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公开(公告)号：US11052484B2
公开(公告)日：2021-07-06
申请号：US15982317
申请日：2018-05-17
IPC分类号： B23K26/16 , B23K26/12 , B23K37/04 , G01N1/04 , B23K26/08 , B23K26/38 , G01N1/28 , B23K26/70 , B23K103/00
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US11067565B2
公开(公告)日：2021-07-20
申请号：US15923840
申请日：2018-03-16
摘要： A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
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公开(公告)号：US20180209964A1
公开(公告)日：2018-07-26
申请号：US15923840
申请日：2018-03-16
CPC分类号： G01N33/5091 , B01L3/50853 , B01L3/545 , B01L2300/02 , G01N35/00732
摘要： A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
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公开(公告)号：US11759888B2
公开(公告)日：2023-09-19
申请号：US17332360
申请日：2021-05-27
IPC分类号： B23K26/16 , B23K26/12 , B23K37/04 , G01N1/04 , B23K26/08 , B23K26/38 , G01N1/28 , B23K26/70 , B23K103/00
CPC分类号： B23K26/16 , B23K26/0853 , B23K26/0876 , B23K26/127 , B23K26/38 , B23K26/702 , B23K37/0408 , B23K37/0443 , G01N1/04 , G01N1/286 , B23K2103/32 , G01N2001/2886
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US20140329249A1
公开(公告)日：2014-11-06
申请号：US14261678
申请日：2014-04-25
发明人： Judith Brand-Meier , Claudio Cherubini , Andreas Drechsler , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
IPC分类号： G01N1/44
CPC分类号： G01N1/44 , C12M33/00 , G01N33/54353
摘要： A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
摘要翻译： 提供了从实体单独地释放包含在生物单元的异质组中的生物单元子组的一个或多个成员的方法。 该方法包括通过接头将包括生物单元亚组的生物单元组结合到实体。 在绑定之后，确定实体上的一个或多个成员的位置。 一旦确定了位置，就将本地化的物理脉冲施加到一个或多个成员。 本地化的物理脉冲通过解离接头单独地从实体释放一个或多个成员。
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公开(公告)号：US20210283714A1
公开(公告)日：2021-09-16
申请号：US17332360
申请日：2021-05-27
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US20180333806A1
公开(公告)日：2018-11-22
申请号：US15982317
申请日：2018-05-17
CPC分类号： B23K26/16 , G01N1/04 , G01N1/286 , G01N2001/2886
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US20150017681A1
公开(公告)日：2015-01-15
申请号：US14325788
申请日：2014-07-08
IPC分类号： G01N33/50
CPC分类号： G01N33/5091 , B01L3/50853 , B01L3/545 , B01L2300/02 , G01N35/00732
摘要： A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
摘要翻译： 一种装置被描述为包括盖子，收集部分支撑件和具有用于接收生物样品的表面的收集部分，所述盖子包括窗口和窗口保持器，所述表面限定第一平面，所述收集部分包括第一， 第二位置标记和第三位置标记，每个位置标记指示中心点标记，所述中心点限定具有与所述第一平面交叉的第二平面，所述装置具有由所述收集部分支撑部分地限定的内部空间， 收集部分，窗口和窗口保持器，窗口允许目视检查位置标记，收集部分支撑件具有流体入口和流体出口，该流体入口和流体出口具有经由内部体积从流体入口到流体出口的流体路径 。
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公开(公告)号：US09939429B2
公开(公告)日：2018-04-10
申请号：US14325788
申请日：2014-07-08
CPC分类号： G01N33/5091 , B01L3/50853 , B01L3/545 , B01L2300/02 , G01N35/00732
摘要： A device is described including a lid, a collection portion support, and a collection portion with a surface for receiving a biological sample, the lid includes a window and a window holder, the surface defines a first plane, the collection portion includes a first, a second, and a third position markers, each position marker indicates a center point marker, the center points define a second plane that has a line of intersection with the first plane, the device has an interior volume defined partially by the collection portion support, the collection portion, the window, and the window holder, the window allows visual inspection of the position markers, the collection portion support has a fluid inlet and a fluid outlet with a fluid path from the fluid inlet to the fluid outlet via the interior volume.
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公开(公告)号：US09638612B2
公开(公告)日：2017-05-02
申请号：US14261678
申请日：2014-04-25
发明人： Judith Brand-Meier , Claudio Cherubini , Andreas Drechsler , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
IPC分类号： C40B80/00 , C40B40/02 , G01N1/44 , G01N33/567 , G01N33/574 , G01N33/543
CPC分类号： G01N1/44 , C12M33/00 , G01N33/54353
摘要： A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
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