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公开(公告)号：US20060263864A1
公开(公告)日：2006-11-23
申请号：US10309407
申请日：2002-12-03
申请人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
发明人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
摘要翻译： 包括编码CreA，AreA，GanB，Gna3，FadA，Gna1，Gpa1，RfeH，An09，PacC，Lys14，LovU，Ste7，Pde2，Nc1，Vps34等基因的调控某些参与次级代谢产物的基因的次级代谢产物生成方法 及其真菌同系物。
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公开(公告)号：US20090075327A1
公开(公告)日：2009-03-19
申请号：US09800863
申请日：2001-03-07
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
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公开(公告)号：US06949356B1
公开(公告)日：2005-09-27
申请号：US09487558
申请日：2000-01-19
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12N15/09 , A61K31/351 , A61K38/00 , A61K45/00 , A61P3/06 , A61P31/04 , A61P35/00 , A61P37/06 , C07D309/30 , C07K14/38 , C07K14/395 , C12N1/15 , C12N15/80 , C12P17/06 , C12P35/00 , C12P35/06 , C12P37/00 , C12R1/66 , C12R1/82 , C12P1/00 , C12P1/02
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
摘要翻译： 本发明涉及由真菌生产次级代谢物。 更具体地，本发明涉及通过真菌改善商业上重要的次级代谢物的生产。 本发明提供了改善真菌中次生代谢物产生的方法，包括调节参与次级代谢产物调节的基因的表达。
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4.发明授权Modulation of secondary metabolite production by zinc binuclear cluster proteins 有权通过锌双核簇蛋白调制次生代谢产物公开(公告)号：US07229784B2
公开(公告)日：2007-06-12
申请号：US10149310
申请日：2001-09-19
申请人： Douglas Holtzman , Kevin T. Madden , Mary Maxon , Amir Sherman
发明人： Douglas Holtzman , Kevin T. Madden , Mary Maxon , Amir Sherman
IPC分类号： C12P1/02
摘要： Methods for improving the production of a secondary metabolite by a fungus by increasing the yield or productivity of the secondary metabolite produced by the fungus are described. The methods include increasing the expression of LYS14, for example, by transforming a cell with a nucleic acid molecule encoding LYS14.
摘要翻译： 描述了通过提高由真菌产生的次级代谢物的产量或生产力来改善真菌产生次级代谢物的方法。 所述方法包括增加LYS14的表达，例如通过用编码LYS14的核酸分子转化细胞。
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公开(公告)号：US20050273271A1
公开(公告)日：2005-12-08
申请号：US11098020
申请日：2005-04-01
申请人： Aibing Rao , David Roof , Mary Maxon , Eugeni Vaisberg
发明人： Aibing Rao , David Roof , Mary Maxon , Eugeni Vaisberg
CPC分类号： G06K9/0014 , C12Q1/04 , G01N15/1463 , G01N2015/1497 , G06K9/48
摘要： An image analysis method characterizes cells based on the elongation. It analyzes an image of the cells and automatically identifies points or locations of high contrast (i.e., regions where the transition from intense signal to weak signal occurs abruptly, over a short distance). Groups of contiguous high contrast points collectively define a putative cell edge. Identified edges are then analyzed to determine whether they are elongated. In one example, edges with relatively low curvature are deemed elongated. The curvature analysis may be accomplished by calculating a shape descriptor for each edge (e.g., calculating the circular variance for each edge). One or more stages of the analysis may employ some degree of filtering, smoothing or other processing to remove certain artifacts in the image.
摘要翻译： 图像分析方法基于伸长率来表征细胞。 它分析单元格的图像，并自动识别高对比度的点或位置（即从短时间内突然发生从强信号到弱信号的转变的区域）。 连续的高对比度组的组合共同定义推定的细胞边缘。 然后分析识别的边缘以确定它们是否伸长。 在一个示例中，具有相对低曲率的边缘被认为是伸长的。 可以通过计算每个边缘的形状描述符（例如，计算每个边缘的圆形方差）来实现曲率分析。 分析的一个或多个阶段可以采用某种程度的滤波，平滑或其他处理来去除图像中的某些伪影。
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公开(公告)号：US06905840B1
公开(公告)日：2005-06-14
申请号：US10414270
申请日：2003-04-14
申请人： David M. Roof , Mary Maxon
发明人： David M. Roof , Mary Maxon
CPC分类号： C12Q1/18
摘要： Provided are methods of identifying potential antifungal agents, and particularly those having antimitotic activity. Fungal cells having double mutations which alter microtubule stability and inhibit cell proliferation are used in the methods. Test compounds are screened to identify those which are able to promote cell proliferation o the mutant fungal cells and counteract the stabilizing effect of the double mutations on the microtubules. High-throughput methods of selecting for the novel antifungal agents are also provided.
摘要翻译： 提供鉴定潜在的抗真菌剂的方法，特别是具有抗有丝分裂活性的那些。 在该方法中使用具有改变微管稳定性和抑制细胞增殖的双重突变的真菌细胞。 筛选测试化合物以鉴定能够促进突变真菌细胞的细胞增殖并抵消双突变对微管的稳定作用的化合物。 还提供了选择新型抗真菌剂的高通量方法。
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