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公开(公告)号：US06683173B2
公开(公告)日：2004-01-27
申请号：US10032307
申请日：2001-12-21
申请人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
发明人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
IPC分类号： C07H2104
CPC分类号： C07H21/00 , C07B2200/11 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , C12Q1/6832 , C40B40/00 , G06F19/22 , C12Q2525/117
摘要： Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译： 提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。
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公开(公告)号：US07368549B2
公开(公告)日：2008-05-06
申请号：US11109923
申请日：2005-04-19
申请人： Robert O. Dempcy , Alexander A Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
发明人： Robert O. Dempcy , Alexander A Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
CPC分类号： C07H19/06 , C07B2200/11 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , C07H21/00 , C12Q1/6832 , C40B40/00 , G06F19/22 , C12Q2525/117
摘要： Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译： 提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。
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3.发明授权Systems and methods for predicting oligonucleotide melting temperature (TmS) 有权用于预测寡核苷酸融合温度（TmS）的系统和方法公开(公告)号：US07715989B2
公开(公告)日：2010-05-11
申请号：US10176972
申请日：2002-06-18
申请人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Karen M. Singer, legal representative , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
发明人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
IPC分类号： G01N33/48
CPC分类号： G06F19/20 , C07B2200/11 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , C07H21/00 , C12Q1/6813 , C12Q1/6827 , C12Q1/6858 , C12Q2600/156 , C40B40/00 , G06F19/22 , C12Q2563/173 , C12Q2527/107 , C12Q2525/117 , C12Q2525/197 , C12Q2541/101 , C12Q2535/125
摘要： Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译： 用于预测寡核苷酸的融解温度（Tm）和其他特征的软件系统和方法，包括修饰的寡核苷酸。 提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。
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公开(公告)号：US07045610B2
公开(公告)日：2006-05-16
申请号：US09796988
申请日：2001-02-28
申请人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
发明人： Robert O. Dempcy , Alexander A. Gall , Sergey G. Lokhov , Irina A. Afonina , Michael J. Singer , Igor V. Kutyavin , Nicolaas M. J. Vermeulen
CPC分类号： C07H19/06 , C07B2200/11 , C07H19/10 , C07H19/16 , C07H19/20 , C07H19/23 , C07H21/00 , C12Q1/6832 , C40B40/00 , G06F19/22 , C12Q2525/117
摘要： Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译： 提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。
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公开(公告)号：US06949367B1
公开(公告)日：2005-09-27
申请号：US09724959
申请日：2000-11-28
CPC分类号： C07H21/02
摘要： Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
摘要翻译： 提供了修饰的寡核苷酸，其含有选自未取代的和3-取代的吡唑并[3,4-d]嘧啶和5-取代的嘧啶的碱，并且任选具有连接的小沟结合剂和报道基团。
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6.发明授权公开(公告)号：US08170580B2
公开(公告)日：2012-05-01
申请号：US12264672
申请日：2008-11-04
申请人： John R. Dingler , Pramodh D. Narayan , Sri Ramanathan , Michael J. Singer , Matthew A. Terry , Matthew B. Trevathan
发明人： John R. Dingler , Pramodh D. Narayan , Sri Ramanathan , Michael J. Singer , Matthew A. Terry , Matthew B. Trevathan
IPC分类号： H04W24/00
摘要： A location based system is provided is configured to provide messages to a recipient based on time and location based information. The a method includes detecting when a mobile user has crossed within a predefined geo-boundary. The method further includes sending a message to the mobile user when the mobile user has crossed within the predefined geo-boundary during a predetermined time period set by an originator of the message.
摘要翻译： 提供基于位置的系统被配置为基于基于时间和位置的信息向接收者提供消息。 该方法包括检测移动用户何时在预定义的地理边界内越过。 该方法还包括当移动用户在由消息的发起者设置的预定时间段内跨越预定义的地理边界时向移动用户发送消息。
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7.发明申请GEO-BOUNDARY TRIGGERED MESSAGING AND SCHEDULE SYSTEM AND METHOD OF USE 有权GEO-BOUNDAL TRIGGERED MESSAGING AND SCHEDULE SYSTEM AND METHOD OF USE公开(公告)号：US20100113066A1
公开(公告)日：2010-05-06
申请号：US12264672
申请日：2008-11-04
申请人： John R. DINGLER , Pramodh D. Narayan , Sri Ramanathan , Michael J. Singer , Matthew A. Terry , Matthew B. Trevathan
发明人： John R. DINGLER , Pramodh D. Narayan , Sri Ramanathan , Michael J. Singer , Matthew A. Terry , Matthew B. Trevathan
摘要： A location based system is provided is configured to provide messages to a recipient based on time and location based information. The a method includes detecting when a mobile user has crossed within a predefined geo-boundary. The method further includes sending a message to the mobile user when the mobile user has crossed within the predefined geo-boundary during a predetermined time period set by an originator of the message.
摘要翻译： 提供基于位置的系统被配置为基于基于时间和位置的信息向接收者提供消息。 该方法包括检测移动用户何时在预定义的地理边界内越过。 该方法还包括当移动用户在由消息的发起者设置的预定时间段内跨越预定义的地理边界时向移动用户发送消息。
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公开(公告)号：US06250127B1
公开(公告)日：2001-06-26
申请号：US09415698
申请日：1999-10-11
申请人： Frank J. Polese , Jack A. Rubin , Michael J. Singer , Walter V. Chichra , Anthony P. Grodio , Vlad Ocher , Henry Escalante , William Dixon , David L. Rose , Stuart Weinshanker
发明人： Frank J. Polese , Jack A. Rubin , Michael J. Singer , Walter V. Chichra , Anthony P. Grodio , Vlad Ocher , Henry Escalante , William Dixon , David L. Rose , Stuart Weinshanker
IPC分类号： B21C2300
CPC分类号： C22F1/04 , C22C32/0063 , H01L21/4878 , H01L2224/16 , H01L2224/73253 , H01L2924/01019 , H01L2924/01078 , H01L2924/1305 , H01L2924/13055 , H01L2924/13091 , H01L2924/16152 , H01L2924/16195 , Y10S72/70 , H01L2924/00
摘要： A process for low cost manufacturing light-weight, heat-dissipating structures such as heatsinks, heat spreaders, and covers or lids for microelectronic components such as flip-chip integrated circuits from difficult-to-machine metal matrix composites such as aluminum silicon carbide (generically referred to as “Al—SiC” or “AlSiC”). The process involves selecting a mass produced quantity of Al—SiC material, forming that material into a thin ribbon, then stamping/coining the ribbon into the structures. The ribbon can be formed by extruding a thin strip from a billet of the Al—SiC material, then plurally rolling it. In this way, commonly available AlSiC composites manufactured in high volume for use in other applications such as cast automotive parts may be used.
摘要翻译： 用于低成本制造轻量级，散热结构的方法，例如散热器，散热器，以及用于微电子部件的覆盖物或盖，例如来自难加工金属基复合材料的倒装芯片集成电路，例如铝碳化硅（ 通常称为“Al-SiC”或“AlSiC”）。 该方法包括选择大量产生的Al-SiC材料量，将该材料形成薄带，然后将带压制/压印成结构。 带可以通过从Al-SiC材料的坯料挤出薄带，然后多次轧制而形成。 以这种方式，可以使用大量制造的常用的AlSiC复合材料，以用于其他应用，例如铸造汽车部件。
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