物的酶还原方法
公开(公告)号：US5420337A
公开(公告)日：1995-05-30
申请号：US975453
申请日：1992-11-12
IPC分类号： C07C231/12 , C07C233/87 , C07C229/28
CPC分类号： C07C231/12 , C07C233/87
摘要： An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
摘要翻译： 一种酶还原方法，特别是立体选择性酶还原方法，用于制备可用作制备紫杉烷类的中间体的化合物。
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5.发明授权Stereoselective microbial or enzymatic reduction of 3,5-dioxo esters to 3-hydroxy-5-oxo, 3-oxo-5-hydroxy, and 3,5-dihydroxy esters 失效将3,5-二氧代酯立体选择性微生物或酶还原为3-羟基-5-氧代，3-氧代-5-羟基和3,5-二羟基酯
公开(公告)号：US5324662A
公开(公告)日：1994-06-28
申请号：US883732
申请日：1992-05-15
IPC分类号： C07D319/06 , C07D405/06 , C12P7/62 , C12P17/16 , C12R1/01 , C12R1/365 , C12R1/645 , C12R1/78 , C12R1/84 , C12R1/865 , C12P41/00 , C12P17/10
CPC分类号： C07D405/06 , C07D319/06 , C12P7/62 , Y10S435/822 , Y10S435/872 , Y10S435/938
摘要： Microorganisms or reductases derived therefrom reduce a diketo ester ##STR1## to form the associated 3-hydroxy, 5-hydroxy, or 3,5-dihydroxy esters. Selected microorganisms produce the preferred stereoisomers ##STR2## which can be used to prepare antihypercholesterolemic agents such as ##STR3##
摘要翻译： 衍生自其的微生物或还原酶减少二酮酯形成相关的3-羟基，5-羟基或3,5-二羟基酯。 所选的微生物产生可用于制备抗高胆固醇血症药物的优选立体异构体
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6.发明授权Systems and methods for remote tagging and tracking of objects using hyperspectral video sensors 有权使用高光谱视频传感器远程标记和跟踪对象的系统和方法公开(公告)号：US08295548B2
公开(公告)日：2012-10-23
申请号：US12818215
申请日：2010-06-18
CPC分类号： G06K9/2018 , G06K9/4661 , G06T7/246 , G06T7/277 , G06T2207/10036 , G06T2207/20081
摘要： Detection and tracking of an object by exploiting its unique reflectance signature. This is done by examining every image pixel and computing how closely that pixel's spectrum matches a known object spectral signature. The measured radiance spectra of the object can be used to estimate its intrinsic reflectance properties that are invariant to a wide range of illumination effects. This is achieved by incorporating radiative transfer theory to compute the mapping between the observed radiance spectra to the object's reflectance spectra. The consistency of the reflectance spectra allows for object tracking through spatial and temporal gaps in coverage. Tracking an object then uses a prediction process followed by a correction process.
摘要翻译： 通过利用其独特的反射特征检测和跟踪对象。 这是通过检查每个图像像素并计算像素的频谱与已知对象光谱签名的匹配程度来完成的。 物体的测量辐射光谱可用于估计其对于宽范围的照明效应不变的其内在反射特性。 这通过结合辐射传递理论来计算观测到的辐射光谱与对象的反射光谱之间的映射来实现。 反射光谱的一致性允许通过覆盖范围内的空间和时间间隙进行物体跟踪。 跟踪对象然后使用预测过程，然后进行校正处理。
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7.发明申请Systems and Methods for Remote Tagging and Tracking of Objects Using Hyperspectral Video Sensors 有权使用高光谱视频传感器远程标记和跟踪对象的系统和方法公开(公告)号：US20100322480A1
公开(公告)日：2010-12-23
申请号：US12818215
申请日：2010-06-18
IPC分类号： G06K9/00
CPC分类号： G06K9/2018 , G06K9/4661 , G06T7/246 , G06T7/277 , G06T2207/10036 , G06T2207/20081
摘要： Detection and tracking of an object by exploiting its unique reflectance signature. This is done by examining every image pixel and computing how closely that pixel's spectrum matches a known object spectral signature. The measured radiance spectra of the object can be used to estimate its intrinsic reflectance properties that are invariant to a wide range of illumination effects. This is achieved by incorporating radiative transfer theory to compute the mapping between the observed radiance spectra to the object's reflectance spectra. The consistency of the reflectance spectra allows for object tracking through spatial and temporal gaps in coverage. Tracking an object then uses a prediction process followed by a correction process.
摘要翻译： 通过利用其独特的反射特征检测和跟踪对象。 这是通过检查每个图像像素并计算像素的频谱与已知对象光谱签名的匹配程度来完成的。 物体的测量辐射光谱可用于估计其对于宽范围的照明效应不变的其内在反射特性。 这通过结合辐射传递理论来计算观测到的辐射光谱与对象的反射光谱之间的映射来实现。 反射光谱的一致性允许通过覆盖范围内的空间和时间间隙进行物体跟踪。 跟踪对象然后使用预测过程，然后进行校正处理。
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8.发明授权Method of chiral epoxidation of benzopyran or pyranopyridine derivatives using microorganisms 失效使用微生物手性环氧化苯并吡喃或吡喃并吡啶衍生物的方法
公开(公告)号：US5478734A
公开(公告)日：1995-12-26
申请号：US192918
申请日：1994-02-07
IPC分类号： C07D311/22 , C07D311/70 , C07D493/04 , C12P17/18 , C12P41/00 , C12P17/06
CPC分类号： C07D493/04 , C07D311/22 , C07D311/70 , C12P17/18 , C12P17/181 , C12P41/004
摘要： An enzymatic process for the preparation of chiral epoxides, monohydroxy or dihydroxy compounds of formula ##STR1## by the stereoselective epoxidation or hydroxylation of benzopyrans of formula ##STR2## or resolution of compounds of formula ##STR3## The compounds of formula I and II are intermediates useful in the preparation of pyranyl cyanoguanidine derivatives.
摘要翻译： 通过式III的苯并吡喃的立体选择性环氧化或羟基化或通式IIa的化合物的拆分来制备式I化合物的手性环氧化物，单羟基或二羟基化合物的酶促方法化合物 式I和II是可用于制备吡喃基氰胍衍生物的中间体。
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公开(公告)号：US5393663A
公开(公告)日：1995-02-28
申请号：US46884
申请日：1993-04-14
申请人： Ramesh N. Patel , Mark Liu , Amit Banerjee , Laszlo J. Szarka
发明人： Ramesh N. Patel , Mark Liu , Amit Banerjee , Laszlo J. Szarka
IPC分类号： C07D239/42 , C12P7/22 , C12P17/12 , C12P17/16 , C12R1/01 , C12R1/06 , C12R1/365 , C12R1/645 , C12R1/72 , C12R1/78 , C12R1/865
CPC分类号： C12P17/165 , C12P17/12 , C12P7/22
摘要： A process is described for selectively preparing a compound of the formula ##STR1## wherein: R.sup.1 is halogen;R.sup.2 is halogen, alkyl, cycloalkyl, aryl or ##STR2## and R.sup.3 hydrogen, alkyl, cycloalkyl, aryl, ##STR3## wherein the process comprises treating the associated ketone with an oxido-reductase or a microorganism comprising an oxidoreductase. Compounds prepared by this process are useful antipsychotic agents or useful intermediates therefor.
摘要翻译： 描述了用于选择性制备下式化合物的方法：其中：R 1是卤素; R 2是卤素，烷基，环烷基，芳基或者R 3氢，烷基，环烷基，芳基，其中所述方法包括用氧化还原酶或包含氧化还原酶的微生物处理相关的酮。 通过该方法制备的化合物是有用的抗精神病药或其有用的中间体。
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公开(公告)号：US08003572B2
公开(公告)日：2011-08-23
申请号：US11647788
申请日：2006-12-28
申请人： Amit Banerjee
发明人： Amit Banerjee
CPC分类号： A61K31/506 , A61K31/53 , A61K31/5383
摘要： The present invention provides methods for identifying compounds that selectively bind one or more active sites within an ubiquitin conjugating enzyme. The compounds identified by the methods are useful in the treatment of disorders attributed to dysregulated ubiquitin conjugating enzyme function, specifically in hyperproliferative disorders.
摘要翻译： 本发明提供了鉴定选择性结合泛素缀合酶内的一个或多个活性位点的化合物的方法。 通过该方法鉴定的化合物可用于治疗归因于调节性泛素缀合酶功能的病症，特别是在过度增殖性疾病中。
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