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公开(公告)号：US20060121520A1
公开(公告)日：2006-06-08
申请号：US11331987
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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公开(公告)号：US20060275788A1
公开(公告)日：2006-12-07
申请号：US11331978
申请日：2006-01-13
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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3.发明申请Identification of molecular interaction sites in RNA for novel drug discovery 审中-公开鉴定用于新药发现的RNA中的分子相互作用位点公开(公告)号：US20050239737A1
公开(公告)日：2005-10-27
申请号：US11146468
申请日：2005-06-07
申请人： David Ecker , Ranga Sampath , Richard Griffey , John McNeil
发明人： David Ecker , Ranga Sampath , Richard Griffey , John McNeil
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P31/04 , C07H21/02 , C07H21/04 , C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6876
摘要： Methods of identifying molecular interaction sites in eukaryotic and prokaryotic nucleic acids, especially RNA, are described. Secondary structural elements are identified from highly conserved sequences. Methods of preparing databases relating to such molecular interaction sites are also provided herein as are databases themselves. Therapeutic, agricultural, industrial, and other applicability results from interaction of such molecular interaction sites with “small” and other molecules.
摘要翻译： 描述了在真核和原核核酸，特别是RNA中鉴定分子相互作用位点的方法。 二级结构元件由高度保守的序列鉴定。 本文还提供了与这种分子相互作用位点相关的数据库的制备方法，数据库本身也是如此。 这种分子相互作用位点与“小”和其他分子的相互作用导致治疗，农业，工业和其他适用性。
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4.发明申请Methods of rapid detection and identification of bioagents using microRNA 审中-公开使用microRNA快速检测和鉴定生物标本的方法公开(公告)号：US20050123952A1
公开(公告)日：2005-06-09
申请号：US10933928
申请日：2004-09-03
申请人： Richard Griffey , David Ecker
发明人： Richard Griffey , David Ecker
IPC分类号： C12N20060101 , C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6888 , C12Q1/6816 , C12Q2600/156 , C12Q2531/113 , C12Q2525/15 , C12Q2565/627
摘要： Methods for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of microRNA containing nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of microRNA containing nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) or molecular mass which is then matched against a database of base composition signatures or molecular masses, by which the species of the bioagent is identified.
摘要翻译： 通过使用与含有衍生自生物制剂的含有核酸的微RNA的保守序列区杂交的引物与包含核酸扩增的微小RNA的组合来检测和识别未知生物标签（包括细菌，病毒等）的方法， 唯一识别生物标签的序列区域。 结果是“基础组成特征”（BCS）或分子量，然后与基础组成特征或分子量的数据库进行匹配，通过该数据库识别出生物代谢物种。
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5.发明申请公开(公告)号：US20070048735A1
公开(公告)日：2007-03-01
申请号：US10660997
申请日：2003-09-12
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke , James Hannis
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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6.发明申请Molecular interaction sites of 16S ribosomal RNA and methods of modulating the same 审中-公开16S核糖体RNA的分子相互作用位点及其调控方法公开(公告)号：US20050250133A1
公开(公告)日：2005-11-10
申请号：US11070519
申请日：2005-03-01
申请人： David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
发明人： David Ecker , Steven Hofstadler , Richard Griffey , Rangarajan Sampath , Kristin Lowery , Christian Massire
CPC分类号： C12N15/11
摘要： Polynucleotides comprising molecular interaction sites of 16S rRNA that have particular secondary structure are provided. Methods of using such polynucleotides to screen, virtually or actually, combinatorial libraries of compounds that bind thereto are also provided. Method of modulating the activity of 16S rRNA by contacting 16S rRNA or prokaryotic cells containing the same with a compound identified by such virtual or actual screening are also provided.
摘要翻译： 提供了包含具有特定二级结构的16S rRNA的分子相互作用位点的多核苷酸。 还提供了使用这样的多核苷酸筛选，实际上或实际上筛选结合其的化合物的组合文库的方法。 还提供了通过将含有该酶的16S rRNA或原核细胞与通过这种虚拟或实际筛选鉴定的化合物接触来调节16S rRNA活性的方法。
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公开(公告)号：US20050142581A1
公开(公告)日：2005-06-30
申请号：US10934798
申请日：2004-09-03
申请人： Richard Griffey , C. Bennett , David Ecker , Donna Ward , Susan Freier
发明人： Richard Griffey , C. Bennett , David Ecker , Donna Ward , Susan Freier
IPC分类号： C12N20060101 , C12N15/11 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/111 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/11 , C12N2330/10 , C12N2310/3525
摘要： The present invention provides methods for the identification of target molecules that bind to ligands, particularly microRNA ligands and mimics thereof and/or microRNA target molecules and mimics thereof, with as little as millimolar (mM) affinity using mass spectrometry. The methods may be used to determine the mode of binding interaction between two or more of these target molecules to the ligand as well as their relative affinities. Also provided are methods for designing compounds having greater affinity to a ligand by identifying two or more target molecules using mass spectrometry methods of the invention and linking the target molecules together to form a novel compound.
摘要翻译： 本发明提供用于使用质谱法以少至毫摩尔（mM）亲和力鉴定结合配体，特别是微小RNA配体及其模拟物和/或微小RNA靶分子及其模拟物的靶分子的方法。 该方法可用于确定这些靶分子中两个或更多个与配体之间的结合相互作用的模式以及它们的相对亲和力。 还提供了通过使用本发明的质谱方法鉴定两个或更多个靶分子并将靶分子连接在一起以形成新化合物来设计对配体具有更大亲和力的化合物的方法。
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8.发明申请Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby 审中-公开定义数据库的二级结构和用于确定未知生物标签的身份和地理起源的方法公开(公告)号：US20050027459A1
公开(公告)日：2005-02-03
申请号：US10439706
申请日：2003-05-16
申请人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
发明人： David Ecker , Richard Griffey , Rangarajan Sampath , Steven Hofstadler , John McNeil , Stanley Crooke
IPC分类号： A61B20060101 , C12P19/34 , C12Q1/68 , C12Q1/70 , G01N31/00 , G01N33/48 , G01N33/50 , G06F19/00 , G06F19/18
摘要： The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
摘要翻译： 本发明一般涉及研究生物信息学领域，更具体地涉及定义数据库的二级结构。 本发明还涉及询问数据库作为已知生物标签的分子量来源的方法，用于与未知或选择的生物标签的分子量进行比较以确定所选择的生物标签的身份，和/或确定所选生物标记的来源 所选的生物标签。 生物制剂的鉴定对于在诸如生物战争的情况下确定生物制剂的适当治疗过程和/或辐照是重要的。 此外，确定所选择的生物制剂的地理起源将有助于确定潜在的犯罪认同。
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公开(公告)号：US08663932B2
公开(公告)日：2014-03-04
申请号：US13332738
申请日：2011-12-21
申请人： John Dresios , Richard Griffey
发明人： John Dresios , Richard Griffey
CPC分类号： G01N33/6887 , A61K9/1271 , A61K38/02 , A61K38/1777 , A61K39/44 , A61K47/42 , A61K47/6801 , A61K47/6803 , A61K47/6811 , A61K47/6847 , A61K49/0058 , C07K16/18 , G01N33/5088 , G01N33/567 , G01N33/6893 , G01N2333/47 , G01N2333/4712 , G01N2333/78
摘要： The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.
摘要翻译： 本公开涉及用于鉴定特异性暴露于伤口部位的细胞内，细胞外或细胞外基质蛋白以及用于治疗伤口的组合物的蛋白质或肽基序的方法及其使用方法。
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公开(公告)号：US20080160512A1
公开(公告)日：2008-07-03
申请号：US11233630
申请日：2005-09-21
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
摘要翻译： 通过核酸扩增和分子量测定的组合来检测和识别未知生物标签的方法，所述引物与衍生自生物制剂的核酸的保守序列区域杂交的引物以及独特的括号可变序列区域 识别生物制剂。 结果是“基本组成签名”（BCS），然后与基础组合签名的数据库进行匹配，通过该数据库识别生物标签。
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