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公开(公告)号:US06756019B1
公开(公告)日:2004-06-29
申请号:US09544711
申请日:2000-04-06
申请人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle , David Chazan , Ernest C. W. Lee , Khushroo Gandhi , Calvin Y. H. Chow
发明人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle , David Chazan , Ernest C. W. Lee , Khushroo Gandhi , Calvin Y. H. Chow
IPC分类号: B01L300
CPC分类号: B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要: The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports. Rings are optionally disposed between the cover layer and the body structure and circumferentially around pairs of aligned apertures and ports. The devices also optionally include conductive coatings and membranes. The invention additionally provides methods of controlling the delivery of a composition of material into a microfluidic device.
摘要翻译: 本发明提供了包括主体结构的微流体装置,其包括至少设置在其中的第一微量通道网络。 身体结构具有设置在身体结构中的多个端口,其中每个端口与第一通道网络中的一个或多个通道流体连通。 这些装置还包括覆盖层,其包括穿过覆盖层设置的多个孔。 覆盖层与主体结构配合,由此每个孔与多个端口中的单独一个对准。 环可选地设置在覆盖层和主体结构之间,并且周向地围绕成对的对齐的孔和端口。 所述装置还可选地包括导电涂层和膜。 本发明另外提供了控制将组合物输送到微流体装置中的方法。
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公开(公告)号:US06498353B2
公开(公告)日:2002-12-24
申请号:US10038525
申请日:2001-10-24
申请人: Robert Nagle , Colin B. Kennedy
发明人: Robert Nagle , Colin B. Kennedy
IPC分类号: G01N1506
CPC分类号: B01L3/5027 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N21/0303
摘要: The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.
摘要翻译: 本发明提供了利用光学检测系统的微流体装置和系统,并且其中一个或多个光改变光学元件被集成到微流体装置的主体结构中。 所得到的装置执行在所采用的光学检测方法中使用的光学操作的至少一部分。
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公开(公告)号:US06488897B2
公开(公告)日:2002-12-03
申请号:US09846694
申请日:2001-05-01
申请人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
发明人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
IPC分类号: B01L300
CPC分类号: B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要: The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports.
摘要翻译: 本发明提供了包括主体结构的微流体装置,其包括至少设置在其中的第一微量通道网络。 身体结构具有设置在身体结构中的多个端口,其中每个端口与第一通道网络中的一个或多个通道流体连通。 这些装置还包括覆盖层,其包括穿过覆盖层设置的多个孔。 覆盖层与主体结构配合,由此每个孔与多个端口中的单独一个对准。
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公开(公告)号:US06100541A
公开(公告)日:2000-08-08
申请号:US30535
申请日:1998-02-24
申请人: Robert Nagle , Colin B. Kennedy
发明人: Robert Nagle , Colin B. Kennedy
CPC分类号: B01L3/5027 , B01L3/502715 , G01N21/0303 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487
摘要: The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.
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5.
公开(公告)号:US06316781B1
公开(公告)日:2001-11-13
申请号:US09595728
申请日:2000-06-16
申请人: Robert Nagle , Colin B. Kennedy
发明人: Robert Nagle , Colin B. Kennedy
IPC分类号: G01N1506
CPC分类号: B01L3/5027 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , G01N21/0303
摘要: The present invention provides microfluidic devices and systems that utilize optical detection systems, and where one or more light altering optical elements are integrated into the body structure of the microfluidic device. The resulting devices perform at least a portion of the optical manipulations used in the optical detection method employed.
摘要翻译: 本发明提供了使用光学检测系统的微流体装置和系统,并且其中一个或多个光改变光学元件被集成到微流体装置的主体结构中。 所得到的装置执行在所采用的光学检测方法中使用的光学操作的至少一部分。
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公开(公告)号:US06251343B1
公开(公告)日:2001-06-26
申请号:US09028965
申请日:1998-02-24
申请人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
发明人: Robert S. Dubrow , Colin B. Kennedy , Robert Nagle
IPC分类号: B01L300
CPC分类号: B01L3/502715 , B01L3/5085 , B01L2200/025 , B01L2200/027 , B01L2200/0605 , B01L2200/0689 , B01L2300/0681 , B01L2300/0887 , B01L2300/16 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , G01N27/44791 , G01N2035/00148 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要: The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports.
摘要翻译: 本发明提供了包括主体结构的微流体装置,其包括至少设置在其中的第一微量通道网络。 身体结构具有设置在身体结构中的多个端口,其中每个端口与第一通道网络中的一个或多个通道流体连通。 这些装置还包括覆盖层,其包括穿过覆盖层设置的多个孔。 覆盖层与主体结构配合,由此每个孔与多个端口中的单独一个对准。
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公开(公告)号:US08367021B2
公开(公告)日:2013-02-05
申请号:US13030379
申请日:2011-02-18
CPC分类号: G01N27/44743 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2300/0816 , B01L2300/0887 , B01L2300/1894 , B01L2400/0421 , B01L2400/0481 , G01N27/44717 , G01N27/44791 , G01N30/84 , G01N33/5438 , Y10T29/49826 , Y10T137/8158 , Y10T137/8376
摘要: The invention provides fluidic devices having incorporated electrodes. One device comprises a card and a caddy. The card includes a channel disposed within the card, first and second vias in fluid communication with the channel through an upper surface of the card, and first and second electrodes disposed on the upper surface of the card. The first via and first electrode are positioned adjacent to a first end of the channel, and the second via and second electrode are positioned adjacent to a second end of the channel. The caddy comprises first and second reservoirs. The caddy is attached to the card such that the first reservoir is positioned over the first via and a portion of the first electrode, and the second reservoir is positioned over the second via and a portion of the second electrode. A portion of each of the electrodes is accessible for dry electrical contact.
摘要翻译: 本发明提供具有并入电极的流体装置。 一个设备包括一个卡和一个球童。 卡片包括布置在卡内的通道,通过卡的上表面与通道流体连通的第一和第二通孔以及设置在卡的上表面上的第一和第二电极。 第一通孔和第一电极定位成与通道的第一端相邻,并且第二通孔和第二电极定位成与通道的第二端相邻。 球童包括第一和第二储层。 所述卡盘连接到所述卡片上,使得所述第一储存器位于所述第一通孔上方,并且所述第一电极的一部分位于所述第二通孔和所述第二电极的一部分上。 每个电极的一部分可用于干电接触。
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公开(公告)号:US07449096B2
公开(公告)日:2008-11-11
申请号:US10915744
申请日:2004-08-11
IPC分类号: G01N27/453 , B01L3/00
CPC分类号: B01L3/502715 , B01L2200/027 , B01L2200/10 , B01L2300/0819 , B01L2400/0421
摘要: In a system for operation or handling of a laboratory microchip (41) for chemical processing or analysis, the microchip (41) is mounted in a first physical unit (42). The microchip (41) is arranged on a mounting plate, such that it is readily accessible from the top and thus the fitting and removal of the microchip is considerably simplified. Furthermore, the first physical unit (42) comprises an optical device (43) for contactless detection of the results of the chemical processes conducted on the microchip. The supply systems necessary for the operation of the microchip are arranged in a module unit that has a separable connection with a second physical unit. The proposed modular layout enables ease of interchangeability of the required supply systems and thus, overall, ease of adaptability of the proposed system for various types of microchips.
摘要翻译: 在用于操作或处理用于化学处理或分析的实验室微芯片(41)的系统中,微芯片(41)安装在第一物理单元(42)中。 微芯片(41)布置在安装板上,使得其从顶部容易接近,因此微芯片的装配和移除被大大简化。 此外,第一物理单元(42)包括用于非接触式检测在微芯片上进行的化学处理结果的光学装置(43)。 微芯片操作所需的供电系统被布置在与第二物理单元具有可分离连接的模块单元中。 所提出的模块化布局使得所需供应系统的可互换性变得容易,并且因此总体而言,所提出的系统适用于各种类型的微芯片。
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公开(公告)号:US6153073A
公开(公告)日:2000-11-28
申请号:US372655
申请日:1999-08-11
IPC分类号: G01N31/20 , B01L3/00 , G01N27/447 , G01N37/00 , G01N27/26
CPC分类号: B01L3/50273 , B01L3/502753 , B01L3/502784 , G01N27/44791 , B01L2200/0605 , B01L2300/0816 , B01L2300/0829 , B01L2300/0861 , B01L2300/0867 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , Y10S366/02 , Y10S366/03
摘要: The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.
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公开(公告)号:US08545771B2
公开(公告)日:2013-10-01
申请号:US13290843
申请日:2011-11-07
IPC分类号: G01N27/447 , G01N27/453
CPC分类号: G01N27/44791 , B01L3/5027 , B01L2200/0636 , B01L2200/0689 , B01L2300/021 , B01L2300/0645 , B01L2300/0861 , B01L2400/0421 , G01N27/44717
摘要: The invention provides fluidic devices having incorporated electrodes. One device comprises a card and first and second caddy segments. The first caddy segment comprises first and second electrodes. The second caddy segment comprises first and second reservoirs disposed on a first surface of the second segment, a channel disposed on a second surface of the second segment, and first and second vias extending between the first and second surfaces. The first caddy segment is attached to the first surface of the second caddy segment. The card is attached to the second surface of the second caddy segment such that the card provides a closed surface for the device.
摘要翻译: 本发明提供具有并入电极的流体装置。 一个设备包括卡和第一和第二球童段。 第一个扇区段包括第一和第二电极。 第二球笼段包括设置在第二段的第一表面上的第一和第二储存器,设置在第二段的第二表面上的通道以及在第一和第二表面之间延伸的第一和第二通孔。 第一个球童段连接到第二个球童段的第一个表面。 该卡被附接到第二球童段的第二表面,使得该卡为该装置提供一个封闭的表面。
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