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公开(公告)号：US20180095046A1
公开(公告)日：2018-04-05
申请号：US15717720
申请日：2017-09-27
摘要： A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
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公开(公告)号：US11052484B2
公开(公告)日：2021-07-06
申请号：US15982317
申请日：2018-05-17
IPC分类号： B23K26/16 , B23K26/12 , B23K37/04 , G01N1/04 , B23K26/08 , B23K26/38 , G01N1/28 , B23K26/70 , B23K103/00
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US10809219B2
公开(公告)日：2020-10-20
申请号：US15717720
申请日：2017-09-27
摘要： A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
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公开(公告)号：US20210283714A1
公开(公告)日：2021-09-16
申请号：US17332360
申请日：2021-05-27
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US20180333806A1
公开(公告)日：2018-11-22
申请号：US15982317
申请日：2018-05-17
CPC分类号： B23K26/16 , G01N1/04 , G01N1/286 , G01N2001/2886
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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公开(公告)号：US20170100715A1
公开(公告)日：2017-04-13
申请号：US15385020
申请日：2016-12-20
发明人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/022 , B01L2300/041 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , C12Q1/686 , G01N21/0332 , G01N21/253 , G01N21/645 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6484 , G01N2035/00346 , G01N2035/00376 , G01N2201/0627
摘要： An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
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公开(公告)号：US09956559B2
公开(公告)日：2018-05-01
申请号：US15385020
申请日：2016-12-20
发明人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/022 , B01L2300/041 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , C12Q1/686 , G01N21/0332 , G01N21/253 , G01N21/645 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6484 , G01N2035/00346 , G01N2035/00376 , G01N2201/0627
摘要： An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the in-ter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
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公开(公告)号：US09638612B2
公开(公告)日：2017-05-02
申请号：US14261678
申请日：2014-04-25
发明人： Judith Brand-Meier , Claudio Cherubini , Andreas Drechsler , Nicole Gwerder , Martin Kopp , Edwin Oosterbroek , Emad Sarofim
IPC分类号： C40B80/00 , C40B40/02 , G01N1/44 , G01N33/567 , G01N33/574 , G01N33/543
CPC分类号： G01N1/44 , C12M33/00 , G01N33/54353
摘要： A method of individually releasing from an entity one or more members of a sub-group of biological units included in a heterogeneous group of biological units is provided. The method includes binding the group of biological units including the sub-group of biological units to the entity via a linker. Following binding, the location of the one or more members on the entity is determined. Once the location is determined, a localized physical pulse is applied to the one or more members. The localized physical pulse individually releases the one or more members from the entity by dissociating the linker.
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9.发明申请公开(公告)号：US20140220669A1
公开(公告)日：2014-08-07
申请号：US14243524
申请日：2014-04-02
发明人： Claudio Cherubini , Roger Iten , Emad Sarofim , Kurt Schildknecht
CPC分类号： B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/022 , B01L2300/041 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , C12Q1/686 , G01N21/0332 , G01N21/253 , G01N21/645 , G01N21/6452 , G01N35/028 , G01N2021/6419 , G01N2021/6484 , G01N2035/00346 , G01N2035/00376 , G01N2201/0627
摘要： An instrument and a method for the automated thermal treatment of liquid samples are disclosed. An inter-distance between a temperature-controlled receptacle for loading with a plurality of vessels for containing the samples and end portions of optical fibers can be varied, wherein the receptacle is configured to form a thermal communication with the loaded vessels and wherein the optical fibers have first and second end portions. The first end portion and the second end portion of each optical fiber is fixed with respect to each other for transmitting light, wherein the variation of the inter-distance allows the vessels to be loaded to or unloaded from the receptacle and to enable detection of light from the samples contained in the one or more receptacle-loaded vessels.
摘要翻译： 公开了用于液体样品的自动热处理的仪器和方法。 用于装载用于容纳样品和光纤的端部的多个容器的温度控制容器之间的距离可以变化，其中容器被配置为与加载的容器形成热连通，并且其中光纤 具有第一和第二端部。 每个光纤的第一端部和第二端部相对于彼此固定以透射光，其中间距的变化允许容器被装载或从插座卸载并且能够检测光 从包含在一个或多个容器加载的容器中的样品。
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公开(公告)号：US11759888B2
公开(公告)日：2023-09-19
申请号：US17332360
申请日：2021-05-27
IPC分类号： B23K26/16 , B23K26/12 , B23K37/04 , G01N1/04 , B23K26/08 , B23K26/38 , G01N1/28 , B23K26/70 , B23K103/00
CPC分类号： B23K26/16 , B23K26/0853 , B23K26/0876 , B23K26/127 , B23K26/38 , B23K26/702 , B23K37/0408 , B23K37/0443 , G01N1/04 , G01N1/286 , B23K2103/32 , G01N2001/2886
摘要： According to the present invention, a system (1; 1′) for processing at least one substrate (2) containing a dried fluid sample (21) is provided, the system (1; 1′) comprising a support (12) configured to position the substrate (2), a laser device (3) for directing a laser beam (31) to the substrate (2), configured to cut at least one area of the substrate (2) containing the dried fluid sample (21) by means of the laser beam (31), a container holder (4; 4′) configured to hold and position a container (5) for receiving the cut area, the container holder (4; 4′) being arranged below the substrate (2), and an extraction subsystem (6) for extracting fume and/or dust generated when laser cutting the substrate (2), wherein the extraction subsystem (6) consists of at least two extraction components (61, 62) sandwiching the substrate (2) there between. Furthermore, a method for automated processing at least one substrate (2) containing a dried fluid (21) sample by means of such a system (1; 1′) is provided.
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