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公开(公告)号:US5004923A
公开(公告)日:1991-04-02
申请号:US472130
申请日:1990-01-30
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01L3/5027 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0822 , B01L2300/0825 , B01L2300/0864 , B01L2400/0406 , B01L3/502715 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5300779A
公开(公告)日:1994-04-05
申请号:US931719
申请日:1992-08-18
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00 , G01N31/22
CPC分类号: B01F5/0646 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B01L3/502723 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/0092 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5204525A
公开(公告)日:1993-04-20
申请号:US732689
申请日:1991-07-19
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B29C65/08 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5144139A
公开(公告)日:1992-09-01
申请号:US732596
申请日:1991-07-19
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B01F15/0232 , B01F13/0059 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/0684 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L3/5025 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US4948961A
公开(公告)日:1990-08-14
申请号:US177625
申请日:1988-04-05
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01F15/0232 , B01F13/0059 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutiniation particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US5164598A
公开(公告)日:1992-11-17
申请号:US651283
申请日:1991-02-05
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/483 , G01N33/487 , G01N33/49 , G01N33/543 , G01N33/86 , G01N35/00
CPC分类号: B01F5/0646 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , G01N33/86 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0654 , B01L2300/0681 , B01L2300/0816 , B01L2300/0825 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/0694 , B01L3/502723 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/0092 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
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公开(公告)号:US5140161A
公开(公告)日:1992-08-18
申请号:US734597
申请日:1991-07-23
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01L3/5027 , B01F13/0059 , B01F15/0232 , B01F5/0618 , B01F5/0646 , B01F5/0655 , B29C65/08 , B29C66/30223 , B29C66/54 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2300/0816 , B01L2300/0825 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2400/0406 , B01L2400/086 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/73921 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastics devices is also described along with various control devices for use with the basic device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及与基本装置一起使用的各种控制装置。
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公开(公告)号:US4963498A
公开(公告)日:1990-10-16
申请号:US144416
申请日:1988-01-15
申请人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
发明人: Robert S. Hillman , Michael E. Cobb , Jimmy D. Allen , Ian Gibbons , Vladimir E. Ostoich , Laura J. Winfrey
IPC分类号: B01F1/00 , B01F3/12 , B01F5/06 , B01F13/00 , B01L3/00 , B29C45/00 , B29C59/16 , B29C65/08 , G01N15/10 , G01N21/03 , G01N21/47 , G01N21/49 , G01N21/82 , G01N33/49 , G01N33/543 , G01N35/00
CPC分类号: B01F5/0618 , B01F13/0059 , B01F15/0232 , B01F5/0646 , B01F5/0655 , B01L3/5027 , B29C65/08 , B29C66/30223 , B29C66/54 , B29C66/73921 , G01N21/82 , G01N33/4905 , B01F1/00 , B01F2003/125 , B01F2215/0037 , B01L2200/0621 , B01L2300/0816 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0688 , B01L2400/0694 , B29C45/00 , B29C59/16 , B29C65/4895 , B29C66/71 , B29C66/9513 , B29K2055/02 , B29L2031/756 , G01N2015/1025 , G01N2021/0346 , G01N2035/00514 , G01N21/47 , G01N21/49 , G01N33/54366 , Y10S366/03 , Y10S435/81 , Y10T436/2575
摘要: Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the device.
摘要翻译: 提供了涉及至少一个室,至少一个毛细管和涉及提供可检测信号的系统中的至少一个试剂的新方法和装置。 适当地,这些装置提供测量样品,将样品与试剂混合,限定流路并读取结果。 特别感兴趣的是使用导致凝集信息的特异性结合对成员的组合,其中所得到的凝集颗粒可以提供流速的变化,流动介质的光图案或光吸收或散射。 还描述了特别适用于在塑料装置中形成内部室的制造技术以及用于该装置的各种控制装置。
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公开(公告)号:US4797283A
公开(公告)日:1989-01-10
申请号:US100123
申请日:1987-09-23
申请人: Jimmy D. Allen , Michael E. Cobb , Robert S. Hillman , Dennis R. Mungall , Vladimir E. Ostoich , Gary H. Stroy
发明人: Jimmy D. Allen , Michael E. Cobb , Robert S. Hillman , Dennis R. Mungall , Vladimir E. Ostoich , Gary H. Stroy
IPC分类号: A61J3/00 , A61J3/08 , A61J7/00 , A61J7/02 , A61J7/04 , A61K9/70 , A61M37/00 , B65D83/00 , B65H35/00 , G04G15/00
CPC分类号: G04G15/006 , A61J7/0076 , A61J7/0481 , A61K9/7007 , B65H35/006 , A61J7/0418 , A61J7/0445 , Y10T83/4455 , Y10T83/889 , Y10T83/896
摘要: An automatic drug tape dispensing and metering device and a roll of drug tape housed in a small portable dispenser unit. The dispenser contains a measurement device for carefully measuring the length of tape as it is dispensed from the dispenser. A counter monitors the remaining doses of drug tape remaining within the dispenser. A timer device may be provided to alert the patient that it is time for the medicament to be dispensed. As the lid of the dispenser unit is opened, the measured length of drug tape is severed from the roll by a cutter blade incorporated into the lid. The device permits a physician to accurately customize the dosage and administration of the medicament to be given a patient by adjusting the tape length released for each single dose and selecting the time intervals between dosages.
摘要翻译: 一种自动药带分配和计量装置和一卷药带,容纳在小型便携式分配器单元中。 分配器包含测量装置,用于在分配器分配时仔细测量胶带的长度。 计数器监测剩余在分配器内的药物胶带的剩余剂量。 可以提供定时器装置来警告患者现在是分发药物的时间。 当分配器单元的盖打开时,通过结合到盖子中的切割刀片将药带的测量长度从辊切断。 该装置允许医师通过调整为每个单一剂量释放的带长度并选择剂量之间的时间间隔来精确地定制要给予患者的药物的剂量和给药。
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公开(公告)号:US4712460A
公开(公告)日:1987-12-15
申请号:US798780
申请日:1985-11-18
申请人: Jimmy D. Allen , Michael E. Cobb , Robert S. Hillman , Dennis R. Mungall , Vladimir E. Ostoich , Gary H. Stroy
发明人: Jimmy D. Allen , Michael E. Cobb , Robert S. Hillman , Dennis R. Mungall , Vladimir E. Ostoich , Gary H. Stroy
IPC分类号: A61J3/00 , A61J3/08 , A61J7/00 , A61J7/02 , A61J7/04 , A61K9/70 , A61M37/00 , B65D83/00 , B65H35/00 , G04G15/00
CPC分类号: G04G15/006 , A61J7/0076 , A61J7/0481 , A61K9/7007 , B65H35/006 , A61J7/0418 , A61J7/0445 , Y10T83/4455 , Y10T83/889 , Y10T83/896
摘要: An automatic drug tape dispensing and metering device and a roll of drug tape housed in a small portable dispenser unit. The dispenser contains a measurement device for carefully measuring the length of tape as it is dispensed from the dispenser. A counter monitors the remaining doses of drug tape remaining within the dispenser. A timer device may be provided to alert the patient that it is time for the medicament to be dispensed. As the lid of the dispenser unit is opened, the measured length of drug tape is severed from the roll by a cutter blade incorporated into the lid. The device permits a physician to accurately customize the dosage and administration of the medicament to be givne a patient by adjusting the tape length released for each single dose and selecting the time intervals between dosages.
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