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公开(公告)号：US09788712B2
公开(公告)日：2017-10-17
申请号：US13882236
申请日：2011-11-04
CPC分类号： A61B1/227 , A61B1/063 , A61B1/0638 , A61B1/0684 , A61B5/0075 , A61B5/0084 , A61B5/12 , A61B5/6817
摘要： A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.
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公开(公告)号：US20130289353A1
公开(公告)日：2013-10-31
申请号：US13882236
申请日：2011-11-04
IPC分类号： A61B1/227
CPC分类号： A61B1/227 , A61B1/063 , A61B1/0638 , A61B1/0684 , A61B5/0075 , A61B5/0084 , A61B5/12 , A61B5/6817
摘要： A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.
摘要翻译： 用于确定受试者中耳中异常流体的存在的装置包括细长探针，容纳在细长探针内的第一光源和容纳在细长探针内的第二光源。 细长的探针包括用于检查耳朵的远端。 第一光源构造成将光束传送通过与受试者的中耳相关联的鼓膜，而不刺穿鼓膜。 第二光源构造成将光通过细长探针的远端传送并照亮鼓膜。
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3.发明授权公开(公告)号：US09089331B2
公开(公告)日：2015-07-28
申请号：US12844944
申请日：2010-07-28
CPC分类号： A61B18/12 , A61B5/0066 , A61B5/6852 , A61B18/02 , A61B18/1492 , A61B18/20 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2090/3735
摘要： Systems, methods, and other embodiments associated with characterizing Radio Frequency Ablation (RFA) lesions using Optical Coherence Tomography (OCT) are described. One example method includes acquiring an OCT signal from a Region Of Interest (ROI) in an ablated material. The example method may also include determining whether a lesion was formed by the ablation by analyzing optical properties of the ROI as recorded in the OCT signal.
摘要翻译： 描述了使用光学相干断层扫描（OCT）表征射频消融（RFA）损伤相关联的系统，方法和其它实施例。 一个示例性方法包括从消融材料中的兴趣区域（ROI）获取OCT信号。 示例性方法还可以包括通过分析记录在OCT信号中的ROI的光学特性来确定是否通过消融形成病变。
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公开(公告)号：US07935058B2
公开(公告)日：2011-05-03
申请号：US11807079
申请日：2007-05-25
摘要： Systems and methods are provided for characterizing biomechanical properties of tissue within an eye. A perturbation component introduces a stress to the eye tissue. An imaging component is operative to obtain an image of the eye tissue. A first image of the tissue can be obtained prior to the introduction of the stress and a second image of the tissue can be obtained after the introduction of the stress. An image analysis component compares the first image and the second image as to determine at least one biomechanical property of the tissue.
摘要翻译： 提供了用于表征眼睛内组织的生物力学性质的系统和方法。 扰动成分引起眼睛组织的压力。 成像组件用于获得眼组织的图像。 在引入应力之前可以获得组织的第一图像，并且可以在引入应力之后获得组织的第二图像。 图像分析部件比较第一图像和第二图像，以确定组织的至少一个生物力学性质。
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5.发明申请公开(公告)号：US20090040521A1
公开(公告)日：2009-02-12
申请号：US12154859
申请日：2008-05-27
申请人： Zhilin Hu , Andrew M. Rollins
发明人： Zhilin Hu , Andrew M. Rollins
IPC分类号： G01J3/45
CPC分类号： G01J3/14 , G01B9/02044 , G01B9/02091 , G01B2290/20 , G01J3/02 , G01J3/0208
摘要： This application describes a spectrometer that includes a set of collimating optics to collimate received EMR to produce a collimated EMR. The spectrometer also includes a first dispersive optical element for dispersing the collimated EMR and a second dispersive optical element spaced apart from the first dispersive optical element to produce further dispersed EMR. The first dispersive optical element and the second dispersive optical element cooperate to disperse received EMR into a plurality of even frequency spaced EMR spectra. The spectrometer also includes a detector positioned to receive the EMR after passing though an optical path that includes the set of collimating optics, the first dispersive optical element, the second dispersive optical element, and a set of focusing optics.
摘要翻译： 该应用描述了一种光谱仪，其包括一组准直光学器件以准直所接收的EMR以产生准直的EMR。 光谱仪还包括用于分散准直EMR的第一色散光学元件和与第一色散光学元件间隔开的第二色散光学元件以产生进一步分散的EMR。 第一色散光学元件和第二色散光学元件协作以将接收到的EMR分散到多个均匀间隔的EMR光谱中。 光谱仪还包括一个检测器，定位成在通过包括准直光学器件组，第一分散光学元件，第二分散光学元件和一组聚焦光学器件的光路之后接收EMR。
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6.发明授权Method and system for quantitative image correction for optical coherence tomography 有权光学相干断层扫描定量图像校正方法与系统公开(公告)号：US07072047B2
公开(公告)日：2006-07-04
申请号：US10619574
申请日：2003-07-14
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , A61B3/102 , G01B9/02083
摘要： A method of correcting optical coherence tomography (OCT) image data obtained from a layered media sample includes identifying at least one interface from the obtained OCT data and correcting the OCT data for distortion at the at least one interface. The OCT image data can be corrected for extrinsic distortions, such as those caused by scan geometry, as well as, intrinsic distortions, such as those caused by refraction at each interface.
摘要翻译： 校正从分层介质样本获得的光学相干断层摄影（OCT）图像数据的方法包括从所获得的OCT数据识别至少一个接口，并且在所述至少一个界面处校正OCT数据以进行失真。 OCT图像数据可以被校正为外部失真，例如由扫描几何引起的失真，以及固有失真，例如由每个界面处的折射造成的。
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公开(公告)号：US07006232B2
公开(公告)日：2006-02-28
申请号：US10408745
申请日：2003-04-07
申请人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
发明人： Andrew M. Rollins , Joseph A. Izatt , Volker Westphal , Cameron J. Pedersen , Siavash Yazdanfar
IPC分类号： G01B9/02
CPC分类号： G01B9/02045 , G01B9/02007 , G01B9/02076 , G01B9/02083 , G01B9/02091 , G01B2290/45
摘要： A phase-referenced Doppler optical coherence tomography (OCT) system includes a low-coherence optical radiation source and a reference source co-propagated to a sample arm and a reference arm. The low-coherence and reference optical radiation reflected from the reference and arms is detected by a pair of detectors, yielding OCT and reference interferometric data output signals. The reference interferometric data output signal can be used to correct the OCT interferometric to yield velocity-indicating images that are free from defects due to sample motion and/or interferometer jitter.
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公开(公告)号：US06775007B2
公开(公告)日：2004-08-10
申请号：US10059723
申请日：2002-01-29
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B902
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02007 , G01B9/0201 , G01B9/02028 , G01B9/02091 , G01B2290/35 , G01B2290/40 , G01N21/4795
摘要： Rapid scan optical delay techniques are used in parallel implementation of OCT using a detector and signal processing can be carried out using algorithms. Frequency encoded parallel OCT and multi-path, frequency encoded reference delay networks are used. A large number of frequency-correlated depth channels are used to acquire multiple depth scans of a sample. A different frequency shift (Doppler shift) on each different path length, or delay, is used to obtain simultaneous respective signals and, thus, information about the sample, from different depths in the sample. Reference delay line functions are obtained using bulk optics, integrated optics and fiber optics.
摘要翻译： 快速扫描光延迟技术用于使用检测器并行执行OCT，并且可以使用算法执行信号处理。 使用频率编码的并行OCT和多路径，频率编码的参考延迟网络。 使用大量频率相关深度通道来采集样本的多个深度扫描。 使用每个不同路径长度或延迟上的不同频移（多普勒频移）来从样本中的不同深度获得相应的信号，从而获得关于样本的信息。 参考延迟线功能使用体光学，集成光学和光纤获得。
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9.发明授权Method and apparatus for polarization-sensitive optical coherence tomography 有权用于偏振敏感光学相干断层扫描的方法和装置公开(公告)号：US07826059B2
公开(公告)日：2010-11-02
申请号：US10055282
申请日：2002-01-22
IPC分类号： G01B9/02
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02011 , G01B9/02072 , G01B9/02091 , G01B9/04 , G01B2290/70 , G01N21/4795 , Y10T29/49716
摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflectivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5° (standard deviation 2.2°) over the retardance range 0° to 180°, and fast axis with average error of 4.8° over the range 0° to 180°.
摘要翻译： 一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。 该方法测量净延迟，净快轴和反射率。 通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。 该方法可以使用非偏振维持光纤和单个检测器来实现。 这种PS-OCT方法报道了快轴测量。 在系统的校准测试中，在0°至180°的延迟范围内测量平均误差为7.5°（标准偏差2.2°）的净延迟，平均误差为4.8°的快轴在0°至 180°。
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公开(公告)号：US07102756B2
公开(公告)日：2006-09-05
申请号：US10646202
申请日：2003-08-22
申请人： Joseph A. Izatt , Andrew M. Rollins
发明人： Joseph A. Izatt , Andrew M. Rollins
IPC分类号： G01B9/02
CPC分类号： G01B9/02091 , G01B9/02022 , G01B2290/35 , G01B2290/70 , G01N21/4795
摘要： An interferometer system includes an optical radiation source, an optical circulator connected between the optical radiation source and a sample location for transmitting optical radiation from the optical radiation source to the sample location, an output of the optical circulator connected to direct optical radiation to an optical detector. Various embodiments of such a system are possible. A method of performing OCDR or OCT imaging of a sample which involves the steps of: (a) producing low coherence optical radiation; (b) directing at least some of the low coherence optical radiation through an optical circulator to the sample; (c) reflecting at least some of the low coherence optical radiation off of the sample; and (d) detecting at least some of the reflected low coherence optical radiation and producing an electrical signal corresponding thereto.
摘要翻译： 干涉仪系统包括光辐射源，连接在光辐射源和用于将光辐射从光辐射源传送到采样位置的采样位置之间的光循环器，连接到直接光辐射的光循环器的输出到光学 探测器。 这种系统的各种实施例是可能的。 执行样本的OCDR或OCT成像的方法，其包括以下步骤：（a）产生低相干光辐射; （b）将至少一些低相干光辐射通过光循环器引导到样品; （c）反射离开样品的至少一些低相干光辐射; 和（d）检测至少一些反射的低相干光辐射并产生与其对应的电信号。
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