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公开(公告)号：US07413659B2
公开(公告)日：2008-08-19
申请号：US11605980
申请日：2006-11-29
IPC分类号： B01D15/08
CPC分类号： G01N30/466 , B01D15/12 , B01D15/166 , B01D15/247 , G01N1/14 , G01N1/38 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/34 , G01N30/74 , G01N30/88 , G01N35/1095 , G01N35/1097 , G01N2001/383 , G01N2030/027 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： To form a smooth gradient and a preparatory liquid chromatographic system having a plurality of syringe type pumps, solvents are alternately drawn and inserted into each cylinder. The solvents are alternately drawn into and through a long narrow path formed of tubing to create axial mixing and spreading out of the interface and then are drawn into the cylinders during the refill stroke of the piston at a sufficiently high velocity to create turbulence. The drawing of the solvents into one side of the cylinder a radial distance from the center creates circular eddy currents.
摘要翻译： 为了形成平滑的梯度和具有多个注射器型泵的准备液相色谱系统，交替地将溶剂抽吸并插入每个气缸中。 这些溶剂被交替地拉入和穿过由管形成的长狭窄的路径，以形成轴向混合并从界面展开，然后在活塞的再充填冲程期间以足够高的速度被吸入气缸中以产生湍流。 将溶剂从中心向径向的一侧绘制成圆形涡流。
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公开(公告)号：US07195461B2
公开(公告)日：2007-03-27
申请号：US10818831
申请日：2004-04-06
CPC分类号： G01N35/1097 , B01D15/12 , B01D15/166 , B01D15/247 , G01N1/38 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/34 , G01N30/466 , G01N30/74 , G01N30/88 , G01N2001/383 , G01N2030/027 , G01N2030/324 , G01N2030/326
摘要： To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding columns. To form a gradient, the pumps are connected to two-way valves that are connected alternately to a first solvent and a second solvent, whereby the time said valve is in a first position controls the amount of solvent drawn from the first reservoir into said pumps and the amount of time in said second position controls the amount of said second solvent drawn from the second reservoir into said pumps and the solvent is mixed in the pumping systems. The detectors are photodiodes mounted to light guides in the flow cells that generate signals related to light absorbance and communicate with a controller, whereby the controller receives signals indicating solute between the light guides and causes collection of solute. An over-pressure system compensates for pressure over a predetermined level.
摘要翻译： 为了经济地进行准备色谱，每个具有多个活塞中的相应一个活塞和多个气缸中的相应一个的多个泵由一个电动机驱动，以将溶剂同时泵送到相应的列中。 为了形成梯度，泵连接到交替地连接到第一溶剂和第二溶剂的二通阀，由此所述阀处于第一位置的时间控制从第一储存器抽吸到所述泵中的溶剂的量 并且所述第二位置中的时间量将从第二储存器抽出的所述第二溶剂的量控制在所述泵中，并且溶剂在泵送系统中混合。 检测器是安装在流通池中的光导的光电二极管，其产生与吸光度相关的信号并与控制器通信，由此控制器接收指示光导之间的溶质并引起溶质的收集的信号。 过压系统补偿超过预定水平的压力。
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公开(公告)号：US07351334B2
公开(公告)日：2008-04-01
申请号：US11605666
申请日：2006-11-28
发明人： Robert W. Allington
IPC分类号： B01D15/08
CPC分类号： G01N30/466 , B01D15/12 , B01D15/166 , B01D15/247 , G01N1/14 , G01N1/38 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/34 , G01N30/74 , G01N30/88 , G01N35/1095 , G01N35/1097 , G01N2001/383 , G01N2030/027 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： A chromatographic monitor includes an array of flow cells with individual light sensors that are collectively an array of photodiodes. The output from the photodiodes are multiplexed. To prevent losing information, the photodiodes are each connected to a different one of a plurality of inputs to the multiplexer through a corresponding one of a plurality of circuits that stores energy during the time the one inlet is not connected through the multiplexer to the signal processing circuitry that forms a part of an absorbance monitor. Preferably, the energy storing circuit is a non-switching circuit with low bandwidth and a flat-topped response to an impulse. This improves the signal to noise ratio. A one pole low pass filter with a (1-1/e) Dirac pulse fall time and equal to the multiplex entire cycle repeat time can perform this function and a one pole low pass filter provides satisfactory results. Still better results can be obtained from a three pole, one or two percent overshoot filter with combined minimum frequency bandwidth and fast rise time. A rise time equal to ½ the multiplex entire cycle.
摘要翻译： 色谱监测器包括具有单独的光传感器的流动池阵列，它们共同地是一组光电二极管。 来自光电二极管的输出被复用。 为了防止丢失信息，光电二极管各自通过多个电路中的相应一个电路将多个输入中的不同的一个输入连接到多个电路，多个电路在一个入口未通过多路复用器连接到信号处理期间存储能量 形成吸光度监测器的一部分的电路。 优选地，能量存储电路是具有低带宽和对脉冲的平顶响应的非开关电路。 这提高了信噪比。 具有（1-1 / e）狄拉克脉冲下降时间并且等于多路复用全周期重复时间的单极低通滤波器可以执行该功能，并且单极低通滤波器提供令人满意的结果。 可以从具有组合的最小频率带宽和快速上升时间的三极，一或二％过冲滤波器获得更好的结果。 上升时间等于多路复用整个周期的1/2。
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公开(公告)号：US06904784B2
公开(公告)日：2005-06-14
申请号：US10082710
申请日：2002-02-25
IPC分类号： B01D15/12 , B01D15/16 , B01D15/24 , G01N1/00 , G01N1/38 , G01N30/02 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/46 , G01N30/74 , G01N30/88
CPC分类号： G01N30/466 , B01D15/12 , B01D15/166 , B01D15/247 , G01N1/14 , G01N1/38 , G01N30/22 , G01N30/24 , G01N30/32 , G01N30/34 , G01N30/74 , G01N30/88 , G01N35/1095 , G01N35/1097 , G01N2001/383 , G01N2030/027 , G01N2030/324 , G01N2030/326 , G01N2030/347
摘要： To economically perform preparatory chromatography, a plurality of pumps each having a corresponding one of a plurality of pistons and a corresponding one of a plurality of cylinders are driven by one motor to draw and pump solvent simultaneously into corresponding columns. To form a gradient, the pumps are connected to two-way valves that are connected alternately to a first solvent and a second solvent, whereby the time said valve is in a first position controls the amount of solvent drawn from the first reservoir into said pumps and the amount of time in said second position controls the amount of said second solvent drawn from the second reservoir into said pumps and the solvent is mixed in the pumping systems. The detectors are photodiodes mounted to light guides in the flow cells that generate signals related to light absorbance and communicate with a controller, whereby the controller receives signals indicating solute between the light guides and causes collection of solute. An over-pressure system compensates for pressure over a predetermined level.
摘要翻译： 为了经济地进行准备色谱，每个具有多个活塞中的相应一个活塞和多个气缸中的相应一个的多个泵由一个电动机驱动，以将溶剂同时泵送到相应的列中。 为了形成梯度，泵连接到交替地连接到第一溶剂和第二溶剂的二通阀，由此所述阀处于第一位置的时间控制从第一储存器抽吸到所述泵中的溶剂的量 并且所述第二位置中的时间量将从第二储存器抽出的所述第二溶剂的量控制在所述泵中，并且溶剂在泵送系统中混合。 检测器是安装在流通池中的光导的光电二极管，其产生与吸光度相关的信号并与控制器通信，由此控制器接收指示光导之间的溶质并引起溶质的收集的信号。 过压系统补偿超过预定水平的压力。
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公开(公告)号：US06997683B2
公开(公告)日：2006-02-14
申请号：US10340817
申请日：2003-01-10
IPC分类号： F04B49/20
CPC分类号： F04B1/02 , F04B11/0058 , F04B11/0083 , F04B49/065 , F04B2203/0209 , F04B2205/05 , F04B2205/09 , G01N30/36 , G01N2030/326
摘要： Pumping for chromatograph applications calls for constant flow at high pressures and for accurate control of liquid composition. A two-cylinder pump, and associated controls provide an accurate, fixed flow rate. During the initial portion of the pumping stroke of a first piston, while its check valve remains closed, a second piston provides all the flow required at a fixed rotational speed. Once the pressure inside the first piston's cylinder has reached that of the discharge and its discharge check valve opens, the control system switches to a constant-pressure control mode, to maintain a fixed flow rate. Constant-pressure control is switched off when the second piston's discharge check valve closes, and pump control returns to fixed rotational speed. Determining the angular displacement at which to effect these control-mode switches is carried out by monitoring changes in the discharge pressure.
摘要翻译： 用于色谱仪应用的泵需要在高压下恒定流动并精确控制液体组成。 双缸泵和相关控制器提供精确的固定流量。 在第一活塞的泵送冲程的初始部分期间，当其止回阀保持关闭时，第二活塞提供以固定转速所需的所有流量。 一旦第一活塞气缸内的压力达到排放压力，排气止回阀打开，则控制系统切换到恒压控制模式，保持固定的流量。 当第二活塞的排放止回阀关闭时，恒压控制关闭，泵控制返回固定的转速。 确定实现这些控制模式开关的角位移是通过监视排出压力的变化进行的。
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公开(公告)号：US07037081B2
公开(公告)日：2006-05-02
申请号：US10763097
申请日：2004-01-22
IPC分类号： F04B49/20
CPC分类号： F04B1/02 , F04B11/0058 , F04B11/0083 , F04B49/065 , F04B2203/0209 , F04B2205/05 , F04B2205/09 , G01N30/36 , G01N2030/326
摘要： Pumping requirements for chromatograph applications are for constant flow at high and variable pressures and for accurate programmable control of liquid composition. A two-cylinder pump, pumping system, and associated controls provide an accurate, fixed flow rate. A low pressure gradient former controls composition. During the initial portion of the pumping stroke of a first piston in which fluid is being compressed due to its finite bulk modulus of elasticity its check valve remains closed, a second piston provides all the flow required at a fixed rotational speed. Then, once the first piston has reached its bottom dead center, the control system switches to a constant-pressure control mode, thereby maintaining the flow rate at a fixed value. Constant-pressure control is again switched off either when the second piston's discharge check valve closes, or when the second piston's inlet check valve opens, and pump control returns to fixed rotational speed. Determining the angular displacement at which to effect these control-mode switches is carried out by monitoring the discharge pressure and storing the values of the angular displacement at which the first temporal derivative of pressure changes rapidly. The invention provides novel arrangement for synchronizing the gradient generator by equating recompression volume to recompression volume of the high pressure pump.
摘要翻译： 色谱仪应用的泵送要求是在高压和可变压力下恒定流量，并可精确控制液体组成。 双缸泵，泵系统和相关控制提供精确的固定流量。 低压梯度成形器控制组成。 在第一活塞的泵送冲程的初始部分期间，其中流体由于其有限的体积弹性模量而被压缩，其止回阀保持关闭，第二活塞提供固定转速所需的所有流量。 然后，一旦第一活塞达到其下止点，则控制系统切换到恒压控制模式，从而将流量维持在固定值。 当第二活塞的排放止回阀关闭时，或者当第二活塞的入口单向阀打开时，恒压控制再次被关闭，并且泵控制返回固定的转速。 确定实现这些控制模式开关的角位移通过监视排出压力并存储压力的第一时间导数快速变化的角位移的值来进行。 本发明提供了通过将再压缩体积与高压泵的再压缩容积相等来使梯度发生器同步的新颖布置。
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公开(公告)号：US5635070A
公开(公告)日：1997-06-03
申请号：US208121
申请日：1994-03-08
申请人： Robert W. Allington , Daniel G. Jameson , Dale A. Davison , Dale Clay , Robin R. Winter , Yoossef Tehrani
发明人： Robert W. Allington , Daniel G. Jameson , Dale A. Davison , Dale Clay , Robin R. Winter , Yoossef Tehrani
IPC分类号： B01D11/00 , B01D11/02 , B01D11/04 , F04B9/04 , F04B15/08 , F04B49/06 , F04B53/08 , F04B53/14 , F16K15/18 , G01F1/34 , G01N1/34 , G01N1/40 , G01N30/02 , G01N30/28 , G01N30/60 , G01N35/04 , G21F5/015
CPC分类号： G01N1/34 , B01D11/0203 , B01D11/0407 , F04B15/08 , F04B49/065 , F04B53/08 , F04B53/143 , F04B9/042 , F16K15/183 , G01F1/34 , G01N1/40 , G01N30/28 , G21F5/015 , F04B2201/0209 , F04B2205/03 , F04B2205/05 , F04B2205/09 , F05B2230/41 , F05C2201/0493 , F05C2253/12 , G01N2001/4033 , G01N2001/4061 , G01N2030/6013 , G01N2035/0441 , G01N30/02
摘要： To pump supercritical carbon dioxide into a supercritical extractor without overpressure in the reservoir and to record the volume being delivered, the pumping speed is controlled and the volume pumped is determined from a pressure-related signal used in a feedback circuit. The feedback controls the velocity of pumping in conjunction with programmed values to avoid destructive reverse torque. A cam in the pump controls piston stroke, has a depressurization portion with an initial slope equal to but in the opposite direction of the final slope, rounded transition slopes, increasing linear velocity to the refill portion and constant velocity in the refill portion.
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公开(公告)号：US6083399A
公开(公告)日：2000-07-04
申请号：US905845
申请日：1997-08-04
IPC分类号： B01D11/02 , B01D11/04 , F04B9/04 , F04B15/08 , F04B49/06 , F04B53/08 , F04B53/14 , F16K15/18 , G01F1/34 , G01N1/34 , G01N1/40 , G01N30/02 , G01N30/28 , G01N30/60 , G01N35/04 , G21F5/015 , B01D11/00
CPC分类号： G21F5/015 , B01D11/0203 , B01D11/0407 , F04B15/08 , F04B49/065 , F04B53/08 , F04B53/143 , F04B9/042 , F16K15/183 , G01F1/34 , G01N1/34 , G01N1/40 , G01N30/28 , F04B2201/0209 , F04B2205/03 , F04B2205/05 , F04B2205/09 , F05B2230/41 , F05C2201/0493 , F05C2253/12 , G01N2001/4033 , G01N2001/4061 , G01N2030/6013 , G01N2035/0441 , G01N30/02
摘要： To avoid deposits on the restrictor that channels extractant into a collector, a heated capillary tube pressure release restrictor, has a thermally insulated outlet end in a collecting trap substantially colder than the capillary tube. The restrictor is heated between the insulation and the capillary tube by Joulean heating. The solvent in the trap is at a pressure of 5 to 200 psi above atmospheric pressure. The thermal resistance of the insulation is selected to reduce the heat added to the extractant to a minimum and yet cause the temperature of the extractant to be in a range within which it is sufficiently hot so it does not freeze when added to the collection solvent but not so hot as to reduce partitioning of the extract and extractant before the extractant leaves the collection solvent. It has a thermal conductivity no greater than 60 BTU's per hour, per square foot, per inch for a one degree Fahrenheit difference.
摘要翻译： 为了避免限流器上的沉积物将通道提取到收集器中，加热的毛细管压力释放限制器在收集阱中具有基本上比毛细管冷的热绝缘出口端。 限流器通过Joulean加热在隔热层和毛细管之间加热。 捕集器中的溶剂的压力高于大气压力5至200 psi。 选择绝缘体的耐热性以将添加到萃取剂中的热量降至最低，并且使提取剂的温度处于足够热的范围内，使其在加入到收集溶剂中时不会冻结，但是 不那么热，以至于在萃取剂离开收集溶剂之前减少提取物和萃取剂的分配。 对于一华氏度的差值，其导热率不大于每小时60BTU，每平方英尺。
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公开(公告)号：US5268102A
公开(公告)日：1993-12-07
申请号：US27077
申请日：1993-03-05
申请人： Dale L. Clay , Robert W. Allington , Phillip B. Liescheski, III , Robin R. Winter , Daniel G. Jameson
发明人： Dale L. Clay , Robert W. Allington , Phillip B. Liescheski, III , Robin R. Winter , Daniel G. Jameson
IPC分类号： B01D11/00 , B01D11/02 , B01D11/04 , F04B9/04 , F04B15/08 , F04B49/06 , F16K15/18 , G01F1/34 , G01N1/34 , G01N1/40 , G01N30/02 , G01N30/28 , G01N30/60 , G01N35/04 , G21F5/015
CPC分类号： F04B9/042 , B01D11/0203 , B01D11/0407 , F04B15/08 , F04B49/065 , F16K15/183 , G01F1/34 , G01N1/34 , G01N1/40 , G01N30/28 , G21F5/015 , F04B2205/03 , F04B2205/05 , F04B2205/09 , F05B2230/41 , F05C2201/0493 , F05C2253/12 , G01N2001/4033 , G01N2001/4061 , G01N2030/6013 , G01N2035/0441 , G01N30/02
摘要： To supply supercritical fluid to an automatic supercritical fluid extractor and collect extract from the extractor, sample holding cartridges are lifted one by one in series by an elevator plug into a pressure chamber. An inlet at the top of the cartridge engages a pressure vessel inlet for the extractant so that extractant flows into the cartridge and into the space between the cartridge and inner walls of the pressure chamber. The outlets from the cartridge and pressure vessel communicate with the collector and exhaust through passageways in the plug. The plug has cleaning ports for cleaning seals and the outlet from the cartridge flows past the seals. The collector lifts vials into place and can precool the collection solvent, and later as part of the collection procedure, heat and pressurize the collector.
摘要翻译： 为了将超临界流体提供给自动超临界流体提取器并从提取器收集提取物，样品保持盒由电梯塞一个接一个地提升到压力室中。 药筒顶部的入口接合用于提取剂的压力容器入口，使得萃取剂流入药筒并进入药筒和压力室的内壁之间的空间。 墨盒和压力容器的出口与收集器连通，并通过插头中的通道排出。 插头具有用于清洁密封件的清洁端口，并且墨盒的出口流过密封件。 收集器将小瓶提升到适当位置，并可预先收集溶剂，然后作为收集过程的一部分，对收集器进行加热和加压。
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公开(公告)号：US5234587A
公开(公告)日：1993-08-10
申请号：US905742
申请日：1992-06-29
IPC分类号： G01N30/34
CPC分类号： G01N30/34 , G01N2030/347
摘要： To supply a programmed gradient to a high pressure pump for introduction into a column, a mixer, degasser and accumulator communicates with the high pressure pump to supply fluid thereto, having a volumn no more than 150 times the chamber volume of the high pressure pump. The mixer, degasser and accumulator includes temperature sensors which sense when the mixer, degasser and accumulator has been emptied to a level where it cannot respond to a demand for fluid from said high pressure pump and provides a signal to a low pressure pump which responds by cycling to again fill the mixer, degasser and accumulator. Upon receiving a demand signal, the low pressure pump fills by drawing fluid from a plurality of fluid sources to compose the gradient being used at that time, with the pump slowing during valve opening and closing so as to avoid cavitation.
摘要翻译： 为了向高压泵提供编程梯度以引入塔中，混合器，脱气器和蓄能器与高压泵连通以向其供应流体，其体积不高于高压泵的室容积的150倍。 混合器，脱气机和蓄能器包括温度传感器，其感测混合器，脱气器和蓄能器何时被排空到不能响应来自所述高压泵的流体需求的水平，并且向低压泵提供信号，该低压泵由 循环再次填充混合器，脱气机和蓄压器。 在接收到需求信号时，通过从多个流体源抽取流体来填充低压泵以构成当时使用的梯度，同时在阀打开和关闭期间泵减慢，以避免空化。
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