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![Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity](/abs-image/US/2006/07/04/US07071207B2/abs.jpg.150x150.jpg)
1.发明授权Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity 失效1,5,6,7-四氢吡咯并[3,2-c]吡啶衍生物的制备和用途，用于治疗肥胖症公开(公告)号：US07071207B2
公开(公告)日：2006-07-04
申请号：US10487976
申请日：2002-09-24
申请人： Roger A. Smith , Stephen J. O'Connor , Wai C. Wong , Soongyu Choi , Harold C. Kluender , Jianmei Fan , Zhonghua Zhang , Rico C. Lavoie , Brent L. Podlogar
发明人： Roger A. Smith , Stephen J. O'Connor , Wai C. Wong , Soongyu Choi , Harold C. Kluender , Jianmei Fan , Zhonghua Zhang , Rico C. Lavoie , Brent L. Podlogar
IPC分类号： A61K31/40 , A61K31/395 , A61K31/437 , C07D471/04 , C07D471/14
CPC分类号： C07D471/04
摘要： This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
摘要翻译： 本发明涉及已被发现抑制食欲并引起体重减轻的1,5,6,7-四氢吡咯并[3,2-c]吡啶衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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公开(公告)号：US06960601B2
公开(公告)日：2005-11-01
申请号：US10255049
申请日：2002-09-24
申请人： Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人： Roger A. Smith , Stephen J. O'Connor , Stephan-Nicholas Wirtz , Wai C. Wong , Soongyu Choi , Harold C. E. Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号： A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/445
CPC分类号： C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要： This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
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3.发明申请Substituted 4-Amino-Pyrrolotriazine Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis 有权用于治疗与血管发生相关的超增殖性疾病和疾病的取代的4-氨基 - 吡咯并嗪衍生物公开(公告)号：US20100063038A1
公开(公告)日：2010-03-11
申请号：US12085880
申请日：2006-12-01
申请人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
发明人： Julie Dixon , Barton Phillips , Furahi Achebe , Harold Kluender , Jason Newcom , Kyle Parcella , Stephen J. O'Connor , Steven Magnuson , Zhenqui Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler
IPC分类号： A61K31/53 , C07D487/04 , A61K31/5377 , A61K31/541 , C12N5/00 , A61P35/00
CPC分类号： C07D487/04
摘要： This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及用作治疗高增殖和/或血管生成障碍的那些化合物或组合物作为唯一试剂或与其它活性成分组合的用途。
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4.发明申请PREPARATION AND USE OF BIPHENYL AMINO ACID DERIVATIVES FOR THE TREATMENT OF OBESITY 审中-公开联苯胺酸衍生物用于治疗肥胖症的制备和使用公开(公告)号：US20100234307A1
公开(公告)日：2010-09-16
申请号：US12775249
申请日：2010-05-06
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K38/06 , C07D211/34 , A61K38/05 , A61P3/04 , C07C229/14 , C07D207/48 , A61K31/401 , C07C311/46 , A61K31/198 , C07D209/42
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯氨基酸化合物，组合物和用于治疗或预防肥胖症和相关疾病的方法。
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5.发明授权Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists 失效二取代氨基甲基 - 苯并二氢吡喃衍生物β-3肾上腺素受体激动剂公开(公告)号：US06699860B2
公开(公告)日：2004-03-02
申请号：US10008928
申请日：2001-12-07
申请人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
发明人： Gaetan H. Ladouceur , William H. Bullock , Steven R. Magnuson , Stephen J. O'Connor , Roger A. Smith , Quanrong Shen , Qingjie Liu , Ning Su , Emil J. Velthuisen , Ann-Marie Campbell , Paul P. Ehrlich
IPC分类号： C07D40112
CPC分类号： C07D405/12 , C07D311/58 , C07D407/04 , C07D409/04 , C07D417/04
摘要： This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3受体介导的病症的新型二取代氨基甲基苯并二氢吡喃衍生物。
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6.发明授权2,6-Substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06660752B2
公开(公告)日：2003-12-09
申请号：US10131448
申请日：2002-04-22
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K3144
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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公开(公告)号：US08013166B2
公开(公告)日：2011-09-06
申请号：US12231878
申请日：2008-09-05
申请人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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8.发明授权Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效芳基烷基酸衍生物的制备和用途用于治疗肥胖症公开(公告)号：US07968576B2
公开(公告)日：2011-06-28
申请号：US12206721
申请日：2008-09-08
申请人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger A. Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen J. O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/4168 , A61K31/421 , A61K31/426 , C07D277/42 , C07D277/82 , C07D263/48 , C07D263/58 , C07D233/88 , C07D235/30
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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9.发明申请Preparation and Use of Biphenyl Amino Acid Derivatives for the Treatment of Obesity 审中-公开联苯氨基酸衍生物治疗肥胖症的制备与应用公开(公告)号：US20100016295A1
公开(公告)日：2010-01-21
申请号：US11989506
申请日：2006-07-31
申请人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
发明人： Roger A. Smith , Derek Lowe , Tatiana Shelekhin , Georgiy Bondar , Philip Coish , Stephen J. O'Connor
IPC分类号： A61K31/198 , C07D211/60 , A61P3/04 , A61K31/44 , C07C229/02 , C07D207/00 , A61K31/40 , C07D261/18 , A61K31/42 , C07D307/00 , A61K31/34 , C07D209/42 , C07D279/12 , A61K31/54 , C07D265/30 , A61K31/5375 , C07D241/04 , A61K31/4965
CPC分类号： C07D211/60 , C07C237/36 , C07C237/42 , C07C275/42 , C07C311/46 , C07C311/47 , C07D207/16 , C07D207/48 , C07D209/08 , C07D209/42 , C07D213/75 , C07D307/84 , C07D413/12
摘要： This invention relates to certain biphenyl amino acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译： 本发明涉及某些联苯氨基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。
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10.发明授权2,6-substituted chroman derivatives useful as beta-3 adrenoreceptor agonists 失效用作β-3肾上腺素受体激动剂的2,6-取代的苯并二氢吡喃衍生物公开(公告)号：US06919371B2
公开(公告)日：2005-07-19
申请号：US10666903
申请日：2003-09-17
申请人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
发明人： Stephen J. O'Connor , Gaetan H. Ladouceur , William H. Bullock , Ann-Marie Campbell , Miao Dai , Robert Dally , Jacques Dumas , Holia N. Hatoum-Mokdad , Uday Khire , Wendy Lee , Qingjie Liu , Derek B. Lowe , Steven R. Magnuson , Ning Qi , Tatiana E. Shelekhin , Quanrong Shen , Roger A. Smith , Ming Wang
IPC分类号： A61K31/353 , A61K31/357 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/506 , A61K31/69 , A61P1/04 , A61P3/04 , A61P3/06 , A61P3/10 , A61P5/48 , A61P9/10 , A61P13/12 , C07D311/58 , C07D405/12 , C07D405/14 , C07D407/04 , C07D407/12 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/352
CPC分类号： C07D405/12 , C07D311/58 , C07D405/14 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/14
摘要： This invention relates to novel 2,6-substituted chroman derivatives which are useful in the treatment of beta-3 adrenoreceptor-mediated conditions.
摘要翻译： 本发明涉及可用于治疗β-3肾上腺素受体介导的病症的新的2,6-取代的苯并二氢吡喃衍生物。
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