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公开(公告)号：US20060263864A1
公开(公告)日：2006-11-23
申请号：US10309407
申请日：2002-12-03
申请人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
发明人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
摘要翻译： 包括编码CreA，AreA，GanB，Gna3，FadA，Gna1，Gpa1，RfeH，An09，PacC，Lys14，LovU，Ste7，Pde2，Nc1，Vps34等基因的调控某些参与次级代谢产物的基因的次级代谢产物生成方法 及其真菌同系物。
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公开(公告)号：US06949356B1
公开(公告)日：2005-09-27
申请号：US09487558
申请日：2000-01-19
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12N15/09 , A61K31/351 , A61K38/00 , A61K45/00 , A61P3/06 , A61P31/04 , A61P35/00 , A61P37/06 , C07D309/30 , C07K14/38 , C07K14/395 , C12N1/15 , C12N15/80 , C12P17/06 , C12P35/00 , C12P35/06 , C12P37/00 , C12R1/66 , C12R1/82 , C12P1/00 , C12P1/02
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
摘要翻译： 本发明涉及由真菌生产次级代谢物。 更具体地，本发明涉及通过真菌改善商业上重要的次级代谢物的生产。 本发明提供了改善真菌中次生代谢物产生的方法，包括调节参与次级代谢产物调节的基因的表达。
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公开(公告)号：US20090075327A1
公开(公告)日：2009-03-19
申请号：US09800863
申请日：2001-03-07
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
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公开(公告)号：US20050095633A1
公开(公告)日：2005-05-05
申请号：US10952045
申请日：2004-09-28
申请人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
发明人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
IPC分类号： C12N15/09 , C07K14/37 , C07K14/38 , C07K14/385 , C12N15/31 , C12Q1/68 , C07H21/04 , C12N1/18 , C12N9/22 , C12N15/74
CPC分类号： C07K14/385 , C07K14/38
摘要： The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
摘要翻译： 本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。 更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。 本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。
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5.发明授权Use of sublethal concentrations of anti-invasin compounds to therapeutically or prophylactically treat fungal infections 失效使用亚致死浓度的抗入侵化合物治疗或预防性治疗真菌感染公开(公告)号：US07291720B2
公开(公告)日：2007-11-06
申请号：US10278703
申请日：2002-10-21
申请人： Brian Cali , Etchell Cordero , Peter Hecht , Todd Milne , Sofie Salama , Eric Summers , Josh Trueheart
发明人： Brian Cali , Etchell Cordero , Peter Hecht , Todd Milne , Sofie Salama , Eric Summers , Josh Trueheart
CPC分类号： A61K31/7048 , A61K31/00 , A61K31/496 , A61K31/513
摘要： The invention relates to the therapeutic or prophylactic treatment of fungal infections. The invention provides new methods for therapeutically or prophylactically treating fungal infections using sub-lethal concentrations of an anti-invasin compound. The methods according to the invention have fewer toxicology problems than existing methods, and thus can be used prophylactically, as well as for early treatment for high risk patients without a firm diagnosis. The methods according to the invention can also be used to treat an established fungal infection. The invention further provides novel genes that regulate fungal hyphal growth.
摘要翻译： 本发明涉及真菌感染的治疗或预防性治疗。 本发明提供了使用亚致死浓度的抗入侵化合物治疗或预防性治疗真菌感染的新方法。 根据本发明的方法与现有方法相比毒物学问题较少，因此可以预防性使用，也可用于早期治疗高危患者，无需坚定的诊断。 根据本发明的方法也可以用于治疗既定的真菌感染。 本发明还提供调节真菌菌丝生长的新基因。
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公开(公告)号：US20060167075A1
公开(公告)日：2006-07-27
申请号：US11340232
申请日：2006-01-25
申请人： James Pearson , G. Milne , Mark Currie , Brian Cali , John Talley
发明人： James Pearson , G. Milne , Mark Currie , Brian Cali , John Talley
IPC分类号： A61K31/415 , A61K31/365
CPC分类号： A61K31/365 , A61K31/415
摘要： Methods for inhibiting the activity of FAAH and methods for preventing and/or treating certain disorders, e.g., anxiety disorders, sleep disorders and weight disorders, by administering celecoxib, valdecoxib or certain structurally related compounds at a dosage that is sufficient to treat and/or prevent the disorder are described.
摘要翻译： 通过以足以治疗和/或治疗的剂量施用塞来考昔，伐地考昔或某些结构相关的化合物来抑制FAAH的活性的方法和预防和/或治疗某些疾病，例如焦虑症，睡眠障碍和体重障碍的方法 防止这种疾病的描述。
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公开(公告)号：US20050234030A1
公开(公告)日：2005-10-20
申请号：US11028896
申请日：2005-01-03
申请人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman
发明人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman
IPC分类号： A61K31/496 , A61K31/497 , A61K31/501 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D209/18 , C07D209/26 , C07D209/28 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
摘要翻译： 描述了作为一种或多种或CRTH2，COX-2和FAAH的调节剂的某些取代的吲哚。 该化合物可用于治疗疼痛和/或炎症以及其它疾病。
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公开(公告)号：US20070161698A1
公开(公告)日：2007-07-12
申请号：US11685542
申请日：2007-03-13
申请人： Yueh-Tyng Chien , G. Milne , Mark Currie , John Talley , Brian Cali , Barbara Chen , Craig Zimmerman , Jing Yang
发明人： Yueh-Tyng Chien , G. Milne , Mark Currie , John Talley , Brian Cali , Barbara Chen , Craig Zimmerman , Jing Yang
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
摘要翻译： 描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。
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公开(公告)号：US20050234244A1
公开(公告)日：2005-10-20
申请号：US10979794
申请日：2004-11-01
申请人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Craig Zimmerman
发明人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Craig Zimmerman
IPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D409/06 , C07D43/02
CPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D409/06
摘要： Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
摘要翻译： 描述了制备有用的COX-2抑制剂和可用于这些方法的中间体的吲哚的方法。
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公开(公告)号：US20070203209A1
公开(公告)日：2007-08-30
申请号：US11507099
申请日：2006-08-18
申请人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman , Alex Monreal
发明人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman , Alex Monreal
IPC分类号： A61K31/428 , A61K31/405 , C07D417/02 , C07D209/20
CPC分类号： C07D409/06 , A61K31/33 , A61K31/404 , C07D209/18 , C07D417/06
摘要： Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.
摘要翻译： 描述了具有各种活性的吲哚，包括CRTH2的吲哚。 该化合物可用于治疗哮喘，神经性疼痛，指肠炎和其他疾病。
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