利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

133 条记录 (耗时 0.09 秒)

    Human Nodal and Lefty Homologues
    2.
    发明申请
    Human Nodal and Lefty Homologues 审中-公开
    人类节点和遗传同源物

    公开(公告)号：US20080242604A1

    公开(公告)日：2008-10-02

    申请号：US11466004

    申请日：2006-08-21

    申请人： Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

    发明人： Reinhard Ebner ,  Daniel R. Soppet ,  Steven M. Ruben

    IPC分类号： A61K38/16 ,  C07H21/00 ,  C12N15/63 ,  C12N5/00 ,  A61K31/7052 ,  G01N33/68 ,  A61P17/02 ,  A61P35/00 ,  G01N33/00 ,  C12N15/00 ,  C07K14/00 ,  C07K16/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/495 ,  C12N2799/026 ,  Y10T436/143333

    摘要： The present invention relates to novel Nodal and Lefty proteins which are members of the TGF-β family. In particular, isolated nucleic acid molecules are provided encoding the human Nodal and Lefty proteins. Nodal and Lefty polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Nodal and Lefty activity. Also provided are diagnostic methods for detecting cell growth and differentiation-related disorders and therapeutic methods for treating cell growth and differentiation-related disorders.

    摘要翻译： 本发明涉及作为TGF-β家族成员的新型Nodal和Lefty蛋白。 特别地，提供了分离的核酸分子，其编码人淋巴结和Lefty蛋白质。 还提供了Nodal和Lefty多肽，载体，宿主细胞以及用于制备它们的重组方法。 本发明还涉及用于鉴定淋巴结和Lefty活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测细胞生长和分化相关疾病的诊断方法以及用于治疗细胞生长和分化相关疾病的治疗方法。