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    COORDINATING INJECTOR-VALVE SWITCHING WITH PUMP-STROKE TIMING TO MITIGATE EFFECTS OF PRESSURE PULSES
    3.
    发明申请
    COORDINATING INJECTOR-VALVE SWITCHING WITH PUMP-STROKE TIMING TO MITIGATE EFFECTS OF PRESSURE PULSES 有权
    协调注射器阀门切换与泵流时间以减轻压力脉冲的影响

    公开(公告)号：US20120303167A1

    公开(公告)日：2012-11-29

    申请号：US13511691

    申请日：2010-11-11

    申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    IPC分类号： G05D7/00 ,  B01D15/08

    CPC分类号： G01N30/20 ,  B01D15/163 ,  B01D15/166 ,  G01N30/24 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N30/8696 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/8804

    摘要： A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.

    摘要翻译： 液相色谱系统包括具有喷射阀的自动进样器，通过该进样阀将样品环内的低压样品引入高压溶剂混合物流中。 溶剂输送系统包括与自动进样器的注射器阀流体连通以将溶剂混合物流输送到其中的泵。 溶剂输送系统还包括处理器，其计算将溶剂混合物流输送到自动进样器的注射器阀所需的泵的数量。 处理器在输送溶剂混合物流期间计算泵的冲程。 响应于等于所计算的冲程次数的冲程计数，处理器发信号通知自动进样器以在泵传送期间将样品引入溶剂混合物流中，在泵输送期间泵执行压力控制以补偿下降 压力。

    Coordinating injector-valve switching with pump-stroke timing to mitigate effects of pressure pulses
    4.
    发明授权
    Coordinating injector-valve switching with pump-stroke timing to mitigate effects of pressure pulses 有权
    协调喷油阀切换与泵冲程时间，以减轻压力脉冲的影响

    公开(公告)号：US09523662B2

    公开(公告)日：2016-12-20

    申请号：US13511691

    申请日：2010-11-11

    申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    IPC分类号： B01D15/16 ,  G01N30/32 ,  G01N30/34 ,  G01N30/88 ,  G01N30/20 ,  G01N30/24 ,  G01N30/86 ,  G01N30/36

    CPC分类号： G01N30/20 ,  B01D15/163 ,  B01D15/166 ,  G01N30/24 ,  G01N30/32 ,  G01N30/34 ,  G01N30/36 ,  G01N30/8696 ,  G01N2030/322 ,  G01N2030/326 ,  G01N2030/8804

    摘要： A liquid chromatography system includes an autosampler with an injector valve by which a sample at low pressure within a sample loop is introduced into a high-pressure solvent mixture stream. A solvent delivery system includes a pump in fluidic communication with the injector valve of the autosampler to deliver the solvent mixture stream thereto. The solvent delivery system further comprises a processor that calculates a number of strokes of the pump needed to deliver the solvent mixture stream to the injector valve of the autosampler. The processor counts strokes of the pump during delivery of the solvent mixture stream. In response to a stroke count equaling the calculated number of strokes, the processor signals the autosampler to switch the injector valve to introduce the sample to the solvent mixture stream during a pump transfer period within which the pump performs pressure control to compensate for a drop in pressure.

    摘要翻译： 液相色谱系统包括具有喷射阀的自动进样器，通过该进样阀将样品环内的低压样品引入高压溶剂混合物流中。 溶剂输送系统包括与自动进样器的注射器阀流体连通以将溶剂混合物流输送到其中的泵。 溶剂输送系统还包括处理器，其计算将溶剂混合物流输送到自动进样器的注射器阀所需的泵的数量。 处理器在输送溶剂混合物流期间计算泵的冲程。 响应于等于所计算的冲程次数的冲程计数，处理器发信号通知自动进样器以在泵传送期间将样品引入溶剂混合物流中，在泵输送期间泵执行压力控制以补偿下降 压力。

    Coordination of solvent delivery with pre-injection operations in a liquid chromatograph
    5.
    发明授权
    Coordination of solvent delivery with pre-injection operations in a liquid chromatograph 有权
    溶剂输送与液相色谱仪中预注射操作的协调

    公开(公告)号：US09519291B2

    公开(公告)日：2016-12-13

    申请号：US13511667

    申请日：2010-11-11

    申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    IPC分类号： G01N30/24 ,  G05D7/06

    CPC分类号： G05D7/0676 ,  G01N30/24

    摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

    摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。

    COORDINATION OF SOLVENT DELIVERY WITH PRE-INJECTION OPERATIONS IN A LIQUID CHROMATOGRAPH
    6.
    发明申请
    COORDINATION OF SOLVENT DELIVERY WITH PRE-INJECTION OPERATIONS IN A LIQUID CHROMATOGRAPH 有权
    溶剂输送协调与液相色谱法中的预注入操作

    公开(公告)号：US20120304745A1

    公开(公告)日：2012-12-06

    申请号：US13511667

    申请日：2010-11-11

    申请人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    发明人： John Heden ,  John Lamoureux ,  Miguel Soares ,  Guo-Zhong Li

    IPC分类号： G01N1/28 ,  G01N30/84

    CPC分类号： G05D7/0676 ,  G01N30/24

    摘要： A liquid chromatography system includes an autosampler that prepares a sample for introduction to a solvent stream and a solvent delivery system that delivers a solvent stream to the autosampler. Delivery of the solvent stream occurs in parallel with the autosampler's pre-injection operations. The autosampler starts pre-injection operations to make the sample ready for injection into the mixture stream, and the solvent delivery system starts delivery of a solvent stream to the autosampler. The start of the solvent stream delivery is coordinated with the start of the pre-injection operations such that the solvent stream arrives at the autosampler approximately coincident with when the autosampler completes the pre-injection operations, making the sample ready for injection.

    摘要翻译： 液相色谱系统包括制备用于引入溶剂流的样品的自动进样器和将溶剂流输送到自动进样器的溶剂递送系统。 溶剂流的传送与自动进样器的预注射操作并行发生。 自动进样器开始预注射操作，使样品准备好注入混合物流，溶剂输送系统开始将溶剂流输送到自动进样器。 溶剂流输送的开始与预喷射操作的开始协调，使得溶剂流到达自动进样器时与自动进样器完成预喷射操作大致一致，使得样品准备好进行注射。

    Apparatus And Methods For Controlling The Composition Of Fluids In A Fluid Stream
    7.
    发明申请
    Apparatus And Methods For Controlling The Composition Of Fluids In A Fluid Stream 审中-公开
    用于控制流体流中流体的组成的装置和方法

    公开(公告)号：US20130148461A1

    公开(公告)日：2013-06-13

    申请号：US13521313

    申请日：2011-01-10

    申请人： Guo-Zhong Li ,  Kurt Joudrey ,  Ryszard Feldman ,  John Heden ,  Michael Jackson ,  John Angelosanto

    发明人： Guo-Zhong Li ,  Kurt Joudrey ,  Ryszard Feldman ,  John Heden ,  Michael Jackson ,  John Angelosanto

    IPC分类号： B01F15/04

    CPC分类号： B01F15/0404 ,  B01D15/166 ,  G01N30/34 ,  G01N2030/347 ,  G05D11/138

    摘要： Embodiments of the present invention are directed to a devices and methods for forming a desired miture of two or more fluids in a conduit. The devices and methods feature control means having error monitoring means and in response to an error event the control means organizes the packet-group of command signals to form at least one first error packet group. The error event occurs during the period of time in which the at least one error packet-group is received by a selectable value. The at least one error packet-group comprising an order or timing of first command signals and second commands signals to minimize deviation from the desired mixture in the flow of mixture-packets forming the desired mixture of two or more fluids in a conduit during the error event.

    摘要翻译： 本发明的实施例涉及一种用于在管道中形成两种或更多种流体的所需要的装置和方法。 所述设备和方法具有控制装置，其具有错误监视装置，并且响应于错误事件，控制装置组织命令信号的分组组以形成至少一个第一错误分组组。 在通过可选择的值接收至少一个错误分组组的时间段期间发生错误事件。 所述至少一个错误分组组包括第一命令信号和第二命令信号的顺序或定时，以最小化在错误期间在导管中形成两个或更多个流体的期望混合物的混合物包流中的期望混合物的偏差 事件。

    SYSTEM AND METHOD FOR ABSOLUTE QUANTIFICATION OF PROTEINS USING LC/MS
    9.
    发明申请
    SYSTEM AND METHOD FOR ABSOLUTE QUANTIFICATION OF PROTEINS USING LC/MS 有权
    使用LC / MS进行蛋白质绝对定量的系统和方法

    公开(公告)号：US20130054149A1

    公开(公告)日：2013-02-28

    申请号：US13589421

    申请日：2012-08-20

    申请人： Scott Geromanos ,  Jeffrey Cruz Silva ,  Hans Vissers ,  Guo-Zhong Li

    发明人： Scott Geromanos ,  Jeffrey Cruz Silva ,  Hans Vissers ,  Guo-Zhong Li

    IPC分类号： G06F19/00 ,  G01N33/48

    CPC分类号： G01N33/6827 ,  G01N33/6848

    摘要： Absolute quantitation of protein in a sample is provided by comparing a sum or average of the N highest ionization intensities observed for peptides of a particular protein along with a calibration standard. The calibration standard can be in the form of a table generated by prior protein peptide analysis performed using one or more pre-determined proteins. The comparison is used to determine a corresponding absolute quantity of protein based on the observed sum or average of ionization intensities. A simple conversion factor can be applied to the calibration standard value to determine the absolute quantity of protein in the sample.

    摘要翻译： 通过比较特定蛋白质肽观察到的N个最高电离强度的和或平均值以及校准标准来提供样品中蛋白质的绝对定量。 校准标准可以是通过使用一种或多种预定蛋白质进行的先前蛋白质肽分析产生的表格的形式。 该比较用于基于观察到的电离强度的总和或平均值来确定相应的绝对量的蛋白质。 可以将简单的转换因子应用于校准标准值，以确定样品中蛋白质的绝对数量。