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公开(公告)号：US20130256368A1
公开(公告)日：2013-10-03
申请号：US13433140
申请日：2012-03-28
申请人： Richard W. Timm , Mark D. Timmer , Tamara Widenhouse , Matthew M. Lang , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Mark H. Ransick , Katherine J. Schmid , Frederick E. Shelton, IV , Chester O. Baxter, III
发明人： Richard W. Timm , Mark D. Timmer , Tamara Widenhouse , Matthew M. Lang , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Mark H. Ransick , Katherine J. Schmid , Frederick E. Shelton, IV , Chester O. Baxter, III
IPC分类号： A61B17/068 , B23P11/00 , B29C65/00
CPC分类号： A61B17/068 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00477 , A61B2017/00526 , A61B2017/0053 , A61B2017/00561 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00942 , A61B2017/00951 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , A61B2090/0811 , A61L17/005 , A61L2300/102 , A61L2300/232 , A61L2300/45 , F04C2270/0421 , Y10T29/49826
摘要： In various embodiments, a tissue thickness compensator can comprise a film body formed from a continuous extruded shape and, in addition, a fibrous medicament core.
摘要翻译： 在各种实施例中，组织厚度补偿器可以包括由连续挤压形状形成的膜体，并且还包括纤维状药剂芯。
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公开(公告)号：US09241714B2
公开(公告)日：2016-01-26
申请号：US13433140
申请日：2012-03-28
申请人： Richard W. Timm , Mark D. Timmer , Tamara Widenhouse , Matthew M. Lang , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Mark H. Ransick , Katherine J. Schmid , Frederick E. Shelton, IV , Chester O. Baxter, III
发明人： Richard W. Timm , Mark D. Timmer , Tamara Widenhouse , Matthew M. Lang , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Mark H. Ransick , Katherine J. Schmid , Frederick E. Shelton, IV , Chester O. Baxter, III
IPC分类号： A61B17/072 , A61B17/00 , A61B19/00
CPC分类号： A61B17/068 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00477 , A61B2017/00526 , A61B2017/0053 , A61B2017/00561 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00942 , A61B2017/00951 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , A61B2090/0811 , A61L17/005 , A61L2300/102 , A61L2300/232 , A61L2300/45 , F04C2270/0421 , Y10T29/49826
摘要： In various embodiments, a tissue thickness compensator can comprise a film body formed from a continuous extruded shape and, in addition, a fibrous medicament core.
摘要翻译： 在各种实施例中，组织厚度补偿器可以包括由连续挤压形状形成的膜体，并且还包括纤维状药剂芯。
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公开(公告)号：US10123798B2
公开(公告)日：2018-11-13
申请号：US13433141
申请日：2012-03-28
申请人： Chester O. Baxter, III , Frederick E. Shelton, IV , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight , Michael S. Cropper , Sean P. Conlon , Jeffrey S. Swayze
发明人： Chester O. Baxter, III , Frederick E. Shelton, IV , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight , Michael S. Cropper , Sean P. Conlon , Jeffrey S. Swayze
IPC分类号： A61B17/072 , A61B17/00 , A61B17/064 , A61B17/115 , A61B17/29 , A61B17/32
摘要： A tissue thickness compensator may generally comprise a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material and a second layer comprising a second biocompatible material comprising at least one encapsulation, wherein the first biocompatible material expands when contacted with a fluid. The tissue thickness compensator may comprise a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a medicament, and/or pharmaceutically active agent. The encapsulation may comprise a biodegradable material to degrade in vivo and/or in situ. The tissue thickness compensator may comprise a hydrogel. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
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4.发明申请公开(公告)号：US20120241493A1
公开(公告)日：2012-09-27
申请号：US13433141
申请日：2012-03-28
申请人： Chester O. Baxter, III , Frederick E. Shelton, IV , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight , Michael S. Cropper , Sean P. Conlon , Jeffrey S. Swayze
发明人： Chester O. Baxter, III , Frederick E. Shelton, IV , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight , Michael S. Cropper , Sean P. Conlon , Jeffrey S. Swayze
IPC分类号： A61B17/068 , B05D7/00
CPC分类号： A61B17/07207 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/072 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00477 , A61B2017/00495 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/0725 , A61B2017/07257 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2946 , A61B2017/320052 , F04C2270/0421
摘要： A tissue thickness compensator may generally comprise a first layer comprising a first biocompatible material sealingly enclosed in a water impermeable material and a second layer comprising a second biocompatible material comprising at least one encapsulation, wherein the first biocompatible material expands when contacted with a fluid. The tissue thickness compensator may comprise a haemostatic agent, an anti-inflammatory agent, an antibiotic agent, anti-microbial agent, an anti-adhesion agent, an anti-coagulant agent, a medicament, and/or pharmaceutically active agent. The encapsulation may comprise a biodegradable material to degrade in vivo and/or in situ. The tissue thickness compensator may comprise a hydrogel. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
摘要翻译： 组织厚度补偿器通常可以包括密封地封闭在不透水材料中的第一生物相容性材料的第一层和包含至少一种封装的第二生物相容性材料的第二层，其中当与流体接触时第一生物相容性材料膨胀。 组织厚度补偿器可以包括止血剂，抗炎剂，抗生素剂，抗微生物剂，抗粘连剂，抗凝剂，药物和/或药物活性剂。 包封可以包括在体内和/或原位降解的可生物降解的材料。 组织厚度补偿器可以包括水凝胶。 反应产物可以包含流体可溶胀组合物。 还描述了包括组织厚度补偿器的制品以及制造和使用组织厚度补偿器的方法。
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公开(公告)号：US20120241503A1
公开(公告)日：2012-09-27
申请号：US13433167
申请日：2012-03-28
申请人： Chester O. Baxter, III , Frederick E. Shelton, IV , Katherine J. Schmid , Taylor W. Aronhalt , Gregory W. Johnson , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Timothy S. Bedard
发明人： Chester O. Baxter, III , Frederick E. Shelton, IV , Katherine J. Schmid , Taylor W. Aronhalt , Gregory W. Johnson , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Timothy S. Bedard
IPC分类号： A61B17/068
CPC分类号： A61B17/105 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00889 , A61B2017/00951 , A61B2017/0641 , A61B2017/0688 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/320052
摘要： A two-part tissue thickness compensator assembly can include a first tissue thickness compensator configured to be positioned relative to an anvil of a surgical stapler, a second tissue thickness compensator configured to be positioned relative to a staple cartridge of the surgical stapler, and a hinge connecting the first tissue thickness compensator to the second tissue thickness compensator. The first and/or second tissue thickness compensators may include additional engagement features, such as a raised ridge that engages a slot in the anvil and/or the staple cartridge. In certain embodiments, the first and/or second tissue thickness compensators may include an encasement that contains a suitable biologic agent. An end effector assembly may be provided for attachment to a surgical instrument that includes, for example, a staple cartridge, an anvil, a first tissue thickness compensator positioned on the anvil, and a second tissue thickness compensator positioned on the staple cartridge.
摘要翻译： 两部分组织厚度补偿器组件可以包括构造成相对于外科缝合器的砧座定位的第一组织厚度补偿器，构造成相对于外科缝合器的钉仓定位的第二组织厚度补偿器，以及铰链 将第一组织厚度补偿器连接到第二组织厚度补偿器。 第一和/或第二组织厚度补偿器可以包括额外的接合特征，例如接合砧和/或钉仓中的狭槽的凸脊。 在某些实施方案中，第一和/或第二组织厚度补偿器可以包括含有合适的生物制剂的包装。 可以提供端部执行器组件用于附接到手术器械，该手术器械包括例如钉仓，砧座，定位在砧座上的第一组织厚度补偿器和定位在钉仓上的第二组织厚度补偿器。
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公开(公告)号：US09220501B2
公开(公告)日：2015-12-29
申请号：US13433167
申请日：2012-03-28
申请人： Chester O. Baxter, III , Frederick E. Shelton, IV , Katherine J. Schmid , Taylor W. Aronhalt , Gregory W. Johnson , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Timothy S. Bedard
发明人： Chester O. Baxter, III , Frederick E. Shelton, IV , Katherine J. Schmid , Taylor W. Aronhalt , Gregory W. Johnson , John L. Stammen , Gary W. Knight , Christopher W. Widenhouse , William B. Weisenburgh, II , Stephanie A. Mutchler , Timothy S. Bedard
IPC分类号： A61B17/068 , A61B17/064 , A61B17/072 , A61B17/115 , A61B17/00 , A61B17/29 , A61B17/32
CPC分类号： A61B17/105 , A61B17/00491 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/0686 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00526 , A61B2017/0053 , A61B2017/00818 , A61B2017/00889 , A61B2017/00951 , A61B2017/0641 , A61B2017/0688 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/320052
摘要： A two-part tissue thickness compensator assembly can include a first tissue thickness compensator configured to be positioned relative to an anvil of a surgical stapler, a second tissue thickness compensator configured to be positioned relative to a staple cartridge of the surgical stapler, and a hinge connecting the first tissue thickness compensator to the second tissue thickness compensator. The first and/or second tissue thickness compensators may include additional engagement features, such as a raised ridge that engages a slot in the anvil and/or the staple cartridge. In certain embodiments, the first and/or second tissue thickness compensators may include an encasement that contains a suitable biologic agent. An end effector assembly may be provided for attachment to a surgical instrument that includes, for example, a staple cartridge, an anvil, a first tissue thickness compensator positioned on the anvil, and a second tissue thickness compensator positioned on the staple cartridge.
摘要翻译： 两部分组织厚度补偿器组件可以包括构造成相对于外科缝合器的砧座定位的第一组织厚度补偿器，构造成相对于外科缝合器的钉仓定位的第二组织厚度补偿器，以及铰链 将第一组织厚度补偿器连接到第二组织厚度补偿器。 第一和/或第二组织厚度补偿器可以包括额外的接合特征，例如接合砧和/或钉仓中的狭槽的凸脊。 在某些实施方案中，第一和/或第二组织厚度补偿器可以包括含有合适的生物制剂的包装。 可以提供端部执行器组件用于附接到手术器械，该手术器械包括例如钉仓，砧座，定位在砧座上的第一组织厚度补偿器和定位在钉仓上的第二组织厚度补偿器。
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公开(公告)号：US20120241491A1
公开(公告)日：2012-09-27
申请号：US13433098
申请日：2012-03-28
申请人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
发明人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
IPC分类号： A61B17/068
CPC分类号： A61B17/0643 , A61B17/00491 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00526 , A61B2017/0053 , A61B2017/00561 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00938 , A61B2017/00942 , A61B2017/0641 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2937 , A61B2017/320052 , A61B2090/0807
摘要： A tissue thickness compensator may generally comprise a biocompatible material, a first component, and a second component, wherein the first component and second component form a reaction product to expand the tissue thickness compensator. The first component may comprise a first hydrogel precursor, the second component may comprise a second hydrogel precursor, and the reaction product may comprise a hydrogel. The reaction product may be formed in vivo and/or in situ by contacting the first component and the second component. The first component and/or second component may be encapsulated and configured to release the components when ruptured. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
摘要翻译： 组织厚度补偿器通常可以包括生物相容性材料，第一组分和第二组分，其中第一组分和第二组分形成用于扩展组织厚度补偿剂的反应产物。 第一组分可以包含第一水凝胶前体，第二组分可以包含第二水凝胶前体，并且反应产物可以包含水凝胶。 反应产物可以通过使第一组分和第二组分接触而在体内和/或原位形成。 第一组分和/或第二组分可以被封装并构造成在破裂时释放组分。 反应产物可以包含流体可溶胀组合物。 还描述了包括组织厚度补偿器的制品以及制造和使用组织厚度补偿器的方法。
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公开(公告)号：US09301753B2
公开(公告)日：2016-04-05
申请号：US13433098
申请日：2012-03-28
申请人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
发明人： Jeffrey L. Aldridge , Chunlin Yang , Charles J. Scheib , Christopher W. Widenhouse , William B. Weisenburgh, II , John L. Stammen , Mark H. Ransick , Stephanie A. Mutchler , Gary W. Knight
IPC分类号： A61B17/068 , A61B17/064 , A61B17/00 , A61B17/072 , A61B17/115 , A61B17/29 , A61B17/32
CPC分类号： A61B17/0643 , A61B17/00491 , A61B17/0644 , A61B17/068 , A61B17/0682 , A61B17/072 , A61B17/07207 , A61B17/07292 , A61B17/105 , A61B17/1155 , A61B17/2909 , A61B2017/00004 , A61B2017/00314 , A61B2017/00327 , A61B2017/00526 , A61B2017/0053 , A61B2017/00561 , A61B2017/00818 , A61B2017/00862 , A61B2017/00884 , A61B2017/00889 , A61B2017/00893 , A61B2017/00898 , A61B2017/00938 , A61B2017/00942 , A61B2017/0641 , A61B2017/07228 , A61B2017/07235 , A61B2017/07242 , A61B2017/07264 , A61B2017/07271 , A61B2017/07278 , A61B2017/07285 , A61B2017/2908 , A61B2017/2919 , A61B2017/2923 , A61B2017/2927 , A61B2017/2933 , A61B2017/2936 , A61B2017/2937 , A61B2017/320052 , A61B2090/0807
摘要： A tissue thickness compensator may generally comprise a biocompatible material, a first component, and a second component, wherein the first component and second component form a reaction product to expand the tissue thickness compensator. The first component may comprise a first hydrogel precursor, the second component may comprise a second hydrogel precursor, and the reaction product may comprise a hydrogel. The reaction product may be formed in vivo and/or in situ by contacting the first component and the second component. The first component and/or second component may be encapsulated and configured to release the components when ruptured. The reaction product may comprise a fluid-swellable composition. Articles of manufacture comprising the tissue thickness compensator and methods of making and using the tissue thickness compensator are also described.
摘要翻译： 组织厚度补偿器通常可以包括生物相容性材料，第一组分和第二组分，其中第一组分和第二组分形成用于扩展组织厚度补偿剂的反应产物。 第一组分可以包含第一水凝胶前体，第二组分可以包含第二水凝胶前体，并且反应产物可以包含水凝胶。 反应产物可以通过使第一组分和第二组分接触而在体内和/或原位形成。 第一组分和/或第二组分可以被封装并构造成在破裂时释放组分。 反应产物可以包含流体可溶胀组合物。 还描述了包括组织厚度补偿器的制品以及制造和使用组织厚度补偿器的方法。
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9.发明申请Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 审中-公开肠制动诱导腔内治疗物质洗脱装置及方法公开(公告)号：US20110295178A1
公开(公告)日：2011-12-01
申请号：US13104321
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Gregory J. Bakos , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , John V. Hunt , Prasanna Malaviya , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , Suzanne Thompson , Richard W. Timm , James W. Voegele , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
IPC分类号： A61M5/00
CPC分类号： A61F5/0079 , A61K9/0065 , A61M5/14276 , A61M31/002 , A61M39/0208 , A61M2210/106 , A61M2210/1064
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices may be accomplished via stabilized implantable systems and ingestible pills. In one aspect, a method of inducing satiety includes implanting an implant within a lumen of a gastrointestinal tract and retaining a portion of chyme that flows by the implant within a body of the implant. The method further involves re-releasing the retained chyme from the implant into the gastrointestinal tract at a predetermined rate slower than a rate caused by natural peristalsis.
摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置可以通过稳定的可植入系统和可摄取的药丸来实现。 一方面，一种诱导饱腹感的方法包括将植入物植入胃肠道的内腔中，并且将植入物流动的部分保持在植入物的体内。 该方法还包括以比由天然蠕动引起的速率慢的预定速率将留置的食糜从植入物再释放到胃肠道中。
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10.发明申请Intestinal Brake Inducing Intraluminal Therapeutic Substance Eluting Devices and Methods 有权肠制动诱导腔内治疗物质洗脱装置及方法公开(公告)号：US20110295185A1
公开(公告)日：2011-12-01
申请号：US13104313
申请日：2011-05-10
申请人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
发明人： Thomas E. Albrecht , Jeffrey L. Aldridge , Sean P. Conlon , Michael S. Cropper , Denzel Z. Herrera-Davis , Daniel F. Dlugos, JR. , Jason L. Harris , Christopher J. Hess , Prasanna Malaviya , Glenda C. Marsh , Mark S. Ortiz , Mark D. Overmyer , Alessandro Pastorelli , Galen C. Robertson , Frederick E. Shelton, IV , Michael J. Stokes , James W. Voegele , Lauren S. Weaner , William B. Weisenburgh, II , Christopher W. Widenhouse , Tamara S. Vetro Widenhouse , James A. Woodard, JR. , David C. Yates , Mark S. Zeiner , Andrew M. Zwolinski
CPC分类号： A61M31/002 , A61F2/04 , A61F5/0013 , A61F5/0026 , A61F2002/045 , A61K9/0065 , A61M5/14276 , A61M39/0208 , A61M2210/106 , A61M2210/1064 , A61N1/0509 , A61N1/36007 , A61N1/37205
摘要： Methods and devices create an intestinal braking effect, are non-invasive or minimally invasive, and may be reversible. These methods and devices are accomplished via stabilized implantable systems and ingestible pills. In one embodiment, a method of producing satiety comprising the steps of accessing a gastrointestinal tract of a patient and implanting an intraintestinal therapeutic substance eluting implant. The implant is capable of eluting a satiety inducing substance selected from at least one of a nutrient, a specific satiety inducing bio-active substance, pancreatic polypeptides, free fatty acids, cholecystokinin, amino acids, glutamine, lipids, linoleic acid, or a combination thereof, from the implant into the gastrointestinal tract.
摘要翻译： 方法和装置产生肠道制动效果，是非侵入性的或微创的，并且可以是可逆的。 这些方法和装置通过稳定的可植入系统和可摄取的药丸来实现。 在一个实施方案中，产生饱腹感的方法包括以下步骤：进入患者的胃肠道并植入肠内治疗物质洗脱植入物。 植入物能够洗脱选自营养物，特定饱腹感生物活性物质，胰腺多肽，游离脂肪酸，缩胆囊素，氨基酸，谷氨酰胺，脂质，亚油酸或组合中的至少一种的饱腹感受物质 从植入物到胃肠道。
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