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公开(公告)号：US20200345000A1
公开(公告)日：2020-11-05
申请号：US16860894
申请日：2020-04-28
Applicant: Regents of the University of Minnesota
Inventor： Bryan Jones , Alptekin Aksan , Advitiya Mahajan
IPC: A01N1/02
Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 μm to 2.5 μm. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.
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2.发明申请公开(公告)号：US20150353399A1
公开(公告)日：2015-12-10
申请号：US14735574
申请日：2015-06-10
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Lawrence Philip Wackett , Alptekin Aksan , Baris Ragip Mutlu , Sujin Yeom , Adi Ish Am Radian , Kelly Aukema
CPC classification number: C02F3/342 , C02F1/76 , C02F2101/38 , C02F2103/42 , C02F2303/04 , C12N1/20 , C12N9/86 , C12Y305/02015 , Y02W10/37
Abstract: This disclosure describes compositions, devices, and methods relating to removal of cyanuric acid from a sample. Generally, the compositions include a cell that expresses at least one enzyme that degrades cyanuric acid and a matrix material that covers at least a portion of the cell. Generally, the methods include contacting the sample with the composition, or a device that includes the composition, and allowing the enzyme of the composition to degrade cyanuric acid in the sample.
Abstract translation: 本公开描述与从样品中除去氰尿酸有关的组合物，装置和方法。 通常，组合物包括表达至少一种降解氰尿酸的酶的细胞和覆盖细胞的至少一部分的基质材料。 通常，所述方法包括使样品与组合物接触，或包含该组合物的装置，并使组合物的酶降解样品中的三聚氰酸。
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公开(公告)号：US10905113B2
公开(公告)日：2021-02-02
申请号：US15349441
申请日：2016-11-11
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Alptekin Aksan , Morwena Jane V. Solivio , Marcus Kramer , Rebekah Less
IPC: A01N1/02
Abstract: This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 μm to 500 μm.
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4.发明申请COMPOSITIONS INCLUDING MATRIX AND BIOMATERIAL, USES THEREOF AND METHODS OF USING THE SAME 审中-公开包括基质和生物材料的组合物，其用途及其使用方法公开(公告)号：US20160175634A1
公开(公告)日：2016-06-23
申请号：US14883053
申请日：2015-10-14
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Adi Ish Am Radian , Jonathan Konstantine Sakkos , Baris Ragip Mutlu , Lawrence Philip Wackett , Alptekin Aksan
CPC classification number: A62D3/02 , A62D2101/04 , A62D2101/26 , B09C1/002 , B09C1/10 , C12N11/02 , C12N11/04 , C12N11/14 , E04H4/1209
Abstract: A composition or article that includes a first silica-matrix encapsulated biomaterial, the first silica-matrix encapsulated biomaterial including a first silica matrix and a first biomaterial; and a second silica-matrix encapsulated biomaterial, the second silica-matrix encapsulated biomaterial including a second silica matrix and a second biomaterial, wherein the first silica-matrix encapsulated biomaterial has at least one property that is different than that of the second silica-matrix encapsulated biomaterial, and wherein the first silica-matrix encapsulated biomaterial forms a first layer and the second silica-matrix encapsulated biomaterial forms a second layer, and the first layer is positioned adjacent the second layer.
Abstract translation: 一种组合物或制品，其包含第一二氧化硅 - 基质包封的生物材料，所述第一二氧化硅基质包封的生物材料包括第一硅石基质和第一生物材料; 和第二二氧化硅 - 基质包封的生物材料，所述第二二氧化硅 - 基质包封的生物材料包括第二硅石基质和第二生物材料，其中所述第一二氧化硅 - 基质包封的生物材料具有不同于所述第二二氧化硅基质的至少一种性质 并且其中所述第一二氧化硅 - 基质包封的生物材料形成第一层，并且所述第二二氧化硅 - 基质密封的生物材料形成第二层，并且所述第一层位于所述第二层附近。
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Patent Agency Ranking
公开(公告)号：US11968975B2
公开(公告)日：2024-04-30
申请号：US16860894
申请日：2020-04-28
Applicant: Regents of the University of Minnesota
Inventor： Bryan Jones , Alptekin Aksan , Advitiya Mahajan
IPC: A01N1/02
CPC classification number: A01N1/0231 , A01N1/0284
Abstract: A lyoprotectant composition includes one or more lyoprotective carbohydrates comprising a non-reducing polysaccharide. The non-reducing polysaccharide may be dextranol. The one or more lyoprotective carbohydrates may include a non-reducing disaccharide. The lyoprotectant composition may be free of or substantially free of reducing sugars. The composition may be in the form of a matrix including a non-woven web of fibers having an average diameter of 0.1 μm to 2.5 μm. A method of storing a liquid biospecimen includes mixing the liquid biospecimen with the lyoprotectant composition to prepare a specimen-loaded composition; drying the specimen-loaded composition; and storing the dried specimen-loaded composition.
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公开(公告)号：US10035719B2
公开(公告)日：2018-07-31
申请号：US14884407
申请日：2015-10-15
Applicant: Regents of the University of Minnesota
Inventor： Paige J. Novak , William Alan Arnold , Alptekin Aksan
IPC: C02F3/34 , C02F11/04 , C12M1/107 , C02F3/30 , B01D69/12 , B01D71/02 , B01D71/38 , C12M1/12 , C12M1/04 , C12M1/00 , C02F3/10 , C02F103/20 , C02F103/26 , C02F103/00
CPC classification number: C02F3/348 , C02F3/102 , C02F3/108 , C02F3/109 , C02F3/341 , C02F2103/001 , C02F2103/002 , C02F2103/005 , C02F2103/20 , C02F2103/26 , C02F2203/006 , C02F2303/10 , C12M21/04 , C12M23/20 , C12M23/24 , C12M23/40 , C12M25/02 , Y02E50/343 , Y02W10/15 , Y02W10/30
Abstract: Systems and methods for producing and extracting a gas from a wastewater fluid including multiple sheets or layers that form a composite membrane. The composite membrane includes a sandwich structure in which a dry matrix layer is surrounded by a first layer including a first immobilized bacteria and a second layer including a second immobilized bacteria. The first immobilized bacteria and the second immobilized bacteria can be configured to produce a gas from one or more compounds in a wastewater fluid. The dry matrix layer can be configured to receive the gas from the first and second layers, and the gas can be extracted from the membrane. The hydrophobic coatings can be disposed between the dry matrix layer and one or both of the first and second layers. An adhesive interface can be disposed between the dry matrix layer and one or both of the first and second layers.
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公开(公告)号：US20200370033A1
公开(公告)日：2020-11-26
申请号：US16959812
申请日：2018-12-31
Applicant: Regents of the University of Minnesota
Inventor： Jonathan Konstantine Sakkos , Alptekin Aksan , Lawrence P. Wackett
Abstract: According to various embodiments of the present disclosure, a biological assembly for performing biocatalysis includes a biological component. The assembly further includes a porous shell layer at least partially coating the biological component. The porous shell layer includes an inorganic network having a cationic component and an anionic component.
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公开(公告)号：US20170135333A1
公开(公告)日：2017-05-18
申请号：US15349441
申请日：2016-11-11
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Alptekin Aksan , Morwena Jane V. Solivio , Marcus Kramer , Rebekah Less
IPC: A01N1/02
CPC classification number: A01N1/0221 , A01N1/0231
Abstract: This disclosure describes a lyoprotectant matrix, compositions including the lyoprotectant matrix and methods for storing a liquid biospecimen using the lyoprotectant matrix. Generally, the lyoprotectant matrix includes a non-woven web having fibers having, as components, at least one lyoprotective carbohydrate and at least one polymer. The matrix further possesses an apparent pore size of 0.1 μm to 500 μm.
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公开(公告)号：US20170087274A1
公开(公告)日：2017-03-30
申请号：US15286861
申请日：2016-10-06
Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA
Inventor： Alptekin Aksan , Allison Hubel , Eduardo Reategui
CPC classification number: A61L27/24 , A61F2/142 , A61L27/025 , A61L27/427 , A61L27/54 , A61L2400/12 , A61L2430/16 , G02B1/043
Abstract: Disclosed herein are synthetic silica-based ocular devices fabricated from a composite material comprising silica and a fibrillar protein, together with methods of making and using the ocular devices.
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