摘要:
A system, method, and computer program for defining a maintenance frequency of a product, comprising the steps of building a frequency expression for a product element based on a frequency expression language; and associating an action with said frequency expression and appropriate means and computer-readable instructions.
摘要:
The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (βTrCP), and modulate the activity of βTrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.
摘要:
The present invention relates to compounds which bind to Beta Trans-ducin repeat-containing protein (PTrCP), and modulate the activity of 13TrCP. In particular, the invention relates to compounds which demonstrate optimised binding to PTrCP. The invention also relates to pharmaceutical compositions comprising such compounds and the use of such compounds as medicaments, specifically for the treatment of disorders associated with aberrant protein degradation, such as cancer. The preferred binding inhibitors are peptides derived from the motive DSGXXS, e.g. DEGFWE, DDGFWD and Succinyl-EGFWE.
摘要:
The present invention provides modified nucleobase compounds, modified nucleic acid mimetic compounds and various uses thereof. In addition, the invention provides methods for nucleobase characterisation, SNP characterisation and nucleic acid sequencing.
摘要:
Compounds of formula (I) wherein: Q represents an amidino group, a cyano group or a group of formula XYN—, (where X and Y are hydrogen or various groups); Ra represents alkylene; Rb and Rc each represents alkylene, the total number of carbon atoms in said straight chains of Rb and Rc being 7); R2 and R3 each represents hydrogen, or a group of formula R, RCO—, ROCO—, or RNHCO—, where R represents alkyl or aryl; the chiral carbon atom indicated by the asterisk is in the L configuration; Z is an aromatic amino acid residue; n is 0 or 1; R1 represents hydrogen, alkyl or aryl; and W represents hydrogen, alkyl or aryl; and pharmaceutically acceptable salts thereof have the ability to protect against the neuronal damage which may be caused by an ischemic event.
摘要翻译:式(I)化合物其中:Q表示脒基,氰基或式XYN-基团(其中X和Y为氢或各种基团); R“>代表亚烷基; R b和R c各自表示亚烷基,R 3和R c的所述直链中的总碳原子数为7); R 2和R 3各自表示氢或式R,RCO-,ROCO-或RNHCO-的基团,其中R表示烷基或芳基; 由星号表示的手性碳原子为L构型; Z是芳香族氨基酸残基; n为0或1; R 1表示氢,烷基或芳基; W表示氢,烷基或芳基; 及其药学上可接受的盐具有保护免受由缺血事件引起的神经元损伤的能力。
摘要:
A method and apparatus for processing a hydrocarbon fuel comprises: a primary fuel processing reactor for converting a feed stream to a first reformate stream comprising hydrogen; a first hydrogen separator located downstream of the primary fuel processing reactor and fluidly connected thereto for receiving the first reformate stream, the first separator comprising a first membrane for separating the first reformate stream into a first hydrogen-rich stream and a first retentate stream; and a secondary fuel processing reactor fluidly connected to the first separator for receiving and converting the first retentate stream to a second reformate stream comprising hydrogen. A fuel cell power generation system includes the present apparatus and a fuel cell stack fluidly connected thereto for receiving hydrogen-rich streams therefrom.
摘要:
Disclosed is a polymer having an affinity for corneal cells such that it can be used as a substrate for the growth of corneal cells, and so is suitable for use in a corneal bandage, especially in the form of a contact lens in which at least the cornea contacting surface is composed of the polymer. The substrate with an affinity for corneal cells is a copolymer comprising units -(A)- and -(B)- in which the units A are derived from aminoalkyl (alkyl)acrylates and the units B are derived from aryloxy, alkoxy or hydroxyalkyl (alkyl)acrylates, and (alkyl)acrylic acids.
摘要:
In a method of measuring a temperature value associated with melting, softening or decomposition of sample substances, an array of samples is deposited onto a support tray. The support tray is placed onto a heating device provided with temperature sensing means, the support tray is illuminated, and the array of samples is observed by a imaging device. WNle varying the temperature of the heating device, the image data from the imaging device is fed to an image recording device and temperature values associated with each feed of image data are also recorded. The image data is reviewed to detect changes in the image, such as image intensity, at each or selected sample locations, and the temperature of the heating device at an image change associated with a change in state of a sample is logged. Image processing software may be used to detect changes in the image, for example in the intensity of the image, at each sample location. The method may be used as a means for rapidly obtaining a melting point value for comparison of the physical characteristics of the members of a library of samples, especially polymer samples.
摘要:
The present invention provides a method, device and tools for the protection of cadmium welds, holidays or the like on underground pipe portions, wherein the device includes a patch having a fibrous material and a hydrophobic agent that is adapted to form a substantial seal about the pipe portion or otherwise coat the pipe portion with an anti-corrosion agent upon application.
摘要:
The present invention provides a method, device and tools for the protection of cadmium welds, holidays or the like on underground pipe portions, wherein the device includes a patch having a fibrous material and a hydrophobic agent that is adapted to form a substantial seal about the pipe portion or otherwise coat the pipe portion with an anti-corrosion agent upon application.