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    Method for forming polymerized microfluidic devices
    3.
    发明授权
    Method for forming polymerized microfluidic devices 有权
    形成聚合微流体装置的方法

    公开(公告)号：US08394312B1

    公开(公告)日：2013-03-12

    申请号：US13237027

    申请日：2011-09-20

    申请人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh ,  Ronald F. Renzi ,  Mark R. Claudnic

    发明人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh ,  Ronald F. Renzi ,  Mark R. Claudnic

    IPC分类号： B81B7/00

    CPC分类号： B01L3/502707 ,  B81B2201/058 ,  B81C1/00119

    摘要： Methods for making a microfluidic device according to embodiments of the present invention include defining˜cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.

    摘要翻译： 根据本发明的实施例的制造微流体装置的方法包括限定腔。 将聚合物前体溶液定位在空腔中并暴露于光以开始聚合过程并限定微通道。 在一些实施方案中，在聚合过程部分完成之后，进行溶剂漂洗，或引入微通道的新鲜聚合物前体。 这可以促进从微通道去除未聚合的材料，并且能够实现更小的特征尺寸。 聚合物前体溶液可以含有引发剂。 因此，聚合特征可以被具有光活性的引发剂覆盖。 引发剂可以帮助以后将聚丙烯酰胺凝胶结合到微通道表面。

    Method for forming polymerized microfluidic devices
    4.
    发明授权
    Method for forming polymerized microfluidic devices 有权
    形成聚合微流体装置的方法

    公开(公告)号：US08047829B1

    公开(公告)日：2011-11-01

    申请号：US12321881

    申请日：2009-01-26

    申请人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh ,  Ronald F. Renzi ,  Mark R. Claudnic

    发明人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh ,  Ronald F. Renzi ,  Mark R. Claudnic

    IPC分类号： B81B7/00

    CPC分类号： B01L3/502707 ,  B81B2201/058 ,  B81C1/00119

    摘要： Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.

    摘要翻译： 根据本发明的实施例的制造微流体装置的方法包括限定空腔。 将聚合物前体溶液定位在空腔中并暴露于光以开始聚合过程并限定微通道。 在一些实施方案中，在聚合过程部分完成之后，进行溶剂漂洗，或引入微通道的新鲜聚合物前体。 这可以促进从微通道去除未聚合的材料并且使得能够更小的特征尺寸。 聚合物前体溶液可以含有引发剂。 因此，聚合特征可以被具有光活性的引发剂覆盖。 引发剂可以帮助以后将聚丙烯酰胺凝胶结合到微通道表面。

    Methods, microfluidic devices, and systems for detection of an active enzymatic agent
    6.
    发明授权
    Methods, microfluidic devices, and systems for detection of an active enzymatic agent 有权
    方法，微流体装置和用于检测活性酶剂的系统

    公开(公告)号：US08871496B1

    公开(公告)日：2014-10-28

    申请号：US12544982

    申请日：2009-08-20

    申请人： Gregory J. Sommer ,  Anson V. Hatch ,  Anup K. Singh ,  Ying-Chih Wang

    发明人： Gregory J. Sommer ,  Anson V. Hatch ,  Anup K. Singh ,  Ying-Chih Wang

    IPC分类号： C12M1/34 ,  C12M3/00

    CPC分类号： C12Q1/37 ,  B01L3/502753 ,  G01N2333/952 ,  Y10T436/11

    摘要： Embodiments of the present invention provide methods, microfluidic devices, and systems for the detection of an active target agent in a fluid sample. A substrate molecule is used that contains a sequence which may cleave in the presence of an active target agent. A SNAP25 sequence is described, for example, that may be cleaved in the presence of Botulinum Neurotoxin. The substrate molecule includes a reporter moiety. The substrate molecule is exposed to the sample, and resulting reaction products separated using electrophoretic separation. The elution time of the reporter moiety may be utilized to identify the presence or absence of the active target agent.

    摘要翻译： 本发明的实施例提供了用于检测流体样品中的活性靶剂的方法，微流体装置和系统。 使用含有可在活性靶剂存在下切割的序列的底物分子。 描述了例如在肉毒杆菌神经毒素存在下可以切割的SNAP25序列。 底物分子包括报道部分。 将底物分子暴露于样品，并使用电泳分离产生的反应产物。 可以使用报道分子的洗脱时间来鉴定活性靶剂的存在或不存在。

    Devices, systems, and methods for microscale isoelectric fractionation
    7.
    发明授权
    Devices, systems, and methods for microscale isoelectric fractionation 有权
    用于微型等电分馏的装置，系统和方法

    公开(公告)号：US09005417B1

    公开(公告)日：2015-04-14

    申请号：US12243817

    申请日：2008-10-01

    申请人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh

    发明人： Gregory J. Sommer ,  Anson V. Hatch ,  Ying-Chih Wang ,  Anup K. Singh

    IPC分类号： G01N27/447

    CPC分类号： B29D7/01 ,  G01N27/4473 ,  G01N27/44791 ,  G01N27/44795

    摘要： Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.

    摘要翻译： 本发明的实施例提供了用于微尺度等电分离的装置，系统和方法。 样品中的分析物可以根据分馏微通道内的等电点分离。 根据本发明实施例的微流体装置包括至少部分地限定分馏微通道的基底。 分级微通道具有至少一个等于或小于1mm的横截面尺寸。 多个不同pH值的膜设置在微通道中。 在膜的pH之间具有等电点的分析物可以通过等电分馏在第一和第二膜之间的分馏通道的区域中收集。

    Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis
    8.
    发明授权
    Microfluidic device having an immobilized pH gradient and PAGE gels for protein separation and analysis 有权
    具有固定化pH梯度的微流控装置和用于蛋白质分离和分析的PAGE凝胶

    公开(公告)号：US08329016B1

    公开(公告)日：2012-12-11

    申请号：US12551047

    申请日：2009-08-31

    申请人： Gregory J. Sommer ,  Anson V. Hatch ,  Anup K. Singh ,  Ying-Chih Wang

    发明人： Gregory J. Sommer ,  Anson V. Hatch ,  Anup K. Singh ,  Ying-Chih Wang

    IPC分类号： G01N27/453

    CPC分类号： G01N27/44747 ,  G01N27/44773

    摘要： Disclosed is a novel microfluidic device enabling on-chip implementation of a two-dimensional separation methodology. Previously disclosed microscale immobilized pH gradients (IPG) are combined with perpendicular polyacrylamide gel electrophoresis (PAGE) microchannels to achieve orthogonal separations of biological samples. Device modifications enable inclusion of sodium dodecyl sulfate (SDS) in the second dimension. The device can be fabricated to use either continuous IPG gels, or the microscale isoelectric fractionation membranes we have also previously disclosed, for the first dimension. The invention represents the first all-gel two-dimensional separation microdevice, with significantly higher resolution power over existing devices.

    摘要翻译： 公开了一种能够实现二维分离方法的片上实现的新型微流体装置。 将以前公开的微尺度固定化pH梯度（IPG）与垂直聚丙烯酰胺凝胶电泳（PAGE）微通道结合，以实现生物样品的正交分离。 器件修改使得能够在第二维度中包含十二烷基硫酸钠（SDS）。 该器件可以制造成使用连续IPG凝胶，或者我们之前已经公开的微型等电分离膜用于第一维度。 本发明代表第一个全凝胶二维分离微型装置，其具有比现有装置显着更高的分辨率功率。

    Antenna including loop and single-pole antenna members interconnected by an inductor
    9.
    发明申请
    Antenna including loop and single-pole antenna members interconnected by an inductor 审中-公开
    天线包括通过电感器互连的环路和单极天线构件

    公开(公告)号：US20070210964A1

    公开(公告)日：2007-09-13

    申请号：US11442368

    申请日：2006-05-25

    申请人： Tiao-Hsing Tsai ,  Chao-Chiang Kuo ,  Ying-Chih Wang

    发明人： Tiao-Hsing Tsai ,  Chao-Chiang Kuo ,  Ying-Chih Wang

    IPC分类号： H01Q1/38

    CPC分类号： H01Q9/30 ,  H01Q7/005 ,  H01Q21/29

    摘要： An antenna includes loop and single-pole antenna members, and an inductor. The single-pole antenna member is spaced apart from the loop antenna member. The inductor has a first inductor terminal coupled to the loop antenna member, and a second inductor terminal coupled to the single pole antenna member. A desired resonance frequency of the antenna can be achieved by simply adjusting the inductance of the inductor.

    摘要翻译： 天线包括环路和单极天线构件以及电感器。 单极天线构件与环形天线构件间隔开。 电感器具有耦合到环形天线构件的第一电感器端子和耦合到单极天线构件的第二电感器端子。 可以通过简单地调整电感器的电感来实现天线的期望谐振频率。

    Mobile device and manufacturing method thereof
    10.
    发明授权
    Mobile device and manufacturing method thereof 有权
    移动设备及其制造方法

    公开(公告)号：US09331379B2

    公开(公告)日：2016-05-03

    申请号：US13442644

    申请日：2012-04-09

    申请人： Chien-Pin Chiu ,  Hsiao-Wei Wu ,  Tiao-Hsing Tsai ,  Ying-Chih Wang

    发明人： Chien-Pin Chiu ,  Hsiao-Wei Wu ,  Tiao-Hsing Tsai ,  Ying-Chih Wang

    IPC分类号： H01Q1/24 ,  H01Q1/38 ,  H01Q1/06 ,  H01Q13/10 ,  H01Q9/42 ,  H01Q5/371

    CPC分类号： H01Q1/243 ,  H01Q5/371 ,  H01Q9/42 ,  Y10T29/49016

    摘要： A mobile device includes a substrate, a ground element, and a radiation branch. The ground element includes a ground branch, wherein an edge of the ground element has a notch extending into the interior of the ground element so as to form a slot region, and the ground branch partially surrounds the slot region. The radiation branch is substantially inside the slot region, and is coupled to the ground branch of the ground element. The ground branch and the radiation branch form an antenna structure.

    摘要翻译： 移动设备包括基板，接地元件和辐射支路。 接地元件包括接地分支，其中接地元件的边缘具有延伸到接地元件内部的凹口，以便形成槽区域，并且接地支路部分地围绕槽区域。 辐射分支基本上位于槽区内，并且耦合到接地元件的接地支路。 地面分支和辐射分支形成天线结构。