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公开(公告)号：US07723084B2
公开(公告)日：2010-05-25
申请号：US10519216
申请日：2003-06-18
申请人： Ping Wang , Darrell Reneker , Hongfei Jia , Guangyu Zhu
发明人： Ping Wang , Darrell Reneker , Hongfei Jia , Guangyu Zhu
CPC分类号： C12N11/02 , C12N11/08 , G01N33/544
摘要： The present invention provides a fibrous protein-immobilization system composition comprising a fiber comprising fiber-forming material, and a protein attached to the fiber-forming material.
摘要翻译： 本发明提供一种纤维蛋白固定系统组合物，其包含含有纤维形成材料的纤维和附着于纤维形成材料的蛋白质。
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公开(公告)号：US20060094096A1
公开(公告)日：2006-05-04
申请号：US10519216
申请日：2003-06-18
申请人： Ping Wang , Darrell Reneker , Hongfei Jia , Guangyu Zhu
发明人： Ping Wang , Darrell Reneker , Hongfei Jia , Guangyu Zhu
IPC分类号： C12N11/16
CPC分类号： C12N11/02 , C12N11/08 , G01N33/544
摘要： The present invention provides a fibrous protein-immobilization system composition comprising a fiber comprising fiber-forming material, and a protein attached to the fiber-forming material.
摘要翻译： 本发明提供一种纤维蛋白固定系统组合物，其包含含有纤维形成材料的纤维和附着于纤维形成材料的蛋白质。
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公开(公告)号：US08222015B2
公开(公告)日：2012-07-17
申请号：US12118171
申请日：2008-05-09
申请人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
发明人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
CPC分类号： A61K9/06 , A61K38/443 , A61K38/4826 , A61K45/06 , A61K47/32 , A61K2300/00
摘要： A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart.
摘要翻译： 生物活性组合物包括水凝胶基质。 至少一种蛋白质固定在水凝胶基质中。 消化蛋白的半衰期比游离消化蛋白对应物的半衰期长至少1000倍。
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4.发明申请BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME 审中-公开包括稳定蛋白质的生物组合物及其生产方法公开(公告)号：US20120093802A1
公开(公告)日：2012-04-19
申请号：US12903312
申请日：2010-10-13
申请人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Minjuan Zhang
发明人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Minjuan Zhang
IPC分类号： A61K38/48 , A61K38/47 , A61K38/46 , A61K38/44 , A61P37/08 , A61K39/395 , A61K31/7105 , A61K38/22 , A61K31/727 , A61K31/715 , A61K38/51
CPC分类号： C12N11/04 , A61K31/7105 , A61K31/715 , A61K31/727
摘要： A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic solvent. A process for stabilizing a bioactive composition includes the steps of: forming hydrogel matrix pores around protein molecules and reducing a water content within the hydrogel matrix pores forming a hydrogel protein composite that is stable in an organic solvent.
摘要翻译： 生物活性组合物包括多孔水凝胶基质。 将至少一种蛋白质固定在多孔水凝胶基质中，形成在有机溶剂中稳定的水凝胶蛋白复合物。 用于稳定生物活性组合物的方法包括以下步骤：在蛋白质分子周围形成水凝胶基质孔，并降低水凝胶基质孔内的含水量，形成在有机溶剂中稳定的水凝胶蛋白复合物。
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5.发明申请公开(公告)号：US20110229916A1
公开(公告)日：2011-09-22
申请号：US12673857
申请日：2008-08-18
CPC分类号： C12N9/0006 , C12N11/04 , C12N11/08 , C12Q1/006 , C12Y101/03004
摘要： The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.
摘要翻译： 本发明提供了高酶加载纳米纤维及其制造中使用的方法，纳米纤维适合用作能够以低水平监测葡萄糖的新一类高度灵敏和稳定的生物传感器。 包含由有机溶剂型聚合物 - 酶体系制造的纳米纤维酶材料的生物传感器可以有效地用于非侵入性透皮生物传感应用。
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6.发明申请Coatings Containing Polymer Modified Enzyme For Stable Self-Cleaning Of Organic Stains 有权含有聚合物改性酶的涂料用于有机污渍的稳定自清洁公开(公告)号：US20130065291A1
公开(公告)日：2013-03-14
申请号：US13229277
申请日：2011-09-09
申请人： Hongfei Jia , Ping Wang , Liting Zhang , Andreas Buthe , Xueyan Zhao , Songtao Wu , Masahiko Ishii , Minjuan Zhang
发明人： Hongfei Jia , Ping Wang , Liting Zhang , Andreas Buthe , Xueyan Zhao , Songtao Wu , Masahiko Ishii , Minjuan Zhang
IPC分类号： C09D189/00
CPC分类号： C09D189/00 , A61K47/60 , C08G65/33337 , C08L2203/02 , C08L2205/02 , C09D5/024 , C09D7/40 , C09D175/16 , C12N9/14 , C12N9/20 , C12N9/2408 , C12N9/2411 , C12N9/54 , C12N9/96 , C12N11/06 , C12N11/08
摘要： Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.
摘要翻译： 提供了通过耐风化来防止灭活的生物活性涂层，包括与化学修饰的酶相关的碱，以及任选地存在于碱中并独立于酶的第一聚氧乙烯。 涂层任选地覆盖在基底上以形成有助于从食品，昆虫或环境中去除有机污渍或有机材料的活性涂层。
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公开(公告)号：US08252571B2
公开(公告)日：2012-08-28
申请号：US12434320
申请日：2009-05-01
申请人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
发明人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
IPC分类号： C12N9/00 , C08F283/00
CPC分类号： C12N11/08 , C07K17/08 , C08L89/00 , C09D5/025 , C09D5/1637 , C08L2666/02
摘要： Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material.
摘要翻译： 根据本发明的实施方案提供了制备蛋白质 - 聚合物复合材料的方法，其包括提供聚合物树脂，表面活性剂和非水有机溶剂的混合物。 含有生物活性蛋白质且基本上不含表面活性剂的水溶液与混合物混合。 将乳液与交联剂混合以制备可固化组合物。 固化组合物固化，由此制备蛋白质 - 聚合物复合材料。
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公开(公告)号：US20100279376A1
公开(公告)日：2010-11-04
申请号：US12434320
申请日：2009-05-01
申请人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
发明人： Ping Wang , Songtao Wu , Hongfei Jia , Masahiko Ishii , Xiaodong Tong , Minjuan Zhang
CPC分类号： C12N11/08 , C07K17/08 , C08L89/00 , C09D5/025 , C09D5/1637 , C08L2666/02
摘要： Processes for preparation of a protein-polymer composite material are provided according to embodiments of the present invention which include providing an admixture of a polymer resin, a surfactant and a non-aqueous organic solvent. An aqueous solution containing bioactive proteins and substantially free of surfactant is mixed with the admixture. The emulsion is mixed with a crosslinker to produce a curable composition. The curable composition is cured, thereby producing the protein-polymer composite material.
摘要翻译： 根据本发明的实施方案提供了制备蛋白质 - 聚合物复合材料的方法，其包括提供聚合物树脂，表面活性剂和非水有机溶剂的混合物。 含有生物活性蛋白质且基本上不含表面活性剂的水溶液与混合物混合。 将乳液与交联剂混合以制备可固化组合物。 固化组合物固化，由此制备蛋白质 - 聚合物复合材料。
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公开(公告)号：US09828597B2
公开(公告)日：2017-11-28
申请号：US11562503
申请日：2006-11-22
申请人： Ping Wang , Minjuan Zhang , Hongfei Jia , Archana H. Trivedi , Masahiko Ishii
发明人： Ping Wang , Minjuan Zhang , Hongfei Jia , Archana H. Trivedi , Masahiko Ishii
CPC分类号： C12N11/14 , C09D5/14 , C09D5/1637 , C09D5/1687 , C12N9/20 , C12N9/54 , C12N9/96 , C12N11/04 , C12N11/06 , C12Y304/21062
摘要： The present invention relates to compositions and a process in the field of self-cleaning system using digestive proteins. One composition includes a substrate, a digestive protein capable of decomposing a stain molecule, and a link moiety bound to both said digestive protein and said substrate. An alternative composition includes a digestive protein capable of decomposing a stain molecule and a coating substrate wherein said digestive protein may be dispersed in said coating substrate. The process claim includes binding a substrate to a surface and forming a linker moiety between a digestive protein and said substrate.
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10.发明授权公开(公告)号：US09376666B2
公开(公告)日：2016-06-28
申请号：US12673857
申请日：2008-08-18
CPC分类号： C12N9/0006 , C12N11/04 , C12N11/08 , C12Q1/006 , C12Y101/03004
摘要： The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.
摘要翻译： 本发明提供了高酶加载纳米纤维及其制造中使用的方法，纳米纤维适合用作能够以低水平监测葡萄糖的新一类高度灵敏和稳定的生物传感器。 包含由有机溶剂型聚合物 - 酶体系制造的纳米纤维酶材料的生物传感器可以有效地用于非侵入性透皮生物传感应用。
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